KR102607435B1 - Composition for improved of respiratory disease comprising complex distilled extracts of a mulberry tree as active ingredient - Google Patents

Abstract

The present invention relates to a beverage composition for improving respiratory diseases containing a complex distilled extract of Kujippong as an active ingredient, and more specifically, to a beverage composition for improving respiratory diseases comprising a complex distilled extract of Cudrania mulberry. Contains 1 part by weight of hot water extract of leaves and stems, 2.5 to 5.5 parts by weight of distilled extract of Cudrania mulberry tree, and 0.1 to 0.5 part by weight of distilled-electrolyzed extract of Cudrania tree,
The distilled extract of the Cudrania tree is obtained by heating a heating container in which the Cudrania tree, which includes the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less, is stored at a temperature of 420 to 500 ° C. Heat for 1 to 2 hours, and indirectly heat at a temperature of 60 to 80 ℃ for 3 to 4 hours to obtain water vapor that escapes from the Cudrania tree and evaporate, and cool and condense the water vapor to a temperature of 3 to 10 ℃ to obtain an extract. Step 1 of manufacturing; Step 2 of producing a redistilled extract by concentrating the extract at 0.7 to 0.9 atm and 65 to 75°C for 1 to 2 hours to obtain evaporated water vapor and cooling and condensing the extract to a temperature of 3 to 10°C; And step 3 of repeating step 2 of the redistilled extract 2 to 5 times to produce a distilled extract of Cudrania tree;
The distillation-electrolysis extract of the Cudrania tree is obtained by heating a heating container containing the Cudrania tree, which includes the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less, at 420 to 500 degrees Celsius. Heating at a temperature of ℃ for 1 to 2 hours, indirectly heating at a temperature of 60 to 80 ℃ for 3 to 4 hours to obtain water vapor that escapes from the Cudrania tree and evaporate, and cooling and condensing the water vapor to a temperature of 3 to 10 ℃. Step 1 of producing an extract; Step 2 of preparing an electrolyzed extract by adding the cooled and condensed extract to an electrolyte solution with a concentration of 0.25 to 0.5 M and electrolyzing it at a glow discharge voltage of 10 to 280 V for 10 to 90 minutes; And a third step of indirectly heating the electrolyzed extract at a temperature of 90 to 100 ° C. for 30 minutes to 1 hour to obtain evaporating water vapor and cooling and condensing it to a temperature of 3 to 10 ° C. to prepare a distillation-electrolyzed extract. It is manufactured by a method containing,
The present invention relates to a beverage composition for improving respiratory diseases, which is non-toxic to the human body, can be used without the burden of fragrance, and contains as an active ingredient a complex distilled extract of Cudrania mulberry, which is highly effective in improving various respiratory diseases such as asthma and bronchitis.

Description

Beverage composition for improving respiratory disease comprising complex distilled extract of kkujippong as an active ingredient {Composition for improved of respiratory disease comprising complex distilled extracts of a mulberry tree as active ingredient}

The present invention contains Cudrania columbine complex distilled extract as an active ingredient, so it is non-toxic to the human body and can be used without burdening the scent, and contains Cudrania columbine complex distilled extract as an active ingredient, which is excellent in improving various respiratory diseases such as asthma and bronchitis. It relates to a beverage composition for improving respiratory diseases.

Recently, respiratory diseases are rapidly increasing due to environmental pollution and changes in dietary habits due to the development of industrial economy. Asthma, a representative respiratory disease, is a disease in which symptoms such as difficulty breathing, coughing, and loud, rough breathing (wheezing) appear repeatedly and paroxysm. However, in reality, asthma patients often complain of atypical symptoms in addition to typical asthma symptoms. In other words, there are cases where there are no symptoms such as difficulty breathing or wheezing, but only a dry cough that appears repeatedly, chest tightness or chest pressure, or only symptoms like phlegm stuck in the throat.

Bronchitis is divided into acute and chronic, and the main symptoms are chronic cough, phlegm, and difficulty breathing during exercise. Phlegm is usually white or slightly yellow, mucoid, and tends to come out in large quantities in the morning. As the disease progresses, shortness of breath gradually worsens over several months to years, leading to difficulty breathing even with the slightest activity. By cause, there are allergic, infectious, and traumatic causes, and pathologically, there are catarrhal, purulent, ulcerative, and infiltrative causes. The most common cause is infections such as bacteria, viruses, and fungi, and even people who are not normally infected are susceptible to infection when the body's resistance is weakened.

Allergic rhinitis is also called nasal allergy or allergic rhinitis. Symptoms include sudden and continuous sneezing, large amounts of watery nasal discharge (clear nasal mucus), nasal congestion, and at the same time, headache and watery eyes. When the symptoms are very similar but the antigen is not clear, it is called vasomotor rhinitis. In other words, if you look at it in a single day, the symptoms mentioned above may occur when you wake up in the morning and your body has temporarily cooled down, and then get better within a few hours, and they often occur during seasonal changes or cold seasons throughout the year. It is often confused with a nasal cold, but it is different from a cold and is often combined with asthma or hives.

As mentioned above, there are some differences in the causes and symptoms of respiratory diseases such as asthma, acute and chronic bronchitis, and allergic rhinitis. Although the development of new drugs is progressing according to respiratory diseases, they only show temporary effects and the symptoms worsen day by day. The problem is aggravating.

As mentioned above, in order to eliminate the side effects and resistance of synthetic chemical new drugs, efforts are being made to develop compositions to improve the treatment of respiratory diseases using medicinal plants to solve these problems with 100% natural ingredients, but the effectiveness is significantly lower than that of actual synthetic chemical new drugs. There was a problem.

