KR20000031276A - Manufacturing method of cleaning solution for washing nasal cavity - Google Patents

Abstract

PURPOSE: A manufacturing method of cleaning solution for washing nasal cavity is provided which prevents acute rhinitis, chronic rhinitis, etiologh, and so forth. CONSTITUTION: A cleaning solution comprises 100% of botanic raw materials of which 90%are used as herb medicine. The main components of cleaning solution are Sanguisorbae radix, liquorice root, and Saururus chinessis. Other components are elm root, green tea leaf, magnolia flower bud and ethanol. Minor component are peppermint, sponge gourd root, ginger, plantain stem, salt, and aroma favor extracted from fragrant plants. A method for manufacturing the cleaning solution is characterized by comprising the steps and methods of: mixing botanic raw materials adding spirits therein; condensing and then isolating; and mixing many other herb medicines.

Description

Method of preparing a cleaning solution for washing the nose (Relieves rhinitis prevention)

The present invention directly disinfects and dilutes harmful components adsorbed in the nasal cavity by directly inserting the cleaning solution prepared by a known method into the nasal cavity, thereby maintaining cleanliness in the nasal cavity, thereby causing acute rhinitis, chronic rhinitis, and allergy. Symptoms such as Etiologh and Atrophic Rhinitis (Horbis) help to alleviate and prevent symptoms. The function of the nose is important for the sense of smell, function as the beginning of the upper respiratory tract, intake control (cleaning, heating, humidity), primary defense against infection, self-cleaning function, nasal resonance function, etc. However, the mouth is washed daily and the nasal cavity has been almost ignored. However, air pollution due to the destruction of the natural environment is so severe that the primary cause of increase, drug, occupational, irritant, food, atrophy and seasonality are increasing allergic and infectious rhinitis caused by bacteria. In the case of acute rhinitis, the infected cough droplets from the patient's cough and respiratory tract enter the nasal cavity and are airborne diseases, but are transmitted directly by kiss or hand. Infections caused by these viruses do not have specific treatments, and most of them require mass therapy such as analgesics, antipyretics, relaxation, temperature control, and nutrition. Sometimes topical mucoconstrictors are used, but with prolonged use, drug rhinitis results. In the case of chronic rhinitis, bacterial rhinitis and special bacterial rhinitis are the main cause of most rhinitis such as infectious thickening rhinitis is the outbreak of the path to the outside of the nose. To prevent the nasal physiology by washing more than twice a day. However, clinical results confirmed that the cleaning solution of the present invention had no effect on specific rhinitis (membranous, non gonorrhea, non syphilis, non-tuberculosis). In particular, allergic rhinitis is paroxysmal, type 1 hyperreactive disease of the nasal mucosa, the main symptom of which is recurrent remission, water repellent nasal passage, nasal obstruction. Major allergens include dust mites, pollen, mold, pet hair and dandruff, and cockroach debris. In addition, air pollutant is the main cause of asthma and allergic rhinitis. Dust, sulfur oxides (sulphite gas), nitrogen oxides (nitrogen dioxide), ozone, carbon monoxide, tobacco smoke, preservation of building materials, formalin and organic coatings It is aimed at the human nose with solvents, oxidized anhydrides, and vapors of nickel and chromium. These different kinds of stimuli respond differently and affect the nasal cavity. These factors are dependent, activated, secreted and expressed in the nasal cavity.

The present invention is to prevent and prevent the antigen-induced response to isolate and reduce the amount of antigens that are hypersensitively induced in the nasal cavity, reduce the amount and degranulate the function. The cleaning solution is administered for the purpose of physically releasing harmful components attached to the secretion adjacent to the epithelial layer and the nasal septum mucosa. Directly administer the mediator, which is the cause of such rhinitis, that is to settle on the exposed part of the nasal cavity by the application of the cleaning solution, and the protective function and response rate and speed of the mediator (allergic patients immediately after skin-induced response occurs) It is used to reduce various factors that contribute to prolongation of the inflammatory response and to reduce the hypersensitivity reaction 4-4 hours after the cold.

The main components of the nasal cleaning solution are as follows.

