CZ217398A3 - Disinfectants and method of disinfecting surfaces - Google Patents

Abstract

The present invention relates to the disinfection of surfaces with a liquid disinfecting composition comprising a peroxygen bleach and an antimicrobial active of essential oil or mixtures thereof.

Description

Technical field

The present invention relates to antimicrobial compositions that are used to disinfect and clean various surfaces including living surfaces (eg, human skin, mouth, and the like) and inanimate surfaces including, but not limited to, solid surfaces such as walls, tiles, table tops , glass, bathroom surfaces, kitchen surfaces, dishes, fabrics, dresses, carpets, and the like.

BACKGROUND OF THE INVENTION

Antimicrobial / antibacterial agents include substances capable of disinfecting. Generally, the disinfectant substantially reduces or even destroys microorganisms, such as bacteria, occurring on the surface. For disinfection purposes, compositions based on halogen-containing compounds such as hypochlorite or quaternary compounds have been widely described in the art. Peroxide bleaching agents are also known as disinfectants.

Compositions containing as the only antimicrobial agent hydrogen peroxide, usually 7% of the total weight of the composition, are however not fully satisfactory when used in larger dilutions, e.g. at 1:50 dilution (composition: water) for disinfection of clean surfaces, i.e.. surfaces free of organic and / or inorganic residues.

Disinfectants are therefore needed which will result in perfect disinfection of clean surfaces even when used in large dilutions.

For example, WO88 / 00795 discloses liquid disinfectants comprising a compound of the group of organic acids, perborates, peracids and salts thereof, together with antimicrobial compounds such as quaternary ammonium salt and essential oils.

A drawback of liquid compositions containing a bleaching agent and essential oil is chemical instability over an extended shelf life. Conventional essential oils are mixtures of ingredients including terpenes, esters, aromatics, chetones, aldehydes, and the like. These essential oils are sensitive to peroxide bleaching agents. In other words, these essential oils are unstable in 9 * 9 9 * 9 9 9

999 · 9 9 99 9 9 090 090

9 9 9 9 9 999 • 9 ** 9 ··· · · ·· The presence of peroxide bleaching agents and decomposes / oxidized with peroxide bleaching agents, resulting in a reduction in the free oxygen content of the peroxygen bleach-containing composition and consequent chemical problems stability with longer shelf life.

It is an object of the present invention to provide a disinfectant composition comprising a peroxide bleaching agent that is chemically stable for long shelf life and results in a perfectly disinfected clean surface when used in large dilutions.

This has been shown to be achieved by a liquid composition comprising a peroxygen bleach and an active antimicrobial component of the essential oil or mixtures thereof. In particular, it has been shown that the liquid compositions of the present invention comprising a peroxygen bleaching agent and an active antimicrobial essential oil component exhibit improved chemical stability upon prolonged storage compared to the same antimicrobial essential oil compositions instead of the active antimicrobial essential oil component. surfaces free of organic and / or inorganic stains even at high dilution, ie. up to a 1: 100 dilution (composition: water).

The advantage of the present invention is the perfect disinfection acting on a wide variety of bacterial strains including Gram positive and Gram negative bacterial strains and more resistant microorganisms such as fungi.

A further advantage of the compositions of the present invention is, in addition to the disinfectant properties, also good cleaning performance, especially in the practice of the present invention, wherein the compositions further comprise a surfactant and / or a solvent.

The compositions of the present invention are suitable for use on all types of surfaces including living surfaces (eg, human skin and / or mouth when used as an oral preparation or toothpaste) and inanimate surfaces. This technology is particularly suitable for applications on solid surfaces as well as laundry, eg as a detergent or additive in so-called 'soak mode', 'wash mode' or in laundry pretreatment in 'pretreatment mode'. The compositions of the present invention are particularly suitable for use on delicate surfaces including surfaces in safe contact with food and / or children. The use of the diluted compositions of the present invention reduces the amount of chemical compounds remaining on

· Disinfected surface. For example, it is not necessary to rinse solid surfaces after application of the diluted compositions of the present invention.

EP-B-288 689 discloses a solid surface liquid comprising an effective amount of an antimicrobial pine oil and at least one oleic soluble organic acid. No other antimicrobial compounds, let alone peroxide bleach, are mentioned.

EP-2413 90 discloses the disinfection of bacteria-contaminated textiles with detergents and then a peroxide bleach in a water bath at pH 9-13 in the presence of uncomplexed calcium. No other antimicrobial compounds, let alone the active antimicrobial components of essential oils, are disclosed.

US-4,404,191 discloses bactericidal, fungicidal and antiviral effects of peroxy compounds such as monoperoxosulfate. US-4,404,191 describes the use of dilute compositions containing monoperoxosulfate on solid surfaces. No other antimicrobial compounds, let alone the active antimicrobial components of essential oils, are disclosed.

US-5,403,587 discloses aqueous antimicrobial compounds used to sanitize, disinfect and clean solid surfaces. In particular, US-5,403,587 discloses aqueous compounds (pH 1-12) containing essential oils (0.02% to 5%) which exhibit antimicrobial properties such as thymic oil, eucalyptic oil, clove oil and the like, and a solubilizing or dispersing agent sufficient to form an aqueous solution or dispersion of essential oils in an aqueous medium. These compositions may additionally contain other antimicrobial additives such as phenolic compounds, quaternary ammonium compounds, but no betaine or sulfobetaine surfactants or peroxide bleaching agents are disclosed.

J-60038497 discloses a foaming detergent two-component composition comprising a) an aqueous solution of hydrogen peroxide (0.5% to 50%), b) an alkaline compound containing an alkaline substance with an alkalinity of 0.1% to 50% expressed by NaOH, such as NaOH, KOH, Na ₂ CO3. At least one of components a) and b) comprises a surfactant and / or at least one compound (0.001% to 10%) selected from terpene alcohols, cyclic terpene alcohols and esters thereof, e.g. menthol, geraniol. This composition cleans stains on solid materials such as plastics, joints and particularly difficult to clean niches or corners. No disinfectant use is indicated.

