KR102723989B1 - 엔젤만 증후군 안티센스 치료 - Google Patents

엔젤만 증후군 안티센스 치료 Download PDF

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KR102723989B1
KR102723989B1 KR1020207016107A KR20207016107A KR102723989B1 KR 102723989 B1 KR102723989 B1 KR 102723989B1 KR 1020207016107 A KR1020207016107 A KR 1020207016107A KR 20207016107 A KR20207016107 A KR 20207016107A KR 102723989 B1 KR102723989 B1 KR 102723989B1
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artificial sequence
synthetic construct
dna
rna
modified
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KR20200094152A (ko
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스콧 빅터 딘돗
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더 텍사스 에이 & 엠 유니버시티 시스템
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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KR1020207016107A 2017-12-01 2018-11-30 엔젤만 증후군 안티센스 치료 Active KR102723989B1 (ko)

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KR1020247035783A KR20240161203A (ko) 2017-12-01 2018-11-30 엔젤만 증후군 안티센스 치료

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Application Number Priority Date Filing Date Title
US201762593431P 2017-12-01 2017-12-01
US62/593,431 2017-12-01
US201862676034P 2018-05-24 2018-05-24
US62/676,034 2018-05-24
PCT/US2018/063416 WO2019109001A1 (en) 2017-12-01 2018-11-30 Angelman syndrome antisense treatment

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KR102723989B1 true KR102723989B1 (ko) 2024-11-01

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US (5) US11198869B2 (https=)
EP (2) EP3717646B1 (https=)
JP (3) JP7297320B2 (https=)
KR (2) KR102723989B1 (https=)
CN (2) CN111433361B (https=)
AU (1) AU2018375807B2 (https=)
BR (1) BR112020009431A2 (https=)
CA (1) CA3079755A1 (https=)
CL (1) CL2020001344A1 (https=)
CO (1) CO2020006361A2 (https=)
DK (1) DK3717646T3 (https=)
ES (1) ES3032315T3 (https=)
FI (1) FI3717646T3 (https=)
HR (1) HRP20250804T1 (https=)
HU (1) HUE072645T2 (https=)
IL (1) IL274146B2 (https=)
LT (1) LT3717646T (https=)
MX (2) MX2020005680A (https=)
PE (1) PE20211238A1 (https=)
PL (1) PL3717646T3 (https=)
PT (1) PT3717646T (https=)
RS (1) RS66986B1 (https=)
RU (1) RU2020121752A (https=)
SG (1) SG11202003596WA (https=)
SI (1) SI3717646T1 (https=)
SM (1) SMT202500334T1 (https=)
WO (1) WO2019109001A1 (https=)

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US20230416851A1 (en) * 2020-10-06 2023-12-28 University Of Maryland, Baltimore Rapid diagnostic electrochemical biosensing targeted with antisense oligonucleotides
CN119384504A (zh) * 2022-03-07 2025-01-28 康涅狄格大学 靶向SNORD115位置以恢复快乐木偶综合征中父系UBE3A基因表达的shRNA
KR20250107262A (ko) 2023-01-31 2025-07-11 후지필름 가부시키가이샤 경화성 조성물, 경화물, 광학 재료, 회절 광학 소자 및 화합물
WO2025100980A1 (ko) * 2023-11-08 2025-05-15 한국과학기술원 Ube3a를 표적으로 하여 발현증강을 유도하는 안티센스 올리고뉴클레오티드 및 이의 용도
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