KR102679310B1 - Low-viscosity cosmetic composition containing ceramide - Google Patents

Abstract

The present invention relates to a low-viscosity cosmetic composition containing ceramide that has excellent stability without precipitating high amounts of ceramide even though it has a low viscosity, and can be used without objection by consumers who prefer a light formulation.
The cosmetic composition of the present invention contains 0.1 to 0.5% by weight of a vesicle with ceramide carrying capacity, 0.4 to 0.6% by weight of a thickener, based on the total weight, has a viscosity of less than 3,500 cps, and has a temperature of 50°C or lower. It is characterized by being manufactured through a medium-low temperature process.

Description

Low-viscosity cosmetic composition containing ceramide}

The present invention relates to a low-viscosity cosmetic composition, and more specifically, to a low-viscosity cosmetic composition containing ceramide, which has excellent stability by maintaining a stable state in which a high content of ceramide does not precipitate even though it has a low viscosity. will be.

Ceramide is one of the lipid membrane components of the stratum corneum of the epidermis among skin cells. It is a substance that protects against moisture loss from the skin surface and prevents the penetration of harmful substances from the outside. It is a sphingosine that has a structure in which a fatty acid is linked to sphingosine or phytosphingosine. It is one of the high lipids. Ceramide accounts for more than 40% of the interstitial lipids that make up the stratum corneum of the skin and is a component of the double-layer cell membrane and skin lipid membrane. Additionally, ceramide is an essential ingredient in the formation and function of the stratum corneum, and ceramides present in the human body are classified into various types depending on the degree of polarity.

Such ceramide is an important element of the skin barrier. It functions as a lipid barrier to suppress evaporation of moisture and maintains the orderly structure of the stratum corneum. It is biocompatible and has an excellent moisturizing effect, and is especially effective in treating atopic dermatitis symptoms. It is known that applying high-content pure ceramide to skin barrier dysfunction conditions such as skin psoriasis can help restore skin barrier function. However, the technical limitation of not being able to apply a sufficient amount of pure ceramide during the actual commercialization process is pure ceramide. This is due to the fact that ceramide is poorly soluble in both water and oil, and due to the physical and chemical properties of ceramide, it is difficult to ensure the usability, transparency, and formulation stability of cosmetics, so there is a limit to its application in cosmetic formulations.

Looking at the technology of applying ceramide to cosmetics, the cosmetic composition containing a cosmetic vehicle containing a high content of poorly soluble substances (Patent Registration No. 10-1985277) is a composition that supports ceramide in a shell containing fatty acid ester. It is a cosmetic composition manufactured by manufacturing an anhydrous type vesicle, but the formulation example presented in the above patent has the problem of being manufactured at a high temperature of 90°C.

In addition, a method of using ceramide by nano-emulsifying it (Patent Registration No. 10-1529480) has been attempted, but the amount of ceramide that can be stably added to cosmetics is small, and the surfactant used for emulsifying it can irritate the skin. There are problems such as causing skin problems.

Patent Registration No. 10-1985277 (registered on May 28, 2019) Patent registration No. 10-1529480 (registered on June 11, 2015)

The technical problem that the present invention aims to solve is a product containing ceramide that has excellent stability by maintaining a stable state in which the high content of ceramide does not precipitate even though it has a low viscosity, and can be used without objection by consumers who prefer a light formulation. The aim is to provide a low viscosity cosmetic composition.

The low-viscosity cosmetic composition containing ceramide of the present invention contains 0.1 to 0.5% by weight of vesicles with ceramide carrying capacity, 0.4 to 0.6% by weight of thickener, and has a viscosity of 3,500 cps based on the total weight. It is characterized by being manufactured through a low- to medium-temperature process of 50°C or lower.

Preferably, the vesicle is a cosmetic composition comprising ceramide, fatty acid ester, solvent, gelling agent, and gel stabilizer. Ceramide is contained in an amount of 30 to 50% by weight based on the total weight of the vesicle, and fatty acid ester is glyceryl citrate/lactate/linoleate/oleate, the solvent is dipropylene glycol and dibutyl adipate, the gelling agent is sodium dilaumidoglutamide lysine, and the gel stabilizer is glyceryl stear. These are lecithin, hydrogenated lecithin, and PEG-100 stearate.

The cosmetic composition of the present invention is provided in the form of a gel or toner containing a high content of ceramide. The cosmetic composition contains a vesicle containing a high content of ceramide, a thickener capable of stabilizing the vesicle, other preservatives, polyhydric alcohol, chelating agent, etc. It contains ceramide, a poorly soluble substance, and maintains a stable state even though it has a low viscosity after undergoing a low-to-medium temperature process below 50℃. This type of cosmetic composition has excellent stability because it maintains a stable state in which ceramide does not precipitate even in storage tests under harsh conditions, and it is possible to manufacture a low-viscosity cosmetic composition containing a high content of ceramide, which can be rejected by consumers who prefer light formulations. It has an effect that can be used without it.