· ♦ · 4 4 4 4 4 4 4 4 4 4 4

4 4 4 4 ·

444 44 44 44 • 44

4 4

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4 4 • 44

SUMMARY OF THE INVENTION

The present invention includes a liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of essential oil or mixtures thereof, with the exception of aqueous compositions containing 0.5 to 50% hydrogen peroxide of the total weight of the composition as a peroxygen bleach and 0.001 to 10% by weight of terpenic alcohol. , a cyclic terpenic alcohol or ester thereof, as the only active antimicrobial component of essential oil.

The present invention further comprises a method of disinfecting a surface with a liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of the essential oil or mixtures thereof.

The present invention also includes a liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of essential oil or mixtures thereof packaged in a nebulizer, as well as wipes impregnated with a liquid disinfectant comprising a peroxygen bleach and the active antimicrobial component of essential oil or mixtures thereof.

Detailed description of the invention.

The liquid disinfectant compositions of the present invention comprise a peroxygen bleach and an active antimicrobial component of essential oil, with the exception of aqueous compositions containing 0.5 to 50% hydrogen peroxide of the total weight of the composition as a peroxygen bleach and 0.001 to 10% by weight of terpenic alcohol, cyclic terpenic. alcohol or an ester thereof, as the only active antimicrobial component of essential oil.

As an essential element, the compositions of the present invention comprise a peroxygen bleach or a mixture thereof. A preferred peroxygen bleaching agent is hydrogen peroxide or a water-soluble source thereof or a mixture thereof. Most preferably, hydrogen peroxide is used in the compositions of the present invention.

The presence of a peroxygen bleach, especially hydrogen peroxide, persulfate, and the like, contributes to the disinfectant properties of the compositions of the present invention. The peroxygen bleaching agent can attack the vital functions of the microorganism cells, for example, it can inhibit the arrangement of ribosomal units in the cytoplasm of the microorganism cells. A peroxygen bleaching agent such as hydrogen peroxide is 9 <9 <ϊ ϊ ϊ ϊ ϊ · · · · · · · · · · · · · · Strong oxidizing agent that generates free hydroxyl radicals that attack proteins and nucleic acids. In addition, the presence of a peroxide bleaching agent, in particular hydrogen peroxide, has a strong stain removal effect, which is noticeable, for example, in laundry and solid surface applications.

A hydrogen peroxide source is used herein to refer to any compound that upon contact with water provides hydrogen peroxide. Suitable water-soluble hydrogen peroxide sources used herein include percarbonates, persilicates, persulfates such as monoperoxosulfate, perborates and peracids such as diperoxododecanedioic acid (DPDA), magnesium peroxophthalic acid salt, and mixtures thereof.

Other classes of peroxides are used as an alternative to hydrogen peroxide and its sources or in combination with hydrogen peroxide and its sources. Suitable classes include dialkyl peroxides, diacyl peroxides, preformed peroxocarboxylic acids, organic and inorganic peroxides and / or hydroperoxides.

The compositions typically comprise at least 0.01% of a peroxygen bleach or mixtures thereof, based on the total weight of the composition, preferably 0.1% to 15%, and most preferably 1% to 10%.

As a second essential component, the compositions of the present invention comprise an active antimicrobial component of the essential oil or mixtures thereof. The compositions typically comprise at least 0.003% of the active antimicrobial component of the essential oil or mixtures thereof, based on the total weight of the composition, preferably 0.006% to 10%, more preferably 0.2% to 4%, and most preferably 0.2% to 2%.

Suitable active antimicrobial essential oil components useful in the compositions include any essential oil component that exhibits antimicrobial activity. Active antimicrobial components of essential oils appear to cause protein denaturation. The active antimicrobial components of essential oils are compounds of natural origin, contributing to the safe profile of the compositions of the present invention when used to disinfect any surfaces. A further advantage of the active ingredients of the essential oils is that they provide a pleasant fragrance to the disinfectants of the present invention without the need for perfume. The disinfectants of the present invention not only perfectly disinfect clean surfaces, but also impart a pleasant odor to them.

• · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · φ ·

Active ingredients of essential oils include, but are not limited to, active antimicrobial ingredients derived from thymol essential oil, lemon grass, citrus, lemons, oranges, anise, cloves, anise spices, cinnamon, geranium, roses, mint, lavender, citronella essential oil, eucalyptus, peppermint , camphor, sandalwood, cedar and mixtures thereof. The active ingredients used include, but are not limited to, thymol (present in, for example, thymol essential oil), eugenol (present in, for example, cinnamon and clove oil), menthol (present in, for example, peppermint oil), geraniol (present in, for example, pink essential oil), verbenone (present for example in verbene essential oil), eucalyptol and pinocarvone (present for example in eucalyptic essential oil), cedrol (present for example in cedar essential oil), anethole (present for example in anise spice oil), carvacrol, hinokitol , berberine, terpineol, limonene, ratanhiae and mixtures thereof. Preferred active ingredients of essential oils are thymol, eugenol, verbenone, eucalyptol, carvacrol, limonene and / or geraniol.

Thymol is commercially available, for example, from Aldrich, eugenol is commercially available, for example, from Sigma, Systems - Bioindustries (SBI) Manheimer Inc.

It has been shown that a liquid composition comprising a peroxygen bleaching agent and an active antimicrobial component of essential oil or mixtures thereof exhibits improved chemical stability upon prolonged storage compared to the chemical stability of the same composition containing the corresponding antimicrobial essential oil instead of the active antimicrobial essential component. high dilution. The chemical decomposition of the peroxygen bleach present in the liquid composition is reduced in the presence of the active antimicrobial component of the essential oil such as eugenol compared to the presence of the corresponding essential oil such as cinnamon and / or clove essential oil.

