KR102937202B1 - 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법 - Google Patents

세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

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KR102937202B1
KR102937202B1 KR1020257033007A KR20257033007A KR102937202B1 KR 102937202 B1 KR102937202 B1 KR 102937202B1 KR 1020257033007 A KR1020257033007 A KR 1020257033007A KR 20257033007 A KR20257033007 A KR 20257033007A KR 102937202 B1 KR102937202 B1 KR 102937202B1
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target
sequence
seq
specific
lactobacillus
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KR20250151588A (ko
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데이먼 킷트릿지 겟맨
안젤라 세브링 허드슨
지미킴 팜
시안쿤 왕
캐롤린 클락
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젠-프로브 인코포레이티드
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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    • C12Q2537/00Reactions characterised by the reaction format or use of a specific feature
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    • C12Q2600/00Oligonucleotides characterized by their use
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020257033007A 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법 Active KR102937202B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267006922A KR20260040117A (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862722627P 2018-08-24 2018-08-24
US62/722,627 2018-08-24
KR1020217008802A KR102868953B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
PCT/US2019/047854 WO2020041671A1 (en) 2018-08-24 2019-08-23 Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis

Related Parent Applications (1)

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KR1020217008802A Division KR102868953B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Related Child Applications (1)

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KR1020267006922A Division KR20260040117A (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Publications (2)

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KR20250151588A KR20250151588A (ko) 2025-10-21
KR102937202B1 true KR102937202B1 (ko) 2026-03-11

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KR1020257033007A Active KR102937202B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
KR1020267006922A Pending KR20260040117A (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
KR1020217008802A Active KR102868953B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

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KR1020267006922A Pending KR20260040117A (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
KR1020217008802A Active KR102868953B1 (ko) 2018-08-24 2019-08-23 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

Country Status (6)

Country Link
US (3) US12291753B2 (enExample)
EP (1) EP3841222A1 (enExample)
JP (4) JP7389111B2 (enExample)
KR (3) KR102937202B1 (enExample)
AU (1) AU2019324196B2 (enExample)
WO (1) WO2020041671A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016233298B2 (en) 2015-03-16 2021-09-02 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
US20220205020A1 (en) * 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
CN117288944A (zh) * 2023-09-20 2023-12-26 天津鸿蒙医学研究有限公司 一种阴道加德纳菌的化学发光检测试剂盒及其使用方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172204A1 (en) 2015-04-24 2016-10-27 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
JP2641880B2 (ja) 1986-08-11 1997-08-20 シスカ・ダイアグノスティックス・インコーポレーテッド 核酸プローブアッセイ法および組成物
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
US5639604A (en) 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
EP0638807B1 (en) 1987-09-21 2002-07-17 Gen-Probe Incorporated Protection assay
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5656207A (en) 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5516663A (en) 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
KR940703846A (ko) 1991-12-24 1994-12-12 비. 린네 파샬 갭(gap)이 형성된 2′ 변성된 올리고뉴클레오티드(gapped 2′ modifed oligonucleotides)
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
CA2135073C (en) 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US5614402A (en) 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
AU689789B2 (en) 1993-07-23 1998-04-09 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
AU2522095A (en) 1994-05-19 1995-12-18 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
ES2271994T3 (es) 1997-05-02 2007-04-16 Gen-Probe Incorporated Hibridacion en dos pasos y captura de un polinucleotido.
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
JP4646404B2 (ja) 1998-07-02 2011-03-09 ジェン−プローブ・インコーポレーテッド 分子トーチ(torch)
DK1778867T3 (da) 2004-07-01 2010-08-02 Gen Probe Inc Fremgangsmåder og sammensætninger til detektering af nucleinsyrer i en biologisk prøve
EP2071031B1 (en) 2004-08-27 2013-10-09 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
CA2599013A1 (en) 2005-02-28 2006-09-08 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
WO2008016988A1 (en) 2006-08-01 2008-02-07 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
WO2011103274A1 (en) * 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
US9970060B2 (en) * 2011-11-23 2018-05-15 Medical Diagnostic Laboratories, Llc Quantitation and profiling of vaginal microflora
CN103045725A (zh) * 2012-10-31 2013-04-17 江南大学 一种同时检测醋醅中四种功能微生物的多重pcr技术
CN103184289A (zh) * 2013-03-30 2013-07-03 江南大学 荧光定量pcr检测醋醅中五种菌的方法
AU2016233298B2 (en) * 2015-03-16 2021-09-02 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
CN104911275B (zh) * 2015-07-13 2016-02-17 北京医研伙伴医学研究所有限公司 一种细菌性阴道炎检测试剂盒

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172204A1 (en) 2015-04-24 2016-10-27 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis

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CA3108906A1 (en) 2020-02-27
KR102868953B1 (ko) 2025-10-13
JP2023171960A (ja) 2023-12-05
AU2019324196B2 (en) 2025-07-10
AU2019324196A1 (en) 2021-03-18
WO2020041671A1 (en) 2020-02-27
JP2026016682A (ja) 2026-02-03
US12291753B2 (en) 2025-05-06
KR20260040117A (ko) 2026-03-23
US20260117314A1 (en) 2026-04-30
JP7839936B2 (ja) 2026-04-02
JP2021534764A (ja) 2021-12-16
EP3841222A1 (en) 2021-06-30
KR20250151588A (ko) 2025-10-21
KR20210063347A (ko) 2021-06-01
US20210198720A1 (en) 2021-07-01
JP2026016681A (ja) 2026-02-03
JP7389111B2 (ja) 2023-11-29
US20250163523A1 (en) 2025-05-22

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