KR102895185B1 - 흥분성 및 비흥분성 세포 내의 Ca2+를 이미지화하기 위한 저친화도 적색 형광 지표 - Google Patents

흥분성 및 비흥분성 세포 내의 Ca2+를 이미지화하기 위한 저친화도 적색 형광 지표

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KR102895185B1
KR102895185B1 KR1020207027497A KR20207027497A KR102895185B1 KR 102895185 B1 KR102895185 B1 KR 102895185B1 KR 1020207027497 A KR1020207027497 A KR 1020207027497A KR 20207027497 A KR20207027497 A KR 20207027497A KR 102895185 B1 KR102895185 B1 KR 102895185B1
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창유펜
우지아휘
메튜 제이 다니엘스
로버트 이 캠벨
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더 거버너스 오브 더 유니버시티 오브 알버타
더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
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KR1020207027497A 2018-03-02 2019-03-01 흥분성 및 비흥분성 세포 내의 Ca2+를 이미지화하기 위한 저친화도 적색 형광 지표 Active KR102895185B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862637808P 2018-03-02 2018-03-02
US62/637,808 2018-03-02
PCT/CA2019/050254 WO2019165563A1 (en) 2018-03-02 2019-03-01 Low affinity red fluorescent indicators for imaging ca2+ in excitable and non-excitable cells

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KR20210002467A KR20210002467A (ko) 2021-01-08
KR102895185B1 true KR102895185B1 (ko) 2025-12-03

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US (1) US20210063404A1 (https=)
EP (1) EP3759128A4 (https=)
JP (1) JP7313636B2 (https=)
KR (1) KR102895185B1 (https=)
CN (1) CN112055716B (https=)
CA (1) CA3093019A1 (https=)
SG (1) SG11202007933VA (https=)
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CN115197301B (zh) * 2022-06-10 2024-07-16 北京师范大学 用于胞内钙信号检测及相关药物筛选的钙指示工具及其应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2017048808A1 (en) 2015-09-15 2017-03-23 The Board Of Trustees Of The Leland Stanford Junior University Light-responsive polypeptides and methods of use thereof

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EP1700865A1 (en) * 2005-03-11 2006-09-13 AXXAM S.r.l. Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators
US20110154515A1 (en) * 2007-08-24 2011-06-23 Oliver Griesbeck Genetically encoded calcium sensors comprising the c-terminal lobe of troponin c and a fluorescence tag
JP6051438B2 (ja) * 2012-06-19 2016-12-27 国立大学法人埼玉大学 赤色蛍光蛋白質を用いたカルシウムセンサー蛋白質
US10836802B2 (en) * 2014-06-11 2020-11-17 Japan Science And Technology Agency Calcium reporter gene
US9644007B2 (en) * 2014-12-23 2017-05-09 Howard Hughes Medical Institute Red genetically encoded calcium indicators and methods of use
WO2017087542A1 (en) * 2015-11-18 2017-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and systems for measuring neural activity
CN205757212U (zh) * 2016-06-29 2016-12-07 湖南中烟工业有限责任公司 无棉型超声波雾化器及电子烟
WO2018034298A1 (ja) * 2016-08-16 2018-02-22 国立研究開発法人理化学研究所 カルシウムインジケーターを有する遺伝子改変トリパノソーマ・クルージおよび抗トリパノソーマ薬のスクリーニングのためのその応用
EP3652339A4 (en) * 2017-07-09 2021-04-14 Montana Molecular LLC BIOSENSORS FOR MEASURING CELL SIGNALING IN STRESSED AND HEALTHY CELLS

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Publication number Priority date Publication date Assignee Title
WO2017048808A1 (en) 2015-09-15 2017-03-23 The Board Of Trustees Of The Leland Stanford Junior University Light-responsive polypeptides and methods of use thereof

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Title
Wu, Jiahui, 2014, Thesis, Doctor of Philosophy, Department of Chemistry University of Alberta, pp 1-182. 1부.*

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EP3759128A1 (en) 2021-01-06
SG11202007933VA (en) 2020-09-29
JP2021515550A (ja) 2021-06-24
CN112055716A (zh) 2020-12-08
WO2019165563A9 (en) 2020-09-10
WO2019165563A1 (en) 2019-09-06
CA3093019A1 (en) 2019-09-06
CN112055716B (zh) 2024-11-01
EP3759128A4 (en) 2021-12-08
KR20210002467A (ko) 2021-01-08
JP7313636B2 (ja) 2023-07-25
US20210063404A1 (en) 2021-03-04

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