KR102811896B1 - 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법 - Google Patents

병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법 Download PDF

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KR102811896B1
KR102811896B1 KR1020177036279A KR20177036279A KR102811896B1 KR 102811896 B1 KR102811896 B1 KR 102811896B1 KR 1020177036279 A KR1020177036279 A KR 1020177036279A KR 20177036279 A KR20177036279 A KR 20177036279A KR 102811896 B1 KR102811896 B1 KR 102811896B1
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디미트리오스 브래드독
로날드 알브라이트
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예일 유니버시티
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01009—Nucleotide diphosphatase (3.6.1.9), i.e. nucleotide-pyrophosphatase
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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KR1020177036279A 2015-05-19 2016-05-19 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법 Active KR102811896B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257016455A KR20250078598A (ko) 2015-05-19 2016-05-19 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562163500P 2015-05-19 2015-05-19
US62/163,500 2015-05-19
PCT/US2016/033236 WO2016187408A1 (en) 2015-05-19 2016-05-19 Compositions for treating pathological calcification conditions, and methods using same

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KR1020257016455A Division KR20250078598A (ko) 2015-05-19 2016-05-19 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법

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KR20180005249A KR20180005249A (ko) 2018-01-15
KR102811896B1 true KR102811896B1 (ko) 2025-05-23

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KR1020257016455A Pending KR20250078598A (ko) 2015-05-19 2016-05-19 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법

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US (10) US10064917B2 (OSRAM)
EP (2) EP3298140B1 (OSRAM)
JP (3) JP6995627B2 (OSRAM)
KR (2) KR102811896B1 (OSRAM)
AU (3) AU2016264364B2 (OSRAM)
CA (2) CA3176123A1 (OSRAM)
ES (1) ES2983910T3 (OSRAM)
MX (2) MX391074B (OSRAM)
PL (1) PL3298140T3 (OSRAM)
RU (2) RU2021129201A (OSRAM)
WO (1) WO2016187408A1 (OSRAM)

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US20130034599A1 (en) 2010-01-19 2013-02-07 Northwestern University Synthetic nanostructures including nucleic acids and/or other entities
WO2014126965A2 (en) 2013-02-13 2014-08-21 Yale University Compositions and methods for treating pathological calcification and ossification
US10434064B2 (en) 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
USRE49529E1 (en) * 2014-12-19 2023-05-16 Inozyme Pharma, Inc. Methods of treating tissue calcification
EP3298140B1 (en) 2015-05-19 2024-04-24 Yale University Compositions for treating pathological calcification conditions, and methods using same
US20180371434A1 (en) 2015-11-20 2018-12-27 Yale University Compositions for Treating Ectopic Calcification Disorders, and Methods Using Same
EP3471747A1 (en) 2016-06-16 2019-04-24 Alexion Pharmaceuticals, Inc. Methods of treating myointimal proliferation
AU2017306549A1 (en) 2016-08-05 2019-02-21 Yale University Compositions and methods for stroke prevention in pediatric sickle cell anemia patients
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
EP3687565A1 (en) * 2017-09-27 2020-08-05 Alexion Pharmaceuticals, Inc. Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1)
WO2019217373A1 (en) * 2018-05-08 2019-11-14 Yale University Compositions and methods for reducing progression of nephrolithiasis
CN120383683A (zh) * 2018-08-31 2025-07-29 耶鲁大学 Enpp1多肽及其使用方法
KR20210142599A (ko) * 2019-01-18 2021-11-25 이노자임 파마, 인코포레이티드 Enpp1 또는 enpp3 결핍을 수반하는 질환의 치료
WO2020154705A1 (en) 2019-01-24 2020-07-30 Northwestern University High-density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds
EP3947660A4 (en) * 2019-04-05 2023-01-25 Yale University Enpp1 polypeptides and methods of using same
CN116406281A (zh) * 2020-05-27 2023-07-07 依诺兹梅制药公司 用于治疗外周动脉疾病的组合物和方法
BR112022024958A2 (pt) 2020-06-09 2022-12-27 Inozyme Pharma Inc Proteínas enpp1 solúveis e usos das mesmas
WO2022076848A1 (en) * 2020-10-08 2022-04-14 Inozyme Pharma, Inc. Liver specific production of enpp1 or enpp3
WO2022109344A1 (en) * 2020-11-19 2022-05-27 Inozyme Pharma, Inc. Treatment of enpp1 deficiency and abcc6 deficiency
EP4404980A4 (en) * 2021-09-24 2025-11-19 Inozyme Pharma Inc LYOPHILIZED POLYPEPTIDE FORMULATIONS OF ENPP1 AND THEIR USES
WO2025042995A1 (en) * 2023-08-22 2025-02-27 Inozyme Pharma, Inc. Treatment of enpp1 deficiency and abcc6 deficiency in children

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WO2014126965A2 (en) * 2013-02-13 2014-08-21 Yale University Compositions and methods for treating pathological calcification and ossification
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