KR19990077185A - Disinfection Compositions and Surface Disinfection Methods - Google Patents

Abstract

The present invention relates to surface disinfection using liquid disinfection compositions comprising peroxygen bleach and antimicrobial active essential oils or mixtures thereof.

Description

Disinfection Compositions and Surface Disinfection Methods

Antimicrobial / antimicrobial compositions include materials that have antiseptic properties. In general, disinfecting materials are known to greatly reduce or even eliminate microorganisms, such as bacteria, present on the surface. Compositions based on halogen-containing compounds or quaternary compounds, such as hypochlorite, are widely described in the art for disinfection purposes. Compositions comprising peroxide bleach are also known as disinfecting compositions.

Typically, however, a composition comprising only 7% by weight of hydrogen peroxide content of the total composition as an antimicrobial agent is typically 1:50 (composition: water) to disinfect clean surfaces, i.e., surfaces containing little organic and / or inorganic residues. Dilution with a high ratio such as the dilution ratio of c) is not satisfactory enough.

Therefore, there is a need to provide a disinfection composition that provides excellent disinfection ability on a clean surface even when used in a diluted state at a high ratio.

Representative prior art discloses liquid disinfection compositions comprising compounds selected from the group consisting of organic acids, perborates, peracids and salts thereof, in addition to other antimicrobial compounds such as, for example, quaternary ammonium salts and essential oils. / 00795.

However, a drawback with liquid compositions comprising bleach and essential oils is that the liquid compositions tend to be chemically unstable during long term storage. Indeed, traditional essential oils are generally made of blends of components including terpenes, esters, aromatic components, chetones and aldehydes and the like. The essential oil is sensitive to peroxygen bleach. That is, the essential oils exhibit significant instability in the presence of peroxygen bleach and are liable to decompose / oxidize peroxygen bleach, reducing the total amount of oxygen available in the composition comprising peroxygen bleach, resulting in chemical stability during long term storage. This is a problem.

Therefore, it is an object of the present invention to provide a liquid disinfectant composition comprising a peroxygen bleach that is chemically stable during long term storage while providing excellent disinfection ability on a clean surface when used in a dilute state with high proportions.

It has been recently known that the above object can be achieved by providing a liquid peroxygen bleach-containing composition comprising, in addition to the peroxygen bleach, an antimicrobial active of essential oil or mixtures thereof. More specifically, the liquid peroxygen bleach-containing composition of the present invention comprising an antimicrobial active essential oil contains a clean surface, i.e. inorganic and / or organic contaminants, even when diluted to a high ratio of up to 1: 100 (composition: water). It has been found to provide good disinfection to untreated surfaces, while also exhibiting improved chemical stability over long term storage when compared to the same composition comprising antimicrobial essential oils instead of antimicrobial active essential oils.

An advantage of the present invention is that it provides excellent disinfection ability over a broad range of more resistant microorganisms, such as pure bacterial strains, including Gram-positive strains and Gram-negative strains, and fungi.

Another advantage of the compositions of the present invention is that in addition to disinfecting properties, in particular in the embodiments of the present invention wherein the compositions further comprise surfactants and / or solvents, good washability is provided.

In addition, the compositions according to the invention are suitable for use on all types of surfaces, including the surfaces of living things (eg, oral preparations when used as human skin and / or oral preparations or toothpastes) and inanimate surfaces. Indeed, this technique is particularly suitable for use on hard surfaces, as well as for washing applications as "washing", "whole washing" laundry detergents or laundry additives or as "pretreatment" laundry pretreatments. More specifically, the compositions according to the invention are suitable for use in a safe manner against delicate surfaces, including surfaces that come in contact with food and / or infants. Indeed, when the composition according to the invention is used in a diluted state, the amount of chemical residue remaining on the sterilized surface is reduced. Therefore, there will be no need to clean the surface after applying the composition of the present invention to a hard surface in a diluted state.

EP-B-288 689 describes a hard surface liquid comprising an oil and an antimicrobial effective amount of at least one fat soluble organic acid. Peroxy bleach, of course, does not mention other antimicrobial compounds.

EP-241390 states that bacterially contaminated fabrics can be disinfected by first treating with a detergent and then with peroxide bleach in an aqueous bath of pH 9-13 in the presence of uncomplexed calcium. Antimicrobially active essential oils as well as other antimicrobial compounds are not described.

US-4,404,191 discloses that per-compounds such as monopersulfate are bactericidal, fungicidal and virucidal. US Pat. No. 4,404,191 discloses that compositions comprising monopersulfate can be used in diluted form to treat hard surfaces. However, as well as antimicrobial active essential oils, other antimicrobial compounds are not disclosed.

US-5,403,587 discloses aqueous antimicrobial compositions that can be used to sanitize, disinfect and clean hard surfaces. More specifically, US-5,403,587 discloses essential oils (0.02-5%) that exhibit antimicrobial properties such as thyme oil, eucalyptus oil and cloves oil, and a solubilizer sufficient to form an aqueous solution or dispersion of the essential oil in a water carrier. Or aqueous compositions (pH 1-12) comprising a dispersant. The composition may further comprise other antimicrobial components, such as phenolic compounds, quaternary ammonium compounds, but is not described for betaine or sulfobetaine surfactants, or peroxygen bleach.

Japanese Patent 95-38497 discloses alkaline compounds containing alkaline substances having an alkalinity of (a) aqueous solution of hydrogen peroxide (0.5 to 50%) and (b) NaOH in terms of NaOH of 0.1 to 50% (e.g., NaOH, KOH , Na ₂ CO ₃ ) is disclosed for a foamable _two- component detergent composition. Further, at least one of the components (a) and (b) is a surfactant and / or at least one compound selected from the group consisting of terpene alcohols, cyclic terpene alcohols and esters thereof such as menthol, geraniol (0.001 to 10%). The composition is for cleaning contaminants on hard materials such as plastics, joints, and especially for cleaning trailing parts or corners that are difficult to clean. Disinfection is not mentioned.

