KR19990058669A - Cosmetic composition containing betel nut extract - Google Patents

Abstract

The present invention dried the seeds of betel nut, an extract extracted with anhydrous or lower alcohol, acetone, ethyl acetate, diethyl ether, benzene, chloroform, hexane and the like cosmetics, in other words, softening (skin), nutrient cosmetics (loshon) , Astringent makeup, nutrition cream, massage cream, essence, pack, emulsified foundation, etc.

Description

Cosmetic composition containing betel nut extract

The present invention relates to a cosmetic composition containing an extract having an inhibitory effect of elastase extracted from betel seeds, which are seeds of Areca catechu L ..

In skin, elastin fibers, along with collagen fibers, form crosslinks inside the dermis and are involved in skin elasticity. With age, the skin shows histologically deficient and aggregated elastin fibers, decreased collagen fibers, increased inflammatory cell infiltration, and a marked increase in the activity of the biochemically elastin degrading enzyme elastase. Therefore, the elasticity of the skin is drastically lowered by the action of elastase, and sagging occurs. Elastase is the only enzyme known so far to break down elastin, and its inhibition can fundamentally reduce skin aging.

In order to delay skin aging, moisturizers, anti-inflammatory agents, elastins and nutrients and additives for tissues for which collagen crosslinking is broken are used in cosmetics, but there is a limit to delaying aging. Therefore, there is a need for inhibitors that fundamentally inhibit the degradation of elastin and collagen to maintain skin elasticity.

For this purpose, animal extracts or synthetic peptide derivatives having a structure similar to collagen and elastin are used. However, due to the disadvantages of insufficient safety, stability, and effect, there are attempts to find new functional substances.

On the other hand, various natural products that have been used as herbals in the past have not only been excellent in safety but also contain various beneficial drug ingredients, and thus have been a good search target for anti-aging and whitening substances.

In view of this reality, the present inventors searched for substances that are fundamentally inhibiting the decrease in skin elasticity due to conventional elastin deterioration and destruction. Not only was it an elastase inhibitor, but also directly applied to human skin, it was found to improve the skin elasticity and improve various skin aging phenomena.

An object of the present invention to provide a cosmetic composition containing betelza extract having an elastase inhibitory effect.

The present invention relates to a cosmetic composition containing an extract having an inhibitory effect of elastase extracted from betel seeds, which are seeds of Areca catechu L ..

The betel extract of the present invention is contained in an amount of 0.0001 to 10% (w / v), preferably 0.001 to 5% (w / v) as a dry weight to the cosmetic composition.

The present invention dried mature betel seeds, the extract extracted with anhydrous or lower alcohol, acetone, ethyl acetate, diethyl ether, benzene, chloroform, hexane and the like, cosmetics, that is, softening (skin), nutrition ), Astringent makeup, nutrition cream, massage cream, essence, pack, emulsified foundation, etc.

Areca catechu L. is distributed in southern China, Taiwan and Malaysia, and is cultivated in tropical regions. Betel nut is known to be effective in indigestion, constipation, abdominal pain, insect repellent, etc. as a dry stomach, digestion, insect repellent (Japanese Patent Laid-Open No. 5-320037).

When the betel nut extract of the present invention is described in more detail, the seeds of betel nut are washed with clean water and then dried to be finely pulverized, and the extraction solvent is methanol, ethanol, propanol, butanol, amyl alcohol, etc. 1 to 15 times the volume of each lower alcohol or mixed with water, and a cooling condenser is installed to prevent the active ingredient from evaporating, heating at 50 to 95 ℃, 2 to 20 hours, 1 to 15 at 5 to 37 ℃ Dip daily to extract the active ingredient. Alternatively, acetone, ethyl acetate, diethyl ether, benzene, chloroform, hexane, and the like are added as extraction solvents, respectively, and the mixture is heated and extracted at 50 to 95 ° C. for 2 to 20 hours while the cooling condenser is installed to prevent the active ingredient from evaporating. Deposition at 5 ~ 37 ℃ 1-15 days to extract the active ingredient. The extract thus obtained was concentrated under reduced pressure while recovering the solvent evaporated using a distillation apparatus equipped with a cooling condenser to produce the betel nut extract of the present invention.

Cosmetics containing betel nut extract of the present invention has a formulation such as softening longevity, nourishing cosmetics, astringent cosmetics, nourishing cream, massage cream, essence, pack and emulsified foundation.

The following examples and prescription examples illustrate the content of the invention, but the content of the invention is not limited thereto.

Example 1

Wash 1kg of betel nut seed with clean water, dry it, put it in 10ℓ of water, boil it for 5 hours in an extractor equipped with cooling condenser, extract it, filter it with 300 mesh filter cloth, and leave it for 5 days at 5 ~ 15 ℃ for aging. Filtered. The extract was concentrated under reduced pressure at 80 ° C. in a distillation apparatus equipped with a cooling condenser to obtain 89 g (dry weight).

