KR102889984B1 - 합성 종양용해성 lnp-레플리콘 rna 및 암 면역요법을 위한 용도 - Google Patents

합성 종양용해성 lnp-레플리콘 rna 및 암 면역요법을 위한 용도

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KR102889984B1
KR102889984B1 KR1020217032460A KR20217032460A KR102889984B1 KR 102889984 B1 KR102889984 B1 KR 102889984B1 KR 1020217032460 A KR1020217032460 A KR 1020217032460A KR 20217032460 A KR20217032460 A KR 20217032460A KR 102889984 B1 KR102889984 B1 KR 102889984B1
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cancer
replicon rna
oncolytic virus
synthetic oncolytic
synthetic
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KR20220006041A (ko
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다렐 제이. 어바인
칼 대인 윗트럽
론 와이스
잉중 리
누르 무민
이조우 동
Original Assignee
메사추세츠 인스티튜트 오브 테크놀로지
오하이오 스테이트 이노베이션 파운데이션
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    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2770/36132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020217032460A 2019-03-08 2020-01-10 합성 종양용해성 lnp-레플리콘 rna 및 암 면역요법을 위한 용도 Active KR102889984B1 (ko)

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KR1020257038746A KR20250171410A (ko) 2019-03-08 2020-01-10 합성 종양용해성 lnp-레플리콘 rna 및 암 면역요법을 위한 용도

Applications Claiming Priority (3)

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US201962815611P 2019-03-08 2019-03-08
US62/815,611 2019-03-08
PCT/US2020/013069 WO2020185293A1 (en) 2019-03-08 2020-01-10 Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy

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KR20220006041A KR20220006041A (ko) 2022-01-14
KR102889984B1 true KR102889984B1 (ko) 2025-11-25

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KR1020257038746A Pending KR20250171410A (ko) 2019-03-08 2020-01-10 합성 종양용해성 lnp-레플리콘 rna 및 암 면역요법을 위한 용도

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US (3) US11717548B2 (https=)
EP (2) EP4729621A2 (https=)
JP (2) JP7561134B2 (https=)
KR (2) KR102889984B1 (https=)
CN (1) CN113966221B (https=)
AU (1) AU2020233788A1 (https=)
BR (1) BR112021017637A8 (https=)
CA (1) CA3132714A1 (https=)
CO (1) CO2021013417A2 (https=)
DK (1) DK3934673T3 (https=)
FI (1) FI3934673T3 (https=)
IL (1) IL285963A (https=)
MX (1) MX2021010808A (https=)
MY (1) MY207334A (https=)
PH (1) PH12021552145A1 (https=)
SG (1) SG11202109514VA (https=)
WO (1) WO2020185293A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113710229B (zh) 2019-02-25 2026-01-06 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
CN113966221B (zh) * 2019-03-08 2026-03-31 麻省理工学院 合成溶瘤lnp复制子rna和用于癌症免疫治疗的用途
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
CN113509542A (zh) * 2021-04-20 2021-10-19 嘉晨西海(杭州)生物技术有限公司 一种基于mRNA的表达白介素12针对肿瘤的药物及其制备方法
CZ310443B6 (cs) * 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
CN119317430A (zh) 2022-04-26 2025-01-14 斯特兰德生物科技公司 包含委内瑞拉马脑炎(vee)复制子的脂质纳米颗粒及其用途
CN115227674B (zh) * 2022-08-05 2023-07-04 武汉滨会生物科技股份有限公司 包封的溶瘤病毒遗传物质及其应用
EP4648781A1 (en) * 2023-01-12 2025-11-19 Bavarian Nordic A/S Recombinant modified sarna (vrp) for cancer vaccine
EP4687854A2 (en) * 2023-04-07 2026-02-11 Flagship Labs 114, Inc. Lipids and lipid-like compounds for therapeutic lipid nanoparticle (lnp) delivery
CN118147171B (zh) * 2024-03-08 2024-12-06 上海复诺健生物科技有限公司 具有增强的外源基因表达水平的自扩增mRNA核酸序列
AU2024299882A1 (en) 2023-07-25 2026-01-08 Strand Therapeutics Inc. Polynucleotides comprising a micro rna detargeting sensor and uses thereof
WO2025087372A1 (zh) * 2023-10-27 2025-05-01 上海元宋生物技术有限公司 溶瘤病毒及其用途
CN119479778B (zh) * 2024-10-16 2025-04-25 北京悦康科创医药科技股份有限公司 一种lnp转染效率预测模型构建方法及装置
CN121081290B (zh) * 2025-11-12 2026-03-10 佑嘉(杭州)生物医药科技有限公司 一种毛囊靶向递送系统及生发防脱化妆品

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016037053A1 (en) 2014-09-05 2016-03-10 Novartis Ag Lipids and lipid compositions for the delivery of active agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
CA2766907A1 (en) * 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
MX342608B (es) * 2010-07-06 2016-10-06 Novartis Ag * Particulas de suministro similares a viriones para moleculas de arn de autorreplicacion.
CA2841047A1 (en) * 2011-07-06 2013-01-10 Novartis Ag Immunogenic compositions and uses thereof
CA2893762A1 (en) * 2012-12-03 2014-06-12 Dipu Mohan-Kumar Ehrlichial invasin for immunization, diagnosis, and cell delivery
KR20170074235A (ko) * 2014-10-31 2017-06-29 메사추세츠 인스티튜트 오브 테크놀로지 면역 세포로의 생체분자의 전달
ES2880103T3 (es) * 2015-05-21 2021-11-23 Ohio State Innovation Foundation Derivados de benceno-1, 3, 5-tricarboxamida y usos de los mismos
CN113966221B (zh) * 2019-03-08 2026-03-31 麻省理工学院 合成溶瘤lnp复制子rna和用于癌症免疫治疗的用途
EP4185274A1 (en) * 2020-07-24 2023-05-31 Strand Therapeutics Inc. Lipidnanoparticle comprising modified nucleotides
US20240140960A1 (en) * 2021-02-12 2024-05-02 Ohio State Innovation Foundation Sugar derived lipid nanomaterials and uses thereof
CA3225064A1 (en) * 2021-07-09 2023-01-12 Nathaniel Stephen Wang Modified eastern equine encephalitis viruses, self-replicating rna constructs, and uses thereof
CN117180454A (zh) * 2022-05-16 2023-12-08 上海行深生物科技有限公司 含有自复制rna分子和脂质纳米颗粒递送载体的组合物及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016037053A1 (en) 2014-09-05 2016-03-10 Novartis Ag Lipids and lipid compositions for the delivery of active agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF NEURO-ONCOLOGY, 2003, 64, 1-2, pp. 147-154.
Vaccines, 2016, 4, 39, pp. 1-23.

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US12383589B2 (en) 2025-08-12
EP4729621A2 (en) 2026-04-22
JP2025011109A (ja) 2025-01-23
BR112021017637A8 (pt) 2022-08-16
AU2020233788A1 (en) 2021-10-07
CN113966221B (zh) 2026-03-31
CO2021013417A2 (es) 2022-01-17
IL285963A (en) 2021-10-31
JP7561134B2 (ja) 2024-10-03
US11717548B2 (en) 2023-08-08
EP3934673A1 (en) 2022-01-12
EP3934673B1 (en) 2026-01-07
DK3934673T3 (da) 2026-04-07
JP2022524391A (ja) 2022-05-02
US20260061013A1 (en) 2026-03-05
BR112021017637A2 (https=) 2021-11-09
WO2020185293A1 (en) 2020-09-17
US20240024394A1 (en) 2024-01-25
CA3132714A1 (en) 2020-09-17
US20200281994A1 (en) 2020-09-10
KR20220006041A (ko) 2022-01-14
MX2021010808A (es) 2021-12-15
MY207334A (en) 2025-02-19
PH12021552145A1 (en) 2022-08-31
SG11202109514VA (en) 2021-09-29
FI3934673T3 (fi) 2026-03-31
KR20250171410A (ko) 2025-12-08
CN113966221A (zh) 2022-01-21

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