KR102724420B1 - 연합된 비-혼합 사용을 위한 돼지 병원체를 함유하는 백신 - Google Patents
연합된 비-혼합 사용을 위한 돼지 병원체를 함유하는 백신 Download PDFInfo
- Publication number
- KR102724420B1 KR102724420B1 KR1020197029516A KR20197029516A KR102724420B1 KR 102724420 B1 KR102724420 B1 KR 102724420B1 KR 1020197029516 A KR1020197029516 A KR 1020197029516A KR 20197029516 A KR20197029516 A KR 20197029516A KR 102724420 B1 KR102724420 B1 KR 102724420B1
- Authority
- KR
- South Korea
- Prior art keywords
- vaccine
- pcv2
- infection
- immunogen
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 119
- 244000052769 pathogen Species 0.000 title description 23
- 241000282898 Sus scrofa Species 0.000 title description 10
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 claims abstract description 81
- 241001465754 Metazoa Species 0.000 claims abstract description 59
- 241001673669 Porcine circovirus 2 Species 0.000 claims abstract description 59
- 230000002163 immunogen Effects 0.000 claims abstract description 44
- 208000015181 infectious disease Diseases 0.000 claims abstract description 44
- 241000700605 Viruses Species 0.000 claims abstract description 41
- 230000003362 replicative effect Effects 0.000 claims abstract description 36
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 claims abstract description 35
- 230000002238 attenuated effect Effects 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 12
- 241001148567 Lawsonia intracellularis Species 0.000 claims description 15
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 210000004207 dermis Anatomy 0.000 claims description 5
- 101150009852 ORF2 gene Proteins 0.000 claims description 3
- 241000701447 unidentified baculovirus Species 0.000 claims description 3
- 241000282887 Suidae Species 0.000 description 28
- 238000002255 vaccination Methods 0.000 description 26
- 241001469654 Lawsonia <weevil> Species 0.000 description 21
- 241001135902 Peanut clump virus Species 0.000 description 15
- 230000001717 pathogenic effect Effects 0.000 description 15
- 239000000427 antigen Substances 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 230000036541 health Effects 0.000 description 11
- 230000003902 lesion Effects 0.000 description 11
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 241001661006 Pepper cryptic virus 2 Species 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 6
- 238000011321 prophylaxis Methods 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 238000011529 RT qPCR Methods 0.000 description 4
- 210000004081 cilia Anatomy 0.000 description 4
- 230000001900 immune effect Effects 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 108090000565 Capsid Proteins Proteins 0.000 description 3
- 102100023321 Ceruloplasmin Human genes 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 206010035664 Pneumonia Diseases 0.000 description 3
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 description 3
- 101710130262 Probable Vpr-like protein Proteins 0.000 description 3
- 206010058874 Viraemia Diseases 0.000 description 3
- 210000001842 enterocyte Anatomy 0.000 description 3
- 208000009326 ileitis Diseases 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 238000007918 intramuscular administration Methods 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 2
- 241000710788 Lelystad virus Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 238000011260 co-administration Methods 0.000 description 2
- 229940001442 combination vaccine Drugs 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 244000144980 herd Species 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 230000008774 maternal effect Effects 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 210000002741 palatine tonsil Anatomy 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- UBCKGWBNUIFUST-YHYXMXQVSA-N tetrachlorvinphos Chemical compound COP(=O)(OC)O\C(=C/Cl)C1=CC(Cl)=C(Cl)C=C1Cl UBCKGWBNUIFUST-YHYXMXQVSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 241001292006 Arteriviridae Species 0.000 description 1
