KR102790127B1 - Egfr 돌연변이와 관련된 암을 치료하는 조성물 및 방법 - Google Patents

Egfr 돌연변이와 관련된 암을 치료하는 조성물 및 방법 Download PDF

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KR102790127B1
KR102790127B1 KR1020207036949A KR20207036949A KR102790127B1 KR 102790127 B1 KR102790127 B1 KR 102790127B1 KR 1020207036949 A KR1020207036949 A KR 1020207036949A KR 20207036949 A KR20207036949 A KR 20207036949A KR 102790127 B1 KR102790127 B1 KR 102790127B1
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plinabulin
pharmaceutical composition
tumor
minutes
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Korean (ko)
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KR20210015875A (ko
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란 황
조지 케네스 로이드
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비욘드스프링 파마수티컬스, 인코포레이티드.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020207036949A 2018-06-01 2019-05-30 Egfr 돌연변이와 관련된 암을 치료하는 조성물 및 방법 Active KR102790127B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862679619P 2018-06-01 2018-06-01
US62/679,619 2018-06-01
PCT/US2019/034726 WO2019232257A1 (en) 2018-06-01 2019-05-30 Composition and method of treating cancer associated with egfr mutation

Publications (2)

Publication Number Publication Date
KR20210015875A KR20210015875A (ko) 2021-02-10
KR102790127B1 true KR102790127B1 (ko) 2025-04-03

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KR1020207036949A Active KR102790127B1 (ko) 2018-06-01 2019-05-30 Egfr 돌연변이와 관련된 암을 치료하는 조성물 및 방법

Country Status (11)

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US (2) US20210161888A1 (https=)
EP (1) EP3801524B1 (https=)
JP (1) JP7500438B2 (https=)
KR (1) KR102790127B1 (https=)
CN (1) CN112543636B (https=)
AU (1) AU2019278886B2 (https=)
CA (1) CA3101612A1 (https=)
DK (1) DK3801524T3 (https=)
ES (1) ES3060133T3 (https=)
MX (1) MX420412B (https=)
WO (1) WO2019232257A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383691B (es) 2015-03-06 2025-03-14 Beyondspring Pharmaceuticals Inc Método de tratamiento de cáncer asociado con una mutación de ras.
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
WO2017139231A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
CN113456643B (zh) * 2021-08-11 2022-04-01 遵义医科大学 一种含普那布林的药物组合及其应用
AU2022357570A1 (en) * 2021-10-03 2024-04-11 Systimmune, Inc. Methods of treating cancer and the pharmaceutical compositions thereof
CN117860672A (zh) * 2022-10-11 2024-04-12 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法
EP4719416A1 (en) * 2023-06-02 2026-04-08 Beyondspring Pharmaceuticals, Inc. Oncology combination therapy and methods of use
CN120682197A (zh) * 2024-03-19 2025-09-23 大连万春布林医药有限公司 普那布林的盐晶型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313363A (pt) * 2002-08-02 2005-08-09 Nereus Pharmaceuticals Inc Deidrofenilahistinas e seus análogos, e sua sìntese
US20120114658A1 (en) * 2009-09-15 2012-05-10 John Ryan Treatment of cancer
US20110160159A1 (en) * 2009-09-15 2011-06-30 John Ryan Treatment of cancer
DK2958943T3 (da) * 2013-02-20 2019-12-09 Univ Pennsylvania Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor
AU2016219204B2 (en) * 2015-02-12 2021-01-21 Beyondspring Pharmaceuticals, Inc. Use of Plinabulin in combination with immune checkpoint inhibitors
MX383691B (es) * 2015-03-06 2025-03-14 Beyondspring Pharmaceuticals Inc Método de tratamiento de cáncer asociado con una mutación de ras.
AU2018236168B2 (en) * 2017-03-13 2024-02-29 Beyondspring Pharmaceuticals, Inc. Compositions of plinabulin and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Clinical Oncology, 35(7), Suppl. 1, 139. 2017.*

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Publication number Publication date
DK3801524T3 (da) 2026-02-02
US20250375440A1 (en) 2025-12-11
US20210161888A1 (en) 2021-06-03
JP2021525768A (ja) 2021-09-27
CN112543636B (zh) 2024-03-01
EP3801524A1 (en) 2021-04-14
MX420412B (es) 2025-02-10
JP7500438B2 (ja) 2024-06-17
CA3101612A1 (en) 2019-12-05
CN112543636A (zh) 2021-03-23
EP3801524B1 (en) 2025-11-05
KR20210015875A (ko) 2021-02-10
AU2019278886B2 (en) 2025-03-20
AU2019278886A1 (en) 2020-12-24
WO2019232257A1 (en) 2019-12-05
MX2020012799A (es) 2021-03-25
ES3060133T3 (en) 2026-03-25
EP3801524A4 (en) 2022-03-02

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