Republic of Korea Patent Publication No. 2022-0078140 Republic of Korea Patent Registration No. 10-2117520

The present invention was devised to solve the above-mentioned problems. One embodiment of the present invention is non-toxic to the human body, can be used without burden of scent, and can achieve excellent improvement effects on various respiratory diseases such as asthma and bronchitis. The purpose of the present invention is to provide a beverage composition for improving respiratory diseases containing the complex distilled extract of Kujippong as an active ingredient.

The various problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

One embodiment of the present invention is a beverage composition for improving respiratory diseases comprising a complex distilled extract of Cudrania mulberry, wherein the complex distilled extract of Cudrania mulberry contains 1 part by weight of hot water extract of Cudrania leaf and stem, 2.5 to 5.5 parts by weight of distilled extract of Cudrania tree, and Contains 0.1 to 0.5 parts by weight of distilled-electrolyzed extract of Cudrania mulberry tree,

The distilled extract of the Cudrania tree is obtained by heating a heating container in which the Cudrania tree, which includes the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less, is stored at a temperature of 420 to 500 ° C. Heat for 1 to 2 hours, and indirectly heat at a temperature of 60 to 80 ℃ for 3 to 4 hours to obtain water vapor that escapes from the Cudrania tree and evaporate, and cool and condense the water vapor to a temperature of 3 to 10 ℃ to obtain an extract. Step 1 of manufacturing; Step 2 of producing a redistilled extract by concentrating the extract at 0.7 to 0.9 atm and 65 to 75°C for 1 to 2 hours to obtain evaporated water vapor and cooling and condensing the extract to a temperature of 3 to 10°C; And step 3 of repeating step 2 of the redistilled extract 2 to 5 times to produce a distilled extract of Cudrania tree;

The distillation-electrolysis extract of the Cudrania tree is obtained by heating a heating container containing the Cudrania tree, which includes the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less, at 420 to 500 degrees Celsius. Heating at a temperature of ℃ for 1 to 2 hours, indirectly heating at a temperature of 60 to 80 ℃ for 3 to 4 hours to obtain water vapor that escapes from the Cudrania tree and evaporate, and cooling and condensing the water vapor to a temperature of 3 to 10 degrees Celsius. Step 1 of producing an extract; Step 2 of preparing an electrolyzed extract by adding the cooled and condensed extract to an electrolyte solution with a concentration of 0.25 to 0.5 M and electrolyzing it at a glow discharge voltage of 10 to 280 V for 10 to 90 minutes; And a third step of indirectly heating the electrolyzed extract at a temperature of 90 to 100 ° C. for 30 minutes to 1 hour to obtain evaporating water vapor and cooling and condensing it to a temperature of 3 to 10 ° C. to prepare a distillation-electrolyzed extract. The object is to provide a beverage composition for improving respiratory diseases prepared by a method comprising:

The hot water extract of the Cudrania leaves and stems includes the steps of drying the washed Cudrania leaves and stems with hot air at a temperature of 55 to 65°C; Add 10 to 25 times the weight of water and 0.1 to 0.5 times the weight of neem fermented extract compared to the weight of the dried Cudrania leaves and stems, heat at a temperature of 100 to 120 ° C. for 0.5 to 1 hour, and then heat to 65 to 75 ° C. Preparing an aqueous extract by extracting at a temperature of ℃ for 3 to 5 hours; And it can be prepared by a method including the step of heating the extract to 75 to 90 ° C and keeping it warm for 15 to 30 minutes to deactivate the enzyme.

The neem fermented extract is prepared by adding 8 to 18 times the weight of water compared to the weight of neem fruit and extracting it for 1.5 to 3 hours at a pressure of 0.7 to 0.8 atmosphere and a temperature of 85 to 105 ° C. to prepare a water extract of neem tree. It can be prepared by a method comprising the step of inoculating the prepared neem water extract with Lactobacillus delbrueckii to produce a neem fermented extract.

The electrolyte solution of the distilled-electrolyzed extract of Cudrania mulberry tree is an aqueous solution of at least one organic acid selected from the group consisting of citric acid (C ₆ H ₈ O ₇ ), formic acid (HCOOH), acetic acid (CH ₃ COOH), and mixtures thereof. It is mixed with fermented bead tree extract at a weight ratio of 1:0.05 to 0.3;

The neem fermented extract is prepared by adding 8 to 18 times the weight of water compared to the weight of neem fruit and extracting it for 1.5 to 3 hours at a pressure of 0.7 to 0.8 atmosphere and a temperature of 85 to 105 ° C. to prepare a water extract of neem tree. It can be prepared by a method comprising the step of inoculating the prepared neem water extract with Bifidobacterium longum to prepare a neem fermented extract.

Another embodiment of the present invention seeks to provide a beverage for improving respiratory diseases comprising the beverage composition for improving respiratory diseases.

A beverage for improving respiratory diseases containing the complex distilled extract of Kujippong as an active ingredient according to an embodiment of the present invention reduces the risk of various respiratory diseases such as asthma and bronchitis caused by environmental pollution (fine dust, etc.), irregular lifestyle, and stress. It can be useful for modern people who are exposed to it.

A beverage for improving respiratory diseases containing a complex distilled extract of Kujippong as an active ingredient according to an embodiment of the present invention uses highly purified, concentrated complex distilled extract of Cujippong, but is non-toxic, has fewer side effects on the human body, and has a pleasant flavor. It has the advantage of being able to be applied casually as a beverage.

1 is a schematic diagram showing the overall layout of a distillation extraction facility according to an embodiment of the present invention.
Figure 2 is a cross-sectional view showing a distiller in a distillation extraction facility according to an embodiment of the present invention.
Figure 3 is a cross-sectional view showing a condenser in a distillation extraction facility according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail. However, this is presented as an example, and the present invention is not limited thereby, and the present invention is only defined by the scope of the claims to be described later.

