KR102735818B1 - 암 예방에서 단쇄 지방산의 용도 - Google Patents

암 예방에서 단쇄 지방산의 용도 Download PDF

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KR102735818B1
KR102735818B1 KR1020177023391A KR20177023391A KR102735818B1 KR 102735818 B1 KR102735818 B1 KR 102735818B1 KR 1020177023391 A KR1020177023391 A KR 1020177023391A KR 20177023391 A KR20177023391 A KR 20177023391A KR 102735818 B1 KR102735818 B1 KR 102735818B1
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pharmaceutical composition
pharmaceutically acceptable
cancer
mice
hbx
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KR20170128247A (ko
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헬레나 엠.지.피.브이. 레이스
마크 에이. 페이텔슨
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템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션
헬레나 엠.지.피.브이. 레이스
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Non-Alcoholic Beverages (AREA)
KR1020177023391A 2015-01-23 2016-01-21 암 예방에서 단쇄 지방산의 용도 Active KR102735818B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562106778P 2015-01-23 2015-01-23
US62/106,778 2015-01-23
PCT/US2016/014292 WO2016118730A1 (en) 2015-01-23 2016-01-21 Use of short chain fatty acids in cancer prevention

Publications (2)

Publication Number Publication Date
KR20170128247A KR20170128247A (ko) 2017-11-22
KR102735818B1 true KR102735818B1 (ko) 2024-11-28