Summary of the Invention

The present invention relates to peroxygen, except for aqueous compositions comprising from 0.5 to 50% by weight of hydrogen peroxide of the total composition as peroxygen bleach and from 0.001 to 10% by weight of terpene alcohol, cyclic terpene alcohol or esters thereof as an antimicrobial active essential oil. Liquid disinfecting compositions comprising bleach and antimicrobial active essential oils or mixtures thereof.

The invention also includes a method of disinfecting a surface, wherein a liquid composition comprising a peroxygen bleach and an antimicrobial active essential oil or mixtures thereof is applied to the surface.

The present invention also provides a liquid disinfectant composition comprising a peroxygen bleach and an antimicrobial active essential oil or mixtures thereof, packaged in a spray dispenser, and a liquid comprising a peroxygen bleach and an antimicrobial active essential oil or mixtures thereof. Wipes immersed in the disinfectant composition.

The present invention provides a surface of living organisms such as human skin and oral cavity; And various surfaces including, for example, walls, tiles, table tops, glass, bathroom surfaces, kitchen surfaces, hard surfaces such as dishes, and inanimate surfaces, including textiles, clothing, carpets, and the like. It relates to a microbial composition.

Liquid disinfecting compositions according to the invention comprise peroxygen bleach and antimicrobial active essential oils, provided that only 0.5-50% by weight of hydrogen peroxide and only antimicrobial active essential oils are terpene alcohols, cyclic terpene alcohols or esters thereof 0.001 Excluding aqueous compositions comprising from 10% by weight.

Thus, the composition according to the invention comprises as an essential element peroxygen bleach or mixtures thereof. Preferred peroxygen bleaches are hydrogen peroxide, their water soluble sources or mixtures thereof. Hydrogen peroxide is most preferred for use in the compositions according to the invention.

The presence of peroxygen bleach, especially hydrogen peroxide, persulfate, and the like in the compositions of the present invention appears to contribute to the disinfectability of the composition. Indeed, the peroxygen bleach can attack the deadly function of microbial cells, for example, inhibit the combination of ribosomal units in the cytoplasm of microbial cells. In addition, peroxygen bleach, such as hydrogen peroxide, is a strong oxidizing agent that generates hydroxy free radicals that attack proteins and nucleic acids.

In addition, the inclusion of peroxygen bleach, in particular hydrogen peroxide, provides strong contaminant removal advantages that are particularly noteworthy in laundry and hard surface applications.

Hydrogen peroxide source, as used herein, refers to any compound that generates hydrogen peroxide in contact with water. Suitable water soluble sources of hydrogen peroxide for use herein include percarbonate; Perilicates; Persulfates such as monopersulfate; Perborate; And peroxyacids such as diperoxydodecanedioic acid (DPDA); Magnesium perphthalic acid and mixtures thereof.

In addition, other peroxides may be used as an alternative to hydrogen peroxide or its source or in combination with hydrogen peroxide or its source. Suitable species include dialkylperoxides, diacylperoxides, preformed percarboxylic acids, organic peroxides, inorganic peroxides and / or hydroperoxides.

Typically, the composition comprises at least 0.01% by weight, preferably 0.1 to 15% by weight, more preferably 1 to 10% by weight of peroxygen bleach or mixtures thereof.

The composition according to the invention comprises an antimicrobial active essential oil or mixtures thereof as the second essential ingredient. Typically, the composition comprises at least 0.003%, preferably 0.006 to 10%, more preferably 0.2 to 4% and most preferably 0.2 to 2% by weight of an antimicrobial active essential oil of the total composition. .

Antimicrobially active essential oils suitable for use in the present compositions include any essential oil component that exhibits antimicrobial activity. The antimicrobial active essential oils are believed to act as protein denaturants. In addition, antimicrobially active essential oils are naturally occurring compounds that, when used to disinfect any surface, contribute to the safety profile of the compositions of the present invention. Another advantage of antimicrobial active essential oils is that they can provide a good aroma to the disinfecting compositions of the present invention without the addition of fragrances. Indeed, the disinfection composition according to the present invention not only provides good disinfectability on the clean surface to be disinfected, but also provides a good fragrance. These antimicrobial active essential oils include thyme, lemongrass, citrus, lemon, orange, anise, cloves, anise fruit, cinnamon, grass, rose, mint, lemon, lavender, citronella, eucalyptus, peppermint, camphor, sandalwood, himalayan cedar And antimicrobial active essential oils obtained from oils of mixtures thereof. Thus, the antimicrobial active essential oils used herein include thymol (eg, present in thyme oil), eugenol (eg, present in cinnamon oil and clove oil), menthol (eg, present in mint oil), gerani All (e.g., present in field oils and rose oils), Verbenones (e.g. present in Verbain oils), Eucalyptol and pinocarbons (e.g. present in eucalyptus oils), Cedrol (e.g., in Himalayan cedar oils) Present), anetitol (eg, present in anise fruit oil), carbacrol, hinokithiol, berberine, terpinol, limonene, rattania and mixtures thereof. Preferred antimicrobial active essential oils for use herein are thymol, eugenol, verbenone, eucalyptol, carbacrol, limonene and / or geraniol.

Timol is commercially available, for example, from Aldrich and Jugenol may be commercially available from Sigma Systems Bioindustry (SBI) -Manheimer Inc.

