CA3101612A1 - Composition and method of treating cancer associated with egfr mutation - Google Patents
Composition and method of treating cancer associated with egfr mutation Download PDFInfo
- Publication number
- CA3101612A1 CA3101612A1 CA3101612A CA3101612A CA3101612A1 CA 3101612 A1 CA3101612 A1 CA 3101612A1 CA 3101612 A CA3101612 A CA 3101612A CA 3101612 A CA3101612 A CA 3101612A CA 3101612 A1 CA3101612 A1 CA 3101612A1
- Authority
- CA
- Canada
- Prior art keywords
- plinabulin
- cancer
- osimertinib
- tumor
- egfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862679619P | 2018-06-01 | 2018-06-01 | |
| US62/679,619 | 2018-06-01 | ||
| PCT/US2019/034726 WO2019232257A1 (en) | 2018-06-01 | 2019-05-30 | Composition and method of treating cancer associated with egfr mutation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3101612A1 true CA3101612A1 (en) | 2019-12-05 |
Family
ID=68696755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3101612A Pending CA3101612A1 (en) | 2018-06-01 | 2019-05-30 | Composition and method of treating cancer associated with egfr mutation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20210161888A1 (https=) |
| EP (1) | EP3801524B1 (https=) |
| JP (1) | JP7500438B2 (https=) |
| KR (1) | KR102790127B1 (https=) |
| CN (1) | CN112543636B (https=) |
| AU (1) | AU2019278886B2 (https=) |
| CA (1) | CA3101612A1 (https=) |
| DK (1) | DK3801524T3 (https=) |
| ES (1) | ES3060133T3 (https=) |
| MX (1) | MX420412B (https=) |
| WO (1) | WO2019232257A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX383691B (es) | 2015-03-06 | 2025-03-14 | Beyondspring Pharmaceuticals Inc | Método de tratamiento de cáncer asociado con una mutación de ras. |
| US10155748B2 (en) | 2015-07-13 | 2018-12-18 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| WO2017139231A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| RU2760348C2 (ru) | 2016-06-06 | 2021-11-24 | Бейондспринг Фармасьютикалс, Инк. | Способ уменьшения нейтропении |
| JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
| BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
| KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
| CA3215047A1 (en) | 2021-04-09 | 2022-10-13 | Lan Huang | Therapeutic compositions and methods for treating tumors |
| CN113456643B (zh) * | 2021-08-11 | 2022-04-01 | 遵义医科大学 | 一种含普那布林的药物组合及其应用 |
| AU2022357570A1 (en) * | 2021-10-03 | 2024-04-11 | Systimmune, Inc. | Methods of treating cancer and the pharmaceutical compositions thereof |
| CN117860672A (zh) * | 2022-10-11 | 2024-04-12 | 大连万春布林医药有限公司 | 一种普那布林胶束组合物及其制备方法 |
| EP4719416A1 (en) * | 2023-06-02 | 2026-04-08 | Beyondspring Pharmaceuticals, Inc. | Oncology combination therapy and methods of use |
| CN120682197A (zh) * | 2024-03-19 | 2025-09-23 | 大连万春布林医药有限公司 | 普那布林的盐晶型 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0313363A (pt) * | 2002-08-02 | 2005-08-09 | Nereus Pharmaceuticals Inc | Deidrofenilahistinas e seus análogos, e sua sìntese |
| US20120114658A1 (en) * | 2009-09-15 | 2012-05-10 | John Ryan | Treatment of cancer |
| US20110160159A1 (en) * | 2009-09-15 | 2011-06-30 | John Ryan | Treatment of cancer |
| DK2958943T3 (da) * | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| AU2016219204B2 (en) * | 2015-02-12 | 2021-01-21 | Beyondspring Pharmaceuticals, Inc. | Use of Plinabulin in combination with immune checkpoint inhibitors |
| MX383691B (es) * | 2015-03-06 | 2025-03-14 | Beyondspring Pharmaceuticals Inc | Método de tratamiento de cáncer asociado con una mutación de ras. |
| AU2018236168B2 (en) * | 2017-03-13 | 2024-02-29 | Beyondspring Pharmaceuticals, Inc. | Compositions of plinabulin and use thereof |
-
2019
- 2019-05-30 ES ES19810149T patent/ES3060133T3/es active Active
- 2019-05-30 US US17/059,694 patent/US20210161888A1/en not_active Abandoned
- 2019-05-30 JP JP2020567029A patent/JP7500438B2/ja active Active
- 2019-05-30 KR KR1020207036949A patent/KR102790127B1/ko active Active
- 2019-05-30 CA CA3101612A patent/CA3101612A1/en active Pending
- 2019-05-30 MX MX2020012799A patent/MX420412B/es unknown
- 2019-05-30 AU AU2019278886A patent/AU2019278886B2/en active Active
- 2019-05-30 EP EP19810149.5A patent/EP3801524B1/en active Active
- 2019-05-30 CN CN201980050963.3A patent/CN112543636B/zh active Active
- 2019-05-30 WO PCT/US2019/034726 patent/WO2019232257A1/en not_active Ceased
- 2019-05-30 DK DK19810149.5T patent/DK3801524T3/da active
-
2025
- 2025-05-23 US US19/217,307 patent/US20250375440A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK3801524T3 (da) | 2026-02-02 |
| US20250375440A1 (en) | 2025-12-11 |
| US20210161888A1 (en) | 2021-06-03 |
| KR102790127B1 (ko) | 2025-04-03 |
| JP2021525768A (ja) | 2021-09-27 |
| CN112543636B (zh) | 2024-03-01 |
| EP3801524A1 (en) | 2021-04-14 |
| MX420412B (es) | 2025-02-10 |
| JP7500438B2 (ja) | 2024-06-17 |
| CN112543636A (zh) | 2021-03-23 |
| EP3801524B1 (en) | 2025-11-05 |
| KR20210015875A (ko) | 2021-02-10 |
| AU2019278886B2 (en) | 2025-03-20 |
| AU2019278886A1 (en) | 2020-12-24 |
| WO2019232257A1 (en) | 2019-12-05 |
| MX2020012799A (es) | 2021-03-25 |
| ES3060133T3 (en) | 2026-03-25 |
| EP3801524A4 (en) | 2022-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250375440A1 (en) | Composition and method of treating cancer associated with egfr mutation | |
| US20160129003A1 (en) | Pharmaceutical Combinations | |
| TWI873485B (zh) | 用於治療癌症之方法及包含cdk2抑制劑及cdk4抑制劑之給藥方案 | |
| AU2013352379B2 (en) | Pharmaceutical combinations | |
| CN105764510A (zh) | H3受体拮抗剂与胆碱酶抑制剂组合用于阿尔茨海默氏病治疗中的用途 | |
| EP4203963B1 (en) | Combination therapy of naporafenib and trametinib for use in the treatment of sarcoma | |
| KR20210084442A (ko) | 포도막 흑색종 치료를 위한 병용 요법 | |
| KR20160086962A (ko) | 삼중 음성 유방 암 치료를 위해 카보플라틴과 병용된 벨리파리브 | |
| HK40038993A (en) | Composition and method of treating cancer associated with egfr mutation | |
| US20240307392A1 (en) | Erk1/2 and egfr inhibitors combination therapy | |
| KR102739607B1 (ko) | 카바메이트 화합물을 포함하는 조현병의 예방, 경감 또는 치료용 배합물 | |
| CN115120596A (zh) | 一种喹唑啉化合物及药物组合物的应用 | |
| WO2024249155A1 (en) | Oncology combination therapy and methods of use | |
| JP2009108058A (ja) | 抗リンパ腫組成物および方法 | |
| HK1215789B (en) | Pharmaceutical combinations |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20240529 |
|
| D00 | Search and/or examination requested or commenced |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D120 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: VOLUNTARY SUBMISSION OF PRIOR ART RECEIVED Effective date: 20240703 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20250123 |
|
| D00 | Search and/or examination requested or commenced |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D123 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIOR ART DISCLOSURE DETERMINED COMPLIANT Effective date: 20250220 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250220 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250507 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250507 |
|
| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20250625 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION Effective date: 20251024 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20251218 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20251218 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20251218 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 7TH ANNIV.) - STANDARD Year of fee payment: 7 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260409 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260409 |