The chemical stability of the compositions is evaluated by measuring the concentration of usable oxygen (often abbreviated as Avox) at a given storage time after manufacture of the compositions. The usable oxygen concentrations are measured by chemical titration methods known in the art, such as the iodometric method, the thiosulfatimetric method, the permanganometric method and the cerimetric method. Methods and criteria for selecting a suitable method are described, for example, in "Hydrogen Peroxide", W. C. Schumb, C. N. Satterfiedel and R. L. Wentworth, Reinhold Publishing Corporation, New York, 1955, and Organic Peroxides, Daniel Swern, Editor Wiley Int. Science, 1972.

• 4 • 44 4 4 4 4 4 4 4 · ~ 9 999 9 · 9 · 4 4 44 / ······ ···

993 99 4 993

944 49 49 49 44

Perfect disinfection is achieved by the compositions of the present invention in a variety of microorganisms including Gram positive bacteria such as Staphylococcus aureus and Gram negative bacteria such as Pseudomonas aeroginosa, as well as fungi such as Candida albicans present on pure surfaces, i. on any surface free of organic and / or inorganic stains at high dilution.

The disinfectant properties of the composition are measured by the bactericidal activity of the composition. A test method suitable for the determination of bactericidal activity of the composition on clean surfaces is described in Europian Standard, prEN 1040, CEN / TC 216 N 78 of November 1995, published by the European Commission for Standardization in Brussels. Europian Standard, prEN 1040, CEN / TC 216 N 78 specifies the test method and the minimum bactericidal activity requirements of the disinfectant. The test is passed if the bacterial colonies forming units (duty) are reduced from ^seven duty 1Ό (initial level) to a 10 ² cfu (final level after contact with the disinfecting product), i.e.. it is necessary to reduce viability in the order of 10 ⁵ . The compositions of the present invention purely pass this test on clean surfaces even at high dilution.

Another suitable test method for determining bactericidal activity of the present compositions on clean surfaces is AFNOR T72-190® and T72-301®.

The compositions of the present invention are liquid cleaning compositions.

The liquid compositions preferably have a pH of not more than 12.0, more preferably 2 to 6, and most preferably 3 to 5. The pH of the compositions is adjusted using organic acids such as citric, succinic, acetic, aspartic, lactic and the like, or inorganic acids or alkalinizing agents. .

The compositions of the present invention may further comprise surfactants known to those skilled in the art, including nonionic, anionic, cationic, zwitterionic and / or amphoteric surfactants. Surfactants contribute to the cleaning properties of the compositions of the invention.

The compositions of the present invention typically comprise up to 50% surfactant or mixtures thereof of the total weight of the composition, preferably 0.01% to 30%, and most preferably 0.1% to 25%.

The compositions of the present invention preferably comprise amphoteric surfactants or mixtures thereof. Suitable amphoteric surfactants include betaine and sulfobetaine surfactants, derivatives thereof or mixtures thereof. Betaine and sulfobetaine surfactants advantageously contribute to the disinfecting properties of the compositions of the invention. They aid disinfection by increasing the permeability of the bacterial cell wall and allowing other active ingredients to enter the cell.

The compositions of the present invention are particularly suitable for cleaning delicate surfaces, for example delicate laundry or surfaces in contact with food and / or children, due to the mild activity of the betaine and sulfobetaine surfactants contained therein. Betaine and sulfobetaine surfactants are very gentle on the cleansed skin and / or surfaces.

Suitable betaine and sulfobetaine surfactants used in the compositions of the present invention are betaine / sulfobetaine and betaine-like detergents whose molecule contains both basic and acidic groups that form an internal salt and impart cationic and anionic hydrophilic groups to the molecule over a wide pH range. Some common examples of such detergents are described in U.S. Pat. 2,082,275, 2,702,279 and 2,255,082, incorporated herein by reference.

Preferred betaine and sulfobetaine surfactants have the general formula I:

h

R ₂ —N— (CH ₃ ) n Y (I)

R ₃ wherein R 1 is an alkyl radical of 1 to 24 carbon atoms, preferably 8 to 18, more preferably 12 to 14, wherein R ₂ and R ₃ contain 1 to 3 carbon atoms, preferably 1 carbon atom, wherein n is an integer from 1 to 10 , preferably 1 to 6 and more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals and wherein the sum of the R 1, R ₂ and R ₃ radicals is 14 to 24 carbon atoms or mixtures thereof.

Examples of suitable betaine surfactants include C _{2 -C] g of} alkyl dimethyl betaine such as the coconut betaine and _{Cio-C] 6} alkyl dimethyl betaine such as the lauryl betaine.

Coconut betaine is commercially available from Seppic under the trade name Amonyl 265®. Laurylbetain is commercially available from Albright & Wilson under the trade name Empigen BB / L®.

Other suitable amphoteric surfactants include amine oxides or mixtures thereof. Preferably, the amine oxides benefit from the disinfectant properties of the compositions of the invention. They assist disinfection by disrupting the cell wall / membrane of the bacterium, thus allowing other antimicrobial components to enter the cell and, for example, attack the internal cell space.

Suitable amine oxides have the general formula R ₁ R ₂ R ₃ NO, wherein each R _b R ₂ and R ₃ is independently a saturated linear or branched hydrocarbon chain having 1 to 30 carbon atoms. Suitable amine oxides of the present invention have the general formula R ₁ R ₂ R ₃ NO, wherein R 1 is a hydrocarbon chain containing 1 to 30 carbon atoms, preferably 6 to 20, more preferably 6 to 14 and most preferably 8 to 10 and wherein R ₂ and R ₃ are independently unsubstituted or substituted linear; branched hydrocarbon chains containing 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, and more preferably are methyl groups. R 1 is a saturated linear or branched hydrocarbon chain.

