KR102733714B1 - 세포 집단의 증대를 위한 방법 및 조성물 - Google Patents
세포 집단의 증대를 위한 방법 및 조성물 Download PDFInfo
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- KR102733714B1 KR102733714B1 KR1020207013360A KR20207013360A KR102733714B1 KR 102733714 B1 KR102733714 B1 KR 102733714B1 KR 1020207013360 A KR1020207013360 A KR 1020207013360A KR 20207013360 A KR20207013360 A KR 20207013360A KR 102733714 B1 KR102733714 B1 KR 102733714B1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570076P | 2017-10-09 | 2017-10-09 | |
| US62/570,076 | 2017-10-09 | ||
| US201862695820P | 2018-07-09 | 2018-07-09 | |
| US62/695,820 | 2018-07-09 | ||
| PCT/US2018/055092 WO2019074980A1 (en) | 2017-10-09 | 2018-10-09 | METHODS AND COMPOSITIONS FOR EXPANSION OF CELL POPULATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200078536A KR20200078536A (ko) | 2020-07-01 |
| KR102733714B1 true KR102733714B1 (ko) | 2024-11-26 |
Family
ID=66101161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207013360A Active KR102733714B1 (ko) | 2017-10-09 | 2018-10-09 | 세포 집단의 증대를 위한 방법 및 조성물 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12359200B2 (enExample) |
| EP (1) | EP3694533A4 (enExample) |
| JP (2) | JP2020536554A (enExample) |
| KR (1) | KR102733714B1 (enExample) |
| CN (2) | CN120366217A (enExample) |
| WO (1) | WO2019074980A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11046969B2 (en) | 2017-05-24 | 2021-06-29 | Epiplanta Biotech Ltd. | Transgenic plant and the method for producing the same |
| CN120366217A (zh) | 2017-10-09 | 2025-07-25 | 斯托瓦斯医学研究所 | 用于扩增细胞群的方法和组合物 |
| US20230018989A1 (en) * | 2019-07-03 | 2023-01-19 | Children's Medical Center Corporation | Inhibiting the rna methyltransferase mettl3 or its interaction with eif3h to suppress oncogene translation and tumorigenesis |
| CA3180620A1 (en) * | 2020-06-09 | 2021-12-16 | Meng Xu | Compositions and methods for enhancing immune response |
| CN116261459A (zh) * | 2020-07-09 | 2023-06-13 | 中国科学院上海药物研究所 | 用于抑制ythdf1的组合物和方法 |
| EP4185305A4 (en) * | 2020-09-09 | 2024-08-28 | Duke University | METHODS OF REPROGRAMMING TARGET CELLS |
| WO2022086935A1 (en) * | 2020-10-19 | 2022-04-28 | The General Hospital Corporation | Targeting xist and rna methylation for x reactivation therapy |
| CN112941102A (zh) * | 2021-01-26 | 2021-06-11 | 南方医科大学 | 一种子痫前期小鼠动物模型的构建方法及其应用 |
| CN112941105A (zh) * | 2021-02-08 | 2021-06-11 | 江西农业大学 | 一种m6A“阅读器”YTHDF2基因改造方法及其应用 |
| CN112899238B (zh) * | 2021-04-01 | 2023-09-26 | 中国药科大学 | 基于RNA-m6A修饰水平的化合物筛选细胞模型及其构建与应用 |
| WO2022241165A2 (en) * | 2021-05-12 | 2022-11-17 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods of use for mutated hotair in the treatment of cancers |
| CN116024326A (zh) * | 2022-09-21 | 2023-04-28 | 安徽中医药大学第一附属医院(安徽省中医院) | 类风湿关节炎m6A甲基化修饰基因PTEN的应用及其检测方法 |
| CN115463155B (zh) * | 2022-11-01 | 2023-05-23 | 卡瑞济(北京)生命科技有限公司 | 间充质干细胞的用途 |
| CN120513295A (zh) * | 2023-01-09 | 2025-08-19 | 韩国生命工学研究院 | Fto基因表达受到抑制的干细胞和由其分化的免疫细胞 |
| WO2024201420A1 (en) * | 2023-03-31 | 2024-10-03 | Biorchestra Co., Ltd. | Mirna-484 inhibitors and uses thereof |
