KR102730367B1 - 그룹 a 스트렙토코쿠스 백신 - Google Patents

그룹 a 스트렙토코쿠스 백신 Download PDF

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Publication number
KR102730367B1
KR102730367B1 KR1020167031477A KR20167031477A KR102730367B1 KR 102730367 B1 KR102730367 B1 KR 102730367B1 KR 1020167031477 A KR1020167031477 A KR 1020167031477A KR 20167031477 A KR20167031477 A KR 20167031477A KR 102730367 B1 KR102730367 B1 KR 102730367B1
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South Korea
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seq
terminus
peptide
derivative
protein
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Korean (ko)
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KR20160144455A (ko
Inventor
마니샤 판데이
마이클 배츠로프
마이클 굿
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그리피스 유니버시티
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Priority claimed from AU2014901382A external-priority patent/AU2014901382A0/en
Application filed by 그리피스 유니버시티 filed Critical 그리피스 유니버시티
Priority to KR1020237007349A priority Critical patent/KR102744193B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020167031477A 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신 Active KR102730367B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237007349A KR102744193B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
AU2014901382A AU2014901382A0 (en) 2014-04-15 Group a streptococcal vaccine
AU2014901382 2014-04-15
AU2014903042 2014-08-06
AU2014903042A AU2014903042A0 (en) 2014-08-06 Group a streptococcal vaccine
AU2014904453A AU2014904453A0 (en) 2014-11-05 Group a streptococcal vaccine
AU2014904453 2014-11-05
PCT/AU2015/050174 WO2015157820A1 (en) 2014-04-15 2015-04-15 Group a streptococcus vaccine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237007349A Division KR102744193B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Publications (2)

Publication Number Publication Date
KR20160144455A KR20160144455A (ko) 2016-12-16
KR102730367B1 true KR102730367B1 (ko) 2024-11-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020167031477A Active KR102730367B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신
KR1020237007349A Active KR102744193B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Family Applications After (1)

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KR1020237007349A Active KR102744193B1 (ko) 2014-04-15 2015-04-15 그룹 a 스트렙토코쿠스 백신

Country Status (16)