Liquid compositions comprising peroxygen bleach and antimicrobial active essential oils or mixtures thereof may be used in a high proportion when diluted with the chemical stability obtained in the same composition containing the corresponding antimicrobial essential oils in place of the antimicrobial active essential oils. It has recently been found that even when it provides good disinfection for clean surfaces, it shows improved chemical stability over long term storage. Indeed, the chemical degradation of the peroxygen bleach contained in the liquid composition is reduced in the presence of antimicrobially active essential oils such as eugenol as compared to the presence of corresponding essential oils such as cinnamon oil and / or clove oil.

The chemical stability of the composition can be assessed by measuring the concentration of oxygen (often abbreviated as Avox) available at certain storage times after the composition has been prepared. The concentration of available oxygen can be determined by chemical titration methods known in the art, such as iodine titration, thiosulfate titration, potassium permanganate titration and celium sulfate titration. For the selection of such and appropriate methods, see, for example, WCSchumb, CNSatterfield and Wentworth (Hydrogen Peroxide, Reinhold Publishing Corporation, New York, 1955) and Daniel. Swern), Organic Peroxides, Editor Wiley Int. Science, 1970.

With the compositions of the present invention, yellow, as well as fungi, such as Candida albicans, which are present on clean surfaces, i.e., on any surface with little organic and / or inorganic contaminants, even when diluted in high proportions. Excellent disinfection is obtained against various microorganisms, including Gram-positive bacteria, such as Staphylococcus, and Gram-negative bacteria, such as Pseudomonas aeruginosa.

Disinfection of a composition can be measured by the bactericidal activity of the composition. Suitable test methods for evaluating the bactericidal activity of the composition on clean surfaces are published in November 1995 by the European Committee for Standardisation, Brussels [European Standard, prEN 1040, CEN / TC 216 N 78]. The European Standard, prEN 1040, CEN / TC 216 N 78 specifies test methods and requirements for the minimal bactericidal activity of disinfectant compositions. If the bacterial colony forming unit (cfu) decreases from 10 ⁷ cfu (initial level) to 10 ² cfu (final level after contact with the sterilization product), then the test passes, i.e. a reduction in viability of 10 ⁵ is essential. . The composition according to the present invention passes the test under clean conditions even when used at high rates of dilution.

Other methods suitable for measuring the bactericidal activity of the composition on clean surfaces are AFNOR T72-190® and T72-301®.

The composition according to the invention is an aqueous liquid wash composition. This aqueous composition preferably has a pH of 12.0 or less, more preferably 2-6, most preferably 3-5. The pH of this composition can be adjusted using organic acids, such as citric acid, succinic acid, acetic acid, aspartic acid, and lactic acid, or an inorganic acid or an alkalizing agent.

The compositions of the present invention may further comprise surfactants known to those skilled in the art, including nonionic, anionic, cationic, zwitterionic and / or zwitterionic surfactants. Such surfactants are preferred because they contribute to the washability of the present compositions.

Typically, the composition according to the invention comprises up to 50% by weight of the total composition, preferably from 0.01 to 30% by weight, more preferably from 0.1 to 25% by weight of the surfactant or mixtures thereof.

Accordingly, it may be desirable for the composition of the present invention to include an amphoteric surfactant or mixtures thereof. Zwitterionic surfactants suitable for use herein include betaine and sulfobetaine surfactants, derivatives thereof, or mixtures thereof. Betaine or sulfobetaine surfactants are preferred herein because they contribute to the disinfectability of the composition. Indeed, these surfactants help to disinfect by increasing the permeability of bacterial cell walls, allowing other active ingredients to invade the cells.

In addition, due to the proper action profile of the betaine or sulfobetaine surfactants, the present compositions comprising these surfactants may be particularly suitable for cleaning delicate surfaces, such as demanding laundry, or surfaces in contact with food and / or babies. . In addition, betaine and sulfobetaine surfactants are very hypoallergenic on the skin and / or surface to be treated.

Betaine and sulfobetaine surfactants suitable for use in the compositions of the present invention include betaine / sulfate, which contains both basic and acidic groups whose molecules form internal salts to provide cationic and anionic hydrophilic groups over a wide pH range. Sulfobetaine and betaine detergents. Some typical examples of such detergents are described in US Pat. Nos. 2,082, 275, 2,702,279 and 2,255,082, which are incorporated herein by reference.

Preferred betaine and sulfobetaine surfactants are of the formula Wherein R 1 is an alkyl radical of C ₁ -C ₂₄ , preferably C ₈ -C ₁₈ , more preferably C ₁₂ -C ₁₄ , and R 2 and R 3 are C ₁ -C ₃ , preferably C ₁ , n is 1 to 10, preferably 1 to 6, more preferably an integer of 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals, and the sum of R1, R2 and R3 radicals is C ₁₄ -C ₂₄ ) or mixtures thereof.

Examples of particularly suitable betaine surfactants include C ₁₂ -C ₁₈ alkyl dimethyl betaine such as coconut betaine, and C ₁₀ -C ₁₆ alkyl dimethyl betaine such as laurylbetaine.

Coconut betaine is commercially available from Seppic under the trade name Amonyl 265 (registered trademark). Laurylbetaine is commercially available from Albright & Wilson under the tradename Empigen BB / L®.

Other zwitterionic surfactants suitable for use herein include amine oxides or mixtures thereof. Amine oxides are preferred herein because they contribute to the disinfectability of the compositions. Indeed, amine oxides disrupt the cell wall / membrane of bacteria, allowing other antimicrobial components to invade the cell, for example by attacking the interior of the cell to aid disinfection.