Figure 1 is a photograph of the cosmetic composition that was subjected to the stability test of Example 1 for 6 months. From the left, acceleration test (50℃), long-term storage test (25℃), severe test (5℃), and severe test (-5∼ This is a photo after 50℃ temperature cycling.

Hereinafter, the present invention will be described in detail.

The low-viscosity cosmetic composition containing a high content of ceramide of the present invention contains 0.1 to 0.5% by weight of vesicles, 0.4 to 0.6% by weight of a thickener capable of stabilizing the vesicles, other preservatives, and polyhydric alcohols, based on the total weight of the cosmetic composition. , and a chelating agent, and the ceramide in the cosmetic composition is characterized in that it contains 30 to 50% by weight based on the total weight of the vesicle.

The vesicle with ceramide carrying capacity of the present invention was developed in prior research (Patent Registration No. 10-1985277), and is a cosmetic vegetable containing a shell containing fatty acid ester and containing a high content of poorly soluble substances. It's big. Vesicles with ceramide carrying capacity are included in an amount of 0.1 to 0.5% by weight based on the total weight of the cosmetic composition. If it is less than 0.1% by weight, it does not meet the purpose of the present invention of containing a high content of ceramide, and if it exceeds 5% by weight, it is difficult to ensure uniformity of effect because it does not mix well in the cosmetic composition.

The ceramide of the present invention is one of the sphingolipids having a structure in which a fatty acid is linked to sphingosine or phytosphingosine, and has the role of a lipid barrier to suppress evaporation of moisture from the skin barrier and the function of maintaining the ordered structure of the stratum corneum. there is. Ceramide is contained in an amount of 30 to 50% by weight based on the total weight of the vesicle. If it is less than 30% by weight, it does not meet the purpose of the present invention of containing a high content of ceramide, and if it exceeds 50% by weight, it is unstable and may precipitate within the cosmetic composition.

The thickener of the present invention uses ammonium acryloyldimethyl taurate/VP copolymer. The thickener is included in an amount of 0.4 to 0.6% by weight based on the total weight of the cosmetic composition. If it is less than 0.4% by weight, ceramide may precipitate due to insufficient viscosity, and if it exceeds 0.6% by weight, it is not suitable for making a low-viscosity cosmetic composition. The viscosity of the cosmetic composition made with the selected thickener is preferably less than 3,500 cps.

The preservative of the present invention is added to preserve cosmetics for a long period of time, and includes an appropriate amount mainly used by people with ordinary knowledge in the industry within the usage limit notified by the Minister of Food and Drug Safety.

Polyhydric alcohol is a raw material added to moisturize the skin. It is used in an appropriate amount according to the degree of moisturization of the cosmetic composition aimed by the manufacturer, and the limit is not set separately.

Chelating agents are added to block metal ions in cosmetic compositions, and include an appropriate amount that is mainly used by those with ordinary knowledge in the industry.

Meanwhile, the low-viscosity cosmetic composition containing a high content of ceramide of the present invention is used in a group of cosmetic formulations consisting of skin lotion, skin softener, and essence.

Hereinafter, the present invention will be described in detail through the following examples. However, the present invention is not limited to the examples.

<Experimental Example 1> Manufacturing of vesicles with ceramide carrying capacity

By partially changing the prescription in [Table 4] of the previous study (Patent Registration No. 10-1985277), a vesicle with ceramide carrying capacity according to the ingredients listed in [Table 1] below was manufactured. Specifically, components 1 to 4 were heated and mixed at 70 to 80°C, then components 5 to 7 were added and stirred. Afterwards, the mixture was cooled to 50°C and post-treated 2 to 3 times in a Microfluidizer at a pressure of 1,000 to 1,500 bar.

Prescription of vesicles with ceramide carrying capacity No Ingredient name weight % One Glyceryl citrate/lactate/linoleate/oleate 30.2 2 Dibutyl adipate 17.5 3 Dipropylene glycol 10 4 Glyceryl Stearate & PEG-100 Stearate 5 5 Ceramide NP 33.3 6 Hydrogenated Lecithin 3 7 Sodium dilauramidoglutamide lysine One

<Experimental Example 2> Preparation of cosmetic composition

Cosmetic compositions of Examples 1 and 2 and Comparative Examples 1 and 2 were prepared using the ingredients listed in Table 2 below. Specifically, component 1 and component 2 are dispersed at room temperature, component 3 and component 4 are dispersed at room temperature, then components 5 to 7 are added and mixed at 45 to 50°C, then cooled to 30°C and discharged.