SANGUISORBAE RADIX This drug is the root of Cucumber Sanguisorba officinalis Linne and related plants (Roseaceae). This drug is a curved spindle, with one or several uneven roots on the rhizome. It is 10-20 centimeters in length, and 5-20 millimeters in diameter. The facets are pale red, the roots are yellowish to grayish white, fibrous and very tough. If you look at the cross section with a magnifying glass on the outside, there are two to three layers of cork, just below it, four to five cork layers, and the formation layer is composed of two to three rows of flow cells. Repairs are 1 to 2 rows and all flow cells are full of starch granules and scattered with crystals of calcium hydroxide. The conduit arrangement in the neck is U-shaped and has a net- ment conduit. It has little smell and tastes slightly bitter. Identification test 1) Put 0.5 ml of powder into 10 grams of water, add ferric chloride solution to the filtrate, and boil the filtered filtrate. A dark purple color comes out. Purity test shall not contain more than 15.0% of stems and other foreign matter. Loss on drying is less than 16.0%, ash is less than 7.0%, acid insoluble ash is less than 1.5%, and the X content is more than 17.0% of water extract and more than 18.0% of dilute ethane. The grade shall be of good futile root with a diameter of 1.0 cm or more. In oriental medicine, the effect of acupuncture points is taken and externally taken.

LIQUORICE ROOT

European licorice Manchurian licorice and the roots and gourds of the same plants are left as is or bark. It is almost conical, 5-30 mm in diameter, and over 1 m long. There are several cork layers of yellowish brown and cork layers of 1 to 3 cell layers inside. The waterline is semicircular, full of starch, the catheter is large, and the licorice lichen is flowable. It has a peculiar smell and tastes sweet. Under the microscope, stone cells should not be visible and the drying loss is 12.0% for ash less than 7.0% and acid insoluble ash for 2.0% or less. X content is more than 25.0% for dilute ethanol extract. Detoxification action is taken to reinforce the blood.

Ocher three hundred seconds

It is being restored to an endangered plant (No. 177) and is designated as Ministry of Environment-specific flora and fauna. It is a perennial herb grown in ocher soil, 30 cm to 90 cm in height, root is white, stem is straight, and leaf shape is pointed in front. It grows in August in the white color of the ear, and forms in September. Water-soluble tannins, especially catechins, are helpful in suppressing tissue cell production of lipid peroxide and are used extensively in the nose for anti-inflammatory, anti-inflammatory and detoxification effects.

Other ingredients included include root bark (true elm root bark), green tea leaf, xinhua (dry magnolia bud), and in small quantities peppermint, loofah root, ginger, plantain coltsfoot, some salt, and aromatic plant. Spices such as aromas extracted from are added.

All raw materials of nasal lavage prepared by the known method are 100% used in plants and more than 90% are herbal herbs used in herbal medicine. The present invention did not find a special kind of side effects caused by mixing of medicines through clinical trials. The various types of nasal onset, constitution of the onset, side effects after long-term use are also natural remedies, and no side effects due to the application of the intranasal rinse solution have been found so far. In particular, when the cleaning solution according to the present invention is administered intranasally, it sometimes passes to the nasopharyngeal esophagus through a path connected with the nasal cavity, but even when a small amount and no harm to the human body is taken as a main ingredient no side effects were found. From the point of view of the product, the present invention has surprisingly extended structural stability. In the combination of each herbal medicine is characterized by the associated linkage of distinct tissue differences between the parts. Even when a single agent is concentrated and synthesized, its inherent characteristics are survived, and a composition containing more than the additionally contained components is produced.