Example 2

Wash 1kg of betel nut seed with clean water, dry it, put it in 10ℓ of 25% ethanol, boil it for 5 hours in an extractor equipped with cooling condenser, filter it with 300 mesh filter cloth, and leave it for 5 days at 5 ~ 15 ℃ for aging. Filter by filter paper. The extract was concentrated under reduced pressure at 60 ° C. in a distillation apparatus equipped with a cooling condenser to obtain 98 g (dry weight).

Example 3

Wash 1kg of betel nut seed with clean water, dry it, add it to 10ℓ of 50% ethanol, boil it for 5 hours in an extractor equipped with a cooling condenser, extract it, filter it with 300 mesh filter cloth, and leave it for 5 days at 5 ~ 15 ℃ for aging. Filter by filter paper. The extract was concentrated under reduced pressure at 60 ° C. in a distillation apparatus equipped with a cooling condenser to obtain 110 g (dry weight).

Example 4

Wash 1kg of betel nut seed with clean water, dry it, add it to 10ℓ of ethanol, boil it for 5 hours in an extractor with cooling condenser, extract it, filter it with 300 mesh filter cloth, and leave it for 5 days at 5 ~ 15 ℃ for aging. Filtered. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser to obtain 122 g (dry weight).

Example 5

1kg of betel seeds were washed with clean water, dried, and then put in 10 l of ethanol, extracted for 7 days at 15-37 ° C., filtered through 300 mesh filter cloth, left to mature at 5-15 ° C. for 7 days, and filtered through Whatman No. 2 filter paper. . The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser to obtain 150 g (dry weight).

Examples 6-20

Using the solvent of Table 1 below, the extraction was carried out in the same manner as in Example 5, and the results are shown in Table 1 below.

Experimental Results of Examples 6-20 Extraction solvent Dry weight of the final extract (unit: g) Example 6 25% ethanol 100 Example 7 50% ethanol 131 Example 8 Methanol 161 Example 9 25% methanol 105 Example 10 50% methanol 140 Example 11 n-propanol 135 Example 12 Isopropanol 133 Example 13 n-butanol 129 Example 14 Acetone 117 Example 15 Ethyl acetate 65 Example 16 Diethyl ether 131 Example 17 benzene 52 Example 18 chloroform 55 Example 19 Hexane 70 Example 20 Purified water 125

Prescription Example 1

A prescription example of the flexible lotion (skin) in the cosmetic containing betel nut extract is as follows.

ingredient Content (unit: parts by weight) Betel Nut Extract 0.1 glycerin 3.0 Butylene Glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 ethanol 10.0 Triethanolamine 0.1 antiseptic a very small amount Pigment a very small amount Spices a very small amount Purified water Remaining amount

Prescription Example 2

A prescription example of nutritional cosmetics (Losshon) in cosmetics containing betel nut extract is as follows.

ingredient Content (unit: parts by weight) Betel Nut Extract 0.1 Beeswax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Liquid paraffin 5.0 Squalane 5.0 Caprylic / Capric Triglycerides 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Triethanolamine 0.2 antiseptic a very small amount Pigment a very small amount Spices a very small amount Purified water Remaining amount

Prescription Example 3

A prescription example of nutrition cream in cosmetics containing betel nut extract is as follows.

ingredient Content (unit: parts by weight) Betel Nut Extract 0.1 Beeswax 10.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Liquid paraffin 10.0 Squalane 5.0 Caprylic / Capric Triglycerides 5.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 antiseptic a very small amount Pigment a very small amount Spices a very small amount Purified water Remaining amount

Prescription Example 4

A prescription example of a massage cream in a cosmetic containing betel nut extract is as follows.

ingredient Content (unit: parts by weight) Betel Nut Extract 0.1 Beeswax 10.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.8 Liquid paraffin 40.0 Squalane 5.0 Caprylic / Capric Triglycerides 4.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 antiseptic a very small amount Pigment a very small amount Spices a very small amount Purified water Remaining amount

Prescription Example 5

A prescription example of a pack of cosmetics containing betel nut extract is as follows.

ingredient Content (unit: parts by weight) Betel Nut Extract 0.1 Polyvinyl alcohol 13.0 Sodium Carboxymethylcellulose 0.2 Allantoin 0.1 ethanol 5.0 Nonylphenyl Ether 0.3 antiseptic a very small amount Pigment a very small amount Spices a very small amount Purified water Remaining amount

Prescription Example 6

Prescription examples of emulsified foundations in cosmetics containing betel nut extract are as follows.

ingredient Content (unit: parts by weight) Betel Nut Extract 0.1 Beeswax 2.0 Pyromethicone 2.0 Liquid paraffin 5.0 Squalane 5.0 Stearic acid 2.0 Caprylic / Capric Triglycerides 4.0 glycerin 4.0 Propylene glycol 3.0 Butylene glycol 3.0 Triethanolamine 1.0 Aluminum Magnesium Silicate 0.5 Pigment 12 antiseptic a very small amount Pigment a very small amount Spices a very small amount Purified water Remaining amount

Experimental Example 1

The elastase inhibitory effect of the betel extract of Examples 1 to 20 was measured.

