KR19990077186A - Disinfection Compositions and Surface Disinfection Methods - Google Patents

Abstract

The present invention provides an antiseptic composition comprising an antimicrobial compound selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants and antimicrobial essential oils or active substances thereof, parabens, glutaraldehyde and mixtures thereof. It is about how to earn the surface.

Description

Disinfection Compositions and Surface Disinfection Methods

Antimicrobial / antimicrobial compositions include materials with the ability to disinfect. It is generally recognized that disinfecting substances significantly reduce or even eliminate microorganisms, such as bacteria, present on the surface. Compositions based on halogen containing compounds or quaternary compounds such as hypochlorite have been widely described in the field of disinfection purposes. Compositions comprising peroxide bleach are also known as disinfecting compositions.

However, as the only antimicrobial agent, a composition comprising hydrogen peroxide, typically in an amount of 7% by weight of the total composition, is typically diluted at a typical dilution, for example, to disinfect slightly soiled surfaces, such as surfaces already cleaned with conventional detergents. It is not satisfactory enough when used in dilutions of: 50 (composition: water) and still organic and / or inorganic dirt remains. In fact, the presence of organic and / or inorganic soils reduces the bactericidal activity of many antimicrobial compounds, such as peroxygen bleach, thereby lowering the bactericidal activity / disinfectability of the compositions comprising them.

Accordingly, it is an object of the present invention to provide a composition which exerts good disinfection on a slightly soiled surface even when used in a very dilute state.

In accordance with the present invention, different antimicrobial components are combined, i.e. peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof (e.g. It has been found that the above object can be achieved by combining antimicrobial compounds selected from the group consisting of thymol, eugenol, etc.), parabens, glutaraldehyde and mixtures thereof. More specifically, the composition comprising the peroxygen bleach, the betaine or sulfobetaine surfactant and the antimicrobial compound is very soiled, ie slightly soiled even when the dilution of the composition to water is 1: 100. It has been shown to provide good disinfection to surfaces.

An advantage of the present invention is that it provides excellent disinfection for a wider range of more resistant microorganisms such as Gram positive and Gram negative bacteria and fungi, in a slightly soiled state.

Another advantage of the compositions of the present invention is that in addition to disinfection properties, good cleaning performance is provided.

In addition, the compositions according to the invention are suitable for use on all types of surfaces, including biological surfaces (eg, mouths when used as human skin and / or oral preparations or toothpastes) and inanimate surfaces. Indeed, this technique is particularly suitable for hard surface applications as well as for laundry applications, for example as so-called "immersion", "wash" laundry detergents or laundry additives, or as "pretreatment" laundry pretreatments. More specifically, the compositions according to the invention are suitable for use in a safe manner on sensitive surfaces, including surfaces in contact with food and / or babies. In fact, when the composition according to the invention is used in a diluted state, the residual amount of chemicals remaining on the surface to be disinfected therein is reduced. Thus, it may not be necessary to rinse off the surface after application of the composition of the invention in a diluted state, for example on a hard surface.

Another advantage of the compositions of the present invention is that different forms, such as liquid forms filled in conventional detergent bottles or sprayed or foamable forms filled in spray / foam dispensers, or wipe forms incorporating such compositions or non-liquid forms It can be provided as.

EP 288,689 discloses liquids for hard surfaces comprising an antimicrobial effective amount of pine oil and at least one oil soluble organic acid. This patent does not mention other antimicrobial components, not to mention peroxygen bleach.

EP 241,390 discloses that bacterially contaminated fabrics can be disinfected by first treating with a detergent and then with peroxide bleach in an aqueous bath of pH 9 to 13 in the presence of uncomplexed calcium. No other antimicrobial component is disclosed.

U.S. Patent No. 4,404,191 discloses that overcompounds such as monopersulfate have bactericidal, fungicidal and virucidal properties. U.S. Patent 4,404,191 discloses that a composition comprising monopersulfate can be used in diluted form to treat hard surfaces. However, other antimicrobial components are not disclosed.

European Patent Application No. 667,392 discloses alkyl ether sulfate surfactants and 31

A hard surface cleaning composition is disclosed that includes a surfactant / thickener component comprising amine oxide or betaine and hydrogen peroxide. The pH of this composition is 7-10. This patent application does not disclose other antimicrobial compounds, not to mention essential oils or their active substances, parabens or glutaraldehyde.

U.S. Patent 5,403,587 discloses aqueous antimicrobial compositions that can be used to sanitize, disinfect and clean hard surfaces. More specifically, US Pat. No. 5,403,587 discloses essential oils (0.02% to 5%) that exhibit antimicrobial efficacy, such as thyme oil, eucalyptus oil, clove oil and the like, and to form aqueous solutions or dispersions in the aqueous carrier of the essential oil. Aqueous compositions (pH 1-12) are disclosed which comprise sufficient solubilizers or dispersants. The composition may further comprise other antimicrobial components, such as phenolic compounds, quaternary ammonium compounds, but no betaine or sulfobetaine surfactants or peroxygen bleaches are disclosed.

U. S. Patent No. 5,368, 749 discloses compositions which inhibit the proliferation of aerobic microorganisms, including bacteria and fungi, which include oxidants and glutaraldehyde. The oxidant may be selected from the group consisting of chlorine, bromine, monopersulfate, perborate, hydrogen peroxide, peracetic acid and percarbonate. The oxidant is said to have a synergistic effect when added to glutaraldehyde. Other antimicrobial compounds, such as essential oils or their actives, parabens or betaine / sulfobetaine surfactants, are not disclosed.

U.S. Patent No. 3,852,210 discloses aqueous oxygen releasing compositions suitable for a wide range of uses in industry and at home, such as laundry bleach detergents or hard surface cleaners. The bactericidal and bactericidal activity of this composition is also suitable for medical use. This composition (pH 2-10) is a compound that releases free radicals, such as hydrogen peroxide (0.1-50%), betaine or sulfobetaine (0.5-50%) (e.g. cetylbetaine or laurylsulfobe Tine) and water solubility is at least 1 g per 100 ml of water and a nonionic polyoxyethylene-polyoxypropylene block copolymer surfactant having a molecular weight of 1000 to 15000. This patent does not disclose essential oils or their actives, parabens or glutaraldehyde, and other antimicrobial compounds.

