KR102728071B1 - Fgf21-연관 장애를 치료하는 방법 - Google Patents

Fgf21-연관 장애를 치료하는 방법 Download PDF

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KR102728071B1
KR102728071B1 KR1020187005700A KR20187005700A KR102728071B1 KR 102728071 B1 KR102728071 B1 KR 102728071B1 KR 1020187005700 A KR1020187005700 A KR 1020187005700A KR 20187005700 A KR20187005700 A KR 20187005700A KR 102728071 B1 KR102728071 B1 KR 102728071B1
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light chain
antibody
heavy chain
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KR20180035852A (ko
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브라이언 보에처
데이비드 랑든 야우
샤리 린 카플란
레기스 체베
구오준 리
존 타라스즈카
팡민 수
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노파르티스 아게
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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KR1020187005700A 2015-08-03 2016-08-02 Fgf21-연관 장애를 치료하는 방법 Active KR102728071B1 (ko)

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Application Number Priority Date Filing Date Title
US201562200445P 2015-08-03 2015-08-03
US62/200,445 2015-08-03
PCT/IB2016/054660 WO2017021893A1 (en) 2015-08-03 2016-08-02 Methods of treating fgf21-associated disorders

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KR20180035852A KR20180035852A (ko) 2018-04-06
KR102728071B1 true KR102728071B1 (ko) 2024-11-11

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US (2) US11236159B2 (https=)
EP (1) EP3331914A1 (https=)
JP (2) JP6940479B2 (https=)
KR (1) KR102728071B1 (https=)
CN (2) CN108350072B (https=)
AU (2) AU2016303545B2 (https=)
CA (2) CA2994516C (https=)
IL (2) IL257252B2 (https=)
RU (1) RU2752530C2 (https=)
WO (1) WO2017021893A1 (https=)

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KR102572663B1 (ko) 2017-02-08 2023-09-01 노파르티스 아게 Fgf21 모방 항체 및 이의 용도
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KR102637908B1 (ko) * 2018-12-28 2024-02-20 씨제이제일제당 (주) 헬리코박터 파일로리 연관 질환에 대한 유전자 마커
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WO2024072872A2 (en) * 2022-09-27 2024-04-04 The Brigham And Women's Hospital, Inc. Klrg1 signalling therapy for infectious disease
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