- 208000031504 Asymptomatic Infections Diseases 0.000 description 1
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 208000031531 Desulfovibrionaceae Infections Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241001662043 Icterus Species 0.000 description 1
- 101710128560 Initiator protein NS1 Proteins 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 238000011887 Necropsy Methods 0.000 description 1
- 241001292005 Nidovirales Species 0.000 description 1
- 101710144127 Non-structural protein 1 Proteins 0.000 description 1
- 101710113540 ORF2 protein Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 241001504982 Pepper cryptic virus 1 Species 0.000 description 1
- 241000202347 Porcine circovirus Species 0.000 description 1
- 101100382437 Porcine circovirus 2 Cap gene Proteins 0.000 description 1
- 101710090523 Putative movement protein Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 208000010399 Wasting Syndrome Diseases 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000234 capsid Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 208000037902 enteropathy Diseases 0.000 description 1
- 244000309457 enveloped RNA virus Species 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 208000002254 stillbirth Diseases 0.000 description 1
- 231100000537 stillbirth Toxicity 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17166590 | 2017-04-13 | ||
| EP17166590.4 | 2017-04-13 | ||
| PCT/EP2018/059389 WO2018189290A1 (en) | 2017-04-13 | 2018-04-12 | Vaccines containing swine pathogens for associated non-mixed use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190134650A KR20190134650A (ko) | 2019-12-04 |
| KR102724420B1 true KR102724420B1 (ko) | 2024-10-30 |
Family
ID=58547447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197029516A Active KR102724420B1 (ko) | 2017-04-13 | 2018-04-12 | 연합된 비-혼합 사용을 위한 돼지 병원체를 함유하는 백신 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11311614B2 (enExample) |
| EP (2) | EP3609533A1 (enExample) |
| JP (2) | JP7665289B2 (enExample) |
| KR (1) | KR102724420B1 (enExample) |
| CN (1) | CN110446502B (enExample) |
| CA (1) | CA3058281A1 (enExample) |
| MX (1) | MX390682B (enExample) |
| RU (1) | RU2756767C2 (enExample) |
| WO (1) | WO2018189290A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3058281A1 (en) * | 2017-04-13 | 2018-10-18 | Intervet International B.V. | Vaccines containing swine pathogens for associated non-mixed use |
| CN115427072A (zh) * | 2020-04-20 | 2022-12-02 | 英特维特国际股份有限公司 | 预防性治疗猪的疫苗组合 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009127684A1 (en) * | 2008-04-18 | 2009-10-22 | Intervet International B.V. | Vaccine for protection against lawsonia intracellularis, mycoplasma hyopneumoniae and porcine circo virus |
| US20130266602A1 (en) * | 2012-04-04 | 2013-10-10 | Zoetis Llc | PCV/Mycoplasma Hyopneumoniae Combination Vaccine |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| JP2004529854A (ja) * | 2000-09-29 | 2004-09-30 | アリゾナ・ボード・オブ・リージエンツ・オン・ビハーフ・オブ・ザ・ユニバーシテイー・オブ・アリゾナ | 増殖性回腸炎のための改善されたワクチン及びその作製と使用の方法 |
| ATE462445T1 (de) | 2005-01-13 | 2010-04-15 | Boehringer Ingelheim Vetmed | Prrs-impfstoffe |
| DK1926496T3 (da) | 2005-09-09 | 2013-09-30 | Intervet Int Bv | PCV-2-vaccine |
| DK2371383T3 (en) | 2005-12-29 | 2015-11-30 | Boehringer Ingelheim Vetmed | Use of a PCV2 immunogenic composition for reduction of clinical symptoms in pigs |
| AU2007333857B2 (en) | 2006-12-15 | 2014-05-15 | Boehringer Ingelheim Animal Health USA Inc. | Treatment of pigs with PCV2 antigen |
| US8728487B2 (en) | 2011-01-20 | 2014-05-20 | Hua Wu | Attenuated live vaccine for prevention of porcine reproductive and respiratory syndrome |