Japanese Patent 85-038497 discloses alkaline substances such as (a) aqueous solutions of hydrogen peroxide (0.5% to 50%), (b) NaOH, KOH, Na ₂ CO ₃ , having an alkalinity of 0.1% to 50% expressed in NaOH. A foamable two-component detergent composition comprising an alkali compound to contain is disclosed. One of the two components (a) and (b) of this detergent composition comprises a surfactant (such as a betaine surfactant) and at least one compound selected from terpene alcohols, cyclic terpene alcohols and esters thereof. The composition of Japanese Patent No. 85-038497 has the purpose of cleaning dirt of hard materials such as plastics, joints and recesses or corners which are particularly difficult to clean. There is no mention of disinfection.

Summary of the Invention

The present invention is selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof. Disinfectant compositions comprising an antimicrobial compound, provided that hydrogen peroxide is used as a peroxygen bleach to 0.5 to 50% by weight of the total composition, terpene alcohol, cyclic terpene alcohol or esters thereof as the only antimicrobial compound to 0.001 to An aqueous composition comprising 10% by weight is excluded.

The invention is also selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof. And a method for disinfecting the surface, by applying to the surface a composition comprising an antimicrobial compound.

The invention is also selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof. Disinfectant compositions filled in a spray dispenser, comprising an antimicrobial compound.

The invention is also selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof. Wipes impregnated with a liquid composition comprising an antimicrobial compound.

The present invention relates to physiological surfaces (eg human skin, mouth, etc.) and inanimate surfaces (eg, walls, tiles, table tops, glass, bathroom surfaces, kitchen surfaces, dishes as well as textiles, clothing, carpets, etc.). Antimicrobial compositions that can be used to disinfect and clean various surfaces, including but not limited to those.

Disinfectant compositions according to the present invention comprise an antimicrobial compound selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants, and antimicrobial essential oils or active substances thereof, parabens, glutaraldehyde and mixtures thereof. Except for aqueous compositions comprising from 0.5 to 50% by weight of hydrogen peroxide as the peroxygen bleach, and from 0.001 to 10% by weight of the total composition of terpene alcohol, cyclic terpene alcohol or esters thereof as the only antimicrobial compound. do.

The compositions according to the invention can be formulated as liquids or non-liquids (eg in the form of gels, pastes, or solids such as powders or granules). If the composition is formulated as a solid, the composition will be mixed with a suitable solvent, typically water, before use. In liquid form, the composition is preferably formulated as an aqueous composition, but need not be so. Liquid compositions are preferred for their ease of use.

The compositions according to the invention comprise as essential elements peroxygen bleach or mixtures thereof. Preferred peroxygen bleach is hydrogen peroxide or its water-soluble source or mixtures thereof. Hydrogen peroxide is most preferred for use in the compositions according to the invention.

The presence of such peroxygen bleach, especially hydrogen peroxide, persulfate, and the like in the composition of the present invention is believed to contribute to the disinfectability of the composition. In fact, peroxygen bleach may attack the functions necessary for the life support of microbial cells (eg, inhibit the combination of ribosomal units in the cytoplasm of microbial cells). Peroxygen bleach, such as hydrogen peroxide, is also a strong oxidizing agent that produces hydroxyl free radicals that attack proteins and nucleic acids. In addition, the presence of peroxygen bleach, in particular hydrogen peroxide, provides strong dirt removal advantages, which are particularly noticeable, for example, in laundry and hard surface applications.

Hydrogen peroxide source as used herein refers to any compound that produces hydrogen peroxide when in contact with water. Suitable water soluble hydrogen peroxide sources for use herein include percarbonates, persilicates, persulfates (e.g. monopersulfates), perborates and peroxy acids (e.g. diperoxydodecanoic acid (DPDA)), magnesium perphthalic acid and Mixtures thereof.

In addition, other classes of peroxides may be used as substitutes for hydrogen peroxide and its sources or in conjunction with hydrogen peroxide and its sources. Suitable classes are dialkylperoxides, diacylperoxides, preformed percarboxylic acids, organic and inorganic peroxides and / or hydroperoxides.

Typically, the compositions herein comprise a peroxygen bleach or mixture thereof at 0.01% by weight, preferably 0.1-15% by weight, more preferably 1% -10%.

As a second essential ingredient, the composition according to the invention comprises a betaine or sulfobetaine surfactant or derivatives thereof, or mixtures thereof. It is assumed that the amphoteric surfactant will act twice. In fact, they help disinfection by increasing the permeability of the bacterial cell wall, allowing other active ingredients to enter the cell. Such surfactants also contribute to the cleaning performance of the compositions herein.

In addition, due to the mild action profile of the betaine and / or sulfobetaine surfactants, the compositions herein may be particularly suitable for cleaning sensitive surfaces such as sensitive laundry or surfaces in contact with food and / or babies. Since betaine and / or sulfobetaine surfactants are also very mild to the skin, it is convenient for the user to use the compositions of the present invention.

Betaines / sulfobetaines suitable for use in the compositions of the present invention include betaines / sulfurs having both basic and acidic groups that form internal salts whose molecules provide both a cationic and anionic hydrophilic group over a wide range of pH values. Forbetaine and betaine detergents. Some common examples of these detergents are described in US Pat. Nos. 2,082,275, 2,702,279, and 2,255,082, which are incorporated herein by reference. Preferred betaine or sulfobetaine surfactants are compounds having the formula (1) or mixtures thereof:

Where

R 1 is an alkyl radical having 1 to 24 carbon atoms, preferably 8 to 18 carbon atoms, more preferably 12 to 14 carbon atoms,

R2 to R3 has 1 to 3 carbon atoms, preferably 1,

n is an integer of 1 to 10, preferably 1 to 6, more preferably 1,

Y is selected from the group consisting of carboxyl radicals and sulfonyl radicals,

The R1, R2 and R3 radicals have 14 to 24 carbon atoms in total.

Particularly suitable betaine surfactants include alkyl dimethyl betaines having 12 to 18 carbon atoms (eg coconut betaine) and alkyl dimethyl betaines having 10 to 16 carbon atoms (eg lauryl betaine).

Coconut betaine and lauryl betaine are commercially available from Seppic and Albright & Wilson under the trade names Amonyl 265® and Ampigen BB / L®, respectively. In the process.

