CN111757868B - 供给一氧化氮的前列腺素类似物的制备方法 - Google Patents

供给一氧化氮的前列腺素类似物的制备方法 Download PDF

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Publication number
CN111757868B
CN111757868B CN201980013990.3A CN201980013990A CN111757868B CN 111757868 B CN111757868 B CN 111757868B CN 201980013990 A CN201980013990 A CN 201980013990A CN 111757868 B CN111757868 B CN 111757868B
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formula
compound
nitrooxy
process according
butyl ether
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Chinese (zh)
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CN111757868A (zh
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N·阿尔米兰特
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Nicox SA
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Nicox SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980013990.3A 2018-02-21 2019-02-12 供给一氧化氮的前列腺素类似物的制备方法 Active CN111757868B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18157888.1 2018-02-21
EP18157888.1A EP3530649B1 (en) 2018-02-21 2018-02-21 Process for the preparation of a nitric oxide donating prostaglandin analogue
PCT/EP2019/053455 WO2019162149A1 (en) 2018-02-21 2019-02-12 Process for the preparation of a nitric oxide donating prostaglandin analogue

Publications (2)

Publication Number Publication Date
CN111757868A CN111757868A (zh) 2020-10-09
CN111757868B true CN111757868B (zh) 2023-03-14

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CN201980013990.3A Active CN111757868B (zh) 2018-02-21 2019-02-12 供给一氧化氮的前列腺素类似物的制备方法

Country Status (15)

Country Link
US (1) US10988438B2 (https=)
EP (2) EP3757089B1 (https=)
JP (2) JP7365349B2 (https=)
KR (1) KR102945338B1 (https=)
CN (1) CN111757868B (https=)
AR (1) AR114262A1 (https=)
CA (1) CA3089530A1 (https=)
ES (2) ES2923623T3 (https=)
HU (1) HUE052204T2 (https=)
MY (1) MY201321A (https=)
PH (1) PH12020551320A1 (https=)
PT (1) PT3530649T (https=)
SG (1) SG11202007113XA (https=)
TW (1) TWI805692B (https=)
WO (1) WO2019162149A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3772511B1 (en) * 2019-08-05 2023-11-08 Nicox S.A. Process for the preparation of a nitric oxide donating prostaglandin analogue
ES3017242T3 (en) 2021-02-03 2025-05-12 Nicox Sa Process for the preparation of a nitric oxide donating prostaglandin analogue
EP4404936A1 (en) 2021-09-20 2024-07-31 Nicox SA Nitric oxide releasing prostamide as neuroprotective agent
LT4303211T (lt) 2022-07-07 2024-11-25 Nicox S.A. Pramoninis procesas, skirtas heksano rūgšties, 6-(nitrooksi)-, (1s,2e)-3- [(1r,2r,3s,5r)-2-[(2z)-7-(etilamino)-7-okso-2-hepten-1-il]-3,5- dihidroksiciklopentil]-1-(2-feniletil)-2-propen-1-ilo esterio ir aukšto grynumo produkto gamybai

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102099330A (zh) * 2008-05-09 2011-06-15 尼科克斯公司 供给氧化氮的前列酰胺
CN103288698A (zh) * 2013-05-07 2013-09-11 北京洛斯顿精细化工有限公司 一种合成前列素类似物的新方法
WO2016155906A1 (en) * 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of fluprostenol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6279409B2 (ja) 2014-06-02 2018-02-14 株式会社ダイセル ポスト処理を行ったスズ置換ゼオライト・ベータを用いたケトン類のエステル類への酸化

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102099330A (zh) * 2008-05-09 2011-06-15 尼科克斯公司 供给氧化氮的前列酰胺
CN103288698A (zh) * 2013-05-07 2013-09-11 北京洛斯顿精细化工有限公司 一种合成前列素类似物的新方法
WO2016155906A1 (en) * 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of fluprostenol

Also Published As

Publication number Publication date
ES2923623T3 (es) 2022-09-29
CN111757868A (zh) 2020-10-09
ES2836118T3 (es) 2021-06-24
JP7661437B2 (ja) 2025-04-14
HUE052204T2 (hu) 2021-04-28
TW202000643A (zh) 2020-01-01
MY201321A (en) 2024-02-16
CA3089530A1 (en) 2019-08-29
US20210040032A1 (en) 2021-02-11
JP2024009896A (ja) 2024-01-23
KR102945338B1 (ko) 2026-03-26
AR114262A1 (es) 2020-08-12
EP3757089A1 (en) 2020-12-30
EP3530649A1 (en) 2019-08-28
PT3530649T (pt) 2020-12-04
US10988438B2 (en) 2021-04-27
TWI805692B (zh) 2023-06-21
EP3757089B1 (en) 2022-05-11
PH12020551320A1 (en) 2021-04-26
KR20200123151A (ko) 2020-10-28
JP2021514371A (ja) 2021-06-10
WO2019162149A1 (en) 2019-08-29
JP7365349B2 (ja) 2023-10-19
SG11202007113XA (en) 2020-09-29
EP3530649B1 (en) 2020-09-30

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