One embodiment of the present invention is a beverage composition for improving respiratory diseases comprising a complex distilled extract of Cudrania mulberry, wherein the complex distilled extract of Cudrania mulberry contains 1 part by weight of hot water extract of Cudrania leaf and stem, 2.5 to 5.5 parts by weight of distilled extract of Cudrania tree, and Contains 0.1 to 0.5 parts by weight of distilled-electrolyzed extract of Cudrania mulberry tree.

The hot water extract of Cudrania leaves and stems according to an embodiment of the present invention includes the steps of drying washed Cudrania leaves and stems with hot air at a temperature of 55 to 65°C; Add 10 to 25 times the weight of water compared to the weight of the dried Cudrania leaves and stems, heat at a temperature of 100 to 120 ℃ for 0.5 to 1 hour, and then extract at a temperature of 65 to 75 ℃ for 3 to 5 hours to obtain water. Preparing an extract; And it can be prepared by a method including the step of heating the extract to 75 to 90 ° C and keeping it warm for 15 to 30 minutes to deactivate the enzyme.

The hot water extraction is a method commonly used in the art, but in the present invention, in order to increase the effect of improving respiratory diseases and reduce the toxicity of the hot water extract of Cudrania leaves and stems, Cudrania leaves and stems obtained under the above temperature and time conditions are used. It is preferable to use the hot water extract of the stem. In particular, it is desirable to maintain the stability of the hot water extract of Cudrania leaves and stems through an enzyme deactivation step as described above. The water used during the hot water extraction is preferably purified water.

In addition, it is preferable to use the hot water extract of Cudrania leaves and stems by mixing a fermented extract of Neem tree with water as an extraction solvent at a certain ratio. Specifically, hot air drying the washed kkujippong leaves and stems at a temperature of 55 to 65°C; Add 10 to 25 times the weight of water and 0.1 to 0.5 times the weight of neem fermented extract compared to the weight of the dried Cudrania leaves and stems, heat at a temperature of 100 to 120 ° C. for 0.5 to 1 hour, and then heat to 65 to 75 ° C. Preparing an aqueous extract by extracting at a temperature of ℃ for 3 to 5 hours; And it can be prepared by a method including the step of heating the extract to 75 to 90 ° C and keeping it warm for 15 to 30 minutes to deactivate the enzyme.

The neem tree (Cedrela fissilis) acts to inhibit airway contraction and suppress airway inflammation. The present invention uses a fermented extract obtained by fermenting the extract of the Neem tree using specific bacteria to not only activate the inhibition of contraction of the airway and improve the inhibition of inflammation in the airway, but also to provide a smooth throat sensation when applied as a beverage.

The neem fermented extract is prepared by adding 8 to 18 times the weight of water compared to the weight of neem fruit and extracting it for 1.5 to 3 hours at a pressure of 0.7 to 0.8 atmosphere and a temperature of 85 to 105 ° C. to prepare a water extract of neem tree. It can be prepared by a method comprising the step of inoculating the prepared neem water extract with Lactobacillus delbrueckii to produce a neem fermented extract.

The neem tree is a deciduous broad-leaved tree belonging to the neem family and the neem genus. In oriental medicine, the fruit is called cheonryeonja and the root bark is called goryeonpi. In the present invention, the extract of Neem tree can be used as a part of the plant, such as flowers, fruits, leaves, roots, etc., or extracts from whole plants, and considering extraction efficiency, etc., neem fruit is preferable. Additionally, it is okay to use commercially available products.

Lactobacillus delbrueckii used in the present invention is not particularly limited, but may be a bacterium or a mutant thereof used in public institutions, a bacteria isolated from nature, or a mutant strain thereof. The mutant strain may be a strain that has the ability to produce a fermented product showing the effect of the present invention.

At this time, the hot water treatment temperature and time, enzyme deactivation temperature and time, and fermentation treatment temperature and time are each in the optimal range for maximizing the yield of the hot water extract and the activity of the fermenting bacteria.

The neem fermented extract is preferably contained in a weight ratio of 0.1 to 0.5 times the weight of dried Cudrania leaves and stems. If the content is less than 0.1 times, the effect may be minimal, and if the content is more than 0.5 times. It has a burdensome aroma and taste, which may limit its use as a beverage.

The distilled extract of Cudrania tree according to one embodiment of the present invention is preferably extracted using the distillation extraction equipment shown in Figures 1 to 3 below. Specifically, FIG. 1 is a schematic diagram showing the overall layout of a distillation extraction facility according to an embodiment of the present invention, FIG. 2 is a cross-sectional view showing a distiller in a distillation extraction facility according to an embodiment of the present invention, and FIG. 3 is a schematic diagram showing the overall layout of a distillation extraction facility according to an embodiment of the present invention. This is a cross-sectional view showing a condenser in a distillation extraction facility according to an embodiment of.

As shown in FIGS. 1 to 3, the distillation and extraction equipment includes a distiller 17 as a means for distilling natural materials such as trees and leaves derived from the Cudrania tree with water and heating them.

The still 17 includes a still body 13 surrounded by a heater 10 and a firebrick 11 and supported on a frame 12, and a pipe pipe extending toward the condenser 23 at the upper end ( It consists of a still cover (16) equipped with an evaporation vapor outlet (14) to which 18) is connected.

Here, a portion of the pipe piping 18 connected to the evaporation vapor outlet 17 is made of a flexible pipe and can be deformed together when the still cover 16 is opened and closed, and thus the still cover 16 It is possible to exclude interference due to pipe piping during the opening and closing operation of .

The still body 13 is in the form of a circular container and may have a double body structure in which two stainless steel sheets with different thicknesses overlap to form an inner wall and an outer wall.

The red clay wall 34 may be applied to the outer wall of the still body 13 to a thickness of approximately 5 to 20 cm.

At this time, in order to allow the far-infrared rays generated from the red clay wall 34 to be irradiated to the wooden material (e.g., Cudrania mulberry) contained inside the container, a plurality of far-infrared ray irradiation holes (not shown) are penetrated through the inner and outer walls of the container. It is desirable to form

The still cover 16 serves to seal the still body 13 containing wood-like material, and is installed on the top of the still body 13 in a structure that can be opened and closed by rotating by a hinge portion 48. .

For this purpose, an actuator 15, for example, a cylinder, is installed on the side of the still body 13, and the rod of the cylinder installed in this way is connected to a cover arm 35 extending on the side of the still cover 16. .

Accordingly, when the actuator 15 is operated, the still cover 16 can be rotated about 90° using the hinge portion 48 to open or close the still body 13.

In addition, the still cover 16 is equipped with a safety valve 36 that opens when the internal temperature of the still body 13 is above a certain temperature, as well as a temperature sensor (not shown) that detects the internal temperature of the still body 13. do.

Accordingly, when the internal temperature of the still body 13 exceeds the preset temperature, for example, 400 to 450° C., the safety valve 36 opens, thereby preventing the internal pressure of the still body from becoming excessively high.

In this regard, it is preferable that the internal temperature of the still body 13 is maintained at a maximum of about 350 to 400 ° C.

In addition, the refractory bricks 11 are built in a structure that surrounds the wall and floor of the still body 13, and a space is formed between the refractory wall 11 and the still body 13. 37) is created.

In addition, a heater 10 is installed along the inner surface of the refractory brick 11, and at this time, the heater 10 is a heater that generates heat up to about 900 ℃ so that the internal temperature of the still body 13 is 350 to 400 C. It is desirable to maintain the temperature around ℃.

Here, the heater 10 can be controlled by a control box 38 that receives a signal from a temperature sensor and outputs a control signal.

In a preferred embodiment, in addition to the evaporated vapor that mostly escapes through the top of the still 17, the remaining evaporated vapor that collects inside the still 17, that is, at the bottom of the still 13, is stored at the bottom of the still 13. Of course, a liquid extract sub-container 46 is installed as a means of recovering the liquid extract, and the liquid extract sub-container 46 installed in this way also contains a liquid extract, for example, a liquid extract of the active ingredient such as sap of a Cudrania tree. can be obtained.

For this purpose, an outlet 42 is formed in the lower part of the still body 13, and a liquid extract sub-vessel 46 is connected to the outlet 42 formed in this way using a screw fastening structure.

In addition, a cooling water jacket 43 for circulation of cooling water is installed on the outer wall of the liquid extract sub-vessel 46, and accordingly, moisture and/or water vapor discharged from the outlet 42 of the still main body 13 is used in the liquid extract. When it enters the sub container 46, condensation occurs due to the temperature difference due to the heat exchange effect with the coolant flowing through the coolant jacket 43, and eventually the liquid extract (sap) can also collect inside the liquid extract sub container 46. do.

In addition, a sub outlet 44 and a sub valve 45 for recovery of the liquid extract are installed at the bottom of the liquid extract sub container 46, through which the liquid extract (sap) can be recovered.

Here, the unexplained symbol 47 represents a filter installed at the extract port 42 to prevent impurities from flowing into the liquid extract sub-container 46.

In addition, the distillation extraction equipment includes a condenser 23 as a means of cooling the evaporated vapor generated in the distiller 17 into a liquid extract.

At the lower end of the condenser 23, there is an evaporated vapor inlet 19 connected to the evaporated vapor outlet 14 on the side of the distiller 17 and a pipe piping 18, as well as a liquid extract inlet 21 of the tank 20. A liquid extract outlet (22) is formed connected to the side by a pipe (18).

Here, it is recommended to use at least one condenser 23, preferably two connected in series.

These condensers 23 are isolated from each other and cool the evaporated vapor using heat exchange between the evaporated vapor and circulating water (e.g., cooling water) flowing inside, and eventually obtain a liquid extract from the evaporated vapor cooled by heat exchange. It becomes possible.

For this purpose, the condenser 23 includes a condenser body 31, a tube 32, and a plurality of perforated plates 33, and the condenser body 31 has an evaporation vapor inlet 19 and a liquid extract outlet at the bottom. (22), and a circulating water inlet 29 and a circulating water outlet 30 at the upper and lower ends, respectively, and maintain an inclined position at a certain angle, and the tube 32 is connected to the condenser body 31. It is installed in a structure connected to the evaporation vapor inlet 19 and the liquid extract outlet 22 from the inside to provide a flow passage for evaporation vapor, and the perforated diaphragm 33 is located inside the condenser body 31 along the length of the condenser body. It is installed in a zigzag form while maintaining regular intervals along the direction, leading to a zigzag flow of circulating water.

Here, the evaporated vapor that enters the lower space of the condenser 23 through the evaporated vapor inlet 19 flows upward along the tube 32, is sent to the upper space of the condenser 23, and then continues along the tube 32. It is induced and exits through the liquid extract outlet (22).

At this time, while the evaporated vapor flows along the inside of the tube 32, heat exchange occurs with the circulating water, allowing it to cool and condense into a liquid state.

In addition, the circulating water, for example, cooling water, entering through the circulating water inlet 29 flows upward along the inside of the condenser 23 and exits through the circulating water outlet 30 after completing heat exchange with the evaporated vapor. .

At this time, the circulating water flowing from the bottom to the top inside the condenser 23 can show a zigzag flow depending on the arrangement characteristics of each perforated diaphragm 33, and ultimately the residence time of the circulating water flowing inside the condenser 23 can be secured for a long time.

In addition, the distillation extraction equipment includes a tank 20 as a means of finally collecting the liquid extract (e.g., active ingredient liquid extract such as sap of Cudrania mulberry tree material) provided from the condenser 23.

The tank 20 is a tank disposed toward the rear end of the condenser 23, and the tank 20 has a liquid extract at the upper end connected to a pipe 18 extending from the liquid extract outlet 22 of the condenser 23. An inlet 21 and a drain 24 at the lower end through which the liquid extract stored inside the tank 20 is discharged are formed.