Typically, the composition herein comprises at least 0.005% by weight of the betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, preferably 0.01% to 10% by weight, more preferably 0.1 wt% to 5 wt%.

As a third essential ingredient, the composition according to the invention comprises an antimicrobial compound or mixtures thereof.

The antimicrobial compound is selected from the group consisting of antimicrobial essential oils or their actives, parabens, glutaraldehyde and mixtures thereof.

Preferred antimicrobial compounds as used herein are antimicrobial essential oils or active agents thereof. Antimicrobial essential oils suitable for use in the compositions herein are essential oils that exhibit antimicrobial activity. By "active substance of essential oil" is meant any essential oil component that exhibits antimicrobial activity. It is speculated that the antimicrobial essential oils and their actives act as protein denaturants. In addition, the antimicrobial oils and their actives are natural compounds that, when used to disinfect any surface, contribute to the safety aspects of the compositions of the present invention. A further advantage of the antimicrobial oils and their actives is that they give a flavor to the disinfecting compositions of the present invention without the need to add fragrances. Indeed, the disinfecting composition according to the present invention provides good antimicrobial as well as good aroma to the slightly soiled surface to be disinfected.

These essential oils include thyme, lemongrass, citrus fruits, lemons, oranges, anise, cloves, anise fruits, cinnamon, geranium, roses, mint, lavender, citronella, eucalyptus, mint, camphor Oils obtained from sandalwood, cedar and cedar, and mixtures thereof, but are not intended to be limiting. The active substances of the essential oils used herein include thymol (for example in thyme), eugenol (for example in cinnamon and cloves), menthol (for example in mint), Laniol (for example in gelatin and roses), verbenone (for example in verbena), eucalyptol and pinocarvone (for eucalyptus), cedrol (cedrol) (for example in cedar), anethol (for example in anise), carvacrol, hinokitiol, berberine, terpineol ( terpineol), limonene, ratanhiae and mixtures thereof. Preferred active agents of the essential oils used herein include thymol, eugenol, verbenone, eucalyptol, limonene and / or geraniol.

Timol is commercially available, for example, from Aldrich and Eugenol is available, for example, from Sigma, Systems Bioindustries (SBI) -Manheimer Inc. Commercially available.

Suitable parabens for use in the compositions herein include ethyl parabens, methyl parabens, propyl parabens or mixtures thereof.

Glutaraldehyde is commercially available from Union Carbide or BASF.

Typically, the compositions herein comprise the antimicrobial compounds or mixtures thereof at least 0.003%, preferably 0.006% to 4%, more preferably 0.2% to 2% by weight of the total composition. .

Disinfection power was improved even when the composition of the present invention was very diluted on a slightly soiled surface, i.e., the composition to water ratio of 1: 100 or less.

"Slightly soiled surface" means a surface contaminated with a residual amount of organic and / or inorganic dirt equivalent to 0.03 g / l bovine albumin and an aqueous solution of hard water [European standard prEN 1276, CEN / TC dated November 1995 216 N59, 3.3, 4], see "Cleaning status"].

Thus, a slightly soiled surface is, for example, any surface that has been washed with a conventional detergent composition but needs further disinfection.

The term "enhanced disinfection" refers to an antimicrobial compound selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants, and antimicrobial essential oils or actives thereof, parabens, glutaraldehyde and mixtures thereof. The composition of the present invention comprising a slightly soiled composition compared to the same composition without peroxygen bleach and / or the betaine or sulfobetaine surfactant or the same composition when used in the above-mentioned antimicrobial compound, especially in diluted form It means to reduce the number of bacteria on the surface. Indeed, good disinfection is achieved on a variety of microorganisms, including Gram positive bacteria (eg Staphylococcus) and Gram negative bacteria (eg Pseudomonase) and fungi present on slightly contaminated surfaces (eg Candida). (Candida)).

Disinfection of a composition can be measured by the bactericidal activity of the composition. Test methods for evaluating the bactericidal activity of the compositions are described in European Standard prEN 1276, CEN / TC 216N 59, dated 11 November 1995, from the European Committee for Standardisation, Brussels, Belgium. The European standard prEN 1276, CEN / TC 216N 59 describes test methods and requirements for the minimal bactericidal activity of disinfectant compositions. The bacterial colony forming unit (cfu) decreases from 10 ⁷ cfu (initial volume) to 10 ² cfu (final amount after contact with a toxic product) and the test passes. In other words, the possibility of survival is reduced by 10 ⁵ . The composition according to the invention passed this test even when used in a slightly soiled, very diluted state.

Other test methods suitable for evaluating the bactericidal activity of the present invention on slightly soiled surfaces, especially hard surfaces, are AFNOR T72-190® and T72-301®.

The compositions according to the invention formulated in liquid form may be applied without dilution. Preferably, the composition according to the invention may be applied to the surface to be disinfected in diluted form.

By "diluted form" herein is meant that the composition according to the invention, in liquid form or in solid form, may be diluted by the user with a liquid, typically water. The composition may typically be diluted by the user with water up to 100 times its weight, preferably 80 to 40 times, more preferably 60 to 30 times.

The present invention therefore also encompasses diluted disinfecting compositions obtainable by diluting the composition according to the invention in water.

In an embodiment of the invention, the composition is an aqueous liquid composition. The pH of the aqueous composition is preferably less than 12, preferably 3.5 to 7.0, more preferably 4.0 to 5.0. The pH of the composition can be adjusted using organic acids (eg citric acid, succinic acid, acetic acid, aspartic acid, lactic acid, etc.) or inorganic acids or alkalizing agents.

Compositions of the present invention are known to those skilled in the art, including nonionic, anionic, cationic, amphoteric and / or amphoteric surfactants, in addition to the betaines and / or sulfobetaines described herein above. Active agents. These surfactants are preferred herein because they further contribute to the cleaning action of the compositions herein. Typically, the composition according to the present invention comprises 50% by weight, preferably 0.3-30% by weight, more preferably, of other surfactants or mixtures thereof in addition to the betaine and / or sulfobetaine surfactants. Preferably from 0.4 wt% to 25 wt%.

