JP7579143B2 - 改変ノロウイルスｖｐ１タンパク質及び改変ノロウイルスｖｐ１タンパク質を含むｖｌｐ - Google Patents

改変ノロウイルスｖｐ１タンパク質及び改変ノロウイルスｖｐ１タンパク質を含むｖｌｐ Download PDF

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JP7579143B2
JP7579143B2 JP2020547260A JP2020547260A JP7579143B2 JP 7579143 B2 JP7579143 B2 JP 7579143B2 JP 2020547260 A JP2020547260 A JP 2020547260A JP 2020547260 A JP2020547260 A JP 2020547260A JP 7579143 B2 JP7579143 B2 JP 7579143B2
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JP2021503962A (ja
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－ オリビエ ラボア、ピエール
－ アンドレ ドウスト、マルク
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アラミス バイオテクノロジーズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/05—Epstein-Barr virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
JP2020547260A 2017-11-30 2018-11-30 改変ノロウイルスｖｐ１タンパク質及び改変ノロウイルスｖｐ１タンパク質を含むｖｌｐ Active JP7579143B2 (ja)

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Application Number Priority Date Filing Date Title
JP2024084260A JP2024109835A (ja) 2017-11-30 2024-05-23 改変ノロウイルスｖｐ１タンパク質及び改変ノロウイルスｖｐ１タンパク質を含むｖｌｐ

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Application Number Priority Date Filing Date Title
US201762593006P 2017-11-30 2017-11-30
US62/593,006 2017-11-30
US201862712744P 2018-07-31 2018-07-31
US62/712,744 2018-07-31
PCT/CA2018/051530 WO2019104439A1 (en) 2017-11-30 2018-11-30 Modified norovirus vp1 proteins and vlps comprising modified norovirus vp1 proteins

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JP2024084260A Division JP2024109835A (ja) 2017-11-30 2024-05-23 改変ノロウイルスｖｐ１タンパク質及び改変ノロウイルスｖｐ１タンパク質を含むｖｌｐ

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JP2021503962A JP2021503962A (ja) 2021-02-15
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JP2024084260A Abandoned JP2024109835A (ja) 2017-11-30 2024-05-23 改変ノロウイルスｖｐ１タンパク質及び改変ノロウイルスｖｐ１タンパク質を含むｖｌｐ

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US (2) US11602558B2 (enExample)
EP (1) EP3717648A4 (enExample)
JP (2) JP7579143B2 (enExample)
KR (1) KR102878449B1 (enExample)
CN (1) CN111727255A (enExample)
AU (1) AU2018375695B2 (enExample)
BR (1) BR112020010799A2 (enExample)
CA (1) CA3083857A1 (enExample)
IL (1) IL274736A (enExample)
MX (1) MX2020005530A (enExample)
PH (1) PH12020550732A1 (enExample)
RU (1) RU2020116307A (enExample)
SG (1) SG11202004668WA (enExample)
WO (1) WO2019104439A1 (enExample)
ZA (2) ZA202003831B (enExample)

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Publication number Priority date Publication date Assignee Title
JP7420339B2 (ja) * 2019-10-11 2024-01-23 学校法人北里研究所 変異ノロウイルス粒子とその生産方法
US20230381293A1 (en) * 2020-10-14 2023-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Stabilized norovirus virus-like particles as vaccine immunogens
CN113481328B (zh) * 2021-07-23 2023-10-27 中国科学院微生物研究所 用于检测临床样本中gi.5型诺如病毒的试剂盒及专用引物
JP2024540061A (ja) * 2021-10-27 2024-10-31 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ノロウイルスワクチン及び使用法
CN118252924A (zh) * 2022-12-27 2024-06-28 远大赛威信生命科学(南京)有限公司 用于诱发哺乳动物针对诺如病毒的免疫反应的药物组合物及其制备方法和用途
WO2025077799A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Method of preparing norovirus vaccine without adjuvant
WO2025076792A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Product Co., Ltd. Methods of preparing norovirus vaccine with low amounts of adjuvant
CN118126202B (zh) * 2024-05-07 2024-07-30 上海瑞宙生物科技有限公司 一种诺如病毒类病毒颗粒及其应用
CN118773218B (zh) * 2024-08-22 2025-09-30 中国医学科学院医学生物学研究所 一种诺如病毒gii.17型病毒样颗粒及其制备方法与应用

Citations (6)

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JP2011530295A (ja) 2008-08-08 2011-12-22 リゴサイト ファーマスーティカルズ，インコーポレイテッド 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子
JP2013505025A (ja) 2009-09-22 2013-02-14 メディカゴ インコーポレイテッド 植物由来のｖｌｐを調製する方法
US20160009788A1 (en) 2013-02-12 2016-01-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Monoclonal antibodies that neutralize a norovirus
US20160102136A1 (en) 2013-05-09 2016-04-14 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Single-domain vhh antibodies directed to norovirus gi.1 and gii.4 and their use
WO2016200951A1 (en) 2015-06-12 2016-12-15 Vaxart, Inc. Formulations for small intestinal delivery of rsv and norovirus antigens
WO2017191264A1 (en) 2016-05-04 2017-11-09 Curevac Ag Nucleic acid molecules and uses thereof

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JP5963811B2 (ja) 2014-07-18 2016-08-03 オリンパス株式会社 治療用超音波振動子
EP3037386A1 (en) 2014-12-23 2016-06-29 Casale SA A plant and a process for ammonia production with cryogenic purification, and a related method of revamping
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JP2011530295A (ja) 2008-08-08 2011-12-22 リゴサイト ファーマスーティカルズ，インコーポレイテッド 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子
JP2013505025A (ja) 2009-09-22 2013-02-14 メディカゴ インコーポレイテッド 植物由来のｖｌｐを調製する方法
US20160009788A1 (en) 2013-02-12 2016-01-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Monoclonal antibodies that neutralize a norovirus
US20160102136A1 (en) 2013-05-09 2016-04-14 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Single-domain vhh antibodies directed to norovirus gi.1 and gii.4 and their use
WO2016200951A1 (en) 2015-06-12 2016-12-15 Vaxart, Inc. Formulations for small intestinal delivery of rsv and norovirus antigens
WO2017191264A1 (en) 2016-05-04 2017-11-09 Curevac Ag Nucleic acid molecules and uses thereof

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Norwalk Virus Minor Capsid Protein VP2 Associates within the VP1 Shell Domain，Journal of Virology，2013年，Vol.87, No.9，p.4818-4825

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CN111727255A (zh) 2020-09-29
US20230293663A1 (en) 2023-09-21
KR102878449B1 (ko) 2025-10-30
MX2020005530A (es) 2021-01-15
AU2018375695B2 (en) 2025-01-02
EP3717648A4 (en) 2021-12-01
AU2018375695A1 (en) 2020-06-11
IL274736A (en) 2020-07-30
US20200330583A1 (en) 2020-10-22
JP2021503962A (ja) 2021-02-15
US12076388B2 (en) 2024-09-03
JP2024109835A (ja) 2024-08-14
CA3083857A1 (en) 2019-06-06
BR112020010799A2 (pt) 2020-11-10
EP3717648A1 (en) 2020-10-07
WO2019104439A1 (en) 2019-06-06
PH12020550732A1 (en) 2021-04-19
KR20200092363A (ko) 2020-08-03
ZA202003831B (en) 2023-10-25
SG11202004668WA (en) 2020-06-29
ZA202306500B (en) 2024-10-30
US11602558B2 (en) 2023-03-14
RU2020116307A (ru) 2021-12-30

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