In addition, a valve 41 is installed on the side of the tank 20 to discharge the liquid extract stored in the tank, and the valve 41 at this time is located at a certain height from the bottom of the tank 20 to It serves to discharge the liquid extract at the top, which has a high water level, among the liquid extracts.

In particular, the area where the liquid extract is finally obtained, that is, the area where the tank 20 belongs, includes a final collection bin 40 that collects the liquid extract at the higher level among the liquid extracts filled in the tank, and the liquid extract filled in the tank. A preliminary collection tank 39 is provided to collect liquid extract at a lower level, for example, liquid extract containing impurities such as residues during primary distillation.

Here, the final collection tank 40 can be placed on the side where the valve 41 is located, and the preliminary collection tank 39 can be placed on the side where the drain 24 is located, and the liquid extract collected in the final collection tank 40 The liquid extract (e.g., liquid extract filtered several times using a strainer) collected in the preliminary collection container 39 can be diluted at a predetermined ratio to make a final product.

In addition, the distillation extraction equipment inserts a material container 27 containing materials such as trees and leaves into the still body 13, or inserts a material container 27 containing carbon dioxide into the still body 13. A container lifting device (28) is included as a means of removing from the interior.

The vessel lifting device 28 consists of a hoist 25 installed on the top of the still 17, and a hoist post 26 installed on the frame 12 to support the hoist 25.

In addition, the material container 27 is made of a mesh-shaped container made of metal, etc., and can be hung on the hoist side through a traction medium such as a wire, hook, or chain.

Accordingly, when inputting materials such as trees and leaves or discharging carbon dioxide, the wooden container 27, which carries a large load, can be easily lifted up or lowered using the container lifting device 28, making the work safe and convenient. You can do it.

Accordingly, the process of extracting a liquid extract, for example, a liquid extract of an active ingredient such as sap of Cudrania tree material using the distillation extraction equipment configured as described above, is as follows.

First, open the still cover 16 using the actuator 15, then cut the wood of the material to be extracted into the inside of the still body 13, and then add a certain amount of water along with the stems and leaves.

Next, after closing the still cover 16, the control box 38 is operated to start the distillation extraction operation.

Next, the heat of the heater 10 generated by the operation of the operation button (not shown) of the control box 38 is conducted to the wall of the still body 13 through the red clay wall 34 to extract distillation inside the still body. The material being heated is heated.

At this time, the heat generated from the heater 10 is conducted through the space 37, so that the material in the still body 13 is carbonized by indirect heat.

Here, the material inside the still body 13, where moisture is evaporated and carbonized by being heated by the heat of the heater 10, is not transmitted directly to the still body 13, but is indirectly transmitted through the space portion 37. Therefore, the material inside the still body 13 is carbonized gradually rather than rapidly, making it possible to obtain high-quality carbide (charcoal).

Next, when the heat of the heater 10 is applied to the material contained inside the still body 13, moisture comes out of the wood, stems, leaves, etc. of the material and evaporates.

Next, the evaporated vapor collected inside the still body 13 escapes through the evaporated vapor outlet 14 under its own pressure, then flows along the pipe 18 and is sent to the condenser 23.

Next, the evaporated vapor entering the inside of the condenser 23 is condensed by heat exchange with the cooling water and changed into a liquid extract, and this liquid extract is sent to the tank 20 along the pipe 18.

Next, the liquid extract collected in the tank 20 is collected in the final collection container 39 and the preliminary collection container 40, and is continuously diluted at an appropriate ratio and then placed in a container such as a bottle or barrel and aged at low temperature for about 6 months or more. After final purification, it is packaged in containers such as bottles to make the final product.

In addition, residual vapor or moisture that fails to escape through the evaporation vapor outlet 14 of the still cover 16 and falls toward the bottom of the still body 13 is discharged through the outlet 42 and is discharged into the liquid extract sub-container. It is collected inside (46) and cooled at the same time to make a liquid extract. The liquid extract thus produced is recovered by opening the sub-valve (45) and then filtered several times to be collected in the preliminary collection tank (40). It is made into a product by diluting it with the extract in an appropriate ratio.

In addition, the carbide (charcoal) remaining inside the still body (13) can be collected by opening the still cover (16) and then shipped and sold as charcoal used for grilling meat or as an addition to animal feed through unit packaging. It becomes possible.

Specifically, the distilled extract of Cudrania tree according to the present invention is prepared by using a heating container containing Cudrania tree, which includes leaves, outposts, and soft woody branches of Cudrania tree with stems with an average diameter of 7 cm or less. Heating at a temperature of 420 to 500 ℃ for 1 to 2 hours, and indirectly heating at a temperature of 60 to 80 ℃ for 3 to 4 hours to obtain water vapor that escapes from the Cudrania tree and evaporates, and heats the vapor to a temperature of 3 to 10 ℃. Step 1 of producing an extract by cooling and condensing; Step 2 of producing a redistilled extract by concentrating the extract at 0.7 to 0.9 atm and 65 to 75°C for 1 to 2 hours to obtain evaporated water vapor and cooling and condensing the extract to a temperature of 3 to 10°C; And it is preferable to include a third step of producing a distilled extract of Cudrania tree by repeating step 2 of the re-distilled extract 2 to 5 times.

The Cudrania tree used in the present invention can be extracted not only from leaves, but also from whole plants, stems, etc. In particular, the Kujimul tree stored in the heating container may include soft woody Kujimul tree branches having stems with an average diameter of 7 cm or less. These soft woody branches of the Cudrania mulberry tree may include not only the leaves of the Cudrania tree, but also the outposts and stems. As a result, not only can the soft wood of Cudrania tree be actively utilized, but it can also be more effective for respiratory diseases, especially asthma and bronchitis.