Other suitable amphoteric surfactants as used herein include amine oxides or mixtures thereof. Amine oxides are preferred herein because they further contribute to the disinfection properties of the compositions herein. Indeed, they further aid disinfection by disrupting the cell wall / membrane of the bacteria, allowing other antimicrobial components to enter the cell, for example attacking the interior of the cell.

Suitable amine oxides as used herein have the general formula R ₁ R ₂ R ₃ NO, wherein R ₁ , R ₂ and R ₃ are each independently a saturated linear or branched hydrocarbon chain having 1 to 30 carbon atoms. Suitable amine oxides used in the present invention are hydrocarbon chains wherein R ₁ is 1 to 30 carbon atoms, preferably 6 to 20, more preferably 6 to 14, most preferably 8 to 10, and R ₂ and R ₃ are Independently are amine oxides of the general formula R ₁ R ₂ R ₃ NO, which is a substituted or unsubstituted, linear or branched hydrocarbon chain, having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, more preferably a methyl group. R ₁ may be saturated linear or branched hydrocarbon chain.

Preferred amine oxides for the present invention include, for example, natural blends of amine oxides having 8 to 10 carbon atoms and amine oxides having 12 to 16 carbon atoms commercially available from Hoechst.

In a preferred embodiment of the invention in which the compositions herein are particularly suitable for disinfecting hard surfaces, the surfactants typically have a weight ratio of amine oxides and betaine or sulfobetaine surfactants (amine oxides to betaine or sulfobetaines preferably). Is 2: 1 to 100: 1, more preferably 6: 1 to 100: 1, most preferably 10: 1 to 50; 1). The use of such surfactant systems in the compositions herein suitable for hard surface disinfection provides effective cleaning performance and provides gloss on the cleaned surfaces (ie, filming on the cleaned surfaces treated with the composition). Amount of streaking is minimal).

In addition, the compositions herein preferably comprise anionic surfactants or mixtures thereof. Particularly suitable anionic surfactants that can be used herein include the general formula ROSO ₃ M [where R is preferably a hydrocarbyl having 6 to 24 carbon atoms, preferably alkyl or hydroxy having an alkyl component having 8 to 20 carbon atoms. Alkyl, more preferably alkyl or hydroxyalkyl having 8 to 16 carbon atoms, M is H or a cation, ie an alkali metal cation (e.g. sodium, calcium, lithium) or ammonium or substituted ammonium (e.g. methyl-, Quaternary ammonium cations derived from dimethyl- and trimethyl-ammonium cations and quaternary ammonium cations such as tetramethyl ammonium and dimethyl pipedinium cations and alkyl amines such as ethylamine, diethylamine, triethylamine and these A mixture thereof); and the like)).

Other suitable anionic surfactants as used herein include alkyl-diphenyl-ether sulfonates and alkyl-carboxylates. Other anionic surfactants include soap salts (e.g., sodium, potassium, ammonium and substituted ammonium salts such as mono-, di- and triethanolamine salts), linear alkylbenzenesulfonates with 9 to 20 carbon atoms, and 8 to 20 carbon atoms. Sulfonated polycarboxylic acids prepared by sulfonating pyrrolation products, primary or secondary alkanesulfonates of 22, olefinsulfonates of 8 to 24 carbon atoms, alkaline earth metal citric acid (e.g., described in British Patent Application No. 1,082,179 Alkylpolyglycol ethersulfate having up to 10 moles of ethylene oxide), alkyl ester sulfonates (e.g. methyl ester sulfonates having 14 to 16 carbon atoms), acyl glycerol sulfonates, fatty acid oles Monoglycerol sulfate, alkyl phenol ethylene oxide ether sulfate, paraffin sulfonate, alkyl phosphate, isothione (E.g. acyl isothionate), N-acyl taurates, alkyl succinates and sulfosuccinates, monoesters of sulfosuccinates (particularly saturated or unsaturated monoesters having 12 to 18 carbon atoms), sulfosuccinate Diesters of cyanates (especially saturated or unsaturated diesters having 6 to 14 carbon atoms), acyl sacosinates, sulfates of alkylpolysaccharides (e.g. sulfates of alkylpolyglucosides (anionic unsulfation as described above) Compounds)), branched primary alkyl sulfates, alkyl polyethoxy carboxylates (e.g., general formula RO (CH ₂ CH ₂ O) _k CH ₂ COO-M ⁺ , wherein R is alkyl having 8 to 22 carbon atoms , k is an integer from 0 to 10 and M is a water-soluble salt-forming cation). Resin acids and hydrogenated resin acids are also suitable and include, for example, resin acids and hydrogenated resin acids present in or derived from rosin, hydrogenated rosin, and enteric oils. Further examples are known from Schwartz, Perry and Berch ("Surface Active Agents and Detergents" (Vol. I and II)). Various such surfactants are also available in December 1975. 30, column 58 to column 29, column 23 of US Pat. No. 3,929,678 to Laughlin et al.

Preferred anionic surfactants for use in the compositions herein include alkyl sulfonates having 8 to 16 carbon atoms, alkyl sulfates having 8 to 16 carbon atoms, alkyl alkoxylated sulfates having 8 to 16 carbon atoms (alkyl ethoxylated sulfates having 8 to 16 carbon atoms). ) And mixtures thereof. Such anionic surfactants are preferred herein because they have been found to further contribute to the disinfection properties of the disinfecting compositions herein. For example, alkyl sulfates having 8 to 16 carbon atoms act by disrupting bacterial cell membranes to inhibit enzymatic activity, interfere with intracellular transport and / or denature intracellular proteins. Indeed, further improved disinfection associated with the addition of anionic surfactants, in particular alkyl sulfonates having 8 to 16 carbon atoms, alkyl sulfates having 8 to 16 carbon atoms, and / or alkyl alkoxylated sulfates having 8 to 16 carbon atoms, to the compositions of the invention. The action is because the manner of attack of the surfactant against bacteria is increased. Thus, another aspect of the present invention provides anionic surfactants, in particular alkyl sulfonates having 8 to 16 carbon atoms, 8 to 16 carbon atoms, for improving the disinfectability of gram negative and / or gram positive bacteria in the disinfecting compositions of the present invention. Alkyl sulfates and / or alkyl alkoxylated sulfates having 8 to 16 carbon atoms.

