KR102868264B1 - Il-4r 길항제를 투여함으로써 백신의 효능을 향상시키는 방법 - Google Patents
Il-4r 길항제를 투여함으로써 백신의 효능을 향상시키는 방법Info
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- KR102868264B1 KR102868264B1 KR1020187026017A KR20187026017A KR102868264B1 KR 102868264 B1 KR102868264 B1 KR 102868264B1 KR 1020187026017 A KR1020187026017 A KR 1020187026017A KR 20187026017 A KR20187026017 A KR 20187026017A KR 102868264 B1 KR102868264 B1 KR 102868264B1
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- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297257P | 2016-02-19 | 2016-02-19 | |
| US62/297,257 | 2016-02-19 | ||
| US201662409936P | 2016-10-19 | 2016-10-19 | |
| US62/409,936 | 2016-10-19 | ||
| PCT/US2017/018487 WO2017143270A1 (en) | 2016-02-19 | 2017-02-17 | Methods for enhancing efficacy of a vaccine by administering an il-4r antagonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180110089A KR20180110089A (ko) | 2018-10-08 |
| KR102868264B1 true KR102868264B1 (ko) | 2025-10-10 |
Family
ID=58192407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187026017A Active KR102868264B1 (ko) | 2016-02-19 | 2017-02-17 | Il-4r 길항제를 투여함으로써 백신의 효능을 향상시키는 방법 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10314904B2 (enExample) |
| EP (2) | EP3416685B1 (enExample) |
| JP (3) | JP7597500B2 (enExample) |
| KR (1) | KR102868264B1 (enExample) |
| CN (1) | CN109069625A (enExample) |
| AU (2) | AU2017220184B2 (enExample) |
| CA (1) | CA3014202A1 (enExample) |
| ES (1) | ES2983475T3 (enExample) |
| HU (1) | HUE067673T2 (enExample) |
| IL (1) | IL261025A (enExample) |
| MA (1) | MA44238B1 (enExample) |
| MX (2) | MX2018009990A (enExample) |
| PL (1) | PL3416685T3 (enExample) |
| PT (1) | PT3416685T (enExample) |
| RU (1) | RU2753869C2 (enExample) |
| WO (1) | WO2017143270A1 (enExample) |
| ZA (1) | ZA201805295B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US9574004B2 (en) | 2012-08-21 | 2017-02-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| PT3889181T (pt) | 2012-09-07 | 2024-05-29 | Regeneron Pharma | Um anticorpo antagonista de il-4r para utilização no tratamento da dermatite atópica por administração |
| TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
| WO2015130975A1 (en) | 2014-02-28 | 2015-09-03 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
| AU2015346150B2 (en) | 2014-11-14 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| WO2017196943A1 (en) * | 2016-05-10 | 2017-11-16 | Minneapolis Medical Research Foundation | Cytokine signaling immunomodulators and methods |
| HUE067888T2 (hu) * | 2016-09-01 | 2024-11-28 | Regeneron Pharma | Módszerek az allergia megelõzésére vagy kezelésére egy IL-4R antagonista adagolásával |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| CA3079946A1 (en) | 2017-10-30 | 2019-05-09 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| US11292847B2 (en) | 2018-05-13 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an IL-4R inhibitor |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| MX2021010560A (es) * | 2019-03-06 | 2021-11-12 | Regeneron Pharma | Inhibidores de la via il-4/il-13 para una eficacia aumentada en el tratamiento de cancer. |
| CA3132587A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| BR112022000740A2 (pt) | 2019-07-16 | 2022-07-05 | Sanofi Biotechnology | Métodos para tratamento ou prevenção de asma por administração de um antagonista de il-4r |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| WO2021026205A1 (en) | 2019-08-05 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| IL293487A (en) | 2019-12-09 | 2022-08-01 | Sanofi Biotechnology | Methods for the treatment of digitally identified il-4/il-13-related disorders |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| MX2022011730A (es) * | 2020-03-27 | 2022-10-13 | Regeneron Pharma | Metodos para el tratamiento de dermatitis atopica mediante la administracion de un antagonista de il-4r. |
| US20240336688A1 (en) * | 2021-07-22 | 2024-10-10 | Icahn School Of Medicine At Mount Sinai | Dual-blockade of il-4 signaling and immune checkpoint proteins for treating cancer |
| IL310962A (en) * | 2021-08-23 | 2024-04-01 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an IL-4R antagonist |
| CN118717989A (zh) * | 2024-05-27 | 2024-10-01 | 中国人民解放军军事科学院军事医学研究院 | Il-4r拮抗剂在制备预防和/或治疗流感病毒感染的药物中的应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040006123A1 (en) * | 2002-04-23 | 2004-01-08 | Alkan Sefik S. | Interleukin-4 gene expression inhibitors |
| WO2013181696A1 (en) * | 2012-06-05 | 2013-12-12 | The Australian National University | Vaccination with interleukin-4 antagonists |
| WO2014039461A1 (en) * | 2012-09-07 | 2014-03-13 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| WO2014197470A1 (en) * | 2013-06-04 | 2014-12-11 | Regeneron Pharmaceuticals, Inc. | Mehods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
| US20210361700A1 (en) * | 2020-05-22 | 2021-11-25 | Trustees Of Tufts College | Nutritional supplement to combat covid-19 and aid vaccination |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2990420T3 (en) | 2000-05-26 | 2017-04-03 | Immunex Corp | USE OF INTERLEUKIN-4 RECEPTOR ANTIBODIES AND COMPOSITIONS THEREOF |
| US20030139364A1 (en) * | 2001-10-12 | 2003-07-24 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| BRPI0416603A (pt) | 2003-11-07 | 2007-01-30 | Immunex Corp | anticorpo que se liga ao receptor interleucina-4 (il-4) humano |
| MY149079A (en) | 2006-10-02 | 2013-07-15 | Regeneron Pharma | High affinity human antibodies to human il-4 receptor |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| KR101759457B1 (ko) | 2007-12-21 | 2017-07-31 | 메디뮨 리미티드 | 인터루킨-4 수용체 알파(IL-4Rα)에 대한 결합 구성원-173 |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| US20120088814A1 (en) * | 2009-03-31 | 2012-04-12 | Isis Pharmaceuticals, Inc. | Methods of modulating an immune response to a viral infection |
| NZ609557A (en) | 2010-10-06 | 2014-12-24 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
| CN111437387B (zh) | 2013-06-21 | 2024-10-01 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗鼻息肉症的方法 |
| KR20190062142A (ko) * | 2017-11-28 | 2019-06-05 | (주)비티엔 | 면역 증강 활성을 가지는 아미노산 미네랄 복합체 및 이를 포함하는 식품, 약학 또는 사료용 조성물 |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040006123A1 (en) * | 2002-04-23 | 2004-01-08 | Alkan Sefik S. | Interleukin-4 gene expression inhibitors |
| WO2013181696A1 (en) * | 2012-06-05 | 2013-12-12 | The Australian National University | Vaccination with interleukin-4 antagonists |
| WO2014039461A1 (en) * | 2012-09-07 | 2014-03-13 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| WO2014197470A1 (en) * | 2013-06-04 | 2014-12-11 | Regeneron Pharmaceuticals, Inc. | Mehods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
| US20210361700A1 (en) * | 2020-05-22 | 2021-11-25 | Trustees Of Tufts College | Nutritional supplement to combat covid-19 and aid vaccination |
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