In addition, the present invention can produce a concentrated extract with high purity by performing a 2-step process of re-distilling the extract that has undergone the 1-step distillation process and a 3-step process of repeatedly re-distilling the re-distilled extract. Not only does it increase the effect of improving respiratory diseases, but it also reduces the toxicity of Cudrania tree, making it harmless to the human body and at the same time reducing its unique scent, making it more suitable for use as a beverage.

Distillation-electrolysis extract of Cudrania tree according to an embodiment of the present invention is performed using the distillation extraction equipment of FIGS. 1 to 3 described above, and the method of using the distillation extraction equipment is the same as above, so the description thereof is Omit it.

Specifically, the distillation-electrolysis extract of the Cudrania tree is obtained by using a heating container containing the Cudrania tree, which includes the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less, at 420 degrees Celsius. Heat to a temperature of 500°C for 1 to 2 hours, and indirectly heat to a temperature of 60 to 80°C for 3 to 4 hours to obtain water vapor that escapes from the Cudrania tree and evaporates, and heats the water vapor to a temperature of 3 to 10°C. Step 1 of producing an extract by cooling and condensing; Step 2 of preparing an electrolyzed extract by adding the cooled and condensed extract to an electrolyte solution with a concentration of 0.25 to 0.5 M and electrolyzing it at a glow discharge voltage of 10 to 280 V for 10 to 90 minutes; And a third step of indirectly heating the electrolyzed extract at a temperature of 90 to 100 ° C. for 30 minutes to 1 hour to obtain evaporating water vapor and cooling and condensing it to a temperature of 3 to 10 ° C. to prepare a distillation-electrolyzed extract. Includes.

As described above, the distillation-electrolysis extract of Cudrania tree according to the present invention is a two-step process of electrolyzing the extract distilled in the first step and a three-step process of re-distilling the electrolyzed extract to produce a distillation-electrolyzed extract. It is carried out as The electrolysis process decomposes the first-stage distilled extract into low-molecular-weight substances and dramatically reduces the viscosity, thereby improving absorbability and making it easier to swallow when applied as a beverage.

The electrolyte solution is not particularly limited to those commonly used in the art, but is specifically selected from the group consisting of citric acid (C ₆ H ₈ O ₇ ), formic acid (HCOOH), acetic acid (CH ₃ COOH), and mixtures thereof. An aqueous solution of one or more organic acids can be used.

In addition, in order to improve the contraction of the airway and the inhibition of inflammation in the airway, the fermented neem extract can be mixed with the organic acid aqueous solution at a weight ratio of 1: 0.05 to 0.3. If the amount of the neem fermented extract used is less than 0.05 weight ratio, the effect may be minimal, and if it exceeds 0.3 weight ratio, it may have a burdensome aroma and taste, which may limit its use as a beverage.

The neem fermented extract is prepared by adding 8 to 18 times the weight of water compared to the weight of neem fruit and extracting it for 1.5 to 3 hours at a pressure of 0.7 to 0.8 atmosphere and a temperature of 85 to 105 ° C. to prepare a water extract of neem tree. It can be prepared by a method comprising the step of inoculating the prepared neem water extract with Bifidobacterium longum to prepare a neem fermented extract.

Bifidobacterium longum used in the present invention is not particularly limited, but may be a bacterium used in public institutions or a mutant strain thereof, a bacterium isolated from nature, or a mutant strain thereof. The mutant strain may be a strain that has the ability to produce a fermented product showing the effect of the present invention.

At this time, the hot water treatment temperature and time and the fermentation treatment temperature and time are each in the optimal range for maximizing the yield of the hot water extract and the activity of the fermenting bacteria.

The Cudrania complex distilled extract according to the present invention is a mixture of the hot water extract of Cudrania leaves and stems, distilled extract of Cudrania tree, and distilled-electrolyzed extract of Cudrania tree, obtained through the above process, mixed at a specific ratio to dramatically treat respiratory diseases. It is characterized by not only improving the taste but also improving the resistance due to toxicity, aroma, and taste when drinking, making it easy to apply as a beverage.

The distilled extract of Cudrania tree preferably contains 2.5 to 5.5 parts by weight based on 1 part by weight of the hot water extract of Cudrania leaves and stems. If the content is less than 2.5 parts by weight, the effect of improving respiratory diseases may be minimal, and if the content is less than 2.5 parts by weight, the effect of improving respiratory diseases may be minimal. If it exceeds parts by weight, there is a problem that the toxicity and flavor reduction effects may be reduced. In addition, the distilled-electrolyzed extract of Cudrania tree preferably contains 0.1 to 0.5 parts by weight based on 1 part by weight of the hot water extract of Cudrania leaves and stems, and if the content is less than 0.1 part by weight, it improves viscosity and swallows, etc. The improvement in effect may be minimal, and if the content exceeds 0.5 parts by weight, there is a problem that processability into various beverages may be reduced due to an increase in components with reduced viscosity.

The beverage composition for improving respiratory diseases according to an embodiment of the present invention preferably contains 1 to 10% by weight of the kkujippong complex distilled extract based on the total weight. If the content of the kkujippong complex distillation extract is less than 1% by weight, the effect may be minimal, and if it exceeds 10% by weight, there is a problem in that the above-mentioned improvement effect is no longer expressed, which may lower economic feasibility.

Another embodiment of the present invention seeks to provide a beverage for improving respiratory diseases comprising the beverage composition for improving respiratory diseases.

The beverage composition for improving respiratory diseases containing the cucurbitum complex distilled extract of the present invention as an active ingredient may further include a foodologically acceptable food auxiliary additive. Foodologically acceptable food supplements that can be used in the present invention include natural carbohydrates such as sugars such as glucose, fructose, maltose, sucrose, dextrin, and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol, and thaumatin. , natural flavors such as stevia extract, synthetic flavors such as saccharin and aspartamic acid, colorants, pectic acid or its salts, alginic acid or its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, Includes, but is not limited to, alcohol, carbonating agent, etc.