For acute rhinitis, especially infections with viruses, there are currently no specific treatments. While local therapy and inflammatory redness, such as relaxation and moisture intake, humidity and temperature control, and nutritional supply, are particularly effective, Histamine is a topical mucosal constrictor. . However, prolonged use of the drug causes rhinitis, and swelling of the mucous membranes causes steroids to be partially helpful. Symptoms can be alleviated with various therapies, but no cure has been established. In addition, conservative treatment can be done more than twice a day with physiological saline or low concentrations of deuterium, but it has not been proven to be effective, and antibiotics or olive oil containing estrogen are often applied to the nasal cavity. Surgical treatment has been attempted to narrow the nasal airways, inject paraffin under the mucosa, or to move the outer wall of the nasal cavity inwardly (Lautenslagr), and to block one or both nasal cavity (Young). In addition, there are prescriptions in Socheongryongtang, Oryeongsan, Galguntanggacheongungsin, Sijintang, Bangpoong Tongseongsan, Yijintang, Sabaeksan, Samnoiseum, Cheonghyeolsamultang, etc. It is effective but hard to cure. Other folk remedies include watermelon vines, loofah vines, aloe, green onions, alumina, swine oil, plantain mugwort garlic, lotus root honey, nectar, dried persimmon, and jalapeno. It also helps relieve symptoms, but it is hard to cure. Most are treated with surgery and long-term treatment. Even when petroleum jelly is applied and when treated with aroma, the use of drugs to administer antibiotics in drops, etc. are conventional techniques. The present invention is not a medicine for the purpose of treatment, and because of the destruction of the natural environment and air pollution, the new strains and fragrances are washed in the first invasion route, thereby preventing the settling of antigens and secondly creating a clean environment in the nasal cavity. The effect of prevention is great. 100% plant-derived cleaning liquid is harmless to the human body and can relieve the pain of rhinitis due to detoxification, anti-inflammatory effect, essential effect, etc. In particular, small blood vessels are concentrated in the nose, so they absorb very rapidly. Pharmacy experts also predict that nasal medications will increase in the future. Because suppositories, injections, or oral intakes can be time consuming and lose much of the drug's effectiveness through the digestive system. Nasal washing liquid of the present invention is directly sprayed into the nasal cavity, the tissue is contracted to promote the flow of mucus to reduce the discomfort and even if the washing liquid flows from the nasal passages to the throat is no harm to the human body. Conventional decongestants are used, but when used excessively, decongestants irritate the (chemical) mucosa, which causes new decongestion. However, the present invention is a pure plant with very low irritation. Symptoms of rhinitis depend on the type of source and the presence or absence of complications, but typical symptoms are similar. Runny nose, stuffy nose, itching, rehabilitation, and sometimes itchy eyes. This cleaning solution was effectively alleviated by continued application to such a wide range of symptoms. Especially, in case of sinusitis, this washing solution has no side effects and is effective in preventing and alleviating rhinitis and sinusitis, rather than nasal drops such as phenylephrine or sprinkles or pseudoephedrine, activide, or beconase vansenase or clomoline. Becomes

All formulations in the former Rhinitis related area are intended for treatment after the onset of Rhinitis. In particular, the long-term use of a wide range of antibiotics can cause bacteria or fungi to remain in the respiratory tract, resulting in abnormal reduction or even death. Instead, non-existent bacteria can multiply more abnormally, leading to a breakdown of the balance between bacteria and fungi. It bothers the nose with other duplicate infections. In addition, the function of immunity may be weakened, and in such a situation, the present invention is a method of preventing the onset by washing in advance in terms of environmental management. It is the function of the nose to remove relatively large contaminants such as dust mixed with inhaled air or small foreign substances such as bacteria and to suppress pathogen activity by secreting substances necessary for human defense, but there is a lot of dust in the air. Highly harmful nitrates, sulfates and other bacteria are reducing the ability to control the intake of the nasal passages. In addition, various factors causing nasal obstruction, nasal secretions, rhinitis, etc., which cause excessive secretion of mucus, are washed with this washing solution at least twice daily to prevent and prevent them. The technical task is to minimize the effects of cleansing and side effects when used, and to relieve rhinitis and rhinitis in progress. This washing solution is a method of washing in case of asthma prognostic symptoms such as mucus swelling in the airways, long-term retention of secretions, and nasal congestion, and effects on the middle ear when used in children under 10 years old. (Sudden hearing in the ear when spraying) and specific rhinitis (membranous, non-glenary, non-tuberculosis) are not clinical trial results.

1 is a flow chart of air at intake

2 is a flow chart of air during exhalation

3 is a washing liquid reaction site

4 is a path of cleaning liquid

5th is cilia movement

6 is nasal enlargement

Figure 7 Throat Relationship Diagram

8 is a process chart of the cleaning liquid manufacturing process of the present invention.