Preferred amine oxides of the present invention are, for example, a natural mixture of C ₈ -C 10 amine oxides and C 12 -C ₁₆ amine oxides commercially available from Hoechst.

In a preferred embodiment of the present invention where the compositions are particularly suitable for disinfecting solid surfaces, the surfactant is typically a surfactant system comprising an amine oxide and a betaine or sulfobetaine surfactant, preferably in a weight ratio of amine oxides to betaine or sulfobetaine of 2: 1 to 100: 1, more preferably 6: 1. up to 100: 1 and most preferably 10: 1 to 50: 1. The use of such a surfactant system in compositions suitable for disinfecting solid surfaces provides effective cleaning and shine of the surfaces to be cleaned, i.e.. The amount of surfactant left by coating or spraying of the surface to be cleaned by the compositions of the invention is minimal.

The compositions of the invention also preferably contain anionic surfactants or mixtures thereof.

Suitable anionic surfactants include water-soluble salts or acids of the formula ROSO 3 M wherein R is preferably a C6-C24 hydrocarbyl, preferably an alkyl or hydroxyalkyl having a _C8-C20 alkyl component, more preferably a Cg-C ₆ alkyl or hydroxyalkyl, and M is H or cations, e.g., alkali metal cations (e.g., sodium, potassium, lithium) or ammonium or substituted ammonium cations (e.g., methyl, dimethyl, and trimethylammonium cations and quaternary ammonium cations such as tetramethylammonium and dimethylpiperidine cations and quaternary ammonium cations derived from alkylamines such as ethylamine, diethylamine, triethylamine and mixtures thereof, and the like).

• · ···

Other suitable anionic surfactants include alkyl diphenyl ether sulfonates and alkyl carboxylates. Other anionic surfactants include soap salts (including, for example, sodium, potassium, ammonium and substituted ammonium salts such as mono-, di-, and triethanolamine salts), C ₉ -C 20 linear alkylbenzene sulfonates, C ₈ -C ₂₂ primary or secondary alkane sulfonates, C ₈ -C ₂₄ olefin sulfonates, sulfonic polycarboxylic acids prepared by sulfonating the pyrolysis product of an alkaline earth metal citrate, as described, for example, in British patent no. 1,082,179, C ₈ -C ₂₄ alkylpolyglycolethersulfates (containing up to 10 moles of ethylene oxide); alkyl ester of sulfonates such as C14-C16 methyl ester of sulfonates; acyl glycerol sulfonates, fatty oleylglycerolsulfátů, alkyl phenol, paraffin sulfonates, alkyl phosphates, isethionates such as the acyl isethionates, N-acyl taurates, alkylsukcinamátů and sulfosuccinates, monoesters of sulfosuccinates (especially saturated and unsaturated C ₂ C ₈ monoesters) diesters of sulfosuccinate (especially saturated and unsaturated C _{6 -C) 4} diesters), acyl sarcosinates, alkylpolysaccharide sulphates such as alkylpolyglucoside sulphates (nonionic non-sulphonated compounds are described below), branched primary alkyl sulphates, alkylpolyethoxycarboxylates of formula RO (CH ₂ CH ₂ O) kCH ₂ COO-M ⁺ , where R is C ₈ -C + _An alkyl group, k is an integer from 0 to 10 and M is a soluble salt-forming cation. Also suitable are resin acids and hydrogenated resin acids such as rosin, hydrogenated rosin and resin acids present in or derived from tall oil. Further examples are given in 'Surface Active Agents and Detergents' (Vol. I and II, Schwartz, Perry and Berch). Various surfactants are also generally described in U.S. Patent 3,929,678, issued December 30, 1975 to Laughlin et al., Column 23, line 58 through column 29, line 23.

Preferred anionic surfactants useful in the compositions herein are the _C8-CI6 alkyl sulfonates, C ₈ -C _J6 alkyl sulphates, C ₆ -C ₈ alkyl alkoxylated sulphate (e.g. _C8 -Ci6 alkyletholxylsulfáty) and mixtures thereof. Such anionic surfactants preferably contribute to the disinfectant properties of disinfectants comprising peroxide bleaching agents and / or the active antimicrobial component of the essential oil. For example, C 1 -C 16 alkyl sulfate causes disruption of the bacterial cell membrane, inhibits enzymatic activities, disrupts cellular transport and / or denatures cellular proteins. It is believed that the improved disinfection action associated with the addition of an anionic surfactant, in particular C ₈ -C 16 alkylsulfonate, C ₈ -C 16 alkylsulfate and C ₈ -C 16 alkylalkoxylsulfate in the composition according to> ♦

999 9

9 · 9

99 of the present invention is caused by a multiplicity of bacterial surfactant attack. Another aspect of the present invention is the use of an anionic surfactant, in particular a C ₈ -C ₁₆ alkylsulfonate, C ₈ -C ₁₆ alkylsulfate and / or C ₈ -C ₁₆ alkylalkoxyl sulfate in a disinfectant composition comprising a peroxygen bleach and / or active antimicrobial component of essential oil to improve the disinfectant properties of the composition. Gram negative and / or Gram positive bacteria.

Suitable nonionic surfactants are fatty alcohol ethoxylates and / or propoxylates which are commercially available with different fatty alcohol chain lengths and varying degrees of ethoxylation. The HLB values of these alkoxylated nonionic surfactants depend mainly on the chain length of the fatty alcohol, the type of alkoxylation and the degree of alkoxylation. The amounts of surfactants, including nonionics together with their respective HLB values, are listed in the surfactant catalogs.

Suitable nonionic surfactants are in particular hydrophobic nonionic surfactants having an HLB (hydrophilic lipophilic balance) value below 16, preferably below 15 and more preferably below 14. These hydrophobic nonionic surfactants have a penetrating grease.

