KR102735275B1 - 바이러스성 색전술을 위한 조성물 및 방법 - Google Patents

바이러스성 색전술을 위한 조성물 및 방법 Download PDF

Info

Publication number
KR102735275B1
KR102735275B1 KR1020187001688A KR20187001688A KR102735275B1 KR 102735275 B1 KR102735275 B1 KR 102735275B1 KR 1020187001688 A KR1020187001688 A KR 1020187001688A KR 20187001688 A KR20187001688 A KR 20187001688A KR 102735275 B1 KR102735275 B1 KR 102735275B1
Authority
KR
South Korea
Prior art keywords
virus
tumor
oncolytic
composition
embolization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020187001688A
Other languages
English (en)
Korean (ko)
Other versions
KR20180021083A (ko
Inventor
황태호
이남희
조몽
전웅배
변두진
Original Assignee
신라젠(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 신라젠(주) filed Critical 신라젠(주)
Publication of KR20180021083A publication Critical patent/KR20180021083A/ko
Application granted granted Critical
Publication of KR102735275B1 publication Critical patent/KR102735275B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165—Mumps or measles virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24171—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020187001688A 2015-06-19 2016-06-17 바이러스성 색전술을 위한 조성물 및 방법 Active KR102735275B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562182383P 2015-06-19 2015-06-19
US62/182,383 2015-06-19
PCT/IB2016/000993 WO2017037523A1 (en) 2015-06-19 2016-06-17 Compositions and methods for viral embolization

Publications (2)

Publication Number Publication Date
KR20180021083A KR20180021083A (ko) 2018-02-28
KR102735275B1 true KR102735275B1 (ko) 2024-11-29

Family

ID=58186857

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187001688A Active KR102735275B1 (ko) 2015-06-19 2016-06-17 바이러스성 색전술을 위한 조성물 및 방법

Country Status (8)

Country Link
US (1) US10517910B2 (OSRAM)
EP (1) EP3310383B1 (OSRAM)
JP (1) JP6827467B2 (OSRAM)
KR (1) KR102735275B1 (OSRAM)
CN (1) CN108025056B (OSRAM)
AU (1) AU2016313969B2 (OSRAM)
ES (1) ES2795010T3 (OSRAM)
WO (1) WO2017037523A1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144564A2 (en) 2015-02-25 2016-09-15 Memorial Sloan-Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
CN107847534B (zh) 2015-04-17 2022-10-04 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
CN108025056B (zh) 2015-06-19 2022-01-14 新罗杰股份有限公司 用于病毒栓塞的组合物和方法
US10512662B2 (en) 2016-02-25 2019-12-24 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human Flt3L or GM-CSF for cancer immunotherapy
US10736962B2 (en) 2016-02-25 2020-08-11 Memorial Sloan Kettering Cancer Center Recombinant MVA or MVADELE3L expressing human FLT3L and use thereof as immuno-therapeutic agents against solid tumors
KR102190326B1 (ko) * 2016-07-21 2020-12-11 코오롱생명과학 주식회사 재조합 백시니아 바이러스 및 이의 용도
US11242509B2 (en) 2017-05-12 2022-02-08 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
CN109554353B (zh) * 2017-09-26 2021-08-06 杭州康万达医药科技有限公司 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
KR20190059421A (ko) * 2017-11-23 2019-05-31 주식회사 바이오녹스 항암바이러스의 간동맥 투여를 이용한 간암 치료방법
KR20210031485A (ko) 2018-07-13 2021-03-19 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 Tnf를 발현하는 점액종 바이러스로 암을 치료하는 방법
MX2021003013A (es) 2018-09-15 2021-08-11 Memorial Sloan Kettering Cancer Center Poxvirus recombinantes para inmunoterapia contra cáncer.
WO2020153734A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 다람쥐 섬유종 바이러스 및 리오바이러스를 포함하는 암 예방 또는 치료용 약학적 조성물
CA3129883A1 (en) * 2019-02-14 2020-08-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
KR20220112241A (ko) * 2019-09-02 2022-08-10 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 점액종 바이러스를 이용하여 암을 치료하기 위한 새로운 종양용해성 바이러스 플랫폼
DE102020101197A1 (de) * 2020-01-20 2021-07-22 Charité - Universitätsmedizin Berlin Medizinprodukt zur Arzneimittelabgabe mit verstärkter Wirkung
CN116322740A (zh) 2020-07-13 2023-06-23 特兰斯吉恩股份有限公司 免疫抑制的治疗
WO2023213763A1 (en) 2022-05-02 2023-11-09 Transgene Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab
WO2023213764A1 (en) 2022-05-02 2023-11-09 Transgene Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
CN116942888B (zh) * 2023-09-11 2026-03-24 科睿驰(深圳)医疗科技发展有限公司 淀粉水凝胶栓塞微球及其制备方法
WO2026041811A1 (en) 2024-08-23 2026-02-26 Transgene Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211165A1 (en) * 2000-03-24 2003-11-13 Jean-Marie Vogel Microspheres for active embolization
US8980246B2 (en) * 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073627A (en) 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
CA2133339A1 (en) 1992-04-08 1993-10-09 Jennifer S. Rota Wild-type measles virus glycoproteins: vaccine and detection method therefor
FR2736358B1 (fr) 1995-07-05 1997-09-26 Agronomique Inst Nat Rech Virus myxomateux recombinant
WO1999012577A1 (en) 1997-09-05 1999-03-18 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
AU2001294458B2 (en) * 2000-10-06 2004-03-11 Jagotec Ag Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
WO2003094938A1 (en) 2002-05-09 2003-11-20 Oncolytics Biotech Inc. Method for reducing pain using oncolytic viruses
EP2269619A1 (en) * 2002-08-12 2011-01-05 Jennerex Biotherapeutics ULC Methods and compositions concerning poxviruses and cancer
CN101351213B (zh) * 2005-09-07 2013-10-02 詹纳里克斯公司 使用表达gm-csf的痘病毒系统性治疗转移性癌和/或全身散布性癌
WO2008105504A1 (ja) * 2007-03-01 2008-09-04 Cosmed Pharmaceutical Co., Ltd. 経皮免疫製剤、その製造方法及びそれを用いた経皮免疫方法
KR20080084528A (ko) * 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
ES2671570T3 (es) * 2009-09-14 2018-06-07 Sillajen Biotherapeutics, Inc. Terapia combinada contra el cáncer con virus oncolítico de vaccinia
WO2011135734A1 (ja) * 2010-04-28 2011-11-03 株式会社アルファ・ナノ・メディカ ウイルスの複合体、それを含有する治療薬及び治療方法
US9724421B2 (en) * 2010-11-29 2017-08-08 Centre Hospitalier Universitaire Vaudois Chemoembolization composition comprising anti-angiogenic agents
CN103429258B (zh) * 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
ES2813413T3 (es) * 2011-08-05 2021-03-23 Sillajen Biotherapeutics Inc Métodos y composiciones para la producción de virus vaccina
WO2014031693A1 (en) * 2012-08-20 2014-02-27 Genelux Corporation Compositions containing protein polymers and vaccinia virus, and methods of use thereof
US20140194370A1 (en) * 2013-01-08 2014-07-10 University Of Utah Research Foundation Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer
CN108025056B (zh) 2015-06-19 2022-01-14 新罗杰股份有限公司 用于病毒栓塞的组合物和方法
HK1255192A1 (zh) * 2015-09-08 2019-08-09 Sillajen, Inc. 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211165A1 (en) * 2000-03-24 2003-11-13 Jean-Marie Vogel Microspheres for active embolization
US8980246B2 (en) * 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEPATOLOGY, Vol. 48, No. 6, 2008*