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Country Link
US (6) US10231941B2 (cg-RX-API-DMAC10.html)
EP (2) EP4748449A3 (cg-RX-API-DMAC10.html)
JP (4) JP6783247B2 (cg-RX-API-DMAC10.html)
KR (1) KR102735818B1 (cg-RX-API-DMAC10.html)
CN (2) CN107405321A (cg-RX-API-DMAC10.html)
AU (3) AU2016209244A1 (cg-RX-API-DMAC10.html)
IL (1) IL253581A0 (cg-RX-API-DMAC10.html)
MX (1) MX387817B (cg-RX-API-DMAC10.html)
RU (1) RU2017127597A (cg-RX-API-DMAC10.html)
SG (2) SG10201907660YA (cg-RX-API-DMAC10.html)
WO (1) WO2016118730A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201704977B (cg-RX-API-DMAC10.html)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
EP4529950A3 (en) 2014-10-31 2025-08-20 Pendulum Therapeutics, Inc. Methods and compositions relating to microbial treatment
DK3193901T3 (en) 2014-12-23 2018-05-28 4D Pharma Res Ltd PIRIN POLYPEPTIDE AND IMMUNMODULATION
PE20171138A1 (es) 2014-12-23 2017-08-09 4D Pharma Res Ltd Modulacion inmunitaria
PE20180243A1 (es) 2015-06-15 2018-01-31 4D Pharma Res Ltd Composiciones que comprenden cepas bacterianas
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
EP3662917A1 (en) 2015-06-15 2020-06-10 4D Pharma Research Limited Compositions comprising bacterial strains
LT3360559T (lt) 2015-06-15 2019-12-27 4D Pharma Research Limited Kompozicijos, apimančios bakterijų kamienus
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
MA41013A (fr) 2015-11-20 2017-08-30 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
MX373290B (es) 2016-03-04 2020-06-18 4D Pharma Plc Composiciones que comprenden cepas bacterianas.
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
TWI802545B (zh) 2016-07-13 2023-05-21 英商4D製藥有限公司 包含細菌菌株之組合物
WO2018089861A1 (en) * 2016-11-11 2018-05-17 The Regents Of The University Of California Methods and compositions for the treatment of cancer and metabolic diseases
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
CN110475551A (zh) 2017-01-27 2019-11-19 英联邦高等教育系统天普大学 使用短链脂肪酸治疗和预防疾病和障碍
WO2018195067A1 (en) 2017-04-17 2018-10-25 The University Of Chicago Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease
US20220304967A1 (en) * 2017-04-24 2022-09-29 Allerpops Oral microbiota promoting composition cross-reference to related applications
MA48940A (fr) 2017-05-22 2020-04-08 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41708A (fr) 2017-05-24 2020-04-08 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
PL3638271T3 (pl) 2017-06-14 2021-03-22 4D Pharma Research Limited Kompozycje zawierające szczepy bakteryjne
JP2020523326A (ja) 2017-06-14 2020-08-06 フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited 細菌株を含む組成物
TWI767013B (zh) 2017-06-14 2022-06-11 英商4D製藥研究有限公司 包含細菌品系之組成物
KR102563191B1 (ko) 2017-07-05 2023-08-02 에벨로 바이오사이언시즈, 인크. 비피도박테리움 애니멀리스 ssp. 락티스를 이용한 암 치료 조성물 및 방법
EP3661371A1 (en) * 2017-08-04 2020-06-10 Société des Produits Nestlé S.A. Probiotic bacteria preconditioned in a gos-containing medium and use thereof
WO2019046646A1 (en) 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
CN110090230B (zh) * 2018-01-30 2022-07-12 青岛东海药业有限公司 凝结芽孢杆菌在制备预防或治疗胆管癌制剂中的应用
LT3743086T (lt) * 2018-05-11 2022-06-10 4D Pharma Research Limited Kompozicijos, apimančios bakterinius kamienus
SG11202011817WA (en) * 2018-06-01 2020-12-30 Evolve Biosystems Inc Compositions and methods to promote host defense and stimulate, expand, and/or reset t cell repertoires
CN113164526A (zh) 2018-07-19 2021-07-23 潘德勒姆治疗公司 用于微生物植入的方法和组合物
AU2020355194B2 (en) * 2019-09-25 2026-06-18 Julius-Maximilians-Universität Würzburg Short-chain fatty acid pentanoate as enhancer for cellular therapy and anti-tumor therapy
KR102510198B1 (ko) * 2019-11-14 2023-03-15 가톨릭대학교 산학협력단 락토바실러스 속 균주 및 SCFA(Short fatty chain acid)를 포함하는 면역 질환의 예방 및 치료용 조성물
TWI734341B (zh) * 2020-01-14 2021-07-21 景岳生物科技股份有限公司 一種副乾酪乳桿菌gmnl-346用於抗口腔癌之用途
EP4134089A1 (en) * 2020-03-05 2023-02-15 Liscure Biosciences Co., Ltd. Pharmaceutical composition comprising genus leuconostoc strain as active ingredient for prevention or treatment of cancer
WO2022031787A1 (en) * 2020-08-04 2022-02-10 Temple University-Of The Commonwealth System Of Higher Education Methods and compositions for treating cytokine release syndrome
US11938152B2 (en) 2020-08-06 2024-03-26 Kedar N Prasad High-dose antioxidants in cancer treatment
US20240009155A1 (en) * 2020-11-12 2024-01-11 Temple University-Of The Commonwealth System Of Higher Education Use of short chain fatty acids in cancer prevention
WO2022177409A1 (ko) * 2021-02-22 2022-08-25 주식회사 리스큐어바이오사이언시스 류코노스톡 메센테로이데스 균주 유래 나노소포체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
KR102942263B1 (ko) * 2021-11-05 2026-03-23 건국대학교 글로컬산학협력단 하이칸톤을 포함하는 우울장애 또는 신경염증질환의 예방 또는 치료용 조성물
CA3249056A1 (en) * 2022-01-19 2023-07-27 Ian Hodgdon SHORT CHAIN FATTY ACIDS FOR CANCER TREATMENT
CN117925434B (zh) * 2022-10-26 2025-02-14 慕恩(广州)生物科技有限公司 粪肠球菌mnh 22871及其应用
CN116212027A (zh) * 2023-02-28 2023-06-06 西湖大学 一种调控Treg细胞内铁水平的试剂的用途
AU2024405251A1 (en) 2023-12-22 2026-07-09 Temple University-Of The Commonwealth System Of Higher Education Short chain fatty acid compounds and uses thereof
WO2025176152A1 (en) * 2024-02-19 2025-08-28 The University Of Hong Kong Probiotics mixtures and methods of use thereof for treating cancers
CN119424400B (zh) * 2024-10-21 2026-03-03 江南大学 缓解衰老的肠道菌群支链氨基酸代谢产物异丁酸和异戊酸及其应用
CN119258047A (zh) * 2024-11-26 2025-01-07 哈尔滨医科大学 琥珀酸在制备防治肝癌药物中的新用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007114697A1 (en) * 2006-03-31 2007-10-11 Erasmus University Medical Center Rotterdam Novel composition for tumor growth control

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735967A (en) 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
AU645070B2 (en) 1990-04-10 1994-01-06 Nb International Technologies Use of short chain fatty acid containing lipids to maintain gastrointestinal integrity and function in patients DO NOT SEAL - SEE LETTER DATED 22.03.94
PH31403A (en) 1991-03-01 1998-10-29 Warner Lambert Co Therapeutic compositions to protect and recuscitate mammalian cells and methods for preparing same.
WO1995011699A1 (en) 1993-10-29 1995-05-04 The Trustees Of Boston University Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
JP2000072667A (ja) 1998-08-25 2000-03-07 Kurasuraa:Kk 大腸炎治療用経口投与剤
US6201077B1 (en) 1998-12-01 2001-03-13 Phillips Petroleum Company Process that produces polymers
EP1034788A1 (en) 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Lactic acid bacteria strains capable of preventing diarrhea
JP4360915B2 (ja) 2002-01-07 2009-11-11 ユーロスクリーン・ソシエテ・アノニム Gタンパク質共役受容体gpr43のリガンドおよびその使用
MXPA04008577A (es) 2002-03-04 2005-07-13 Aton Pharma Inc Metodos para inducir diferenciacion terminal.
JP2005530734A (ja) 2002-04-15 2005-10-13 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 癌の処置のための併用療法
US8846039B2 (en) 2002-04-26 2014-09-30 Asan Laboratories Company (Cayman), Limited Method for ameliorating pruritus
CN1681505A (zh) 2002-09-13 2005-10-12 弗吉尼亚州立大学 用于治疗白血病的а ) N-{ 5-[ 4-( 4-甲基-哌嗪-1-基-甲基)-苯甲酰氨基]-2-甲基苯基}-4-( 3-吡啶基 ) -2-嘧啶-胺和b )组蛋白脱乙酰基酶抑制剂的组合
US20050023179A1 (en) 2003-07-31 2005-02-03 Albritton Charles Wade Fragile-product cage for vacuum packaging appliances
CN102349927A (zh) 2003-08-29 2012-02-15 Hdac默克研究有限责任公司 联合治疗癌症的方法
WO2007016953A1 (en) 2005-07-29 2007-02-15 Matuschka-Greiffenclau Markus Composition for reducing alcohol induced liver cancer risk
WO2008054293A1 (en) * 2006-11-03 2008-05-08 Salutary Care Limited Composition, its use for treating systemic diseases a conditions, and product containing said composition
US20080153908A1 (en) 2006-12-20 2008-06-26 Jani Dharmendra M Method of Treating Mucin Deficiency with an Active Pharmaceutical and Related Composition
US9078864B2 (en) 2008-01-08 2015-07-14 Akthelia Pharmaceuticals Agonists for antimicrobial peptide systems
CN101214234B (zh) 2008-01-10 2010-09-08 中国人民解放军第二军医大学 α-羟基酸在制备癌瘤体内注射治疗药物中的应用
EP2398444A4 (en) 2009-02-18 2015-06-17 Sea Qiq As MIXTURE FROM INORGANIC COMPOUNDS, PREPARATIONS WITH THE MIXTURE AND USE OF THE MIXTURE
EP3181134B1 (en) 2009-06-19 2019-10-30 DuPont Nutrition Biosciences ApS Bifidobacteria for treating diabetes and related conditions
US8962686B2 (en) 2010-04-28 2015-02-24 The Chinese University Of Hong Kong Method and medication for prevention and treatment of ocular hypertension and glaucoma
EP2389932A1 (en) 2010-05-28 2011-11-30 Lunamed AG Compositions for use in genetic disorders comprising 4-phenyl-butyric acid and its salts
US20130115280A1 (en) 2010-07-29 2013-05-09 Cosmo Technologies Ltd Pharmaceutical and/or dietary compositions based on sort chain fatty acids
SG183544A1 (en) 2010-11-29 2012-10-30 Univ Putra Malaysia Tumour cytotoxic agent and methods thereof
CN111518866A (zh) * 2011-03-01 2020-08-11 群体创新有限责任公司 用于治疗与致病生物膜相关之病症的材料和方法
WO2012131069A1 (en) 2011-03-31 2012-10-04 Proponent Biotech Gmbh Short chain fatty acids and their derivatives for use in treatment immunogenic disorders
WO2012145684A1 (en) * 2011-04-22 2012-10-26 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Transient hypoxia inducers and their use
SG10202013014RA (en) * 2012-01-16 2021-02-25 Mckenna Elizabeth Compositions and Methods for the Treatment of Hepatic Diseases and Disorders
GB201215289D0 (en) 2012-08-28 2012-10-10 Medical Res Council Nanoparticle formulation
TWI463986B (zh) 2012-08-29 2014-12-11 Univ China Medical 胚芽乳酸桿菌cmu995菌株之新用途
TWI472324B (zh) * 2013-05-14 2015-02-11 應用二甲雙胍與丁酸鈉於kras基因突變癌症治療之用途、醫藥組合物與醫藥套組
US9764019B2 (en) 2013-07-09 2017-09-19 Vedanta Biosciences, Inc. Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
EP3033091B1 (en) * 2013-08-16 2022-09-07 Versitech Limited Probiotic composition and use thereof in the prevention and treatment of hepatocellular carcinoma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007114697A1 (en) * 2006-03-31 2007-10-11 Erasmus University Medical Center Rotterdam Novel composition for tumor growth control

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