Preferred hydrophobic nonionic surfactants useful in the compositions of the present invention are surfactants having an HLB value below 16 of the general formula RO (C ₂ H ₄ O) _n (C ₃ H ₆ O) _m H, wherein R is a C ₆ -C ₂₂ alkyl chain or C ₉ - A C ₂₈ alkylbenzene chain and wherein n + m is 0 to 20 and n is 0 to 15 and m is 0 to 20, preferably n + m is 1 to 15 and n is 0 to 15, more preferably n + m is 1 to 10 and n are Preferred R chains are C ₈ -C ₂₂ alkyl chains. Suitable hydrophobic nonionic surfactants are Dobanol ^R 912.5 (HBL = 8.1; R is a mixture of C9 and Cn alkyl chains, n is 2.5 am is 0) or Lutensol ^R TO3 (HBL = 8; R is a C13 alkyl chain, n is 3 am is 0) or Lutensol ^R AO3 (HBL = 8; R is a mixture of C 13 and C 15 alkyl chains, n is 3 am is 0) or Tergitol ^R 25L3 (HBL = 7.7; R is within the chain length of C 12 alkyl chains - Cu, n is 3 and m is 0) or Dobanol ^R 23-3 (HBL = 8.1; R is a mixture of C, 2 and C13 alkyl chains, n is 3 and m is 0) or Dobanol ^R 23-2 (HBL = 6 R is a mixture of C12 and C13 alkyl chains, n is 2 and m is 0) or Dobanol ^R 45-7 (HBL = 11.6; R is a mixture of Cu and C11 alkyl chains, n is 7 and m is 0), Dobanol ^R 23-6.5 (HBL = 11.9; R is a mixture of C 12 and C 13 alkyl chains, n is

6.5 am is 0) or Dobanol ^R 25-7 (HBL = 12; R is a mixture of C 12 and C 15 alkyl chains, n is 7 am is 0) or Dobanol ^R 91-5 (HBL = 11.6; R is a mixture of C 9 and C Cn alkyl chains, n is 6 and m is 0) or Dobanol ^R 91-6 (HBL = 12.5; R is a mixture of C ₉ and Cu). φ ΦΦΦ ·· φφ φφ alkyl chains, η is 6 am is 0) or Dobanol ^R 91-8 (HBL = 13,7; R is a mixture of C8 and Cn alkyl chains, n is 8 am is 0) or Dobanol ^R 91- 10 (HBL = 14.2; R is a mixture of C8 and Cu alkyl chains, n is 10 and m is 0) or mixtures thereof. Preferred are Dobanol ^R 91-2.5 or Lutensol ^R TO3 or Lutensol ^R AO3 or Tergitol ^R 25L3 or Dobanol ^K 23-3 or Dobanol ^R 23-2 or mixtures thereof. Dobanol ^R surfactants are commercially available from Shell. Lutensol ^R surfactants are commercially available from BASF and Tergitol ^R surfactants are commercially available from UNION CARBIDE.

Other suitable surfactants also include C ₆ -C ₂₀ customary soaps (C ₆ -C ₂ alkali metal salts of fatty acids, preferably sodium salts).

The compositions of the present invention include, as a further preferred ingredient, other antimicrobial ingredients that contribute to the antimicrobial activity of the compositions of the present invention. Such additives include parabens such as ethylparaben, propylparaben, methylparaben, gluteraldehyde or mixtures thereof.

The compositions may further comprise a chelating agent as a further preferred component. Suitable chelating agents are known to those skilled in the art, and can be selected from the group of phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctional substituted aromatic chelating agents, biodegrading agents, biodegradable chelating agents acid or mixtures thereof.

Suitable phosphonate chelating agents include etidronic acid (1-hydroxyethylenediphosphonic acid HEDP) and / or alkali metal 1-hydroxydiphosphonate ethane.

Suitable aminophosphonate chelating agents include aminoalkylene polyalkylene phosphonates, nitrilotris (methylene) triphosphonates, ethylenediaminetetramethylene phosphonates and / or diethylenetriaminepentamethylene phosphonates. Preferred aminophosphonate chelating agents are diethylenetriamine pentamethylene phosphonates.

These phosphonate / aminophosphonate chelating agents may be present either in the form of acids or salts of different cations of some or all of the acid functions. These phosphonate / aminophosphonate chelating agents are commercially available from Monsanto under the trade name DEQUEST®.

9 9 9 9 9 9 9 9999 9999 9999 9999 9999 9999 9999 99 • •• 99 99 · · 9 9 ·

Substituted heteroaromatic chelating agents include hydroxypiperidine oxide or derivatives thereof.

Suitable hydroxypiperidine N-oxides or derivatives thereof useful according to the present invention have the general formula II:

AND

Y wherein X is nitrogen, Y is oxygen, -GHO, -OH, - (CH ₂ ) _n -COOH, wherein n is an integer from 0 to 20, preferably 0 to 10, and more preferably 0, Y is preferably oxygen. A particularly preferred hydroxypiperidine N-oxide is 2-hydroxypiperidine N-oxide and derivatives thereof.

Hydroxypiperidine N-oxide and derivatives thereof are commercially available from the company

Sigma.

Polyfunctional substituted aromatic chelating agents are also useful in the compositions of the invention. See U.S. Pat. No. 3,812,044, issued to Connor et al. May 21, 1974. Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydroxy-3,5-disulfobenzene.

A preferred biodegradable chelating agent is ethylenediamine N, N-disuccinic acid or its alkali metal, alkaline earth, ammonium or substituted ammonium salts or mixtures thereof. Ethylenediamine N, N-disuccinic acids, especially the (S, S) -isomer, are disclosed in U.S. Pat. No. 4,704,233 issued to Hartman and Perkins on November 3, 1987. Ethylenediamine N, N-disuccinic acid is commercially available, for example, from Palmer Research Laboratories under the trade name ssEDDS®. Ethylenediamine Ν, Ν'-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable aminocarboxylate chelating agents include ethylenediaminetetraacetates, such as ethylenediaminetetraacetates, such as ethylenediaminetetrapropionates (such as ethylenediaminetetraacetate, ethanediamine tetraacetate, ethanediamine tetraacetate) alkali metal, ammonium or substituted ammonium salts. Dimethylentriaminepentaacetic acid is particularly suitable.