| UA114504C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| US9457073B2 (en) | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
| CN110354258A (zh) * | 2013-12-03 | 2019-10-22 | 英特维特国际股份有限公司 | 抗猪圆环病毒2型的疫苗 |
| US20160303219A1 (en) * | 2013-12-03 | 2016-10-20 | Intervet Inc. | Swine Vaccine Against PRRS and Lawsonia Intracellularis |
| WO2015082457A1 (en) * | 2013-12-03 | 2015-06-11 | Intervet International B.V. | Vaccine against lawsonia intracellularis and porcine circovirus 2 |
| CA3045556A1 (en) * | 2016-12-22 | 2018-06-28 | Intervet International B.V. | Needleless injector |
| CA3058281A1 (en) * | 2017-04-13 | 2018-10-18 | Intervet International B.V. | Vaccines containing swine pathogens for associated non-mixed use |
-
2018
- 2018-04-12 CA CA3058281A patent/CA3058281A1/en active Pending
- 2018-04-12 WO PCT/EP2018/059389 patent/WO2018189290A1/en not_active Ceased
- 2018-04-12 MX MX2019012220A patent/MX390682B/es unknown
- 2018-04-12 EP EP18719484.0A patent/EP3609533A1/en not_active Ceased
- 2018-04-12 EP EP23217834.3A patent/EP4335455A3/en active Pending
- 2018-04-12 RU RU2019136252A patent/RU2756767C2/ru active
- 2018-04-12 US US16/604,188 patent/US11311614B2/en active Active
- 2018-04-12 KR KR1020197029516A patent/KR102724420B1/ko active Active
- 2018-04-12 JP JP2019555621A patent/JP7665289B2/ja active Active
- 2018-04-12 CN CN201880022778.9A patent/CN110446502B/zh active Active
-
2022
- 2022-12-06 JP JP2022194985A patent/JP2023025210A/ja not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009127684A1 (en) * | 2008-04-18 | 2009-10-22 | Intervet International B.V. | Vaccine for protection against lawsonia intracellularis, mycoplasma hyopneumoniae and porcine circo virus |
| US20130266602A1 (en) * | 2012-04-04 | 2013-10-10 | Zoetis Llc | PCV/Mycoplasma Hyopneumoniae Combination Vaccine |
Non-Patent Citations (1)
| Title |
|---|
| FANGMAN, T. et al.,Allen D. Leman Swine Conference Abstract (2011)* |
Also Published As
| Publication number | Publication date |
|---|---|
| US11311614B2 (en) | 2022-04-26 |
| RU2019136252A (ru) | 2021-05-13 |
| CN110446502A (zh) | 2019-11-12 |
| US20200046825A1 (en) | 2020-02-13 |
| MX390682B (es) | 2025-03-21 |
| JP7665289B2 (ja) | 2025-04-21 |
| WO2018189290A1 (en) | 2018-10-18 |
| CA3058281A1 (en) | 2018-10-18 |
| KR20190134650A (ko) | 2019-12-04 |
| EP4335455A2 (en) | 2024-03-13 |
| EP3609533A1 (en) | 2020-02-19 |
| CN110446502B (zh) | 2024-01-26 |
| JP2020513027A (ja) | 2020-04-30 |
| EP4335455A3 (en) | 2024-05-22 |
| JP2023025210A (ja) | 2023-02-21 |
| RU2019136252A3 (enExample) | 2021-05-13 |
| MX2019012220A (es) | 2019-12-09 |
| RU2756767C2 (ru) | 2021-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9669086B2 (en) | PCV2 Mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions | |
| JP6907227B2 (ja) | Pcv2ウイルス及びマイコプラズマ・ハイオニューモニエ感染症に対する混合ワクチン | |
| WO2008121958A1 (en) | Use of prrsv vaccines to reduce pcv2 viremia | |
| CN105579060A (zh) | Pcv2b趋异株疫苗组合物以及使用方法 | |
| TW201828982A (zh) | 抗豬小病毒及豬生殖與呼吸道症候群病毒之疫苗及其製造方法 | |
| JP2020514266A (ja) | 豚用混合ワクチン | |
| JP2023025210A (ja) | 組合せ非混合使用のためのブタ病原体含有ワクチン | |
| CN115427072A (zh) | 预防性治疗猪的疫苗组合 | |
| US11654191B2 (en) | Vaccine for intradermal application against PCV2 and PRRS virus infection | |
| RU2834834C1 (ru) | Комбинация вакцин для профилактического лечения свиней | |
| US10953084B2 (en) | Combination vaccine against PCV2 and PRRS virus infection comprising albumin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20191008 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20210309 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20230802 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20240226 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20241011 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20241028 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20241028 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration |