AU2020233788A1 - Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy - Google Patents

Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy Download PDF

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Publication number
AU2020233788A1
AU2020233788A1 AU2020233788A AU2020233788A AU2020233788A1 AU 2020233788 A1 AU2020233788 A1 AU 2020233788A1 AU 2020233788 A AU2020233788 A AU 2020233788A AU 2020233788 A AU2020233788 A AU 2020233788A AU 2020233788 A1 AU2020233788 A1 AU 2020233788A1
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AU
Australia
Prior art keywords
vims
replicon rna
synthetic oncolytic
synthetic
self
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Pending
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AU2020233788A
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Inventor
Yizhou Dong
Darrell J. Irvine
Yingzhong Li
Noor MOMIN
Ron Weiss
Karl Dane Wittrup
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Massachusetts Institute of Technology
Ohio State Innovation Foundation
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Massachusetts Institute of Technology
Ohio State Innovation Foundation
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Publication of AU2020233788A1 publication Critical patent/AU2020233788A1/en
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, OHIO STATE INNOVATION FOUNDATION reassignment MASSACHUSETTS INSTITUTE OF TECHNOLOGY Request for Assignment Assignors: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE OHIO STATE UNIVERSITY
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C—CHEMISTRY; METALLURGY
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • Veterinary Medicine (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020233788A 2019-03-08 2020-01-10 Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy Pending AU2020233788A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962815611P 2019-03-08 2019-03-08
US62/815,611 2019-03-08
PCT/US2020/013069 WO2020185293A1 (en) 2019-03-08 2020-01-10 Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy

Publications (1)

Publication Number Publication Date
AU2020233788A1 true AU2020233788A1 (en) 2021-10-07

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AU2020233788A Pending AU2020233788A1 (en) 2019-03-08 2020-01-10 Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy

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US (3) US11717548B2 (https=)
EP (2) EP3934673B1 (https=)
JP (2) JP7561134B2 (https=)
KR (2) KR20250171410A (https=)
CN (1) CN113966221B (https=)
AU (1) AU2020233788A1 (https=)
BR (1) BR112021017637A8 (https=)
CA (1) CA3132714A1 (https=)
CO (1) CO2021013417A2 (https=)
DK (1) DK3934673T3 (https=)
FI (1) FI3934673T3 (https=)
IL (1) IL285963A (https=)
MX (1) MX2021010808A (https=)
MY (1) MY207334A (https=)
PH (1) PH12021552145A1 (https=)
SG (1) SG11202109514VA (https=)
WO (1) WO2020185293A1 (https=)

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DK3934673T3 (da) * 2019-03-08 2026-04-07 Massachusetts Inst Technology Syntetisk onkolytisk lnp-replikon-rna og anvendelser til cancerimmunterapi
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
CN113509542A (zh) * 2021-04-20 2021-10-19 嘉晨西海(杭州)生物技术有限公司 一种基于mRNA的表达白介素12针对肿瘤的药物及其制备方法
CZ310443B6 (cs) * 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
EP4514328A1 (en) 2022-04-26 2025-03-05 Strand Therapeutics Inc. Lipid nanoparticles comprising venezuelan equine encephalitis (vee) replicon and uses thereof
CN115227674B (zh) * 2022-08-05 2023-07-04 武汉滨会生物科技股份有限公司 包封的溶瘤病毒遗传物质及其应用
EP4648781A1 (en) * 2023-01-12 2025-11-19 Bavarian Nordic A/S Recombinant modified sarna (vrp) for cancer vaccine
CN121311221A (zh) * 2023-04-07 2026-01-09 旗舰实验室114股份有限公司 用于治疗性脂质纳米颗粒 (lnp)递送的脂质和脂质样化合物
CN118147171B (zh) * 2024-03-08 2024-12-06 上海复诺健生物科技有限公司 具有增强的外源基因表达水平的自扩增mRNA核酸序列
AU2024299882A1 (en) 2023-07-25 2026-01-08 Strand Therapeutics Inc. Polynucleotides comprising a micro rna detargeting sensor and uses thereof
WO2025087372A1 (zh) * 2023-10-27 2025-05-01 上海元宋生物技术有限公司 溶瘤病毒及其用途
CN119479778B (zh) * 2024-10-16 2025-04-25 北京悦康科创医药科技股份有限公司 一种lnp转染效率预测模型构建方法及装置
CN121081290B (zh) * 2025-11-12 2026-03-10 佑嘉(杭州)生物医药科技有限公司 一种毛囊靶向递送系统及生发防脱化妆品

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Also Published As

Publication number Publication date
WO2020185293A1 (en) 2020-09-17
KR20220006041A (ko) 2022-01-14
EP3934673A1 (en) 2022-01-12
JP2025011109A (ja) 2025-01-23
US20240024394A1 (en) 2024-01-25
BR112021017637A2 (https=) 2021-11-09
KR102889984B1 (ko) 2025-11-25
US20260061013A1 (en) 2026-03-05
CA3132714A1 (en) 2020-09-17
CN113966221A (zh) 2022-01-21
KR20250171410A (ko) 2025-12-08
EP3934673B1 (en) 2026-01-07
SG11202109514VA (en) 2021-09-29
EP4729621A2 (en) 2026-04-22
DK3934673T3 (da) 2026-04-07
JP2022524391A (ja) 2022-05-02
CN113966221B (zh) 2026-03-31
FI3934673T3 (fi) 2026-03-31
US12383589B2 (en) 2025-08-12
CO2021013417A2 (es) 2022-01-17
US11717548B2 (en) 2023-08-08
JP7561134B2 (ja) 2024-10-03
PH12021552145A1 (en) 2022-08-31
IL285963A (en) 2021-10-31
BR112021017637A8 (pt) 2022-08-16
US20200281994A1 (en) 2020-09-10
MX2021010808A (es) 2021-12-15
MY207334A (en) 2025-02-19

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