Suitable nonionic surfactants for use herein are commercial fatty acid alcohol ethoxylates and / or propoxylates of varying fatty acid chain lengths and varying degrees of ethoxylation. Indeed, the hydrophilic-lipophilic balance (HLB) value of such alkoxylated nonionic surfactants is fundamentally dependent on the length of the chain, the alkoxylation properties and the degree of alkoxylation of the fatty alcohol. Surfactant catalogs that list a number of surfactants, including nonionic surfactants with respective HLB values, are useful.

Hydrophobic nonionic surfactants having an HLB of less than 16, preferably less than 15, more preferably less than 14 are particularly suitable for use herein as nonionic surfactants. These hydrophobic nonionic surfactants have been found to provide excellent grease cutting properties.

Preferred hydrophobic nonionic surfactants used in the compositions according to the invention have an HLB of less than 16 and a general formula RO- (C ₂ H ₄ O) _n (C ₃ H ₆ O) _m H, wherein R is 6 to 22 carbon atoms. Is an alkyl chain or an alkyl benzene chain having 6 to 28 carbon atoms, n + m is 0 to 20, n is 0 to 15, m is 0 to 20, preferably n + m is 1 to 15 and n and m are 0.5-15, more preferably n + m is 1-10 and n and m are 0-10). Preferred R chains for use herein are alkyl chains having 8 to 22 carbon atoms. Accordingly, suitable hydrophobic nonionic surfactants for use herein are Dobanol® 91-2.5 (HLB = 8.1; R is a mixture of alkyl chains having 9 to 11 carbon atoms and n is 2.5 and m is 0. ), Lutensol® TO3 (HLB = 8; R is an alkyl chain of 13 carbon atoms, n is 3 and m is 0), Lutensol AO3 (HLB = 8; R is an alkyl chain of 13 carbon atoms) And a mixture of alkyl chains having 15 carbon atoms, n is 3, m is 0), Tergitol® 25L3 (HLB = 7.7; R is an alkyl chain length region of 12 to 15 carbon atoms, n is 3, m is 0), dobanol 23-3 (HLB = 8.1; R is a mixture of an alkyl chain having 12 carbon atoms and an alkyl chain having 13 carbon atoms, n is 3, m is 0), dobanol 23 -2 (HLB = 6.2; R is a mixture of an alkyl chain of 12 carbon atoms and an alkyl chain of 13 carbon atoms, n is 2, m is 0), dobanol 45-7 (HLB = 11.6; R is a carbon atom of 12 carbon atoms) A mixture of an alkyl chain and an alkyl chain of 13 carbon atoms, n Is 6.5, m is 0), dobanol 25-7 (HLB = 12; R is a mixture of an alkyl chain of 12 carbon atoms and an alkyl chain of 15 carbon atoms, n is 7 and m is 0), dobanol 91-5 (HLB = 11.6; R is a mixture of an alkyl chain of 9 carbon atoms and an alkyl chain of 11 carbon atoms, n is 5, m is 0), dobanol 91-6 (HLB = 12.5; R is 9 carbon atoms) Is a mixture of an alkyl chain of and an alkyl chain of 11 carbon atoms, n is 6, m is 0, dobanol 91-8 (HLB = 13.7; R is an alkyl chain mixture of 9 carbon atoms and 11 carbon atoms, n is 8 And m is 0), dobanol 91-10 (HLB = 14.2; R is a mixture of alkyl chains having 9 to 11 carbon atoms, n is 10, m is 0), or a mixture thereof. . Preferred herein are dobanol 91-2.5, lutenzol TO3, lutenzol AO3, tertitol 25L3, dobanol 23-3, dobanol 23-2 or mixtures thereof. Such dobanol R surfactants are commercially available from SHELL. The rutensol surfactants are commercially available from BASF and the tertitol surfactants are commercially available from Union Carbide.

Further, other surfactants include conventional soaps having 6 to 20 carbon atoms (alkali metal salts of fatty acids having 6 to 20 carbon atoms, preferred sodium salts).

The compositions herein may further comprise chelating agents as preferred optional components. Suitable chelating agents include phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, amino carboxylated chelating agents, other carboxylated chelating agents, aromatic chelating agents that are multifunctional, biodegradable chelates It may be any chelating agent known to those skilled in the art, such as a chelating agent selected from the group comprising an agent such as ethylene diamine N, N'-disuccinic acid or mixtures thereof.

Suitable phosphonate chelating agents as used herein include etidronic acid (1-hydroxyethylene-diphosphonic acid (HEDP)) and / or alkali metal ethane 10 hydroxydiphosphonates.

Suitable amino phosphonate chelating agents as used herein include amino alkylene poly (alkylene phosphonates), nitrilotris (methylene) triphosphonates, ethylene diamine tetra methylene phosphonates and / or diethylene triamine Penta methylene phosphonate. A preferred aminophosphonate chelating agent as used herein is diethylene triamine penta methylene phosphonate.

Such phosphonate / amino phosphonate chelating agents may be in the form of acids or in the form of salts with different cations in some or all of these acid functional groups. Such phosphonate / amino phosphonate chelating agents are commercially available from Monsanto under the tradename DEQUEST®.

Substituted heteroaromatic chelating agents as used herein include hydroxypyridine-N-oxides or derivatives thereof.

Suitable hydroxy pyridine N-oxides and their derivatives according to the invention follow the general formula:

Where

X is nitrogen,

Y is one of the groups of oxygen, -CHO, -OH or-(CH ₂ ) _n -COOH, wherein n is an integer from 0 to 20, preferably 0 to 10, more preferably 0 It is oxygen. Thus, particularly preferred hydroxy pyridine N-oxides and derivatives thereof as used herein are 2-hydroxy pyridine N oxides.

Hydroxy pyridine N-oxides and derivatives thereof are commercially available from Sigma.

Multifunctionally substituted aromatic chelating agents are also useful in the compositions herein (see US Pat. No. 3,812,044 to Connor et al. On May 21, 1974). Preferred compounds of this type in the form of acids are dihydroxydisulfobenzenes (eg 1,2-dihydroxy-3,5-disulfobenzene).