Also Published As

Publication number Publication date
CN108025056B (zh) 2022-01-14
WO2017037523A1 (en) 2017-03-09
CN108025056A (zh) 2018-05-11
ES2795010T3 (es) 2020-11-20
JP6827467B2 (ja) 2021-02-10
EP3310383B1 (en) 2020-02-19
AU2016313969B2 (en) 2021-12-23
CA2990133A1 (en) 2017-03-09
EP3310383A1 (en) 2018-04-25
JP2018517778A (ja) 2018-07-05
US10517910B2 (en) 2019-12-31
US20180303886A1 (en) 2018-10-25
KR20180021083A (ko) 2018-02-28
AU2016313969A1 (en) 2018-02-15
EP3310383A4 (en) 2019-02-27
HK1252004A1 (en) 2019-05-10

Similar Documents

Publication Publication Date Title
US10517910B2 (en) Compositions and methods for viral embolization
Wollmann et al. Oncolytic virus therapy for glioblastoma multiforme: concepts and candidates
US8227440B2 (en) Use of Myxoma virus for the therapeutic treatment of cancer and chronic viral infection
US12319931B2 (en) Oncolytic virus expressing interferon and application therefor
CA2681096C (en) Oncolytic vaccinia virus cancer therapy
EP1121137B1 (en) Method for killing tumor and tumor associated endothelial cells using adenoviral mutants
CN101137748B (zh) 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用
Meerani et al. Oncolytic viruses in cancer therapy
CA2990133C (en) Compositions and methods for viral embolization
Kirn Monthly Update: Oncologic, Endocrine & Metabolic: Replicating oncolytic viruses: An overview
HK1252004B (en) Compositions and methods for viral embolization
Saha et al. Viral oncolysis of glioblastoma
CN100451109C (zh) 重组1型单纯疱疹病毒及制备方法和应用
CN100379453C (zh) 粘液瘤病毒在治疗癌症和慢性病毒感染中的用途
Bell et al. HISTORY OF ONCOLYTIC VIRUSES
HK1081099B (en) Use of myxoma virus for therapeutic treatment of cancer and chronic viral infection

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20180118

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20210616

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20240220

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20241010

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20241125

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20241126

End annual number: 3

Start annual number: 1

PG1601 Publication of registration