Oxidized amines suitable for use herein have the formula R 1 R 2 R 3 NO, wherein R 1, R 2 and R 3 are each independently a saturated linear or branched hydrocarbon chain of C ₁ -C ₃₀ . Suitable amine oxides for use according to the invention are those of the formula R1R2R3NO, wherein R1 is C ₁ -C ₃₀ , preferably C ₆ -C ₂₀ , more preferably C ₆ -C ₁₄ , most preferably C _8- Oxidation with C ₁₀ hydrocarbon chain, R 2 and R 3 are independently C ₁ -C ₄ , preferably C ₁ -C ₃ substituted or unsubstituted linear or branched hydrocarbon chains, more preferably methyl groups). Amine. R 1 is a substituted linear or branched hydrocarbon chain.

Preferred amine oxides for use herein are, for example, natural blends of C ₈ -C ₁₀ oxidized amines and C ₁₂ -C ₁₆ oxidized amines commercially available from Hoechst.

In a preferred embodiment of the invention in which the composition is particularly suitable for disinfecting hard surfaces, the surfactants typically contain amine oxides and betanes or sulfobetaines, preferably 2: 1 to 100: 1, more preferably 6: Surfactant systems in a weight ratio of 1 to 100: 1, most preferably 10: 1 to 50: 1. Use of the surfactant system in the present compositions suitable for disinfecting hard surfaces provides effective washability and gloss on the cleaned surfaces to minimize the amount of film / layer remaining on the cleaned surfaces treated with the composition.

It may also be desirable for the composition to include anionic surfactants or mixtures thereof.

Particularly suitable anionic surfactants for use herein are alkyl or hydroxyalkyl having an alkyl component of the formula ROSO ₃ M, wherein R is preferably C ₆ -C ₂₄ hydrocarbyl, preferably C ₈ -C ₂₀ , More preferably C ₈ -C ₁₆ alkyl or hydroxyalkyl; M is H, or an alkali metal cation (eg sodium, potassium, lithium), ammonium or substituted ammonium (eg methyl ammonium salt, dimethyl ammonium salt, trimethyl Ammonium salts; quaternary ammonium cations such as tetramethyl-ammonium and dimethyl piperidinium cations; quaternary ammonium cations derived from alkylamines such as ethylamine, diethylamine, triethylamine; and mixtures thereof) It includes.

Other anionic surfactants suitable for use herein include alkyl-diphenyl-ether-sulfonates and alkyl-carboxylates. Other anionic surfactants include salts of soap (eg, substituted ammonium salts such as sodium, potassium, ammonium, and monoethanolamine salts, diethanolamine salts and triethanolamine salts), C ₉ -C ₂₀ linear Sulfonation prepared by sulfonating pyrolysis products of alkylbenzenesulfonates, C ₈ -C ₂₂ primary or secondary alkanesulfonates, C ₈ -C ₂₄ olefinsulfonates, alkaline earth metal citrate as described in British Patent No. 1,082,179 Polycarboxylic acid, C ₈ -C ₂₄ alkylpolyglycol ether sulfate (containing 10 mol or less of ethylene oxide); Alkyl ester sulfonates such as C ₁₄ -C ₁₆ methyl ester sulfonates; Acyl glycerol sulfonate, fatty oleyl glycerol sulfate, alkyl phenol ethylene oxide ether sulfate, paraffin sulfonate, alkyl phosphate, isethionate such as acyl isethionate, N-acyl taurate, alkyl succinate, alkyl sulfosuccinate , Monoesters of sulfosuccinates (particularly saturated and unsaturated C ₁₂ -C ₁₈ monoesters), diesters of sulfosuccinate (particularly saturated and unsaturated C ₆ -C ₁₄ diesters), acyl sarcosy Nate, alkylpolysaccharide sulfates such as alkylpolyglucoside sulfates (nonionic nonsulfated compounds are described below), branched primary alkyl sulfates, formula RO (CH ₂ CH ₂ O) _k CH ₂ COO-M ⁺ of compounds such as alkyl poly (wherein, R is a C ₈ -C ₂₂ alkyl, k is an integer from 0 to 10, M is a water-soluble salt forming cation) ethoxy carboxylate les A bit. Resin acids and hydrogenated resin acids are also suitable, for example, rosin, hydrogenated rosin, resin acids, and hydrogenated resin acids present in or derived from tall oil. Further examples are provided in Surface Active Agents and Detergents, Vol I and II, by Schwartz, Perry and Berch. Such various surfactants are also generally described in US Pat. No. 3,929,678, column 23, lines 58 to 29 column 23, issued December 30, 1975 to Laughlin et al.

Preferred anionic surfactants for use in the compositions include C ₈ -C ₁₆ alkyl sulfonates, C ₈ -C ₁₆ alkyl sulfates, C ₈ -C ₁₆ alkyl alkoxylated sulfates (eg, C ₈ -C ₁₆ alkyl ethoxylated sulfates). ) And mixtures thereof. Such anionic surfactants are preferred herein because they have been found to contribute to the disinfectability of disinfectant compositions comprising peroxygen bleach and / or antimicrobial active essential oils. For example, C ₈ -C ₁₆ alkyl sulphate acts to disrupt bacterial cell membranes, inhibit enzyme activity, disrupt cell transport and / or denature cellular proteins. Indeed, for example, improved disinfection associated with the addition of anionic surfactants, in particular C ₈ -C ₁₆ alkyl sulfonates, C ₈ -C ₁₆ alkyl sulfates and / or C ₈ -C ₁₆ alkyl alkoxylated sulfates, in the compositions of the invention The ability tends to be due to the complex attack form of the surfactant against bacteria. Thus, another aspect of the present invention is an anionic surfactant, in particular C, in disinfectant compositions comprising peroxygen bleach and / or antimicrobial active essential oils for improving the disinfection of the composition against gram negative and / or gram positive bacteria. ₈ -C ₁₆ alkyl sulfonate, C ₈ -C ₁₆ alkyl sulfate and / or C ₈ -C ₁₆ alkyl alkoxylated sulfate.

