KR102680924B1 - 인간 항-세마포린 4d 항체 - Google Patents

인간 항-세마포린 4d 항체 Download PDF

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Publication number
KR102680924B1
KR102680924B1 KR1020197034009A KR20197034009A KR102680924B1 KR 102680924 B1 KR102680924 B1 KR 102680924B1 KR 1020197034009 A KR1020197034009 A KR 1020197034009A KR 20197034009 A KR20197034009 A KR 20197034009A KR 102680924 B1 KR102680924 B1 KR 102680924B1
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antibody
sema4d
antigen
binding
fragment
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KR20200004324A (ko
Inventor
어니스트 에스 스미스
엔젤리카 코넬리슨
마리아 쥐 엠 스크리븐스
마크 패리스
모리스 자우더러
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백시넥스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020197034009A 2017-05-05 2018-05-04 인간 항-세마포린 4d 항체 Active KR102680924B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762501981P 2017-05-05 2017-05-05
US62/501,981 2017-05-05
PCT/US2018/031263 WO2018204895A1 (en) 2017-05-05 2018-05-04 Human anti-semaphorin 4d antibody

Publications (2)

Publication Number Publication Date
KR20200004324A KR20200004324A (ko) 2020-01-13
KR102680924B1 true KR102680924B1 (ko) 2024-07-02

Family

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KR1020197034009A Active KR102680924B1 (ko) 2017-05-05 2018-05-04 인간 항-세마포린 4d 항체

Country Status (14)

Country Link
US (3) US11427634B2 (https=)
EP (1) EP3618865A4 (https=)
JP (3) JP7246320B2 (https=)
KR (1) KR102680924B1 (https=)
CN (1) CN110636858B (https=)
AU (2) AU2018261947B2 (https=)
BR (1) BR112019023138A2 (https=)
CA (1) CA3061963A1 (https=)
IL (1) IL270244B2 (https=)
MX (2) MX2019013110A (https=)
NZ (1) NZ758300A (https=)
SG (1) SG11201909466RA (https=)
WO (1) WO2018204895A1 (https=)
ZA (1) ZA201907148B (https=)

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BR112019001944A2 (pt) 2016-08-02 2019-05-07 Vaccinex, Inc. métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia
CA3061963A1 (en) * 2017-05-05 2018-11-08 Vaccinex, Inc. Human anti-semaphorin 4d antibody
AU2020322474A1 (en) 2019-08-01 2022-03-10 Vaccinex,Inc. Combined inhibition of semaphorin-4D and TGFβ and compositions therefor
CN117597360A (zh) * 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
JP2024535403A (ja) 2021-09-27 2024-09-30 バクシネックス インコーポレーティッド 神経変性障害を処置するための抗セマフォリン４ｄ結合分子の使用に関する予測アウトカムプロファイリング
US20230331863A1 (en) 2022-02-13 2023-10-19 Vaccinex, Inc. Combination therapy with semaphorin-4d blockade and htt-lowering agent for treatment of huntington's disease
KR102875105B1 (ko) * 2023-04-03 2025-10-21 주식회사 사이알바이오 재조합 세마포린 4d 차단항체를 유효성분으로 포함하는 쇼그렌 증후군 예방 또는 치료용 약학 조성물
CN117924494B (zh) * 2024-01-23 2025-02-25 首都医科大学附属北京积水潭医院 特异性结合sema4d的抗原结合蛋白及其应用
WO2026030311A1 (en) 2024-07-29 2026-02-05 Vaccinex, Inc. Use of semaphorin-4d inhibitory molecules to treat cognitive impairment
WO2026080818A1 (en) 2024-10-10 2026-04-16 Vaccinex, Inc. Use of anti-semaphorin-4d inhibitory molecules in combination with flt3 ligand to inhibit tumor growth and metastasis

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US20100285036A1 (en) 2009-05-08 2010-11-11 Vaccinex, Inc. Anti-CD100 Neutralizing Antibodies and Methods of Using the Same
JP2014530239A (ja) 2011-10-11 2014-11-17 バクシネックス インコーポレーティッド 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用
JP2017502920A (ja) 2013-10-21 2017-01-26 バクシネックス インコーポレーティッド 神経変性障害の処置のためのセマフォリン−４ｄ結合分子の使用

Also Published As

Publication number Publication date
CN110636858B (zh) 2024-03-19
JP2024081694A (ja) 2024-06-18
US20220356249A1 (en) 2022-11-10
EP3618865A1 (en) 2020-03-11
EP3618865A4 (en) 2021-05-05
IL270244B2 (en) 2025-01-01
CA3061963A1 (en) 2018-11-08
KR20200004324A (ko) 2020-01-13
JP7460819B2 (ja) 2024-04-02
WO2018204895A1 (en) 2018-11-08
RU2019131732A (ru) 2021-06-07
US20240309091A1 (en) 2024-09-19
US20210032329A1 (en) 2021-02-04
NZ758300A (en) 2025-11-28
US12006365B2 (en) 2024-06-11
ZA201907148B (en) 2025-06-25
JP2023075271A (ja) 2023-05-30
JP7246320B2 (ja) 2023-03-27
IL270244A (en) 2019-12-31
AU2018261947B2 (en) 2024-06-13
BR112019023138A2 (pt) 2020-07-28
JP2020518248A (ja) 2020-06-25
MX2023003519A (es) 2023-04-19
CN110636858A (zh) 2019-12-31
US11427634B2 (en) 2022-08-30
IL270244B1 (en) 2024-09-01
SG11201909466RA (en) 2019-11-28
AU2024204752A1 (en) 2024-08-01
MX2019013110A (es) 2019-12-16
RU2019131732A3 (https=) 2021-09-28
AU2018261947A1 (en) 2019-11-07

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