In addition to the above, the beverage composition for improving respiratory diseases containing the complex distilled extract of Kujippong of the present invention as an active ingredient includes various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and its salts, alginic acid and its salts, organic acids, and protective properties. It may contain colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, etc. In addition, the beverage composition for improving respiratory diseases containing the complex distilled extract of Kujippong of the present invention as an active ingredient may contain pulp for the production of natural fruit juice, fruit juice beverages, and vegetable beverages. These ingredients can be used independently or in combination.

Above, the present invention has been described in detail with preferred embodiments, but the present invention is not limited to the above embodiments, and various modifications may be made by those skilled in the art within the scope of the technical idea of the present invention. This is possible.

<Preparation Example 1> Hot water extract of Cudrania leaves and stems

The washed Cudrania leaves and stems were dried with hot air at a temperature of 60°C, 20 times the weight of water compared to the weight of the dried Cudrania leaves and stems was added, heated at a temperature of 100℃ for 1 hour, and then heated at a temperature of 70℃ for 4 hours. An aqueous extract was prepared by extraction for a period of time.

The prepared extract was heated to 80°C and kept for 30 minutes to deactivate the enzyme to prepare a hot water extract of Cudrania leaves and stems.

<Preparation Example 2> Hot water extract of Cudrania leaves and stems (containing Neem fermented extract)

Preparation Example 1 was carried out in the same manner as above, but water extract was prepared by adding 20 times the weight of water and 0.3 times the weight of the fermented neem extract compared to the weight of the dried Cudrania leaves and stems, and then deactivating the enzyme to prepare the Cudrania leaves and stems. A hot water extract was prepared.

At this time, the neem fermentation extract was prepared by mixing 10 g of neem fruit with 100 g of water, treating it at 0.7 atm and a temperature of 95°C for 2 hours, and then cooling to 30°C. Afterwards, Lactobacillus delbrueckii NBRC3202 was inoculated to about 5×10 ⁶ cfu/g and fermented at 30° C. for 48 hours.

<Preparation Example 3> Cudrania tree distilled extract

A Kujimul tree was prepared by mixing 100 parts by weight of logs with an average diameter of about 10 cm or more, 25 parts by weight of Kujimul tree leaves, and 25 parts by weight of soft woody Kujimul tree branches with stems with an average diameter of 7 cm or less. .

Using the distillation extraction equipment shown in Figures 1 to 3 below, a distillation extract of Cudrania tree was extracted. More specifically, washing the prepared Cudrania tree, placing it in the still 17 of the distillation extraction equipment, heating the internal temperature of the still 17 at a temperature of 480 ° C. for 1 hour, and 4 hours at a temperature of about 70 ° C. After heating for 3 hours using a pulse-type indirect heating method in which the heating step was repeated, and then cooling with cooling water at 5° C., a distilled Cudrania tree extract was obtained.

The Cudrania tree is removed from the distiller (17), the obtained Cudrania tree extract is placed, and the inside of the distiller (17) is subjected to low-temperature, low-pressure concentration at 0.8 atm, 70 ° C. for 1 hour to obtain water vapor evaporated at 5 ° C. By cooling with cooling water, a redistilled Cudrania tree extract was obtained.

The process of obtaining the re-distilled liquefied extract of Cudrania mulberry tree was repeated twice to obtain a distilled extract of Cudrania communis.

<Preparation Example 4> Cudrania tree distilled extract

The same procedure as in Preparation Example 3 was carried out, but the process of obtaining the re-distilled liquefied extract of Cudrania mulberry was repeated 5 times to obtain a distilled extract of Cudrania communis.

<Preparation Example 5> Cudrania tree distillation-electrolysis extract

A Kujimul tree was prepared by mixing 100 parts by weight of logs with an average diameter of about 10 cm or more, 25 parts by weight of Kujimul tree leaves, and 25 parts by weight of soft woody Kujimul tree branches with stems with an average diameter of 7 cm or less. .

Cudrania tree extract was extracted using the distillation extraction equipment shown in Figures 1 to 3 below. More specifically, washing the prepared Cudrania tree, placing it in the still 17 of the distillation extraction equipment, heating the internal temperature of the still 17 at a temperature of 480 ° C. for 1 hour, and 4 hours at a temperature of about 70 ° C. After heating for 3 hours using a pulse-type indirect heating method in which the heating step was repeated, and then cooling with cooling water at 5° C., a distilled Cudrania tree extract was obtained.

Afterwards, two electrodes and a thermometer were fixed to a 500 ml polypropylene beaker, and an electrolyzer consisting of a silicone stopper with a tube through which the generated gas can leak was inserted. At this time, a platinum wire with a diameter of 50 μm was used as an anode, and stainless steel with a thickness of 1 mm and an area of 10 × 30 mm was used as a cathode. 200 ml of fucoidan solution was added to the electrolytic cell, C ₆ H ₈ O ₇ was added to bring the concentration to 0.5 M, and the mixture was stirred with a magnetic bar. The two electrodes were connected to a direct current power supply, 150 V was applied, and the distilled Cudrania tree extract was electrolyzed to finally obtain a Cudrania chinensis distilled-electrolyzed extract.

<Preparation Example 6> Cudrania tree distillation-electrolysis extract (containing Neem tree fermentation extract)

Preparation Example 5 was carried out in the same manner as above, except that 200 ml of the cooled and condensed extract was added, and a mixture of citric acid (C ₆ H ₈ O ₇ ) at a weight ratio of 1 and neem fermented extract at a weight ratio of 0.1 was added to obtain a concentration of 0.5. M and electrolysis was performed to finally obtain a distillation-electrolysis extract of Cudrania tree.

