KR102892389B1 - 시료 디지털화를 위한 마이크로유체 어레이 - Google Patents

시료 디지털화를 위한 마이크로유체 어레이

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Publication number
KR102892389B1
KR102892389B1 KR1020217021153A KR20217021153A KR102892389B1 KR 102892389 B1 KR102892389 B1 KR 102892389B1 KR 1020217021153 A KR1020217021153 A KR 1020217021153A KR 20217021153 A KR20217021153 A KR 20217021153A KR 102892389 B1 KR102892389 B1 KR 102892389B1
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Prior art keywords
channel
chamber
chambers
microfluidic device
inlet port
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Korean (ko)
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KR20210102324A (ko
Inventor
로버트 린
주-숭 훙
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콤비네티 인코포레이티드
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
KR1020217021153A 2018-12-10 2019-12-09 시료 디지털화를 위한 마이크로유체 어레이 Active KR102892389B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862777616P 2018-12-10 2018-12-10
US62/777,616 2018-12-10
PCT/US2019/065287 WO2020123406A1 (en) 2018-12-10 2019-12-09 Microfluidic array for sample digitization

Publications (2)

Publication Number Publication Date
KR20210102324A KR20210102324A (ko) 2021-08-19
KR102892389B1 true KR102892389B1 (ko) 2025-12-01

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KR1020217021153A Active KR102892389B1 (ko) 2018-12-10 2019-12-09 시료 디지털화를 위한 마이크로유체 어레이

Country Status (9)

Country Link
US (1) US12465915B2 (https=)
EP (1) EP3737505A4 (https=)
JP (2) JP7565274B2 (https=)
KR (1) KR102892389B1 (https=)
CN (1) CN113423503A (https=)
AU (1) AU2019397371B2 (https=)
CA (1) CA3122712A1 (https=)
SG (1) SG11202106138SA (https=)
WO (1) WO2020123406A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
AU2017363076B2 (en) 2016-11-17 2021-04-29 Combinati Incorporated Methods and systems for nucleic acid analysis and quantification
AU2019397371B2 (en) 2018-12-10 2025-09-18 Combinati Incorporated Microfluidic array for sample digitization
KR20230024417A (ko) * 2020-06-22 2023-02-20 콤비네티 인코포레이티드 생물학적 샘플을 분석하기 위한 시스템 및 방법
CN116368213A (zh) * 2020-09-28 2023-06-30 康比纳蒂股份有限公司 用于样品处理的装置和方法
WO2022140585A1 (en) * 2020-12-23 2022-06-30 Cornell University Gradient-based microfluidic circuit, device, and method for performing an assay
JP2024502039A (ja) * 2020-12-29 2024-01-17 コンビナティ インコーポレイテッド 試料分配のためのデバイス及び方法
WO2023043848A1 (en) 2021-09-14 2023-03-23 Combinati, Inc. Microfluidic device and method for processing biological samples
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
US20250216378A1 (en) 2023-12-28 2025-07-03 Biobridge Global Methods for performing miniaturized dynamic assays using microfluidics and related systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014695A1 (en) 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
JP2008514901A (ja) 2004-09-28 2008-05-08 クリーブランド バイオセンサーズ プロプライエタリー リミテッド マイクロ流体デバイス
JP2009513978A (ja) 2005-10-26 2009-04-02 ゼネラル・エレクトリック・カンパニイ 流体試料をセンサーアレイにデリバリーするための方法及びシステム
WO2017176699A1 (en) 2016-04-04 2017-10-12 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7133726B1 (en) 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
NZ502303A (en) 1997-06-18 2002-02-01 Ulrich J Krull Nucleic acid biosensor system & diagnostic use
US6977145B2 (en) 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
AU2082701A (en) 1999-12-09 2001-06-18 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US7010391B2 (en) * 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
EP1384022A4 (en) * 2001-04-06 2004-08-04 California Inst Of Techn NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES
US20050009101A1 (en) 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
WO2003050035A2 (en) 2001-12-06 2003-06-19 Nanostream, Inc. Adhesiveless microfluidic device fabrication
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US7169602B2 (en) 2002-12-04 2007-01-30 Applera Corporation Sample substrate for use in biological testing and method for filling a sample substrate
US20060094108A1 (en) 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20070099290A1 (en) * 2003-09-02 2007-05-03 Kazuhiro Iida Customizable chip and method of manufacturing the same
US20050226779A1 (en) 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
JP2005329333A (ja) 2004-05-20 2005-12-02 Japan Science & Technology Agency マイクロ脱気デバイス
US8715446B2 (en) 2004-10-13 2014-05-06 Rheonix, Inc. Latent solvent-based microfluidic apparatus, methods, and applications
US7608160B2 (en) 2004-10-13 2009-10-27 Rheonix, Inc. Laminated microfluidic structures and method for making
DE102004063438A1 (de) 2004-12-23 2006-07-06 Oktavia Backes Neuartige mikrofluidische Probenträger
CN101351542A (zh) 2005-07-15 2009-01-21 阿普尔拉公司 液体加工装置和方法
US7939312B2 (en) 2006-08-30 2011-05-10 Dxna Llc Rapid thermocycler with movable cooling assembly
GB2445738A (en) 2007-01-16 2008-07-23 Lab901 Ltd Microfluidic device
US9550184B2 (en) 2007-02-05 2017-01-24 Shimadzu Corporation Reactor plate and reaction processing method
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
EP2255010B1 (en) 2008-02-20 2018-05-30 Streck Inc. Thermocycler and sample vessel for rapid amplification of dna
JP2009236555A (ja) 2008-03-26 2009-10-15 Shimadzu Corp 流体デバイス及びその製造方法
US20090250347A1 (en) 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
RU2385940C1 (ru) 2008-10-23 2010-04-10 Общество с ограниченной ответственностью "ВИНТЕЛ" Способ определения нуклеиновых кислот методом полимеразно-цепной реакции в режиме реального времени и устройство для его осуществления
EP2248915B1 (en) 2009-05-05 2013-09-18 Qiagen GmbH Detection of multiple nucleic acid sequences in a reaction cartridge
EP2432597A2 (en) * 2009-05-19 2012-03-28 Stokes Bio Limited Sampling device
EP3586945A3 (en) * 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
US9238346B2 (en) 2009-10-08 2016-01-19 National Research Council Of Canada Microfluidic device, composition and method of forming
GB0919159D0 (en) * 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
US8376317B2 (en) 2010-03-29 2013-02-19 Purdue Research Foundation Microfluidic purge valve
EP3236260B1 (en) 2011-04-13 2020-09-30 Akonni Biosystems, Inc. Method for making a microarray assembly
