KR102848971B1 - 중수소 함유 화합물 - Google Patents

중수소 함유 화합물

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Publication number
KR102848971B1
KR102848971B1 KR1020217011490A KR20217011490A KR102848971B1 KR 102848971 B1 KR102848971 B1 KR 102848971B1 KR 1020217011490 A KR1020217011490 A KR 1020217011490A KR 20217011490 A KR20217011490 A KR 20217011490A KR 102848971 B1 KR102848971 B1 KR 102848971B1
Authority
KR
South Korea
Prior art keywords
melflufen
deuterium
compound
iii
delete delete
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217011490A
Other languages
English (en)
Korean (ko)
Other versions
KR20210078487A (ko
Inventor
프레드릭 레만
Original Assignee
온코펩타이드즈 이노베이션 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1816998.7A external-priority patent/GB201816998D0/en
Priority claimed from GBGB1909695.7A external-priority patent/GB201909695D0/en
Application filed by 온코펩타이드즈 이노베이션 아베 filed Critical 온코펩타이드즈 이노베이션 아베
Publication of KR20210078487A publication Critical patent/KR20210078487A/ko
Application granted granted Critical
Publication of KR102848971B1 publication Critical patent/KR102848971B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020217011490A 2018-10-18 2019-10-17 중수소 함유 화합물 Active KR102848971B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1816998.7A GB201816998D0 (en) 2018-10-18 2018-10-18 Compounds
GB1816998.7 2018-10-18
GBGB1909695.7A GB201909695D0 (en) 2019-07-05 2019-07-05 Compounds
GB1909695.7 2019-07-05
PCT/EP2019/078250 WO2020079165A1 (en) 2018-10-18 2019-10-17 Compounds containing deuterium

Publications (2)

Publication Number Publication Date
KR20210078487A KR20210078487A (ko) 2021-06-28
KR102848971B1 true KR102848971B1 (ko) 2025-08-21

Family

ID=68290247

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217011490A Active KR102848971B1 (ko) 2018-10-18 2019-10-17 중수소 함유 화합물

Country Status (19)

Country Link
US (2) US12152087B2 (enExample)
EP (1) EP3866931B1 (enExample)
JP (2) JP7603199B2 (enExample)
KR (1) KR102848971B1 (enExample)
CN (1) CN112930214B (enExample)
AU (1) AU2019362389B2 (enExample)
BR (1) BR112021007060A2 (enExample)
CA (1) CA3116198A1 (enExample)
DK (1) DK3866931T3 (enExample)
ES (1) ES2942468T3 (enExample)
FI (1) FI3866931T3 (enExample)
HU (1) HUE061801T2 (enExample)
IL (1) IL282231B2 (enExample)
MA (1) MA53904A (enExample)
MX (1) MX2021004474A (enExample)
PL (1) PL3866931T3 (enExample)
SG (1) SG11202103726RA (enExample)
WO (1) WO2020079165A1 (enExample)
ZA (1) ZA202102492B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
ES3034388T3 (en) * 2021-06-01 2025-08-18 Synthon Bv Process for making melflufen or a salt thereof
JP2024524552A (ja) 2021-07-08 2024-07-05 オンコペプティデス エービー 多発性骨髄腫の治療に使用するためのメルフルフェン
GB202109894D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109896D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109895D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202204171D0 (en) 2022-03-24 2022-05-11 Oncopeptides Ab Novel formulations
WO2026057823A1 (en) * 2024-09-13 2026-03-19 Oncopeptides Ab Bis-chloroethylamino derivatives for treating leukemia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012146625A1 (en) 2011-04-28 2012-11-01 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
WO2014065751A1 (en) 2012-10-26 2014-05-01 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002202D0 (sv) 2000-06-13 2000-06-13 Karolinska Innovations Ab New peptides
CA2972242A1 (en) 2008-09-18 2010-04-22 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
EP3351247A1 (en) 2010-06-01 2018-07-25 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
EP4345100A3 (en) 2012-09-18 2024-04-10 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
JP2016506957A (ja) 2013-01-31 2016-03-07 オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｖｍａｔ２のベンゾキノロン阻害剤
ES2901752T3 (es) * 2013-02-05 2022-03-23 Teva Pharmaceuticals Int Gmbh Derivados de catecolamina enriquecidos con deuterio asimétrico de posición específica y medicamentos que comprenden dichos compuestos
WO2015084622A1 (en) 2013-12-03 2015-06-11 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds
CN110229159B (zh) 2013-12-18 2021-08-24 康塞特医药品有限公司 卢索替尼的氘代衍生物
AU2016229949B2 (en) 2015-03-06 2021-04-08 Auspex Pharmaceuticals Llc Methods for the treatment of abnormal involuntary movement disorders
GB201507903D0 (en) 2015-05-08 2015-06-24 Oncopeptides Ab Process for preparation of nitrogen mustard derivatives
GB201521217D0 (en) * 2015-12-01 2016-01-13 Oncopeptides Ab Dosage regimens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012146625A1 (en) 2011-04-28 2012-11-01 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
WO2014065751A1 (en) 2012-10-26 2014-05-01 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide

Also Published As

Publication number Publication date
JP7603199B2 (ja) 2024-12-20
FI3866931T3 (fi) 2023-05-10
CN112930214A (zh) 2021-06-08
MX2021004474A (es) 2021-08-24
EP3866931B1 (en) 2023-02-15
IL282231A (en) 2021-05-31
MA53904A (fr) 2021-08-25
ES2942468T3 (es) 2023-06-01
US20250115637A1 (en) 2025-04-10
HUE061801T2 (hu) 2023-08-28
BR112021007060A2 (pt) 2021-07-20
KR20210078487A (ko) 2021-06-28
EP3866931A1 (en) 2021-08-25
IL282231B2 (en) 2025-07-01
US12152087B2 (en) 2024-11-26
JP2024150488A (ja) 2024-10-23
CN112930214B (zh) 2025-05-16
US20210388024A1 (en) 2021-12-16
AU2019362389A1 (en) 2021-06-03
WO2020079165A1 (en) 2020-04-23
IL282231B1 (en) 2025-03-01
JP2022512736A (ja) 2022-02-07
PL3866931T3 (pl) 2023-06-19
DK3866931T3 (da) 2023-04-24
CA3116198A1 (en) 2020-04-23
SG11202103726RA (en) 2021-05-28
ZA202102492B (en) 2024-04-24
AU2019362389B2 (en) 2024-12-12

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