Suitable nonionic surfactants for use herein are commercial fatty alcohol ethoxylates and / or propoxylates having various fatty alcohol chain lengths and various degrees of ethoxylation. Indeed, the hydrophilic-lipophilic balance (HLB) value of such alkoxylated nonionic surfactants is essentially dependent on the chain length of the fatty alcohol, the nature of the alkoxylation and the degree of alkoxylation. A list of surfactants is commercially available, listing a number of surfactants, including nonionics, with their respective HLBs.

Hydrophobic nonionic surfactants having an HLB of less than 16, preferably less than 15, more preferably less than 14 are particularly suitable for use herein as nonionic surfactants. Hydrophobic nonionic surfactants have been found to provide good oily cleavage.

Preferred hydrophobic nonionic surfactants for use in the compositions according to the invention are those having the formula RO- (C ₂ H ₄ O) _n (C ₃ H ₆ O) _m H, wherein R is C _6- An alkyl chain of C ₂₂ or an alkyl benzene chain of C ₆ -C ₂₈ , n + m is 0-20, n is 0-15, m is 0-20, preferably n + m is 1-15 , n and m are 0.5 to 15, more preferably n + m is 1 to 10, and n and m are 0 to 10). Preferred R chains for use herein are C ₈ -C ₂₂ alkyl chains. Accordingly, hydrophobic nonionic surfactants suitable for use herein are Dobanol ^R 91-2.5 (HLB = 8.1; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 2.5, m is 0 Or Lutensol ^R TO3 (HLB = 8; R is a C ₁₃ alkyl chain, n is 3 and m is 0), Lutensol ^R AO3 (HLB = 8; R is C ₁₃ and C ₁₅ Is a mixture of alkyl chains, n is 3, m is 0, Tergitol ^R 25L3 (HLB = 7.7; R is an alkyl chain length of C ₁₂ -C ₁₅ , n is 3, m is 0), dovanol ^R 23-3 (HLB = 8.1; R is a mixture of C ₁₂ and C ₁₃ alkyl chains, n is 3, m is 0), dovanol ^R 23-2 (HLB = 6.2 R is a mixture of alkyl chains of C ₁₂ and C ₁₃ , n is 2 and m is 0, dobanol ^R 45-7 (HLB = 11.6; R is a mixture of alkyl chains of C ₁₄ and C ₁₅ ) , n is 7, m is 0, dovanol ^R 23-6.5 (HLB = 11.9; R is a mixture of alkyl chains of C ₁₂ and C ₁₃ , n is 6.5, m is 0), dobanol ^R 25-7 (HLB = 12; R is C ₁ A mixture of ₂ and C ₁₅ alkyl chains, n is 7 and m is 0, dobanol ^R 91-5 (HLB = 11.6; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 5 , M is 0), dovanol ^R 91-6 (HLB = 12.5; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 6, m is 0), dobanol ^R 91-8 (HLB = 13.7; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 8, m is 0), dobanol ^R 91-10 (HLB = 14.2; R is alkyl of C ₉ -C ₁₁ Chains, n is 10 and m is 0) or mixtures thereof. Doban ol ^R 91-2.5, ruten Sol ^R TO3, ruten Sol ^R AO3, tolyl ether group ^R 25L3, doban ol ^R 23-3, ^R 23-2 doban ol or mixtures thereof is preferred herein. Dovanol ^R surfactant is commercially available from Shell. Lutensol ^R surfactants are commercially available from BASF, and Tergitol R surfactants are commercially available from UNION CARBIDE.

In addition, other suitable surfactants include the (alkali metal salts, preferably sodium salts of C ₆ -C ₂₀ fatty acid) C ₆ -C ₂₀ conventional soaps.

The composition according to the invention may comprise further antimicrobial components as any desired component which contributes to the antimicrobial activity of the composition of the invention. Such components include parabens such as ethyl paraben, propyl paraben, methyl paraben, glutaraldehyde or mixtures thereof.

The composition may further comprise a chelating agent as any desired component. Suitable chelating agents include phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, multifunctional-substituted aromatic chelating agents, biodegradable chelating agents ( Ethylene diamine N, N'-disuccinic acid) or mixtures thereof, and may be any known to those skilled in the art.

Phosphonate chelating agents suitable for use herein include etidronic acid (1-hydroxyethylene-diphosphonic acid (HEDP)) and / or alkali metal ethane 1-hydroxydiphosphonate.

Amino phosphonate chelating agents suitable for use herein are amino alkylene poly (alkylene phosphonates), nitrilotris (methylene) triphosphonates, ethylene diamine tetra methylene phosphonates and / or diethylene triamine Penta methylene phosphonate. Preferred aminophosphonate chelating agents for use herein are diethylene triamine penta methylene phosphonates.

These phosphonate / amino phosphonate chelating agents may be present in acid form or as salts of different cations in some or all of their acid functional groups. Such phosphonate / amino phosphonate chelating agents are commercially available from Monsanto under the trade name DEQUEST®.

As used herein, substituted heteroaromatic chelating agents include hydroxypyridine-N-oxides or derivatives thereof.

Suitable hydroxy pyridine N-oxides and derivatives thereof used according to the invention are Wherein X is nitrogen, Y is one selected from the group consisting of oxygen, -CHO-, -OH,-(CH ₂ ) _n -COOH, preferably oxygen, and n is 0 to 20, preferably 0 To 10, more preferably an integer of 0). Thus, particularly preferred hydroxy pyridine N-oxides and derivatives thereof as used herein are 2-hydroxy pyridine N-oxides.

Hydroxy pyridine N-oxides and derivatives thereof are derivatives which may be commercially available from Sigma.

