KR102945338B1 - 산화질소 제공 프로스타글란딘 유사체를 제조하는 방법 - Google Patents
산화질소 제공 프로스타글란딘 유사체를 제조하는 방법Info
- Publication number
- KR102945338B1 KR102945338B1 KR1020207025676A KR20207025676A KR102945338B1 KR 102945338 B1 KR102945338 B1 KR 102945338B1 KR 1020207025676 A KR1020207025676 A KR 1020207025676A KR 20207025676 A KR20207025676 A KR 20207025676A KR 102945338 B1 KR102945338 B1 KR 102945338B1
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- nitrooxy
- iii
- vol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18157888.1 | 2018-02-21 | ||
| EP18157888.1A EP3530649B1 (en) | 2018-02-21 | 2018-02-21 | Process for the preparation of a nitric oxide donating prostaglandin analogue |
| PCT/EP2019/053455 WO2019162149A1 (en) | 2018-02-21 | 2019-02-12 | Process for the preparation of a nitric oxide donating prostaglandin analogue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200123151A KR20200123151A (ko) | 2020-10-28 |
| KR102945338B1 true KR102945338B1 (ko) | 2026-03-26 |
Family
ID=61563114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207025676A Active KR102945338B1 (ko) | 2018-02-21 | 2019-02-12 | 산화질소 제공 프로스타글란딘 유사체를 제조하는 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10988438B2 (https=) |
| EP (2) | EP3757089B1 (https=) |
| JP (2) | JP7365349B2 (https=) |
| KR (1) | KR102945338B1 (https=) |
| CN (1) | CN111757868B (https=) |
| AR (1) | AR114262A1 (https=) |
| CA (1) | CA3089530A1 (https=) |
| ES (2) | ES2923623T3 (https=) |
| HU (1) | HUE052204T2 (https=) |
| MY (1) | MY201321A (https=) |
| PH (1) | PH12020551320A1 (https=) |
| PT (1) | PT3530649T (https=) |
| SG (1) | SG11202007113XA (https=) |
| TW (1) | TWI805692B (https=) |
| WO (1) | WO2019162149A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3772511B1 (en) * | 2019-08-05 | 2023-11-08 | Nicox S.A. | Process for the preparation of a nitric oxide donating prostaglandin analogue |
| ES3017242T3 (en) | 2021-02-03 | 2025-05-12 | Nicox Sa | Process for the preparation of a nitric oxide donating prostaglandin analogue |
| EP4404936A1 (en) | 2021-09-20 | 2024-07-31 | Nicox SA | Nitric oxide releasing prostamide as neuroprotective agent |
| LT4303211T (lt) | 2022-07-07 | 2024-11-25 | Nicox S.A. | Pramoninis procesas, skirtas heksano rūgšties, 6-(nitrooksi)-, (1s,2e)-3- [(1r,2r,3s,5r)-2-[(2z)-7-(etilamino)-7-okso-2-hepten-1-il]-3,5- dihidroksiciklopentil]-1-(2-feniletil)-2-propen-1-ilo esterio ir aukšto grynumo produkto gamybai |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011519910A (ja) * | 2008-05-09 | 2011-07-14 | ニコックス エス エイ | 硝酸酸化物供与プロスタミド類 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103288698A (zh) * | 2013-05-07 | 2013-09-11 | 北京洛斯顿精细化工有限公司 | 一种合成前列素类似物的新方法 |
| JP6279409B2 (ja) | 2014-06-02 | 2018-02-14 | 株式会社ダイセル | ポスト処理を行ったスズ置換ゼオライト・ベータを用いたケトン類のエステル類への酸化 |
| US10280138B2 (en) | 2015-03-31 | 2019-05-07 | Nicox S.A. | Nitric oxide donating derivatives of fluprostenol |
-
2018
- 2018-02-21 PT PT181578881T patent/PT3530649T/pt unknown
- 2018-02-21 EP EP20185329.8A patent/EP3757089B1/en active Active
- 2018-02-21 EP EP18157888.1A patent/EP3530649B1/en active Active
- 2018-02-21 ES ES20185329T patent/ES2923623T3/es active Active
- 2018-02-21 ES ES18157888T patent/ES2836118T3/es active Active
- 2018-02-21 HU HUE18157888A patent/HUE052204T2/hu unknown
-
2019
- 2019-02-12 US US16/967,057 patent/US10988438B2/en active Active
- 2019-02-12 SG SG11202007113XA patent/SG11202007113XA/en unknown
- 2019-02-12 CN CN201980013990.3A patent/CN111757868B/zh active Active
