KR102929403B1 - 면역글로불린 단일 가변 도메인을 이용한 ttp의 초기 에피소드의 치료 방법 - Google Patents

면역글로불린 단일 가변 도메인을 이용한 ttp의 초기 에피소드의 치료 방법

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Publication number
KR102929403B1
KR102929403B1 KR1020207024118A KR20207024118A KR102929403B1 KR 102929403 B1 KR102929403 B1 KR 102929403B1 KR 1020207024118 A KR1020207024118 A KR 1020207024118A KR 20207024118 A KR20207024118 A KR 20207024118A KR 102929403 B1 KR102929403 B1 KR 102929403B1
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South Korea
Prior art keywords
polypeptide
ttp
vwf
human
treatment
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KR1020207024118A
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Korean (ko)
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KR20200118444A (ko
Inventor
필립 칼레베르트
힐데 데 빈터
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아블린쓰 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020207024118A 2018-02-06 2019-02-06 면역글로불린 단일 가변 도메인을 이용한 ttp의 초기 에피소드의 치료 방법 Active KR102929403B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862627082P 2018-02-06 2018-02-06
US62/627,082 2018-02-06
US201862662381P 2018-04-25 2018-04-25
US62/662,381 2018-04-25
PCT/EP2019/052929 WO2019154867A1 (en) 2018-02-06 2019-02-06 Methods of treating initial episode of ttp with immunoglobulin single variable domains

Publications (2)

Publication Number Publication Date
KR20200118444A KR20200118444A (ko) 2020-10-15
KR102929403B1 true KR102929403B1 (ko) 2026-02-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207024118A Active KR102929403B1 (ko) 2018-02-06 2019-02-06 면역글로불린 단일 가변 도메인을 이용한 ttp의 초기 에피소드의 치료 방법

Country Status (15)

Country Link
US (1) US11999797B2 (https=)
EP (1) EP3749696A1 (https=)
JP (2) JP2021512947A (https=)
KR (1) KR102929403B1 (https=)
CN (1) CN111670202A (https=)
AU (1) AU2019217584B2 (https=)
BR (1) BR112020015991A2 (https=)
CA (1) CA3089211A1 (https=)
IL (1) IL276200B2 (https=)
MX (1) MX2020008294A (https=)
MY (1) MY204220A (https=)
SG (1) SG11202006902QA (https=)
TW (1) TWI889647B (https=)
WO (1) WO2019154867A1 (https=)
ZA (1) ZA202004370B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201805064SA (en) * 2011-06-23 2018-07-30 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015193326A1 (en) * 2014-06-16 2015-12-23 Ablynx Nv Methods of treating ttp with immunoglobulin single variable domains and uses thereof

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US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5043429B1 (en) 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
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CA2361678A1 (en) 1999-02-05 2000-08-10 Rijksuniversiteit Leiden Method of modulating metabolite biosynthesis in recombinant cells
IL147920A0 (en) 1999-08-02 2002-08-14 Keygene Nv Method for generating cgmmv resistant plants, genetic constructs, and the obtained cgmmv-resistant plants
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AU2003251238A1 (en) 2002-08-07 2004-02-25 Umc Utrecht Holding B.V. Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
BRPI0315666B8 (pt) 2002-10-23 2021-05-25 Ludwig Inst For Cancer Res Ltd dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos
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EP2121757A2 (en) 2007-02-21 2009-11-25 Ablynx N.V. Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization
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Also Published As

Publication number Publication date
ZA202004370B (en) 2024-08-28
US20210221912A1 (en) 2021-07-22
KR20200118444A (ko) 2020-10-15
BR112020015991A2 (pt) 2020-12-15
JP2021512947A (ja) 2021-05-20
TW201945030A (zh) 2019-12-01
WO2019154867A1 (en) 2019-08-15
RU2020129228A (ru) 2022-03-09
CA3089211A1 (en) 2019-08-15
MY204220A (en) 2024-08-16
CN111670202A (zh) 2020-09-15
SG11202006902QA (en) 2020-08-28
IL276200B1 (en) 2024-09-01
MX2020008294A (es) 2020-11-18
TWI889647B (zh) 2025-07-11
JP2024001135A (ja) 2024-01-09
US11999797B2 (en) 2024-06-04
IL276200B2 (en) 2025-01-01
EP3749696A1 (en) 2020-12-16
AU2019217584B2 (en) 2025-08-14
IL276200A (en) 2020-09-30
AU2019217584A1 (en) 2020-09-17

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