| WO2025117708A2 (en) * | 2023-11-28 | 2025-06-05 | Baruch S. Blumberg Institute | Method and system for use of mutant mrna in liquid biopsies to risk stratify and manage cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012027376A2 (en) | 2010-08-23 | 2012-03-01 | The Research Foundation Of State University Of New York | Method for expansion of stem cells and the use of such cells |
| US20160264934A1 (en) * | 2015-03-11 | 2016-09-15 | The General Hospital Corporation | METHODS FOR MODULATING AND ASSAYING m6A IN STEM CELL POPULATIONS |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04503957A (ja) | 1989-03-07 | 1992-07-16 | ジェネンテク,インコーポレイテッド | 脂質とオリゴヌクレオチドの共有結合コンジュゲート |
| WO1991004753A1 (en) | 1989-10-02 | 1991-04-18 | Cetus Corporation | Conjugates of antisense oligonucleotides and therapeutic uses thereof |
| US7018801B2 (en) | 2000-02-11 | 2006-03-28 | Board Of Regents, The University Of Texas System | Selection of peptides with antibody-like properties |
| US20070065447A1 (en) | 2003-10-29 | 2007-03-22 | Novo Nordisk A/S | Laminin-5 gamma2-binding peptides, related compositions, and use thereof |
| US8263403B2 (en) * | 2007-04-23 | 2012-09-11 | Stowers Institute For Medical Research | Methods and compositions for stem cell self-renewal |
| US9920317B2 (en) * | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| ES2672693T3 (es) | 2011-04-20 | 2018-06-15 | The Regents Of The University Of California | Método para el acondicionamiento y quimioselección combinadas en un único ciclo |
| CN107207557B (zh) * | 2015-01-26 | 2020-07-10 | 中国科学院动物研究所 | miRNA对m6A修饰水平的调控方法及其应用 |
| CN120366217A (zh) | 2017-10-09 | 2025-07-25 | 斯托瓦斯医学研究所 | 用于扩增细胞群的方法和组合物 |
-
2018
- 2018-10-09 CN CN202510125361.7A patent/CN120366217A/zh active Pending
- 2018-10-09 KR KR1020207013360A patent/KR102733714B1/ko active Active
- 2018-10-09 CN CN201880079157.4A patent/CN111511376B/zh active Active
- 2018-10-09 WO PCT/US2018/055092 patent/WO2019074980A1/en not_active Ceased
- 2018-10-09 JP JP2020520317A patent/JP2020536554A/ja active Pending
- 2018-10-09 US US16/754,714 patent/US12359200B2/en active Active
- 2018-10-09 EP EP18866285.2A patent/EP3694533A4/en active Pending
-
2023
- 2023-10-05 JP JP2023173609A patent/JP2023171952A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012027376A2 (en) | 2010-08-23 | 2012-03-01 | The Research Foundation Of State University Of New York | Method for expansion of stem cells and the use of such cells |
| US20160264934A1 (en) * | 2015-03-11 | 2016-09-15 | The General Hospital Corporation | METHODS FOR MODULATING AND ASSAYING m6A IN STEM CELL POPULATIONS |
Non-Patent Citations (3)
| Title |
|---|
| Cell Stem Cell. Vol.13, 520-533(2013) |
| NATURE. VOL 549, 273-276(2017.09.) |
| Nucleic Acids Research. Vol. 41, No. 21, 9753-9763(2013) |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200078536A (ko) | 2020-07-01 |
| US20200370044A1 (en) | 2020-11-26 |
| US12359200B2 (en) | 2025-07-15 |
| EP3694533A1 (en) | 2020-08-19 |
| CN120366217A (zh) | 2025-07-25 |
| JP2023171952A (ja) | 2023-12-05 |
| WO2019074980A1 (en) | 2019-04-18 |
| CN111511376B (zh) | 2025-02-25 |
| EP3694533A4 (en) | 2021-07-14 |
| JP2020536554A (ja) | 2020-12-17 |
| CN111511376A (zh) | 2020-08-07 |
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