- 2019-02-12 JP JP2020544224A patent/JP7365349B2/ja active Active
- 2019-02-12 KR KR1020207025676A patent/KR102945338B1/ko active Active
- 2019-02-12 MY MYPI2020004198A patent/MY201321A/en unknown
- 2019-02-12 WO PCT/EP2019/053455 patent/WO2019162149A1/en not_active Ceased
- 2019-02-12 CA CA3089530A patent/CA3089530A1/en active Pending
- 2019-02-18 TW TW108105320A patent/TWI805692B/zh active
- 2019-02-22 AR ARP190100442A patent/AR114262A1/es active IP Right Grant
-
2020
- 2020-08-11 PH PH12020551320A patent/PH12020551320A1/en unknown
-
2023
- 2023-10-06 JP JP2023174240A patent/JP7661437B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011519910A (ja) * | 2008-05-09 | 2011-07-14 | ニコックス エス エイ | 硝酸酸化物供与プロスタミド類 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2923623T3 (es) | 2022-09-29 |
| CN111757868A (zh) | 2020-10-09 |
| ES2836118T3 (es) | 2021-06-24 |
| JP7661437B2 (ja) | 2025-04-14 |
| HUE052204T2 (hu) | 2021-04-28 |
| TW202000643A (zh) | 2020-01-01 |
| MY201321A (en) | 2024-02-16 |
| CA3089530A1 (en) | 2019-08-29 |
| US20210040032A1 (en) | 2021-02-11 |
| JP2024009896A (ja) | 2024-01-23 |
| AR114262A1 (es) | 2020-08-12 |
| EP3757089A1 (en) | 2020-12-30 |
| EP3530649A1 (en) | 2019-08-28 |
| PT3530649T (pt) | 2020-12-04 |
| US10988438B2 (en) | 2021-04-27 |
| TWI805692B (zh) | 2023-06-21 |
| EP3757089B1 (en) | 2022-05-11 |
| PH12020551320A1 (en) | 2021-04-26 |
| KR20200123151A (ko) | 2020-10-28 |
| CN111757868B (zh) | 2023-03-14 |
| JP2021514371A (ja) | 2021-06-10 |
| WO2019162149A1 (en) | 2019-08-29 |
| JP7365349B2 (ja) | 2023-10-19 |
| SG11202007113XA (en) | 2020-09-29 |
| EP3530649B1 (en) | 2020-09-30 |
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| Publication | Publication Date | Title |
|---|---|---|
| JP7661437B2 (ja) | 一酸化窒素を供与するプロスタグランジン類似体の製造方法 | |
| EP4296258A2 (en) | Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide | |
| TW202241390A (zh) | 製備一氧化氮供體型前列腺素類似物之方法 | |
| CN114174261B (zh) | 制备一氧化氮供体型前列腺素类似物的方法 | |
| EP4303211B1 (en) | Industrial process for the preparation of hexanoic acid, 6(nitrooxy)-,(1s,2e)-3-[(1r,2r,3s,5r)-2-[(2z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]3,5-dihydroxycyclopentyl]-1-(2-phenyl ethyl)-2-propen-1-yl ester and high pure product | |
| HK40037543A (en) | Process for the preparation of a nitric oxide donating prostaglandin analogue | |
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| HK40071158B (zh) | 制备一氧化氮供体型前列腺素类似物的方法 | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
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| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
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| A201 | Request for examination | ||
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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| P13-X000 | Application amended |
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| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
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| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
St.27 status event code: N-2-6-B10-B15-exm-PE0601 |
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| AMND | Amendment | ||
| E13-X000 | Pre-grant limitation requested |
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| P13-X000 | Application amended |
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| PX0901 | Re-examination |
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