JP7313636B2 - 興奮性細胞および非興奮性細胞でＣａ２＋を画像化するための低親和性赤色蛍光指示薬 - Google Patents

興奮性細胞および非興奮性細胞でＣａ２＋を画像化するための低親和性赤色蛍光指示薬 Download PDF

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JP7313636B2
JP7313636B2 JP2020545529A JP2020545529A JP7313636B2 JP 7313636 B2 JP7313636 B2 JP 7313636B2 JP 2020545529 A JP2020545529 A JP 2020545529A JP 2020545529 A JP2020545529 A JP 2020545529A JP 7313636 B2 JP7313636 B2 JP 7313636B2
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－ フェン チャン、ユー
ウー、ジアフイ
ジェイ． ダニエルズ、マシュー
イー． キャンベル、ロバート
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ザ・ガバナーズ・オブ・ザ・ユニバーシティー・オブ・アルバータ
ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニヴァーシティ・オブ・オックスフォード
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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JP2020545529A 2018-03-02 2019-03-01 興奮性細胞および非興奮性細胞でＣａ２＋を画像化するための低親和性赤色蛍光指示薬 Active JP7313636B2 (ja)

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US201862637808P 2018-03-02 2018-03-02
US62/637,808 2018-03-02
PCT/CA2019/050254 WO2019165563A1 (en) 2018-03-02 2019-03-01 Low affinity red fluorescent indicators for imaging ca2+ in excitable and non-excitable cells

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JP2021515550A JP2021515550A (ja) 2021-06-24
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JP7313636B2 true JP7313636B2 (ja) 2023-07-25

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CN115197301B (zh) * 2022-06-10 2024-07-16 北京师范大学 用于胞内钙信号检测及相关药物筛选的钙指示工具及其应用

Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2014001161A (ja) 2012-06-19 2014-01-09 Saitama Univ 赤色蛍光蛋白質を用いたカルシウムセンサー蛋白質
WO2015190083A1 (ja) 2014-06-11 2015-12-17 国立研究開発法人科学技術振興機構 カルシウム指示遺伝子
WO2017048808A1 (en) 2015-09-15 2017-03-23 The Board Of Trustees Of The Leland Stanford Junior University Light-responsive polypeptides and methods of use thereof
WO2017087542A1 (en) 2015-11-18 2017-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and systems for measuring neural activity
WO2018034298A1 (ja) 2016-08-16 2018-02-22 国立研究開発法人理化学研究所 カルシウムインジケーターを有する遺伝子改変トリパノソーマ・クルージおよび抗トリパノソーマ薬のスクリーニングのためのその応用

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EP1700865A1 (en) * 2005-03-11 2006-09-13 AXXAM S.r.l. Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators
US20110154515A1 (en) * 2007-08-24 2011-06-23 Oliver Griesbeck Genetically encoded calcium sensors comprising the c-terminal lobe of troponin c and a fluorescence tag
US9644007B2 (en) * 2014-12-23 2017-05-09 Howard Hughes Medical Institute Red genetically encoded calcium indicators and methods of use
CN205757212U (zh) * 2016-06-29 2016-12-07 湖南中烟工业有限责任公司 无棉型超声波雾化器及电子烟
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Patent Citations (5)

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JP2014001161A (ja) 2012-06-19 2014-01-09 Saitama Univ 赤色蛍光蛋白質を用いたカルシウムセンサー蛋白質
WO2015190083A1 (ja) 2014-06-11 2015-12-17 国立研究開発法人科学技術振興機構 カルシウム指示遺伝子
WO2017048808A1 (en) 2015-09-15 2017-03-23 The Board Of Trustees Of The Leland Stanford Junior University Light-responsive polypeptides and methods of use thereof
WO2017087542A1 (en) 2015-11-18 2017-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and systems for measuring neural activity
WO2018034298A1 (ja) 2016-08-16 2018-02-22 国立研究開発法人理化学研究所 カルシウムインジケーターを有する遺伝子改変トリパノソーマ・クルージおよび抗トリパノソーマ薬のスクリーニングのためのその応用

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Red fluorescent genetically encoded Ca２＋ indicators for use in mitochondria and endoplasmic reticulum，Biochem. J.，Vol. 464，2014年，p. 13-22

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EP3759128A1 (en) 2021-01-06
SG11202007933VA (en) 2020-09-29
JP2021515550A (ja) 2021-06-24
KR102895185B1 (ko) 2025-12-03
CN112055716A (zh) 2020-12-08
WO2019165563A9 (en) 2020-09-10
WO2019165563A1 (en) 2019-09-06
CA3093019A1 (en) 2019-09-06
CN112055716B (zh) 2024-11-01
EP3759128A4 (en) 2021-12-08
KR20210002467A (ko) 2021-01-08
US20210063404A1 (en) 2021-03-04

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