Prescription of cosmetic composition No Ingredient name Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Example 2
(weight%) One Purified water To 100 To 100 To 100 To 100 2 Ammonium Acryloyl Dimethyl Taurate/VPicopolymer 0.5 0.2 0.3 0.6 3 Dipropylene glycol 8 8 8 8 4 xanthan gum 0.03 - - - 5 1,2-hexanediol 2 2 2 2 6 Vesicle with ceramide carrying capacity of Experimental Example 1 0.3 0.3 0.3 0.3 7 Disodium EDTA 0.03 0.03 0.03 0.03 Viscosity (cps) 3,430 40 100 3,180

<Experimental Example 3> Stability test

Using the Examples and Comparative Examples prepared through Experimental Example 2 above, accelerated tests, long-term storage tests, and stress tests were conducted according to the Cosmetic Stability Test Guidelines (Ministry of Food and Drug Safety, June 2011) as shown in Figure 1. . Immediately after the experiment, cosmetics and cosmetics stored for 6 months at each temperature were sensory evaluated for differences in uniformity, odor, color, and feeling of use, which are general test items for cosmetics, and the results were reported in [Table 3], [Table 4], [ It is shown in [Table 5] and [Table 6].

Accelerated test results of manufactured examples and comparative examples accelerated test
(50℃) Example 1 Comparative Example 1 Comparative Example 2 Example 2 uniformity no change Precipitation occurs no change no change scent no change no change no change no change color no change no change no change no change feeling of use no change no change no change no change

Long-term storage test results of manufactured examples and comparative examples Long-term preservation test
(25℃) Example 1 Comparative Example 1 Comparative Example 2 Example 2 uniformity no change Precipitation occurs no change no change scent no change no change no change no change color no change no change no change no change feeling of use no change no change no change no change

Stress test results of manufactured examples and comparative examples harsh test
(5℃) Example 1 Comparative Example 1 Comparative Example 2 Example 2 uniformity no change Precipitation occurs Precipitation occurs no change scent no change no change no change no change color no change no change no change no change feeling of use no change no change no change no change

Stress test results of manufactured examples and comparative examples harsh test
(-5~50℃ temperature circulation) Example 1 Comparative Example 1 Comparative Example 2 Example 2 uniformity no change Precipitation occurs Precipitation occurs no change scent no change no change no change no change color no change no change no change no change feeling of use no change no change no change no change

As a result of the measurement, no significant changes occurred in scent, color, or feeling of use in all examples. However, in Comparative Example 1, ceramide precipitated in the form of a band at the top under all conditions, and in Comparative Example 2, as a result of the stress test, ceramide was in the form of powder. It was confirmed that it precipitated.

<Experimental Example 4> Quality evaluation

After using the cosmetic composition in Example 1 on 20 random adults, the quality was evaluated using a 5-point evaluation method for a total of 6 items: skin absorption / skin moisture / skin oiliness / feeling of use / degree of improvement in skin condition / excellence of quality. , The detailed survey results are shown in [Table 7].

Quality evaluation results of the manufactured Example 1 and cosmetic composition No. skin absorption skin moisturization skin oiliness feeling of use Degree of improvement in skin condition excellence in quality One 3 5 5 3 4 4 2 4 4 4 4 4 3 3 4 4 3 4 3 4 4 3 4 2 5 4 4 5 4 3 3 4 3 3 6 3 4 3 4 3 4 7 5 5 4 4 4 4 8 4 5 3 4 3 4 9 2 3 2 3 3 3 10 5 4 3 3 4 4 11 4 3 3 4 3 4 12 2 2 4 2 3 3 13 4 4 4 4 3 4 14 4 3 3 4 3 3 15 5 2 2 4 3 3 16 4 4 3 4 3 3 17 4 5 4 4 3 4 18 4 4 3 4 4 4 19 4 4 4 4 3 4 20 3 4 4 4 3 3 average 3.75 3.80 3.30 3.80 3.30 3.60 overall average 3.59

As a result of the survey, it was confirmed that the overall average score was 3.59, indicating that the product quality was above average.

Claims (4)

It contains 0.1 to 0.5% by weight of a vesicle with ceramide carrying capacity and 0.4 to 0.6% by weight of a thickener that can stabilize the vesicle,
The viscosity is less than 3,500cps, and it is manufactured through a medium-low temperature process below 50℃.
Contains preservatives, polyhydric alcohols, and chelating agents.
The vesicle is a cosmetic composition comprising ceramide, fatty acid ester, solvent, gelling agent, and gel stabilizing agent,
The ceramide is contained in an amount of 30 to 50% by weight based on the total weight of the vesicle,
The fatty acid ester is glyceryl citrate/lactate/linoleate/oleate,
The solvents are dipropylene glycol and dibutyl adipate,
The gelling agent is sodium dilaumidoglutamidrisine,
A low-viscosity cosmetic composition containing ceramide, wherein the gel stabilizer is glyceryl stearate, hydrogenated lecithin, and PEG-100 stearate.
delete According to paragraph 1,
A cosmetic composition, characterized in that the thickener is ammonium acryloyldimethyl taurate/V picopolymer.
Any one cosmetic formulation selected from the group consisting of skin lotion, skin softener, and essence containing the cosmetic composition of claim 1 as an active ingredient.