Preferred biodegradable chelating agents for use herein are ethylene diamine N, N'-disuccinic acid or salts of alkali metals, alkaline earth metals, ammonium or substituted ammonium or mixtures thereof. Ethylenediamine N, N'-disuccinic acid, particularly the (S, S) isomer, is described broadly in US Patent Application No. 4,704,233, issued November 3, 1987 to Hartman and Perkins. Ethylenediamine N, N'-disuccinic acid is commercially available, for example, under the trade name ssEDDS® from Palmer Research Laboratories. Ethylene diamine N, N'-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable amino carboxylate chelating agents useful herein are two forms of ethylene diamine tetra acetate, diethylene triamine pentaacetate, diethylene triamine pentoacetate (DTPA) in the form of an acid or in the form of an alkali metal, ammonium and substituted ammonium salts thereof. , N-hydroxyethylethylenediamine triacetate, nitrilotriacetate, ethylenediamine tetrapropionate, triethylenetetraamine hexaacetate, ethanol diglycine, propylene diamine tetraacetic acid (PDTA) and methyl glycine di-acetic acid (MGDA) Can be mentioned. Use by diethylene triamine penta acetic acid (DTPA), propylene diamine tetraacetic acid (PDTA) (e.g., available under the trade name Trilon FS® from BASF) and methylene glycine di-acetic acid (MGDA) Particularly suitable for

In addition, the carboxylate chelating agents used herein include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid or mixtures thereof.

Such chelating agents, in particular phosphonate chelating agents such as diethylene triamine penta methylene phosphonate, are particularly preferred in the compositions according to the invention because they further contribute to the disinfection of hydrogen peroxide. Accordingly, another aspect of the present invention relates to chelating agents, particularly phosphonate chelating agents (e.g., diethylene triamine penta) in disinfecting compositions comprising hydrogen peroxide to enhance the disinfectability of gram negative and / or gram positive bacteria. Methylene phosphonate).

Typically, the compositions according to the invention comprise up to 5% by weight, preferably 0.002% to 3% by weight, more preferably 0.002% to 1.5% by weight of the chelating agent or mixtures thereof, based on the total composition. do.

The compositions herein may also include radical scavengers as preferred optional components. Suitable radical scavengers for use herein include known substituted mono- and di-hydroxy benzenes and derivatives thereof, alkyl and aryl carboxylates and mixtures thereof. Preferred radical scavengers for use herein include di-tertiary butyl hydroxy toluene (BHT), p-hydroxy-toluene, hydroquinone (HQ), di-tert-butyl hydroquinone (DTBHQ), mono- Tert-butyl hydroquinone (MTBHQ), tert-butyl-hydroxy anisol (BHA), p-hydroxy-anisol, benzoic acid, 2,5-dihydroxy benzoic acid, 2,5-dihydroxyterephthalic acid , Toluic acid, catechol, t-butyl catechol, 4-allyl-catechol, 4-acetyl atechol, 2-methoxy-phenol, 2-ethoxy-phenol, 2-methoxy-4- (2-pro Phenyl) phenol, 3,4-dihydroxy benzaldehyde, 2,3-dihydroxy benzaldehyde, benzylamine, 1,1,3-tris (2-methyl-4-hydroxy-5-tert-butyl Phenyl) butane, tert-butyl-hydroxy-aniline, p-hydroxy aniryl and n-propyl gallate. Di-tert-butyl hydroxy toluene (commercially available from Shell under the trade name IONOL CP®) and / or tert-butyl-hydroxy anisol are preferred for use herein. In addition such radical scavengers further contribute to the safety of the compositions herein containing hydrogen peroxide.

Typically, the compositions according to the invention comprise up to 5% by weight of the radical scavengers or mixtures thereof, preferably from 0.001% to 1.5% by weight, more preferably from 0.01% to 1% by weight. .

The compositions herein may comprise a solvent or mixtures thereof as preferred optional components. When using a solvent, the solvent preferably provides improved cleaning power to the compositions herein. Suitable solvents for incorporation into the compositions according to the invention include propylene glycol derivatives (e.g., n-butoxypropanol or n-butoxypropoxypropanol), water soluble carbitol (CARBITOL®) solvents or water soluble cellosolves (CELLOSOLVE). (Trademark) a solvent. Water-soluble carbitol solvents are compounds of the class 2- (2-alkoxyethoxy) ethanol in which the alkoxy group is derived from ethyl, propyl or butyl. Preferred water soluble carbitol is 2- (2-butoxyethoxy) ethanol, known as butyl carbitol. Water-soluble cellosolve solvents are compounds of the class 2-alkoxyethoxyethanol, with 2-butoxyethoxyethanol being preferred. Other suitable solvents include diols such as benzyl alcohol, methanol, ethanol, isopropyl alcohol and 2-ethyl-1,3-hexadiol and 2,2,4-trimethyl-1,3-pentadiol and mixtures thereof. Can be. Preferred solvents for use herein include n-butoxypropoxypropanol, butyl carbitol, benzyl alcohol, isopropanol and mixtures thereof. Most preferred solvents for use herein are butyl carbitol, benzyl alcohol and / or isopropanol.

The solvent may typically be present in the composition of the present invention at up to 15% by weight, preferably from 2% to 7% by weight of the composition.

In addition, the compositions herein can be used in various other optional ingredients such as buffers (e.g. borate buffers), builders, stabilizers, bleach activators, dirt suspensions, infectious agents, varnishes, flavorings, dedusting agents, enzymes, Dispersants, infection inhibitors, pigments, perfumes, and dyes.

Package form of disinfection composition

The compositions herein may be packaged in a variety of suitable detergent packaging known to those skilled in the art. The liquid composition herein may preferably be packaged in a spray dispensing container which is generally composed of synthetic organic polymeric plastics material and which is operated manually.

Accordingly, the present invention relates to a group consisting of peroxygen bleach, betaine and / or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof. And a disinfecting composition packaged in a spray dispenser, preferably a trigger spray dispenser or a pumped spray dispenser, comprising an antimicrobial compound selected from. Such liquid compositions may further comprise optional components as described above.

Indeed, spray-type dispensers may be prepared on a relatively large surface to be disinfected, with peroxygen bleach, betaine and / or sulfobetaine surfactants or derivatives or mixtures thereof and antimicrobial essential oils or their actives, parabens, glues. A liquid disinfection composition comprising an antimicrobial compound selected from the group consisting of taraldehyde and mixtures thereof can be uniformly applied, contributing to the disinfectability of the composition. Such liquid compositions may further comprise optional components as described above. Such spray-type dispensers are particularly suitable for vertical surfaces to be sterilized.