9 9 9 9 9 9 ·

9 9 · · · ··

9,999 9,999 9 ·

9 9 9 9 9

999 99 * acid (DTPA), propylenediaminetetraacetic acid (PDTA), which is commercially available, for example, from BASF under the trade name Trilon FS (R), and methyl glycine diacetic acid (MGDA).

Other carboxylate chelating agents include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid, or mixtures thereof.

Chelating agents, particularly phosphonate chelating agents such as diethylenetriaminepentamethylene phosphonates, preferably contribute to the disinfecting properties of hydrogen peroxide in the disinfectants of the invention. Another aspect of the present invention is the use of a chelating agent, in particular a phosphonate chelating agent such as diethylenetriamine pentamethylene phosphonate in a disinfectant composition comprising a peroxygen bleach to improve the disinfectant properties of the composition for Gram negative and / or Gram positive bacteria.

The compositions of the present invention typically comprise up to 5% of a chelating agent or mixtures thereof of the total weight of the composition, preferably 0.002% to 3% by weight, and more preferably 0.002% to 1.5%.

The compositions of the invention include as a further preferred component a radical scavenger. Suitable radical scavengers include the well-known substituted mono- and dihydroxybenzenes and their derivatives, alkyl and aryl carboxylates and mixtures thereof. Preferred radical scavengers include di-tert-butylhydroxytoluene (BHT), p-hydroxytoluene, hydroquinone (HQ), di-tert-butyl hydroquinone (DTBHQ), mono-tert-butyl hydroquinone (MTBHQ), tert-butyl-hydroxyanisole ( BHA), p-hydroxyanisole, benzoic acid, 2,5-dihydroxybenzoic acid, 2,5-dihydroxyterephthalic acid, toluylic acid, cateehol, t-butylcatechol, 4-allylcatechol, 4-acetylcatechol, 2-methoxyphenol, 2-ethoxyphenol, 2-methoxy -4- (2-propenyl) phenol, 3,4-dihydroxybenzaldehyde, 2,3-dihydroxybenzaldehyde, benzylamine, 1,1,3-tris- (2-methyl-4-hydroxy-5-t-butylphenyl) butane, tert-butylhydroxyaniline, p-hydroxyaniline, and n-propyl gallate. Highly preferred is di-tert-butylhydroxytoluene, which is available, for example, from SHELL under the tradename IONOL CP®, and / or tert-butylhydroxyanisole. These radical scavengers further contribute to the stability of the peroxygen bleach-containing compositions.

00 • 0 0

00

0 0 0 0

0 0

91 • 00 0 0

0 • 00

00

0 0 *

0 0 0

0 · 00

0 0 • 0 0

The compositions of the present invention typically comprise up to 5% of radical scavengers or mixtures thereof of the total weight of the composition, preferably 0.001% to 1.5% by weight, and more preferably 0.01% to 1%.

The compositions of the invention include, as a further preferred component, solvents or mixtures thereof. When using a solvent, they preferably improve the cleaning properties of the compositions. Suitable solvents included in the compositions of the present invention include propylene glycol derivatives such as n-butoxypropanol or n-butoxypropoxypropanol, water-soluble CARBITOL® solvents or water-soluble CELLOSOLVE® solvents. Water-soluble CARBITOL® solvents are compounds of the 2- (2-alkoxyethoxy) ethanol class, wherein the alkoxy group is derived from an ethyl, propyl or butyl group. A preferred water-soluble carbitol is 2- (2-butoxyethoxy) ethanol, also known as butylcarbitol. Water-soluble CARBITOL® solvents are compounds of the 2-alkoxyethoxyethanol class, preferably 2-butoxyethoxyethanol. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol, and diols such as 2-ethyl-1,3-hexanediol and 2,2,4-trimethyl-1,3-pentadiol and mixtures thereof. Preferred solvents are n-butoxypropoxypropanol, Butylcarbitol®, benzyl alcohol, isopropanol and mixtures thereof. Most preferred solvents are Butylcarbitol (R), benzyl alcohol and isopropanol.

The compositions of the invention typically contain up to 15% of the solvents by weight of the total composition, preferably 2% to 7% by weight of the composition.

The compositions of the invention may further include various other preferred components such as buffers (e.g., borate buffers), fillers, stabilizers, bleach activators, stain suspensions, dye transfer agents, brighteners, perfumes, dusting agents, enzymes, dispersants, dye transfer inhibitors, pigments, fragrances and dyes.

Packaging of funds.

The compositions of the invention are packaged in various suitable detergent packages known to those skilled in the art. The liquid compositions of the invention are conveniently packaged in hand-held spray containers, which are usually made of synthetic organic polymeric plastics. The present invention includes liquid disinfectants comprising a peroxygen bleach and an active antimicrobial component of essential oil packaged in

99 ·· ·· «· • 0 0 0» * 090

009 0 «« 0 0 9 9 9 9 990 9 90 909 9900 0

0090 0 000

The sprayer is preferably triggered or pumped. These liquid compositions may further comprise preferred ingredients as mentioned above.

The nebulizers will allow uniform application of a liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of the essential oil to a relatively large portion of the disinfected surface, thereby contributing to the disinfectant properties of the composition. Sprayers are particularly suitable for disinfecting vertical surfaces.

Suitable nebulisers useful in the present invention include manually actuated foam nebulisers marketed, for example, by Specialty Packaging Products, Inc. or Continental Sprayers, Inc. These types of nebulizers are described, for example, in U.S.-4,701,311 to Dunnining et al. and U.S, -4,646,973, Focarracci et al

U.S.-4,538,745, Focarracci. Sprayers such as T 8500® or T 8900®, commercially available from Continental Spray International or T 8100®, commercially available from Canyon, Northern Ireland are particularly preferred. In such a sprayer, the liquid composition becomes fine liquid spray droplets which are sprayed directly onto the surface to be cleaned. When pumping the user, the composition contained in the dispenser container gets out through the dispenser head. The device in the sprayer head is pushed over an obstacle, such as a grid or coil, and the impacts help to atomize the liquid composition, i. aid in the formation of liquid droplets.

The present invention also includes disinfectant wipes. 'Cloths' refers here to disposable wipes, e.g., disposable paper towels impregnated with a liquid composition comprising a peroxygen bleach and an active antimicrobial component of the essential oil, for example, wipes can be moistened with the composition of the invention. These liquid compositions may further comprise preferred ingredients as mentioned above.

The wipes are preferably packaged in a plastic box. The advantage of this embodiment is the faster use of the disinfectant by the user even outside the home; it is not necessary to pour the liquid composition of the present invention onto the cleaned / disinfected surfaces and to dry with a cloth. In other words, wipes allow surface disinfection in one step.

Method of disinfection.

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In the broadest sense, the present invention includes a method of disinfecting surfaces with a liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of the essential oil or mixtures thereof.

'Surface' here means any surface, including living surfaces such as human skin, mouth, teeth, and inanimate surfaces. Inanimate surfaces include, without limitation, solid surfaces, typically found in kitchens, bathrooms, or car interiors, such as tiles, walls, floors, chrome surfaces, glass, plain vinyl, any plastic, plasticized wood, table tops, sinks, showers , shower curtains, cooker plates, dishes, sanitary equipment such as sinks, showers, shower curtains, bathtubs, toilets, glass, etc., as well as fabrics including clothes, curtains, curtains, bed linen, tablecloths, sleeping bags, tents, upholstered furniture, carpets, and the like. Inanimate surfaces also include household appliances including, but not limited to, refrigerators, freezers, washing machines, automatic dryers, ovens, microwaves, dishwashers, etc.

In the surface disinfecting method of the present invention, the compositions of the invention may be applied undiluted or diluted to the disinfected surface.

'Diluted' here means the ability of the user to dilute the liquid composition up to 100 times with water, preferably 80 to 30 times, and more preferably 60 to 40 times, when disinfecting.

In a preferred embodiment of the disinfection of the present invention, the liquid composition is applied to the disinfected solid surface diluted, there is no need to rinse the surface after application of the composition, no visible residue remains on the surface.

The present invention is further illustrated by the following examples.

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DETAILED DESCRIPTION OF THE INVENTION

The following compositions were prepared by mixing the ingredients in the indicated proportions (weight percent unless otherwise indicated). These products have been tested by the European Commission standardization prEN 1040. These products perfectly disinfect clean surfaces when used in both undiluted and diluted form, eg at 1: 100, 1:25, 1:50 dilution, and also deliver superior surface safety and excellent stability in longer storage times.

Resources AND II III IV IN VI Hydrogen peroxide 7.0 6.0 - 6.0 6.0 2,0 Monoperoxosulfate - - 2,0 - - - Thymol 0.5 - - - 0.5 - Eugenol - 1.0 - - - 0.1 Geraniol 0.5 1.5 - - - Eucalyptol - - - 1.0 - - Water and minor components add up to 100% H2SO4 to pH 4 Resources VII VIII IX X Hydrogen peroxide 7.0 6.0 - 1.0 Monoperoxosulfate - - 2,0 - Thymol - - - - Eugenol / Eucalyptol (2: 1) 1.0 - 0.5 0.05 Geraniol - 0.5 - - Eucalyptol - 0.5 - -

add up to 100%

Water and minor components of H2SO4 to pH 4 ··· · · · · · · · ·

19 Dec • ··· • · · · • · · • · · · · • · · · • · · · · · • · · • · · · • · · · • · · · · • · · • · · · Resources XI XII XIII XIV XV Hydrogen peroxide 7.0 6.0 - 1.0 1.0 Monoperoxosulfate - - 2,0 - - C 10 AJ alkyl sulfate 4.0 3.0 1.5 0.9 - Cio Aminoxid - 1.5 0.5 0.6 0.9 Laurylbetain - - - - 0.05 Thymol - - - - 0.03 Eugenol / Eucalyptol 1.0 - 0.5 0.5 - Geraniol - 0.5 - - - Eucalyptol - 0.5 - - 0.02 Water and minor components add up to 100% H2SO4 to pH 4 Industrial applicability

The antimicrobial compositions of the present invention are used to disinfect and clean various surfaces including living surfaces (eg, human skin, mouth) and non-living surfaces (eg, solid surfaces, fabrics). The disinfectants of the present invention perfectly disinfect cleaned surfaces even when used in large dilutions and are suitable for delicate fabrics as well as for use on delicate surfaces in safe contact with food and / or children. The disinfectants of the present invention perfectly act on Gram positive and Gram negative bacterial strains as well as fungi. The compositions of the invention are packaged in liquid detergent bottles in conventional detergent bottles, or as a spray or foam in a spray / foam dispenser, or impregnated with wipes for rapid cleaning in one step.