Multifunctional-substituted aromatic chelating agents may also be useful in the present compositions. See, US Pat. No. 3,812,044, issued May 21, 1974 to Connor et al. Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydroxy-3,5-disulfobenzene.

Preferred biodegradable chelating agents for use herein are ethylene diamine N, N'-disuccinic acid, alkali metal salts, alkaline earth metal salts, ammonium salts, substituted ammonium salts or mixtures thereof. Ethylenediamine N, N'-disuccinic acid, in particular (S, S) isomers, is described extensively in US Pat. No. 4,704,233, issued November 3, 1987 to Hartman and Perkins. Ethylenediamine N, N'-disuccinic acid is commercially available, for example, under the name ssEDDS® from Palmer Research Laboratories. Ethylene diamine N, N'-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable amino carboxylate chelating agents useful herein are ethylene diamine tetra acetate, diethylene triamine pentaacetate, diethylene triamine pentoacetate (DTPA), N-hydroxyethylethylenediamine triacetate, nitrilotriacetate, ethylene diamine tetraprop Cypionate, triethylenetetraamine hexaacetate, ethanol diglycine, propylene diamine tetraacetic acid (PDTA) and methyl glycine diacetic acid (MGDA) are included in acid form, or their alkali metal salts, ammonium salts and substituted ammonium salt forms. Diethylene triamine penta acetic acid (DTPA), propylene diamine tetraacetic acid (PDTA) sold by BASF under the trade name Trilon FS®, and methyl glycine diacetic acid (MGDA) for use herein. Especially suitable.

Additional carboxylate chelating agents as used herein include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid or mixtures thereof.

Such chelating agents, in particular phosphonate chelating agents such as diethylene triamine penta methylene phosphonate, are known to further contribute to the disinfection of hydrogen peroxide and are therefore particularly preferred in the compositions according to the invention. Accordingly, another aspect of the present invention is a chelating agent in a disinfectant composition comprising hydrogen peroxide, in particular a force such as diethylene triamine pentamethylene phosphonate, to improve the disinfectability of the composition against Gram-negative and / or Gram-positive bacteria. Phosphate chelating agent.

Typically the compositions according to the invention comprise up to 5% by weight, preferably 0.002 to 3% by weight, more preferably 0.002 to 1.5% by weight of chelating agents or mixtures thereof.

The composition may comprise a radical scavenger as any desired component. Suitable radical scavengers for use herein include well known substituted monohydroxybenzenes and dihydroxy benzenes and derivatives thereof, alkyl carboxylates, aryl carboxylates and mixtures thereof. Preferred radical scavengers for use herein are di-tert-butyl hydroxy toluene (BHT), p-hydroxy-toluene, hydroquinone (HQ), di-tert-butyl hydroquinone (DTBHQ), mono-tertiary -Butyl hydroquinone (MTBHQ), tert-butyl-hydroxy anisole (BHA), p-hydroxy-anisole, benzoic acid, 2,5-dihydroxy benzoic acid, 2,5-dihydroxyterephthalic acid, toluic acid , Catechol, t-butyl catechol, 4-allyl-catechol, 4-acetyl catechol, 2-methoxy-phenol, 2-ethoxy-phenol, 2-methoxy-4- (2-propenyl) Phenol, 3,4-dihydroxy benzaldehyde, 2,3-dihydroxy benzaldehyde, benzylamine, 1,1,3-tris (2-methyl-4-hydroxy-5-t-butylphenyl) butane, 3 Tert-butyl hydroxy aniline, p-hydroxy aniline and n-propyl-gallate. Di-tert-butyl hydroxy toluene (e.g., sold under the trade name IONOL CP® by Shell) and / or tert-butyl-hydroxy anisole are very preferred. These radical scavengers further contribute to the stability of the present compositions containing peroxygen bleach.

Typically, the composition according to the invention comprises up to 5%, preferably 0.001 to 1.5%, more preferably 0.01 to 1% by weight of radical scavengers or mixtures thereof.

The composition may comprise a solvent or mixtures thereof as any desired component. The use of a solvent advantageously enhances the washability of the composition. Suitable solvents for incorporation into the compositions according to the invention include propylene glycol derivatives such as n-butoxypropanol or n-butoxypropoxypropanol; Water soluble Carbitol® solvents or water soluble Cellosolve® solvents. Water-soluble carbitol® solvents are compounds of 2- (2-alkoxyethoxy) ethanol in which the alkoxy group is derived from ethyl, propyl or butyl. Preferred water-soluble carbitol is 2- (2-butoxyethoxy) ethanol, also known as butyl carbitol. The water-soluble cellosolve (trademark) solvent is a compound of 2-alkoxyethoxyethanols, and 2-butoxyethoxyethanol is preferable. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol, diols such as 2-ethyl-1,3-hexanediol, 2,2,4-trimethyl-1,3-pentanediol and mixtures thereof . Preferred solvents for use herein are n-butoxypropoxypropanol, butyl carbitol® benzyl alcohol, isopropanol and mixtures thereof. Most preferred solvents for use herein are butyl carbitol®, benzyl alcohol and isopropanol.

The solvent may typically be contained in the composition of the present invention in an amount of up to 15%, preferably 2 to 7% by weight of the composition.

The compositions include buffers (e.g. borate buffers), laundry builders, stabilizers, bleach activators, contaminant suspensions, dye transfer agents, brighteners, flavoring agents, antidust agents, enzymes, dispersants, dye transfer inhibitors, pigments and dyes. It may further comprise various other optional ingredients, such as.

Packing form of the composition

The composition can be packaged in a variety of suitable detergent packages known to those skilled in the art. The liquid composition may preferably be packaged in a manual spray dispenser container generally made of synthetic organic polymeric plastics material. Accordingly, the present invention also includes a liquid disinfecting composition packaged in a spray dispenser, preferably a trigger spray dispenser or a pump spray dispenser, comprising peroxygen bleach and an antimicrobial active essential oil. These liquid compositions may further comprise optional ingredients as described above.