Show 1

90% Fat Milk, + 5% Licorice + 300% 5% --- A

Licorice 80% + Licorice 5% + 300 seconds 5% + Root skin 10% --- B

Licorice 70% + Licorice 5% + 300 seconds 5% + Root skin 8% + Green tea, 12% --- C

Licorice 72% + Licorice 5% + Triticale 5% + Root Skin 7% + Green Tea 10% + Alcohol- D

Example 1

Clinical trials (randomized to 1 year to 8 years for patients with rhinitis and non-nasal)

Results after 1 week of administration twice a day

40 people (10 in each group)

A--Effect is acknowledged. 50% normal. 20% I'm not sure. 10% No effect 20%

B--Effect is acknowledged. 50% normal. 20% I'm not sure. 10% No effect 20%

C--Effect is acknowledged. 60% normal. 20% I'm not sure. 10% No effect 10%

D-effect is recognized. 60% normal. 20% I'm not sure. 10% No effect 10%

(The purpose of washing of the intranasal lavage of the present invention is to prevent, but as a method of clinical trials, it is administered to a patient already suffering from rhinitis, nasal mucosa, allergic rhinitis, and chronic sinusitis, and the preventive value is clinically tested by its calming effect.)

Results of Example 1-In order to investigate the effect of the sample (30 ml) of D of the indication 1, the results of random extraction and measurement by the administration method according to the time were observed. Judging by.

Example 2.

Clinical trials (by age)

10 or less (not carried out)

Teens to 20s-Recognition 60% Usually 20% I don't know. 20% Ineffective 0%

20s to 40s-70% effective 20% I don't know. 10% No effect 0%

40's to 60's-50% normal 10% 20% disapproval 20%

3 people over 60 years-33.3%, 33.3%, 33.3%.

Example 3.

Clinical trial (seasonal) 40 persons

Spring to Summer-Effect Recognition 60% Moderate 20% Effect Disapproval 20%

Summer to Autumn-Effect Recognition 70% Normal 20% Effect Disapproval 10%

Fall to Winter-Effect Recognition 60% Moderate 30% Effect Disapproval 10%

Winter in Spring-Effect Recognition 50% Normal 30% Effect Disapproval 20%

Example 4.

40 clinical trials (by gender)

Males-60% Normal 20%

Women-70% Moderate 20% Effect 10%

Example 5.

100 clinical trials (rhinitis, infection duration)

A) Less than 1 year ----------- Recognized. 72%, Normal 20%, Unauthorized 8%,

B) 1 year to 2 years-effective. 60%, normal 25%, disqualified 15%,

C) 2 to 5 years-effective. 52%, normal 22%, disagree 26%,

D) 5 to 8 years-effective. 45%, average 20%, 35% disapproval of effect,

E) More than 8 years ---------- Recognized. 32%, Moderate 20%, Ineffective 48%,

2. symptoms after implementation,

100 people (per infection period of Example 5)

My nose is cool. -A, 72% B, 70% C, 65% D, 53% E, 45%

Runny nose is reduced. -A, 68% B, 60% C, 54% D, 42% E, 38%

Less stuffy nose-A, 75% B, 68% C, 60% D, 54% E, 50%

Easy to breathe -A, 80% B, 74% C, 63% D, 57% E, 45%

Less smell -A, 45% B, 36% C, 30% D, 18% E, 12%

3. Possible recurrence after implementation

100 persons (per infection period of Example 5)

After 1 month-A, 24% B, 56% C, 72% D, 80% E, 88%

After 2 months-A, 20% B, 45% C, 68% D, 75% E, 80%

6 months continued-A, 14% B, 30% C, 55% D, 60% E, 70%

The structure of this invention is a manufacturing method of the wash | cleaning liquid in a nasal cavity, and makes 75% or more of fats and oils a main raw material. Primarily

It contains about 9 to 12 times the total purified water by the ratio of 90% fat milk + 5% licorice + 5% ocher 300 seconds. Here, 10% of spirits of purified water are mixed. 3 hours to 4 hours are distilled in a primary distillation column with the high heat of 100 degreeC or more, and distillation is carried out until the total amount reduces to about half. ------ 1st distillate

The first distillate is subjected to the second distillation column and freeze degreasing again. It is to concentrate and recover the frozen degreased distillate. In this process, about 10% of the purified water first introduced is separated .---------- A (see Fig. 8)

Xinyi (Magnolia Peak) 40% + Scrubber (30%) + Mint (30%) -------- B

Green Tea (40%) + Schisandra (30%) + Salt (5%) + Ginger (25%) ---- C

A (80%) + B (6%) + C (5%) = ABC

Boil again in the blending tank.

