KR102627418B1 - 변형된 올리고뉴클레오티드 및 사용 방법 - Google Patents

변형된 올리고뉴클레오티드 및 사용 방법 Download PDF

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KR102627418B1
KR102627418B1 KR1020237006131A KR20237006131A KR102627418B1 KR 102627418 B1 KR102627418 B1 KR 102627418B1 KR 1020237006131 A KR1020237006131 A KR 1020237006131A KR 20237006131 A KR20237006131 A KR 20237006131A KR 102627418 B1 KR102627418 B1 KR 102627418B1
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oligonucleotide
nucleotides
modified
sequence
hbv
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KR20230033736A (ko
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세르게이 그랴즈노프
레오니드 베이겔만
진 홍
비베크 라즈완시
몬테로 사울 마르티네즈
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얀센 바이오파마, 인크.
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
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    • C12N2310/30—Chemical structure
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    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020237006131A 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법 Active KR102627418B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247001776A KR20240010761A (ko) 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662394739P 2016-09-14 2016-09-14
US201662394738P 2016-09-14 2016-09-14
US62/394,739 2016-09-14
US62/394,738 2016-09-14
PCT/US2017/051644 WO2018053185A1 (en) 2016-09-14 2017-09-14 Modified oligonucleotides and methods of use
KR1020197010486A KR102533038B1 (ko) 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법

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KR20230033736A KR20230033736A (ko) 2023-03-08
KR102627418B1 true KR102627418B1 (ko) 2024-01-19

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KR1020237006131A Active KR102627418B1 (ko) 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법
KR1020197010486A Active KR102533038B1 (ko) 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법
KR1020247001776A Abandoned KR20240010761A (ko) 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법

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KR1020247001776A Abandoned KR20240010761A (ko) 2016-09-14 2017-09-14 변형된 올리고뉴클레오티드 및 사용 방법

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US (3) US10793859B2 (enExample)
EP (1) EP3512949A1 (enExample)
JP (3) JP6970187B2 (enExample)
KR (3) KR102627418B1 (enExample)
CN (1) CN109952378B (enExample)
AU (2) AU2017326372B2 (enExample)
BR (1) BR112019004911A2 (enExample)
CA (1) CA3037042A1 (enExample)
IL (2) IL265359B2 (enExample)
MA (1) MA46422A (enExample)
MX (2) MX2019002960A (enExample)
TW (1) TWI769177B (enExample)
WO (1) WO2018053185A1 (enExample)

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WO2021198958A1 (en) * 2020-04-01 2021-10-07 Janssen Biopharma, Inc. Nucleic acid polymers
US20220056451A1 (en) * 2020-07-27 2022-02-24 Aligos Therapeutics, Inc. Hbv binding oligonucleotides and methods of use
CN114057816B (zh) * 2020-07-30 2025-02-11 浙江柏拉阿图医药科技有限公司 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用
JP7517475B2 (ja) 2021-01-12 2024-07-17 日本電気株式会社 秘密計算システム、秘密計算サーバ装置、秘密計算方法および秘密計算プログラム
TW202340468A (zh) 2022-01-10 2023-10-16 中國大陸商杭州浩博醫藥有限公司 B型肝炎病毒(hbv)表現之調節
TW202508607A (zh) * 2023-05-19 2025-03-01 大陸商北京炫景瑞醫藥科技有限公司 雙股寡核苷酸及其共軛物和用途
US20250345389A1 (en) * 2024-05-13 2025-11-13 Gilead Sciences, Inc. Combination therapies

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