In practice, the spray dispenser evenly applies a liquid disinfecting composition comprising peroxygen bleach and an antimicrobial active essential oil over a relatively large area to be disinfected, contributing to the disinfectability of the composition. Such spray dispensers are particularly suitable for disinfecting vertical surfaces.

Spray dispensers suitable for use in accordance with the present invention are manual foamable triggered dispensers sold by Specialty Packaging Products, Inc. or Continental Sprayers, Inc. It includes. Dispensers of this type are described, for example, in US Pat. No. 4,701,311 to Dunninging et al. And US Pat. No. 4,646,973 to Focalarracci and US Pat. No. 4,538,745. Spray dispensers such as the T 8500® or T 8900® available from Continental Spray International, or the T 8100® available from Canon, Northern Ireland. In such dispensers the liquid composition is divided into fine liquid fractions and sprayed towards the surface to be treated. Indeed, in such spray dispensers, the composition contained in the dispenser container advances through the head of the spray dispenser by the energy delivered by the user to the pumping mechanism when the user activates the pumping mechanism. More specifically, in the spray dispenser head, the composition pushes the obstruction, such as a lattice or cone, to form a liquid droplet by providing an impact for subdividing the liquid composition.

The present invention also includes a disinfecting wipe. By “wipe” is meant herein a disposable towel such as a disposable paper towel immersed in a liquid composition comprising a peroxygen bleach and an antimicrobial active essential oil (eg, the wipe may be immersed in the composition). This liquid composition may further comprise optional ingredients as described above.

Preferably the wipe is packaged in a plastic box. The advantage of doing this is that it is not necessary to pour the liquid composition according to the invention on the surface to be treated / disinfected and wipe the water with a cloth so that the user can use the disinfectant composition more quickly outside the home. In other words, the wipe allows the surface to be disinfected in one step.

Disinfection Method

In a broad aspect, the present invention includes a method for disinfecting a surface wherein the composition used is a liquid disinfecting composition comprising a peroxygen bleach and an antimicrobial active essential oil or mixtures thereof.

By “surface” is meant herein any surface, including human skin, oral cavity, surfaces of living things such as teeth, and inanimate surfaces. Inanimate surfaces are hard surfaces typically found inside a house or car, such as a kitchen or bathroom, such as tiles, walls, floors, chrome, glass, flat vinyl, any plastics, plasticized wood, table tops, sinks, countertops. Fabrics such as garments, curtains, thin curtains, bed linens, bathroom linens, tablecloths, sleeping bags, tents, covered furniture, as well as tops, plates, sanitary parts (e.g. sinks, showers, shower curtains, washbasins, WC, etc.); Carpets and the like, but is not limited thereto. In addition, the inanimate surface includes, but is not limited to, household appliances including refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, washing machines, and the like.

In the method for disinfecting surfaces according to the invention, the liquid composition can be applied to the surface to be disinfected in pure form or in diluted form.

By "diluted form" as used herein is meant that the liquid composition to be used in the disinfection method can be diluted with up to 100 times its weight, preferably 80 to 30 times, more preferably 60 to 40 times water. .

In a preferred embodiment of the method of the invention wherein the liquid composition is applied to a hard surface to be disinfected in diluted form, the surface does not have to be cleaned after application of the composition and in practice no visible residue remains on the surface.

The invention is better demonstrated in the following examples.

The following compositions were prepared by mixing the listed ingredients in the listed ratios (% by weight unless otherwise indicated). These compositions passed the prEN 1040 test of the European Standardization Community. These compositions provide disinfectability when used in the pure state or in dilution of 1: 100, 1:25, 1:50 while providing surface safety and exhibiting excellent stability in long term storage.

Composition I II III IV V VI Hydrogen peroxide 7.0 6.0 - 6.0 6.0 2.0 Monopersulfate - - 2.0 - - - Thymol 0.5 - - - 0.5 - Jugenol - 1.0 - - - 0.1 Geraniol 0.5 - 1.5 - - - Eucalyptol - - - 1.0 - - Water, trace substance Remainder H ₂ SO ₄ below pH 4

Composition VII VIII IX X Hydrogen peroxide 7.0 6.0 - 1.0 Monopersulfate - - 2.0 - Thymol - - - - Eugenol / Eucalyptol (1: 1) 1.0 - 0.5 0.05 Geraniol - 0.5 - - Eucalyptol - 0.5 - - Water, trace substance Remainder H ₂ SO ₄ below pH 4

Composition XI XII XIII XIV XV Hydrogen peroxide 7.0 6.0 - 1.0 1.0 Monopersulfate - - 2.0 - - C10 Alkyl Sulfate 4.0 3.0 1.5 0.9 - C10 oxide amine - 1.5 0.5 0.6 0.9 Lauryl betaine - - - - 0.05 Thymol - - - - 0.03 Eugenol / Eucalyptol (1: 1) 1.0 - 0.5 0.05 - Geraniol - 0.5 - - - Eucalyptol - 0.5 - - 0.02 Water, trace substance Remainder H ₂ SO ₄ below pH 4

Claims (19)

