ATE230414T1 - Mimetika von beta-faltblatt und verfahren zur verwendung davon - Google Patents
Mimetika von beta-faltblatt und verfahren zur verwendung davonInfo
- Publication number
- ATE230414T1 ATE230414T1 AT98908551T AT98908551T ATE230414T1 AT E230414 T1 ATE230414 T1 AT E230414T1 AT 98908551 T AT98908551 T AT 98908551T AT 98908551 T AT98908551 T AT 98908551T AT E230414 T1 ATE230414 T1 AT E230414T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- protein
- sheet mimetics
- beta sheet
- sheet
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 102000040945 Transcription factor Human genes 0.000 abstract 2
- 108091023040 Transcription factor Proteins 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/002891 WO1999041276A1 (en) | 1998-02-12 | 1998-02-12 | β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE230414T1 true ATE230414T1 (de) | 2003-01-15 |
Family
ID=22266392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98908551T ATE230414T1 (de) | 1998-02-12 | 1998-02-12 | Mimetika von beta-faltblatt und verfahren zur verwendung davon |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1053246B1 (https=) |
| JP (1) | JP2002503674A (https=) |
| KR (1) | KR20010040939A (https=) |
| AT (1) | ATE230414T1 (https=) |
| AU (1) | AU748887B2 (https=) |
| CA (1) | CA2319766A1 (https=) |
| DE (1) | DE69810513T2 (https=) |
| ES (1) | ES2192764T3 (https=) |
| WO (1) | WO1999041276A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1261611A2 (en) * | 2000-02-29 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
| US6534651B2 (en) | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
| US20060276497A1 (en) | 2000-05-09 | 2006-12-07 | Cephalon, Inc. | Novel multicyclic compounds and the use thereof |
| US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| AU2003219809A1 (en) * | 2002-02-14 | 2003-09-04 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
| ES2408932T3 (es) | 2008-06-25 | 2013-06-24 | Merck Sharp & Dohme Corp. | Síntesis y uso de agentes antibacterianos heterocíclicos |
| MX378266B (es) | 2014-10-06 | 2025-03-10 | Lighthouse Pharmaceuticals Inc | Inhibidores de gingipaina de lisina. |
| CN108602787A (zh) | 2015-11-09 | 2018-09-28 | 库特克希米公司 | 精氨酸牙龈卟啉菌蛋白酶的抑制剂 |
| HUE057289T2 (hu) | 2016-08-31 | 2022-05-28 | Jiangsu Hengrui Medicine Co | Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása |
| CN109983012B (zh) | 2016-09-16 | 2023-12-01 | 莱特豪斯制药公司 | 赖氨酸牙龈蛋白酶的酮抑制剂 |
| WO2020007256A1 (zh) | 2018-07-02 | 2020-01-09 | 江苏恒瑞医药股份有限公司 | 一种氧代吡啶酰胺类衍生物的晶型及制备方法 |
| CN116120240A (zh) | 2019-09-27 | 2023-05-16 | 深圳信立泰药业股份有限公司 | FXIa抑制剂化合物及其制备方法和医药用途 |
| KR20260032556A (ko) | 2023-06-30 | 2026-03-09 | 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 | 다치환된 거대환식 화합물 및 이의 제조 방법과 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69317764T2 (de) * | 1992-02-14 | 1998-07-30 | Merrell Pharmaceuticals Inc., Cincinnati, Ohio | Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung |
| WO1993023403A1 (en) * | 1992-05-15 | 1993-11-25 | Merrell Dow Pharmaceuticals Inc. | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
| EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents. |
| AP9701004A0 (en) * | 1994-12-22 | 1997-07-31 | Iaf Biochem Int | Low molecular weight bicyclic thrombin inhibitors. |
| JPH10508034A (ja) * | 1995-03-24 | 1998-08-04 | モレキュメティックス リミテッド | βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用 |
| WO1996030396A1 (en) * | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
| US5877313A (en) * | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
| NZ334227A (en) * | 1996-08-05 | 2000-10-27 | Molecumetics Ltd | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
-
1998
- 1998-02-12 DE DE69810513T patent/DE69810513T2/de not_active Expired - Lifetime
- 1998-02-12 JP JP2000531467A patent/JP2002503674A/ja active Pending
- 1998-02-12 KR KR1020007008856A patent/KR20010040939A/ko not_active Ceased
- 1998-02-12 CA CA002319766A patent/CA2319766A1/en not_active Abandoned
- 1998-02-12 AU AU66557/98A patent/AU748887B2/en not_active Ceased
- 1998-02-12 EP EP98908551A patent/EP1053246B1/en not_active Expired - Lifetime
- 1998-02-12 ES ES98908551T patent/ES2192764T3/es not_active Expired - Lifetime
- 1998-02-12 AT AT98908551T patent/ATE230414T1/de not_active IP Right Cessation
- 1998-02-12 WO PCT/US1998/002891 patent/WO1999041276A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69810513D1 (de) | 2003-02-06 |
| DE69810513T2 (de) | 2004-03-18 |
| EP1053246B1 (en) | 2003-01-02 |
| EP1053246A1 (en) | 2000-11-22 |
| ES2192764T3 (es) | 2003-10-16 |
| AU6655798A (en) | 1999-08-30 |
| CA2319766A1 (en) | 1999-08-19 |
| AU748887B2 (en) | 2002-06-13 |
| JP2002503674A (ja) | 2002-02-05 |
| KR20010040939A (ko) | 2001-05-15 |
| WO1999041276A1 (en) | 1999-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |