KR102784592B1 - 치환된 벤즈이미다졸, 그의 제조법 및 제약으로서의 그의 용도 - Google Patents

치환된 벤즈이미다졸, 그의 제조법 및 제약으로서의 그의 용도 Download PDF

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KR102784592B1
KR102784592B1 KR1020187006581A KR20187006581A KR102784592B1 KR 102784592 B1 KR102784592 B1 KR 102784592B1 KR 1020187006581 A KR1020187006581 A KR 1020187006581A KR 20187006581 A KR20187006581 A KR 20187006581A KR 102784592 B1 KR102784592 B1 KR 102784592B1
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KR20180039669A (ko
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메르나즈 포우라스라프
기욤 자크모트
스테판 클라리지
말켄 베이라크다리안
숀 존스톤
제프리 에스. 알베르트
앤드류 그리핀
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에피제네틱스, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Emergency Medicine (AREA)
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KR1020187006581A 2015-08-12 2016-08-12 치환된 벤즈이미다졸, 그의 제조법 및 제약으로서의 그의 용도 Active KR102784592B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562204178P 2015-08-12 2015-08-12
US62/204,178 2015-08-12
US201662358101P 2016-07-04 2016-07-04
US62/358,101 2016-07-04
PCT/CA2016/050952 WO2017024412A1 (en) 2015-08-12 2016-08-12 Substituted benzimidazoles, their preparation and their use as pharmaceuticals

Publications (2)

Publication Number Publication Date
KR20180039669A KR20180039669A (ko) 2018-04-18
KR102784592B1 true KR102784592B1 (ko) 2025-03-19

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US (4) US10703740B2 (enExample)
EP (1) EP3334719B1 (enExample)
JP (1) JP6912039B2 (enExample)
KR (1) KR102784592B1 (enExample)
CN (2) CN114605387A (enExample)
AU (2) AU2016305515A1 (enExample)
CA (1) CA2994478C (enExample)
ES (1) ES2904258T3 (enExample)
IL (1) IL257340B2 (enExample)
MX (1) MX382832B (enExample)
WO (1) WO2017024412A1 (enExample)

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