US9902990B2 (en) 2011-05-27 2018-02-27 The University Of British Columbia Microfluidic cell trap and assay apparatus for high-throughput analysis
DE102011078770B4 (de) * 2011-07-07 2016-04-28 Robert Bosch Gmbh Mikrofluidische Vorrichtung, mikrofluidisches System und Verfahren zum Transport von Fluiden
WO2013130910A1 (en) 2012-02-29 2013-09-06 Integenx Inc. Sample preparation, processing and analysis systems
US9050593B2 (en) * 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
JP2013130396A (ja) * 2011-12-20 2013-07-04 Sony Corp マイクロチップ
WO2013101741A1 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
WO2013177206A2 (en) 2012-05-21 2013-11-28 Fluidigm Corporation Single-particle analysis of particle populations
ITTO20120703A1 (it) * 2012-08-03 2014-02-04 Biomerieux Sa Dispositivo microfluidico monouso, cartuccia includente il dispositivo microfluidico, apparecchio per eseguire una amplificazione di acido nucleico, metodo di fabbricazione del dispositivo microfluidico, e metodo di uso del dispositivo microfluidico
WO2014039963A1 (en) 2012-09-10 2014-03-13 Biofire Diagnostics, Inc. Multiple amplification cycle detection
CN105164246B (zh) 2013-03-15 2018-09-25 富鲁达公司 用于分析定义的多细胞组合的方法和设备
DE102013205412A1 (de) 2013-03-27 2014-10-02 Robert Bosch Gmbh Normal-geschlossenes Ventil für mikrofluidische Bauteile aus einem polymeren Schichtsystem sowie Verfahren
WO2015021425A1 (en) 2013-08-09 2015-02-12 The Regents Of The University Of California Digital fluid sample separation apparatus and methods for one-step quantitative sample analysis
WO2015023616A2 (en) 2013-08-12 2015-02-19 The Johns Hopkins University Method for comprehensive, quantitative, and highly sensitive discrimination of nucleic acid sequences in homogeneous and heterogeneous populations
JP6427753B2 (ja) 2013-09-11 2018-11-28 国立大学法人大阪大学 熱対流生成用チップ、熱対流生成装置、及び熱対流生成方法
EP3077806B1 (en) 2013-12-06 2019-09-11 Ortho Clinical Diagnostics, Inc. Assay device having a wash port
KR101562318B1 (ko) 2014-02-10 2015-10-22 나노바이오시스 주식회사 미세유체 칩 및 이를 이용한 실시간 분석 장치
EP3117221B1 (en) 2014-03-13 2020-09-09 Genapsys Inc. Microfluidic devices and methods for sample preparation and analysis
CN204727866U (zh) 2014-03-31 2015-10-28 博奥生物集团有限公司 一种集核酸扩增和微阵列检测于一体的微流控装置
US9856521B2 (en) * 2015-01-27 2018-01-02 BioSpyder Technologies, Inc. Ligation assays in liquid phase
CA2982884C (en) 2015-04-24 2021-03-30 F. Hoffmann-La Roche Ag Digital pcr systems and methods using digital microfluidics
CN104877905A (zh) 2015-05-04 2015-09-02 清华大学深圳研究生院 细胞体外共培养微流控芯片、系统及方法
CN104894106A (zh) 2015-05-23 2015-09-09 浙江大学 高集成度等距等分核酸扩增微流控芯片及应用
CN108291184B (zh) 2015-12-01 2022-07-01 日本板硝子株式会社 Pcr反应容器、pcr装置、pcr方法
CN107238573A (zh) * 2016-03-29 2017-10-10 光宝电子(广州)有限公司 流体检测装置
US11285478B2 (en) * 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US10913063B2 (en) 2016-07-12 2021-02-09 EMULATE, Inc. Removing bubbles in a microfluidic device
AU2017363076B2 (en) 2016-11-17 2021-04-29 Combinati Incorporated Methods and systems for nucleic acid analysis and quantification
EP3346262A1 (en) 2017-01-10 2018-07-11 Universite d'Aix-Marseille (AMU) Optical thermal method and system for diagnosing pathologies
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
CN112533627A (zh) 2018-03-27 2021-03-19 G+Flas 生命科学公司 序列特异性体内细胞靶向
PL425106A1 (pl) 2018-03-30 2019-10-07 Bacteromic Spółka Z Ograniczoną Odpowiedzialnością Chip mikroprzepływowy
AU2019397371B2 (en) 2018-12-10 2025-09-18 Combinati Incorporated Microfluidic array for sample digitization
BR112022014571A2 (pt) 2020-01-24 2022-10-04 Combinati Incorporated Métodos e sistemas para fabricação de dispositivo microfluídico
KR20230024417A (ko) 2020-06-22 2023-02-20 콤비네티 인코포레이티드 생물학적 샘플을 분석하기 위한 시스템 및 방법
WO2022067184A1 (en) 2020-09-28 2022-03-31 Combinati Incorporated Devices and methods for sample processing
CN116368213A (zh) 2020-09-28 2023-06-30 康比纳蒂股份有限公司 用于样品处理的装置和方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008514901A (ja) 2004-09-28 2008-05-08 クリーブランド バイオセンサーズ プロプライエタリー リミテッド マイクロ流体デバイス
US20070014695A1 (en) 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
JP2009513978A (ja) 2005-10-26 2009-04-02 ゼネラル・エレクトリック・カンパニイ 流体試料をセンサーアレイにデリバリーするための方法及びシステム
WO2017176699A1 (en) 2016-04-04 2017-10-12 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification

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AU2019397371A1 (en) 2021-07-22
CA3122712A1 (en) 2020-06-18
WO2020123406A1 (en) 2020-06-18
US12465915B2 (en) 2025-11-11
AU2019397371B2 (en) 2025-09-18
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SG11202106138SA (en) 2021-07-29
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US20200384471A1 (en) 2020-12-10
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