Claims (19)

PATENT CLAIMS CLAIMS 1. A liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of essential oil or mixtures thereof, with the exception of aqueous compositions containing from about 0.5% to about 50% hydrogen peroxide as peroxygen bleach, and from about 0.001% to about 10% by weight. terpene alcohol, cyclic terpene alcohol or ester thereof, as the only active antimicrobial component of essential oils. 2. A method of disinfecting a surface comprising applying to the surface a liquid composition comprising a peroxygen bleach and an active antimicrobial component of the essential oil or mixtures thereof. The method according to claim 2, characterized in that the composition is aqueous and applied to the surface after dilution by up to 100 times by weight of water, preferably 80 to 40 times by weight and even more preferably from 60 to 30 times by weight. The composition or process according to any one of the preceding claims 1 to 3, wherein the peroxygen bleach is hydrogen peroxide or a water-soluble source thereof of the group of percarbonates, peroxosilicates, persulphates, perborates, peracids, dialkylperoxides, diacylperoxides, pre-prepared peroxycarboxylic acids. organic and inorganic peroxides, organic and inorganic hydroperoxides and mixtures thereof, hydrogen peroxide is preferred. The composition or method according to any one of the preceding claims 1 to 4, characterized in that the composition comprises at least 0.01% of a peroxygen bleach or mixtures thereof, based on the total weight of the composition, preferably 0.1% to 15% and most preferably 1% to 10%. %. A composition or method according to any one of claims 1 to 5, wherein the active antimicrobial component is a thymol. 444 eugenol, menthol, geraniol, verbenone, eucalyptol, pinocarvone, cedrol, carvacrol, anethole, hinokitol, berberine, terpineol, limonene, ratanhiae or mixtures thereof, and thymol is preferred, eugenol, verbenone, eucalyptol, carvacrol, limonene and / or geraniol. The composition or method according to any one of the preceding claims 1 to 6, characterized in that the composition comprises at least 0.003% active antimicrobial component of the essential oil or mixtures thereof, preferably 0.006% to 10% and more preferably 0.2% to 4% . A composition or method according to any one of claims 1 to 7, wherein the composition further comprises a surfactant selected from the group of anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants and mixtures thereof, the surfactant being present up to 50% of the total. % by weight of the composition, preferably 0.01% to 30% and more preferably 0.1% to 25%. A composition or method according to claim 8, characterized in that the surfactant is an amphoteric surfactant or a mixture thereof, preferably a betaine and a sulfobetaine surfactant, a derivative thereof or a mixture thereof according to the general formula 1: h R ₂ —N— (CH ₃ ) n “Y (I) R ₃ wherein R 1 is an alkyl radical of 1 to 24 carbon atoms, preferably 8 to 18, more preferably 12 to 14, wherein R ₂ and R ₃ contain 1 to 3 carbon atoms, preferably 1 carbon atom, wherein n is an integer from 1 to 10, preferably 1 to 6, and more preferably 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals and wherein the sum of the R 1, R ₂ and R ₃ radicals is 14 to 24 carbon atoms and / or an amine oxide of R ₁ R ₂ R ₃ NO; R ₂ and R ₃ are independently a saturated linear or branched hydrocarbon chain having 1 to 30 carbon atoms, preferably 6 to 20, and wherein R ₂ and R ₃ are independently unsubstituted or substituted linear or branched hydrocarbon chains having 1 to 4 carbon atoms, preferably · ······· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·· C 1 -C 3 and more preferably methyl. The composition or method of any one of claims 1 to 9, wherein the composition further comprises a chelating agent selected from the group of phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctionally substituted aromatic chelating agents. chelating agents, ethylenediamine N, N-disuccinic acid, and mixtures thereof. The composition or method according to any one of the preceding claims 1 to 10, wherein the composition further comprises at least one preferred component from the group of radical scavengers, solvents, buffers, fillers, stabilizers, bleach activators, stain suspensions, dye transfer agents, brighteners. additives, perfumes, dusting agents, enzymes, dispersants, dye transfer inhibitors, pigments, fragrances, dyes and mixtures thereof. The composition or method of any one of claims 1 to 11, wherein the composition further comprises an additional antimicrobial additive selected from the group of gluteraldehyde, ethylparaben, propylparaben, methylparaben, or mixtures thereof. The composition or method according to any one of the preceding claims 1 to 12, wherein the composition has a pH not exceeding 12.0, preferably not exceeding 7, more preferably 2 to 6 and most preferably 3 to 5. 14. A liquid disinfectant comprising a peroxygen bleach and an active antimicrobial component of essential oil or mixtures thereof packaged in a nebulizer. 15. A wipe impregnated with a liquid composition comprising a peroxygen bleach and an active antimicrobial component of the essential oil or mixtures thereof. Liquid composition according to claim 14 or wipe according to claim 15, characterized in that the composition comprises at least 0.01% of a peroxygen bleach or mixtures thereof, based on the total weight of the composition, preferably 0.1% to 15% and more preferably 1% to 10% and the peroxygen bleaching agent is hydrogen peroxide or a water-soluble source thereof selected from the group of percarbonates, peroxosilicates, persulfates, perborates, peracids, dialkyl peroxides, diacyl peroxides, preformed peroxycarboxylic acids, organic and inorganic peroxides, organic and inorganic hydroperoxides. A liquid composition according to any one of the preceding claims 14 or 16 or a wipe according to any one of the preceding claims 15 or 16, characterized in that the composition comprises at least 0.003% of the active antimicrobial component of the essential oil or mixtures thereof. and more preferably 0.2% to 4% and that the active antimicrobial component is thymol, eugenol, menthol, geraniol, verbenone, eucalyptol, pinocarvone, cedrol, carvacrol, anethole, hinokitol, berberine, terpineol, limonene, ratanhiae or mixtures thereof. Use of a chelating agent, preferably a phosphonate chelating agent, more preferably diethylenetriaminepentamethylene phosphonate in a composition comprising a peroxygen bleach to improve the disinfectant properties of the composition for Gram negative and / or Gram positive bacteria. 19. Use of an anionic surfactant, in particular C ₈ -C ₆ alkylsulfonate, C _g -C ₆ alkyl sulfate and / or Cg-Cu alkyl alkoxylated sulfate, in a disinfecting composition comprising a peroxygen bleach and / or antimicrobial active of essential oil, to improve the disinfecting properties of said composition on gram negative and / or Gram positive bacteria.