Country Link
US (2) US10301362B2 (enExample)
EP (1) EP3131575B1 (enExample)
JP (2) JP2017513849A (enExample)
KR (2) KR102730367B1 (enExample)
CN (1) CN106794236B (enExample)
AU (1) AU2015246654B2 (enExample)
BR (1) BR112016023915B1 (enExample)
CA (1) CA2945052C (enExample)
DK (1) DK3131575T3 (enExample)
IL (1) IL248266B (enExample)
MX (1) MX392514B (enExample)
MY (1) MY191217A (enExample)
NZ (1) NZ725212A (enExample)
SG (1) SG11201608380PA (enExample)
WO (1) WO2015157820A1 (enExample)
ZA (1) ZA201607355B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY191217A (en) 2014-04-15 2022-06-09 Univ Griffith Group a streptococcus vaccine
CN106606775A (zh) * 2015-10-27 2017-05-03 格里菲斯大学 脂质体a群链球菌疫苗
TWI598360B (zh) * 2016-12-19 2017-09-11 義守大學 Ｆｓｂｍ重組蛋白及其用途
CN111344007A (zh) * 2017-08-23 2020-06-26 格里菲斯大学 抗a组链球菌的免疫原性肽
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
KR102437436B1 (ko) * 2019-04-26 2022-08-30 주식회사 엠디헬스케어 스트렙토코커스 파이오제네스 세균 유래 단백질 및 이의 용도
NL2023863B1 (en) 2019-09-20 2021-05-25 Univ Griffith Protein particles and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047238A (en) 1983-06-15 1991-09-10 American Home Products Corporation Adjuvants for vaccines
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5811105A (en) 1987-12-23 1998-09-22 Glaxo Wellcome, Inc. Vaccines containing bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
US5785973A (en) 1988-02-01 1998-07-28 Praxis Biologics, Inc. Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
GB8912330D0 (en) 1989-05-30 1989-07-12 Wellcome Found Live vaccines
GB9007194D0 (en) 1990-03-30 1990-05-30 Wellcome Found Live vaccines
AUPM885194A0 (en) * 1994-10-14 1994-11-10 Council Of The Queensland Institute Of Medical Research, The Synthetic peptides and vaccines comprising same
AUPO007396A0 (en) 1996-05-24 1996-06-20 Csl Limited Ebv ctl epitopes
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
AU2005294275B2 (en) * 2004-10-08 2012-09-13 Glaxosmithkline Biologicals S.A. Immunogenic and therapeutic compositions for Streptococcus pyogenes
EP1879613B1 (en) * 2005-05-05 2011-11-30 Merck Sharp & Dohme Corp. Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease
EP1962961B1 (en) 2005-11-29 2013-01-09 The University Of Sydney Demibodies: dimerisation-activated therapeutic agents
AU2007271350B2 (en) * 2006-07-07 2013-03-21 Intercell Ag Small Streptococcus pyogenes antigens and their use
US20090010929A1 (en) 2006-12-04 2009-01-08 Good Michael F Therapeutic Antibodies, Antibody Fragments and Antibody Conjugates
US8482298B2 (en) 2006-12-18 2013-07-09 Schrader Electronics Ltd. Liquid level and composition sensing systems and methods using EMF wave propagation
CA2699513C (en) * 2007-09-12 2018-03-13 Novartis Ag Gas57 mutant antigens and gas57 antibodies
US20090162369A1 (en) * 2007-12-12 2009-06-25 Katin Helena Threse Nordstrom Synthetic chimeric peptides
JP5680536B2 (ja) 2008-09-17 2015-03-04 ノバルティス アーゲー 組み合わせｇａｓワクチンおよび治療法
MY191217A (en) 2014-04-15 2022-06-09 Univ Griffith Group a streptococcus vaccine
CN111344007A (zh) * 2017-08-23 2020-06-26 格里菲斯大学 抗a组链球菌的免疫原性肽

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Proceedings of the Tenth Global Vaccine Research Forum and Parallel Satellite Symposia, Immunization, Vaccines and Biologicals, WHO(2011.6.26.-29.)*
The Journal of Infectious Disease, 제187권, 1598-1608면(2003.5.15.)*
Vaccine, 제27권, 4923-4929면(2009)*

Also Published As

Publication number Publication date
EP3131575B1 (en) 2024-05-08
BR112016023915A2 (pt) 2017-10-17
JP2021042247A (ja) 2021-03-18
MX2016013277A (es) 2017-01-18
EP3131575A4 (en) 2017-11-01
CA2945052C (en) 2023-05-02
JP2017513849A (ja) 2017-06-01
BR112016023915B1 (pt) 2024-03-12
KR102744193B1 (ko) 2024-12-19
JP7072921B2 (ja) 2022-05-23
CA2945052A1 (en) 2015-10-22
CN106794236B (zh) 2021-09-03
DK3131575T3 (da) 2024-05-21
KR20160144455A (ko) 2016-12-16
ZA201607355B (en) 2019-03-27
EP3131575A1 (en) 2017-02-22
US10513544B2 (en) 2019-12-24
SG11201608380PA (en) 2016-11-29
US20170037087A1 (en) 2017-02-09
WO2015157820A1 (en) 2015-10-22
CN106794236A (zh) 2017-05-31
MY191217A (en) 2022-06-09
MX392514B (es) 2025-03-24
KR20230039751A (ko) 2023-03-21
US20190256562A1 (en) 2019-08-22
NZ725212A (en) 2023-04-28
US10301362B2 (en) 2019-05-28
AU2015246654A1 (en) 2016-11-03
IL248266B (en) 2021-09-30
IL248266A0 (en) 2016-11-30
AU2015246654B2 (en) 2019-08-08

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