An aqueous composition comprising from 0.5 to 50% by weight of hydrogen peroxide as a peroxygen bleach and from 0.001 to 10% by weight of terpene alcohol, cyclic terpene alcohol or esters thereof as an antimicrobial active of essential oil. Excluding, peroxygen bleach and liquid disinfectant composition comprising an antimicrobial active essential oil. A method of disinfecting said surface, wherein a liquid composition comprising a peroxygen bleach and an antimicrobial active essential oil or mixtures thereof is applied to the surface. The method of claim 2, Wherein said composition is aqueous and said composition is diluted to 100 times or less, preferably 80 to 40 times, more preferably 60 to 30 times, water by weight and applied to the surface. The method according to any one of claims 1 to 3, The peroxygen bleach may be hydrogen peroxide, or percarbonate, perilicate, persulfate, perborate, peroxyacid, dialkylperoxide, diacylperoxide, preformed percarboxylic acid, organic peroxide, inorganic peroxide, organic hydroperoxide, A composition or method which is a water-soluble source of hydrogen peroxide selected from the group consisting of inorganic hydroperoxides and mixtures thereof, preferably hydrogen peroxide. The method according to any one of claims 1 to 4, The composition or method wherein said composition comprises at least 0.01%, preferably 0.1-15%, more preferably 1-10% by weight of peroxygen bleach or mixtures thereof. The method according to any one of claims 1 to 5, Antimicrobial active oils include thymol, eugenol, menthol, geraniol, verbenone, eucalyptol, pinocarbon, cedrol, carbacroll, anetol, hinokithiol, berberine, terpinol, limonene, rattania or these Or a mixture of and preferably thymol, eugenol, verbenone, eucalyptol, carbacrol, limonene and / or geraniol. The method according to any one of claims 1 to 6, A composition or method in which the composition comprises at least 0.003%, preferably 0.006 to 10%, more preferably 0.2 to 4% by weight of an antimicrobial active essential oil or mixture thereof. The method according to any one of claims 1 to 7, The composition further comprises a surfactant selected from the group consisting of anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants, and mixtures thereof, the surfactants being total A composition or method which is present in an amount of up to 50%, preferably 0.01 to 30%, more preferably 0.1 to 25% by weight of the composition. The method of claim 8, The surfactant is an amphoteric surfactant or mixtures thereof, preferably in the formula Wherein R 1 is an alkyl radical of C ₁ -C ₂₄ , preferably C ₈ -C ₁₈ , more preferably C ₁₂ -C ₁₄ , and R 2 and R 3 are C ₁ -C ₃ , preferably C ₁ , n is 1 to 10, preferably 1 to 6, more preferably an integer of 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals, and the sum of the R 1, R 2 and R 3 radicals is C ₁₄ -C ₂₄ betaine or sulfobetaine surfactants or derivatives or mixtures thereof, and / or oxidizing amines of the formula R 1 R 2 R 3 NO, wherein R 1, R 2 and R 3 are each independently C ₁ -C ₃₀ , preferably C _6- A saturated linear or branched hydrocarbon chain of C ₂₀ , R 2 and R 3 are independently a substituted or unsubstituted linear or branched hydrocarbon chain of C ₁ -C ₄ , preferably C ₁ -C ₃ , more preferably Methyl group). The method according to any one of claims 1 to 9, The composition comprises phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, amino carboxylate chelating agents, other carboxylate chelates, multifunctional-substituted aromatic chelating agents, ethylene diamine N, N'-di A composition or method further comprising a chelating agent selected from the group consisting of succinic acid and mixtures thereof. The method according to any one of claims 1 to 10, The composition may comprise radical scavengers, solvents, buffers, builders, stabilizers, bleach activators, contaminant suspensions, dye transfer agents, brighteners, flavoring agents, antidust agents, enzymes, dispersants, dye transfer inhibitors, pigments, dyes and A composition or method further comprising at least one optional component selected from the group consisting of mixtures thereof. The method according to any one of claims 1 to 11, The composition or method wherein the composition further comprises another antimicrobial component selected from the group consisting of glutaraldehyde, ethyl paraben, propyl paraben, methyl paraben and mixtures thereof. The method according to any one of claims 1 to 12, A composition or method having a pH of 12 or less, preferably less than 7, more preferably 2 to 6, most preferably 3 to 5. A liquid disinfectant composition packaged in a spray dispenser comprising peroxygen bleach and an antimicrobial active essential oil or mixtures thereof. Wipe dipped with a liquid disinfecting composition comprising a peroxygen bleach and an antimicrobial active essential oil or mixtures thereof. The method according to claim 14 or 15, The liquid composition comprises at least 0.01%, preferably 0.1 to 15%, more preferably 1 to 10% by weight of peroxygen bleach and mixtures thereof, wherein the peroxygen bleach is hydrogen peroxide, or percarbonate , Persilicate, persulfate, perborate, peracid, dialkylperoxide, diacylperoxide, preformed percarboxylic acid, organic peroxide, inorganic peroxide, organic hydroperoxide, inorganic hydroperoxide and mixtures thereof A liquid composition or wipe that is a water soluble source of selected hydrogen peroxide. The method according to any one of claims 14 to 16, The liquid composition comprises at least 0.003% by weight, preferably 0.006 to 10%, more preferably 0.2 to 4% by weight of the antimicrobial active essential oil or mixtures thereof, wherein the antimicrobial active essential oil is thymol, oil Liquid compositions or wipes which are genols, menthol, geraniol, verbenone, eucalyptol, pinocarbon, cedrol, carbacroll, anetol, hinokithiol, berberine, terpinol, limonene, rattania or mixtures thereof. Improving the disinfection of the composition against gram negative and / or gram positive bacteria of chelating agents, preferably phosphonate chelating agents, more preferably diethylene triamine pentamethylene phosphonate, in peroxygen bleach-containing compositions For use. Anionic surfactants, in particular C ₈ -C ₁₆ alkyl sulfonates, C ₈ -C ₁₆ alkyl sulfates and / or C ₈ -C ₁₆ alkyl alkoxylated sulfates, in disinfectant compositions comprising peroxygen bleach and / or antimicrobial active essential oils Use for improving the disinfection of the composition against Gram-negative and / or Gram-positive bacteria.