Soak the root skin (5%) in water for 1 hour and boil it (about 30 minutes). When it gets wet like a nose, remove the residue completely and settle it. ------- D

Mix A, B, C, + D + Alcohol (3%) + Aroma Scent (1%)-Total

The finished product is made by automatic packaging in a sterilized container and sterilized and dried through a filter through an automatic filling machine and manufactured in a spray coating type (see FIG. 9).

Known cleaning solution prepared by the present invention is that the inhalation of the antigenic material due to severe air pollution in the air coming in the inhalation in Fig. 1 and the bacteria and harmful substances in the dust infiltrated during the exhalation in Fig. will be. When the cleaning solution according to the present invention is added and washed in the method of FIG. It is sprayed and applied to the invasive part of the incense source to inhibit the induction reaction of the incense source and activates the lowered nasal cavity to promote ciliary movement of FIG. 5 and to prevent the action of the region of FIG. 6 and also to wash the secretion in the nasal cavity. The disease is truly alleviated by reducing the activity of the fungus. 7 is a case where the washing liquid is passed through the nasopharyngeal cavity to the throat when applied in the method of FIG. Even in this case, the cleaning liquid is not harmed by drinking. The whole is herbal, 100% extracted from pure plants. In particular, long-term reactions during clinical trials showed no abnormalities and no harm. In addition, even if this cleaning solution clogged in the throat, it does not adversely affect the rhinitis disease.

Followed by rehabilitation and runny nose does not stop. Nose, tears and itchy nose appear, these symptoms appear especially when the season changes, especially in the spring and autumn, and relapses well after the better. Severe runny nose, nasal congestion, headache, heavy head feeling, and smell can not be. Runny nose is a clear runny nose or pus in acute cases, but in chronic cases it becomes sticky mucus. Sometimes a runny nose stinks and flows towards the neck, causing a nasty throat. In oriental medicine, the disease of the nose is regarded as an illness from the outside (air conditioning) and emotion from the inside. Lack of exercise, life in a confined space, and stress caused by weakening of the air flowing through the surface of the lumen, constitution and a runny nose occur. In the early stages of acute rhinitis, the first one to pay attention to the stability and warmth of mind and body as if you have a cold, the second important drug therapy, mass therapy, surgical treatment. In this case, astringent sterilization may be performed with the cleaning solution of the nasal mucosa according to the present invention. In most cases, acute rhinitis infections have symptoms such as incubation period, progenitor period, rhinitis period, redness, mucus, absorber, and secondary infection. In this process, spraying and applying the cleaning solution in the nasal cavity prevents the settling of the fragrance source penetrating into the nasal cavity first, and reduces the active proliferative function of bacteria or secondary degranulation and discharges it with secretions. Inhibits and relieves redness of the nasal mucosa. In addition, it provides nutrition to promote the growth of intranasal cells, which helps to reduce runny nose, stuffy nose and stuffiness.

Claims (2)

The present invention relates to a method of preparing a cleaning solution for the purpose of preventing and relieving rhinitis. The method includes a method of mixing raw materials and a spirit, separating after concentration recovery, a method of mixing other drugs, and a method for preventing rhinitis cleaning. Manufacturing process process. Unlike the cleansing liquid of chemical ingredients, herbal medicine contains 100% pure vegetable extract, the main ingredient of which is a non-irritating cleanser, which hinders the composition of the fragrance in airway mucosa exposed to fragrances, and suppresses excessive expression of bacteria and viruses, and enhances the environment. Separating sensitive source and reducing the amount, degranulates the mediating material and discharges it with secretion, and sprays and sprays the intranasal area to promote anti-inflammatory, weight loss, detoxification and growth of intranasal cells. Supplying, complementary action to alleviate the activity of rhinitis, inhibit the inflammatory response of fragrance, characterized in that it relates to pharmaceutical raw materials and combinations to prevent rhinitis.