KR102878449B1 - 변형된 노로바이러스 vp1 단백질 및 변형된 노로바이러스 vp1 단백질을 포함하는 vlp - Google Patents

변형된 노로바이러스 vp1 단백질 및 변형된 노로바이러스 vp1 단백질을 포함하는 vlp

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KR102878449B1
KR102878449B1 KR1020207018576A KR20207018576A KR102878449B1 KR 102878449 B1 KR102878449 B1 KR 102878449B1 KR 1020207018576 A KR1020207018576 A KR 1020207018576A KR 20207018576 A KR20207018576 A KR 20207018576A KR 102878449 B1 KR102878449 B1 KR 102878449B1
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gii
seq
norovirus
protein
amino acid
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KR20200092363A (ko
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피에르-올리비에 라브와
마르크-안드레 다우스트
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아라미스 바이오테크놀로지스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/05—Epstein-Barr virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
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    • C12N2770/00011—Details
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    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
KR1020207018576A 2017-11-30 2018-11-30 변형된 노로바이러스 vp1 단백질 및 변형된 노로바이러스 vp1 단백질을 포함하는 vlp Active KR102878449B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762593006P 2017-11-30 2017-11-30
US62/593,006 2017-11-30
US201862712744P 2018-07-31 2018-07-31
US62/712,744 2018-07-31
PCT/CA2018/051530 WO2019104439A1 (en) 2017-11-30 2018-11-30 Modified norovirus vp1 proteins and vlps comprising modified norovirus vp1 proteins

Publications (2)

Publication Number Publication Date
KR20200092363A KR20200092363A (ko) 2020-08-03
KR102878449B1 true KR102878449B1 (ko) 2025-10-30

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KR1020207018576A Active KR102878449B1 (ko) 2017-11-30 2018-11-30 변형된 노로바이러스 vp1 단백질 및 변형된 노로바이러스 vp1 단백질을 포함하는 vlp

Country Status (15)

Country Link
US (2) US11602558B2 (enExample)
EP (1) EP3717648A4 (enExample)
JP (2) JP7579143B2 (enExample)
KR (1) KR102878449B1 (enExample)
CN (1) CN111727255A (enExample)
AU (1) AU2018375695B2 (enExample)
BR (1) BR112020010799A2 (enExample)
CA (1) CA3083857A1 (enExample)
IL (1) IL274736A (enExample)
MX (1) MX2020005530A (enExample)
PH (1) PH12020550732A1 (enExample)
RU (1) RU2020116307A (enExample)
SG (1) SG11202004668WA (enExample)
WO (1) WO2019104439A1 (enExample)
ZA (2) ZA202003831B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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JP7420339B2 (ja) * 2019-10-11 2024-01-23 学校法人北里研究所 変異ノロウイルス粒子とその生産方法
US20230381293A1 (en) * 2020-10-14 2023-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Stabilized norovirus virus-like particles as vaccine immunogens
CN113481328B (zh) * 2021-07-23 2023-10-27 中国科学院微生物研究所 用于检测临床样本中gi.5型诺如病毒的试剂盒及专用引物
JP2024540061A (ja) * 2021-10-27 2024-10-31 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ノロウイルスワクチン及び使用法
CN118252924A (zh) * 2022-12-27 2024-06-28 远大赛威信生命科学(南京)有限公司 用于诱发哺乳动物针对诺如病毒的免疫反应的药物组合物及其制备方法和用途
WO2025077799A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Method of preparing norovirus vaccine without adjuvant
WO2025076792A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Product Co., Ltd. Methods of preparing norovirus vaccine with low amounts of adjuvant
CN118126202B (zh) * 2024-05-07 2024-07-30 上海瑞宙生物科技有限公司 一种诺如病毒类病毒颗粒及其应用
CN118773218B (zh) * 2024-08-22 2025-09-30 中国医学科学院医学生物学研究所 一种诺如病毒gii.17型病毒样颗粒及其制备方法与应用

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JP2011530295A (ja) * 2008-08-08 2011-12-22 リゴサイト ファーマスーティカルズ，インコーポレイテッド 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子
WO2017191264A1 (en) * 2016-05-04 2017-11-09 Curevac Ag Nucleic acid molecules and uses thereof

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AU2007303608B2 (en) 2006-09-29 2013-05-02 Takeda Vaccines, Inc. Norovirus vaccine formulations
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Also Published As

Publication number Publication date
CN111727255A (zh) 2020-09-29
US20230293663A1 (en) 2023-09-21
MX2020005530A (es) 2021-01-15
JP7579143B2 (ja) 2024-11-07
AU2018375695B2 (en) 2025-01-02
EP3717648A4 (en) 2021-12-01
AU2018375695A1 (en) 2020-06-11
IL274736A (en) 2020-07-30
US20200330583A1 (en) 2020-10-22
JP2021503962A (ja) 2021-02-15
US12076388B2 (en) 2024-09-03
JP2024109835A (ja) 2024-08-14
CA3083857A1 (en) 2019-06-06
BR112020010799A2 (pt) 2020-11-10
EP3717648A1 (en) 2020-10-07
WO2019104439A1 (en) 2019-06-06
PH12020550732A1 (en) 2021-04-19
KR20200092363A (ko) 2020-08-03
ZA202003831B (en) 2023-10-25
SG11202004668WA (en) 2020-06-29
ZA202306500B (en) 2024-10-30
US11602558B2 (en) 2023-03-14
RU2020116307A (ru) 2021-12-30

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