Suitable spray-type dispensers used in accordance with the invention are manually operated, foamable triggerer-type dispensers, for example Specialty Packing Products, Inc. or Continental Sprayers Inc. Available from Continental Sprayers, Inc. Dispensers of this type are described, for example, in US Pat. No. 4,701,311 to Dunning et al. And US Pat. No. 4,646,973 to Focalarcci and US Pat. No. 4,538,745. Spray-type dispensers such as the T 8500® or T 8900® available from Continental Spray International or the T 8100® available from Canyon, Ireland Preferred for use herein. In such dispensers, the liquid composition is divided into fine droplets and sprayed onto the surface to be treated. Indeed, in such a spray-type dispenser, the composition contained in the body of the dispenser passes through the head of the spray-type dispenser by the energy delivered by the user to the pumping device when the user operates the pump device. More specifically, at the head of the spray-shaped dispenser, the composition is forced against an obstacle (such as a lattice or cone) to help spray the liquid composition, i.e., form droplets, with its impact. .

The composition of the present invention may also be prepared in the form of a wipe. The term "wipe" means a disposable towel impregnated with the composition according to the invention. Preferably, the wipe is packaged in a plastic box. Indeed, the present invention also relates to wipes, such as peroxygen bleach, betaine and / or sulfobetaine surfactants or derivatives thereof, or mixtures thereof and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and Disposable paper towels impregnated / wet with a liquid disinfection composition comprising an antimicrobial compound selected from the group consisting of mixtures thereof.

The advantage of this practice is that the user uses the disinfecting composition faster, even outside the home, i.e. after pouring the liquid composition according to the invention to the surface to be treated / disinfected, the surface does not need to be dried with a cloth. In other words, the wipe disinfects the surface at once.

Disinfection process

The present invention provides an antimicrobial agent selected from the group consisting of peroxygen bleach, betaine and / or sulfobetaine surfactants or mixtures thereof, and antimicrobial essential oils or active substances thereof, parabens, glutaraldehyde and mixtures thereof. A method of disinfecting a surface, wherein the composition comprising a compound is applied to the surface.

By “surface” is meant herein any surface, including biological surfaces (eg, human skin, mouth, teeth) and inanimate surfaces. Inanimate surfaces include hard surfaces typically found in homes and car interiors such as kitchens and bathrooms, such as tiles, walls, flooring, chrome, glass, soft vinyl, any plastics, plasticized wood, and table tops. , Sinks, cookware tops, plates, sanitary utensils (e.g. sinks, showers, shower curtains, washbasins, toilets, etc.), textiles (e.g. clothing, curtains, drapes, bedspreads, bath linens, Tablecloths, sleeping bags, tents, covered furniture, etc.) and carpets. Inanimate surfaces also include, but are not limited to, household appliances such as refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, and the like.

In the process of the invention, the composition, preferably in liquid form, is applied to the surface in pure form or in diluted form with water. Preferably, the composition is diluted with water up to 100 times, preferably 80 to 40 times, more preferably 60 to 30 times, with water before being applied to the surface.

In a preferred embodiment of the method of the present invention wherein the composition is applied to the hard surface to be disinfected in diluted form, there is no need to wash the surface after applying the composition since no visual residue remains substantially on the surface.

The invention will be further illustrated by the following examples.

The compositions of Tables 1 to 4 below are prepared by mixing the components of the following list in proportions (in weight percent unless otherwise indicated). This composition passed the prEN 1276 test (0.03% albumin / hard water) of the European Commission. Such compositions, when used in pure form or in diluted form (e.g. when the dilution is 1: 100, 1:25, 1:50), provide good surface safety while providing good disinfection to slightly soiled surfaces. .

Composition I II III IV V VI Hydrogen peroxide 7.0 6.0 7.0 3.5 6.0 8.0 Betaine ^* 3.0 2.5 4.0 2.5 4.5 3.0 Thymol - 1.0 - - - - Ethyl paraben - - 0.4 - - 0.8 Glutaraldehyde 0.8 - - - - - Eugenol - - - 0.3 0.5 - Small amount of H ₂ SO ₄ to bring water and pH to 4.0 Applied until 100% Betaine ^* is coconut betaine commercially available from Seppic under the tradename Amonyl 265, or launil betaine commercially available from Albright and Wilson under the tradename Ampgen BB / L® or a mixture thereof.

Composition VII VIII IX X XI XII Hydrogen peroxide 7.0 6.0 7.0 6.0 2.0 8.0 Coconut Betaine - 2.5 - - - 3.0 Lauryl betaine 3.0 - 4.0 3.0 0.05 - Thymol / eugenol (1: 1) 1.0 - - 2.0 0.1 - GDA / eugenol (1: 1) - 1.0 1.0 - - 1.5 Small amount of H ₂ SO ₄ to bring water and pH to 4.0 Applied until 100% GDA is glutaraldehyde.

Composition XIII XIV XV XVI XVII XVIII Hydrogen peroxide 7.0 6.0 0.2 6.0 6.0 8.0 Betaine ^* 3.0 2.5 0.1 3.0 4.5 3.0 Nonionic Surfactants ^** 1.2 1.5 0.2 1.1 1.3 1.5 Nonionic Surfactant ^*** 1.6 2.0 - 1.7 1.8 2.0 Thymol - 1.0 - - 0.5 - Ethyl paraben - - - - - 0.4 Glutaraldehyde 0.8 - - - - - Eugenol - - 0.01 One - - Small amount of H ₂ SO ₄ to bring water and pH to 4.0 Applied until 100% Betaine ^* is coconut betaine marketed under the tradename Amonyl 265 at Seppic or launil betaine marketed under the brand name Ampgen BB / L® at Albright and Wilson. ** is dobanol 23-3. *** is Tobanol 91-10 (registered trademark).