1) Experiment Method

Elastase was extracted from porcine pancreas and used Sigma company. In the assay based on the hydrolysis of the synthetic peptide substrate (Sigma) by pancreatic elastase, the increase in the amount of 4-nitroaniline per unit time at a light wavelength of 410 nm was taken as the catalytic activity of elastase. First, 1.0 ml of substrate solution was put in a test tube, and potassium phosphate buffer solution and distilled water were added thereto. For each extract sample, 0.2 ml of the extract sample solution contained in an appropriate concentration in ethanol solution was added to the reaction solution and reacted for 10 minutes in a 37 ° C thermostat. In this case, 0.2 ml of solvent was added instead of each extract, and the absorbance at the wavelength of 410 nm was measured by a photo spectrophotometer. The elastase inhibitory effect of each extract was calculated by the following equation.

2) Experiment result

Elastase Inhibitory Effect of Betel Nut Extract Example Of the extract contained in the reaction solution. Final concentration (μg / ml) Elastase Inhibition Rate (%) Example 1 100 59 1,000 100 Example 2 100 68 1,000 100 Example 3 100 75 1,000 100 Example 4 100 81 1,000 100 Example 5 100 85 1,000 100 Example 6 100 70 1,000 100 Example 7 100 78 1,000 100 Example 8 100 83 1,000 100 Example 9 100 69 1,000 100 Example 10 100 72 1,000 100 Example 11 100 78 1,000 100 Example 12 100 80 1,000 100 Example 13 100 81 1,000 100 Example 14 85 32 1,000 100 Example 15 100 61 1,000 100 Example 16 82 49 1,000 100 Example 17 40 21 1,000 100 Example 18 42 19 1,000 100 Example 19 37 8 1,000 100 Example 20 100 61 1,000 100

Experimental Example 2

Skin moisturizing effect and skin elasticity effect was measured for Formulation Examples 1-6.

1) Experiment Method

To test the effect of betel nut extract on skin elasticity, it was applied twice a day to the left eye edge of 20 subjects. Untreated right eye edge was used as a control. The skin elasticity of the skin surface was measured by the skin moisture meter CM 80 and the skin elasticity measurer SEM 474 before and 14 days after treatment with the betel extract extract cosmetics. Skin moisture measurement by the skin moisture meter CM 820 showed the increased moisturizing power value in% compared to the control group, the average value of 20 subjects is shown in the results. Skin elasticity measurement by the skin elasticity measuring instrument SEM 474 is to measure the depth of wrinkles, the smaller the value is the better elasticity. The elasticity value was shown as a percentage decrease compared to the control, and the average value of 20 subjects was shown in the results.

2) Experiment result

Effect of Betel Nut Extract on Skin Surface Moisturizing and Elasticity Prescription Skin moisturizing effect (%) Skin elasticity effect (%) Prescription Example 1 13 19 Prescription Example 2 32 35 Prescription Example 3 39 46 Prescription Example 4 33 41 Prescription Example 5 33 40 Prescription Example 6 15 28

As can be seen in the experimental example, betel extract extract has an elastase inhibitory effect to increase skin elasticity and improve various skin aging phenomenon.

Claims (7)

A cosmetic composition containing an extract of betel nut, which is a seed of betel nut ( Areca catechu L. ). The betel extract extract is characterized in that the betel nut seed is a methanol, ethanol, propanol, butanol, amyl alcohol or a mixed solvent of water with a cooling condenser at 50 ~ 95 ℃ for 2 to 20 hours A cosmetic composition obtained by heating and dipping for 1 to 15 days at 5 to 37 ° C. According to claim 1, the betel extract is a betel seed is acetone, ethyl acetate, diethyl ether, benzene, chloroform, hexane was deposited for 1 to 15 days at 5 ~ 37 ℃ or 50 ~ 95 ℃ Cosmetic composition, characterized in that obtained by the method of heating by extraction for 2 to 20 hours. The cosmetic composition according to claim 1, wherein the betel extract is contained in an amount of 0.0001 to 10% (w / v) as its dry weight. The cosmetic composition according to claim 1, wherein the betel nut extract is contained in an amount of 0.001 to 5% (w / v) as its dry weight. The cosmetic composition according to claim 1, wherein the betel nut extract is an elastase inhibitor. The cosmetic composition according to claim 1, having a formulation of a flexible lotion, a nourishing lotion, a convergent lotion, a nourishing cream, a massage cream, a pack, an emulsified foundation.