KR20010040939A - β-시트 미메틱 및 이의 사용과 관련된 방법 - Google Patents

β-시트 미메틱 및 이의 사용과 관련된 방법 Download PDF

Info

Publication number
KR20010040939A
KR20010040939A KR1020007008856A KR20007008856A KR20010040939A KR 20010040939 A KR20010040939 A KR 20010040939A KR 1020007008856 A KR1020007008856 A KR 1020007008856A KR 20007008856 A KR20007008856 A KR 20007008856A KR 20010040939 A KR20010040939 A KR 20010040939A
Authority
KR
South Korea
Prior art keywords
compound
mmol
formula
solution
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020007008856A
Other languages
English (en)
Korean (ko)
Inventor
콰버마허엔
맥밀리안마이클케이
칸마이클에스
툴린스키존이
매튜제씨몰
Original Assignee
몰레큐메틱스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 몰레큐메틱스 리미티드 filed Critical 몰레큐메틱스 리미티드
Publication of KR20010040939A publication Critical patent/KR20010040939A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020007008856A 1998-02-12 1998-02-12 β-시트 미메틱 및 이의 사용과 관련된 방법 Ceased KR20010040939A (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/002891 WO1999041276A1 (en) 1998-02-12 1998-02-12 β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF

Publications (1)

Publication Number Publication Date
KR20010040939A true KR20010040939A (ko) 2001-05-15

Family

ID=22266392

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007008856A Ceased KR20010040939A (ko) 1998-02-12 1998-02-12 β-시트 미메틱 및 이의 사용과 관련된 방법

Country Status (9)

Country Link
EP (1) EP1053246B1 (https=)
JP (1) JP2002503674A (https=)
KR (1) KR20010040939A (https=)
AT (1) ATE230414T1 (https=)
AU (1) AU748887B2 (https=)
CA (1) CA2319766A1 (https=)
DE (1) DE69810513T2 (https=)
ES (1) ES2192764T3 (https=)
WO (1) WO1999041276A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1261611A2 (en) * 2000-02-29 2002-12-04 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US20060276497A1 (en) 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
AU2003219809A1 (en) * 2002-02-14 2003-09-04 Myriad Genetics, Inc. Beta-sheet mimetics and composition and methods relating thereto
ES2408932T3 (es) 2008-06-25 2013-06-24 Merck Sharp & Dohme Corp. Síntesis y uso de agentes antibacterianos heterocíclicos
MX378266B (es) 2014-10-06 2025-03-10 Lighthouse Pharmaceuticals Inc Inhibidores de gingipaina de lisina.
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
HUE057289T2 (hu) 2016-08-31 2022-05-28 Jiangsu Hengrui Medicine Co Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása
CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
WO2020007256A1 (zh) 2018-07-02 2020-01-09 江苏恒瑞医药股份有限公司 一种氧代吡啶酰胺类衍生物的晶型及制备方法
CN116120240A (zh) 2019-09-27 2023-05-16 深圳信立泰药业股份有限公司 FXIa抑制剂化合物及其制备方法和医药用途
KR20260032556A (ko) 2023-06-30 2026-03-09 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 다치환된 거대환식 화합물 및 이의 제조 방법과 용도

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
WO1993023403A1 (en) * 1992-05-15 1993-11-25 Merrell Dow Pharmaceuticals Inc. NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
EP0618223A3 (en) * 1993-03-08 1996-06-12 Sandoz Ltd Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
AP9701004A0 (en) * 1994-12-22 1997-07-31 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors.
JPH10508034A (ja) * 1995-03-24 1998-08-04 モレキュメティックス リミテッド βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
NZ334227A (en) * 1996-08-05 2000-10-27 Molecumetics Ltd Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors

Also Published As

Publication number Publication date
DE69810513D1 (de) 2003-02-06
DE69810513T2 (de) 2004-03-18
EP1053246B1 (en) 2003-01-02
EP1053246A1 (en) 2000-11-22
ES2192764T3 (es) 2003-10-16
AU6655798A (en) 1999-08-30
ATE230414T1 (de) 2003-01-15
CA2319766A1 (en) 1999-08-19
AU748887B2 (en) 2002-06-13
JP2002503674A (ja) 2002-02-05
WO1999041276A1 (en) 1999-08-19

Similar Documents

Publication Publication Date Title
EP0915700B1 (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
AU712581B2 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6372744B1 (en) β-sheet mimetics and methods relating to the use thereof
US6245764B1 (en) β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
EP1053246B1 (en) Beta-sheet mimetics and methods relating to the use thereof
WO1996030396A1 (en) β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
US6020331A (en) β-sheet mimetics and use thereof as protease inhibitors
US6699869B1 (en) β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US20030191109A1 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
EP1661566A2 (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
AU733205B2 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
AU5421301A (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20000811

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20030211

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20041129

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20050302

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20041129

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I