Composition XIX XX XXI XXII XXIII XXIV Hydrogen peroxide 7.0 6.0 0.2 6.0 6.0 8.0 Betaine ^* 3.0 2.5 0.1 3.0 4.5 1.5 Nonionic Surfactants ^** 1.2 1.5 0.2 1.1 1.3 1.5 Nonionic Surfactant ^*** 1.6 2.0 - 1.7 1.8 2.0 Alkyl sulfates with 10 carbon atoms 4.0 - - 2.0 - - Amine oxides with 10 carbon atoms - 5.0 1.0 0.5 - 4.0 Thymol - 1.0 - - 0.5 - Ethyl paraben - - - - - 0.4 Glutaraldehyde 0.8 - - - - - Eugenol - - 0.01 One - - Small amount of H ₂ SO ₄ to bring water and pH to 4.0 Applied until 100%

Claims (18)

Antimicrobial selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof An aqueous composition comprising a compound, provided that the hydrogen peroxide is 0.5-50% by weight of the total composition as the peroxygen bleach, and the terpene alcohol, the cyclic terpene alcohol or ester thereof as the only antimicrobial compound is 0.001-10% by weight of the total composition. Non-sterilizing composition. Antimicrobial selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof A method of disinfecting a surface, wherein a composition comprising a compound is applied to a surface. The method of claim 2, A method of diluting the composition to 100 times or less, preferably 80 to 40 times, more preferably 60 to 30 times its weight with water before applying the composition to the surface. The method according to any one of claims 1 to 3, Hydrogen peroxide bleach is hydrogen peroxide, or percarbonate, perilicate, persulfate, perborate, peroxy acid, dialkylperoxide, diacylperoxide, preformed percarboxylic acid, organic and inorganic peroxides, organic and inorganic hydroperoxides And a water-soluble source of hydrogen peroxide selected from the group consisting of mixtures thereof, preferably hydrogen peroxide. The method according to any one of claims 1 to 4, A composition or method wherein the betaine or sulfobetaine surfactant is a compound of Formula 1 or a mixture thereof: Formula 1 Where R 1 is an alkyl radical having 1 to 24 carbon atoms, preferably 8 to 18 carbon atoms, more preferably 12 to 14 carbon atoms, R2 and R3 have 1 to 3 carbon atoms, preferably 1, n is an integer of 1 to 10, preferably 1 to 6, more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals, The R1, R2 and R3 radicals have 14 to 24 carbon atoms in total. The method according to any one of claims 1 to 5, A composition or method wherein the antimicrobial compound is an essential oil or an active substance thereof or a mixture thereof. The method according to any one of claims 1 to 6, Essential oils are thyme, lemongrass, citrus, lemon, orange, anise, cloves, anise fruit, cinnamon, geranium, rose, lavender, citronella, eucalyptus, mint, camphor, Obtained from sandalwood, cedar and mixtures thereof, the active ingredients of essential oils are thymol, eugenol, menthol, carvacrol, verbenone, eucalyptol, Cedrol, anethol, pinocarvone, geraniol, hinokitiol, berberine, terpineol, limonene, la A composition or method selected from the group consisting of ratanhiae and mixtures thereof, preferably thymol, eugenol, verbenone, eucalyptol, limonene and / or geraniol. The method according to any one of claims 1 to 7, The composition or method wherein the paraben is ethyl paraben, methyl paraben, propyl paraben or mixtures thereof. The method according to any one of claims 1 to 8, A composition or method comprising the antimicrobial compound in at least 0.003%, preferably 0.006 to 4%, more preferably 0.2 to 2% by weight of the total composition. The method according to any one of claims 1 to 9, A composition or method comprising peroxygen bleach or mixtures thereof in an amount of at least 0.01%, preferably 0.1 to 15%, more preferably 1 to 10% by weight of the total composition. The method according to any one of claims 1 to 10, A composition or method comprising betaine or sulfobetaine surfactants, derivatives thereof, or mixtures thereof in an amount of at least 0.005%, preferably 0.01-10%, more preferably 0.1-5% by weight of the total composition. The method according to any one of claims 1 to 11, Phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, amino carboxylate chelating agents, other carboxylate chelating agents, aromatic chelating agents substituted to be multifunctional, ethylene multiamine N, N'- A composition or method further comprising a chelating agent selected from the group consisting of disuccinic acid and mixtures thereof. The method according to any one of claims 1 to 12, Group consisting of surfactants, radical scavengers, builders, stabilizers, bleach activators, dirt-sustaining agents, infectious agents, varnishes, dedusting agents, solvents, enzymes, dispersants, infectious agents, pigments, flavorings, dyes and mixtures thereof A composition or method further comprising an optional component selected from. Antimicrobial selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof A disinfectant composition packaged in a spray dispenser comprising a compound. Antimicrobial selected from the group consisting of peroxygen bleach, betaine or sulfobetaine surfactants or derivatives thereof, or mixtures thereof, and antimicrobial essential oils or active agents thereof, parabens, glutaraldehyde and mixtures thereof Wipes impregnated with a liquid composition comprising a compound. The method according to claim 14 or 15, Antimicrobial compounds are obtained from thyme, lemongrass, citrus fruits, lemons, oranges, anise, cloves, anise fruit, cinnamon, geranium, rose, lavender, citronella, eucalyptus, peppermint, camphor, sandalwood, cedar and mixtures thereof Petroleum essential oils, thymol, eugenol, menthol, carbacrol, verbenone, eucalyptol, cedrol, anetol, pinocarbon, geraniol, hinokithiol, berberine, terpineol, limonene, rattania and these A wipe or liquid composition which is an active substance of an essential oil selected from the group consisting of a mixture of The method according to any one of claims 14 to 16, Hydrogen peroxide bleach is hydrogen peroxide, or percarbonate, perilicate, persulfate, perborate, peroxy acid, dialkylperoxide, diacylperoxide, preformed percarboxylic acid, organic and inorganic peroxides, organic and inorganic hydroperoxides And a wipe or liquid composition which is an aqueous source of hydrogen peroxide selected from the group consisting of: and mixtures thereof. The method according to any one of claims 14 to 17, Wipes or liquid compositions wherein the betaine or sulfobetaine surfactant is a compound of Formula 1 or a mixture thereof: Formula 1 Where R 1 is an alkyl radical having 1 to 24 carbon atoms, preferably 8 to 18 carbon atoms, more preferably 12 to 14 carbon atoms, R2 and R3 have 1 to 3 carbon atoms, preferably 1, n is an integer of 1 to 10, preferably 1 to 6, more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals, The R1, R2 and R3 radicals have 14 to 24 carbon atoms in total.