At this time, the neem fermentation extract was prepared by mixing 10 g of neem fruit with 100 g of water, treating it at 0.7 atm and a temperature of 95°C for 2 hours, and then cooling to 30°C. Afterwards, Bifidobacterium longum was inoculated to about 5×10 ⁶ cfu/g and fermented at 30° C. for 48 hours.

<Preparation Example 7> Cudrania tree distillation-electrolysis extract (containing Neem tree fermentation extract)

Preparation Example 5 was carried out in the same manner, except that 200 ml of the cooled and condensed extract was added, and an organic acid aqueous solution containing citric acid (C ₆ H ₈ O ₇ ) and acetic acid (CH ₃ COOH) mixed in equal weight ratios was added at a weight ratio of 1 and A mixture of 0.2 weight ratio of fermented extract of Gujippul tree was added to bring the concentration to 0.5 M and subjected to electrolysis to finally obtain a distilled-electrolyzed extract of Cudrania tree.

At this time, the neem fermentation extract was prepared by mixing 10 g of neem fruit with 100 g of water, treating it at 0.7 atm and a temperature of 95°C for 2 hours, and then cooling to 30°C. Afterwards, Bifidobacterium longum was inoculated to about 5×10 ⁶ cfu/g and fermented at 30° C. for 48 hours.

<Examples 1 to 3> and <Comparative Examples 1 to 3>

The active ingredients of the beverage composition for improving respiratory disease and the comparative composition according to an embodiment of the present invention were prepared by stirring and mixing the ingredients and contents as shown in Table 1 below.

Classification (weight) Example 1 Example 2 Example 3 Comparative Example 1 Comparative example 2 Comparative example 3 Cudrania complex distilled extract Hot water extract of Cudrania leaves and stems Manufacturing example 1
(One) Manufacturing example 2
(One) Manufacturing example 2
(One) Manufacturing example 1
(One) - Manufacturing Example 1
(One) Cudrania tree distilled extract Manufacturing example 3
(3) Manufacturing Example 3
(3) Manufacturing example 4
(5) - Manufacturing example 3
(3) Manufacturing example 3
(3) Cudrania tree distillation-electrolysis extract Manufacturing example 5
(0.3) Manufacturing example 6
(0.3) Manufacturing example 7
(0.3) - - -

<Experimental Example 1> Sensory test

Sensory evaluations such as taste and overall preference were measured for the compositions according to Examples 1 to 3 and Comparative Examples 1 to 3, and the results are shown in Table 2 below. The above sensory evaluation was measured by having 40 adult men and women in their 30s to 50s (20 men and women each) with sensory discrimination ability with more than 3 years of experience in the food-related field evaluate.

[Assessment Methods]

1 point: The taste is very dry and bitter, has a lot of the unique taste and off-flavor of kkujippong, and the overall preference is not very good.

3 points: The taste is strong and bitter, has a unique taste and smell of kkujippong, and the overall preference is not good.

5 points: The taste is average, there is a slight taste and off-flavor unique to kkujippong, and the overall preference is average.

7 points: The taste is excellent, there is almost no taste or off-flavor characteristic of kkujippong, and the overall preference is good.

9 points: The taste is very excellent, there is no taste or off-flavor characteristic of kkujippong, and the overall preference is very good.

division taste already Off-flavor overall preference Example 1 9.5 9.2 9.3 9.3 Example 2 9.4 9.5 9.4 9.4 Example 3 9.6 9.8 9.6 9.7 Comparative Example 1 4.9 5.5 5.0 5.2 Comparative Example 2 5.7 5.6 5.1 5.5 Comparative Example 3 6.2 8.1 7.3 7.2

As shown in Table 2 above, in the sensory test, the beverage compositions for improving respiratory diseases of Examples 1 to 3 according to an embodiment of the present invention were compared to the compositions of Comparative Examples 1 to 3 in terms of taste, taste and off-flavor, and overall preference. It was confirmed that it was remarkably excellent.

<Experimental Example 2> Bronchial inflammation inhibition test

In order to confirm whether the beverage composition for improving respiratory disease of Examples 1 to 3 and the composition prepared in Comparative Examples 1 to 3 have an effect of suppressing pulmonary bronchial inflammation in models of asthma and chronic obstructive respiratory disease, sensitized mice were exposed to the antigen. The increase in leukocytes in the pulmonary bronchial tubes caused by this treatment was confirmed (Pharmacological Research, 2010, 61, 288~297; Biochemical Pharmacology, 2010, 79,888~896).

For this purpose, 0.2 ml of a 1:1 mixture of 10 ㎍ ovalbumin (Ovalbumin, OVA, Sigma) and aluminum hydroxide (4 mg, aluminum hydroxide, Alum, Pierce) was administered to BALB/c female mice (65 weeks old) at 0, 7, and 0. Sensitization was achieved by intraperitoneal administration on day 14. Eight and ten days after the final sensitization date, 10% ovalbumin was made into an aerosol using high-pressure compressed air and sprayed for 50 minutes to induce airway inflammation. Each test substance (400 mg/kg of freeze-dried product of each composition, bid) was administered orally twice a day in the morning and afternoon from the 21st to the 23rd after the first sensitization. 24 hours after the last oral administration, bronchoalveolar lavage was performed using 15 ml of phosphate buffer solution (pH 7.2), and bronchoalveolar lavage fluid was collected. The number of white blood cells in the washing liquid was counted using a hematology analyzer (Drew Scientific Inc, HEMAVET HV950FS, M-950HV). The results are shown in Table 3 below by calculating the lung bronchial inflammation inhibition rate (%) based on the white blood cell count of the negative control group (1% CMC [carboxymethyl cellulose] administered group).

division Pulmonary bronchial inflammation inhibition rate (%) Example 1 37 Example 2 39 Example 3 42 Comparative Example 1 11 Comparative Example 2 21 Comparative Example 3 29

As shown in Table 3, it was confirmed that the lung bronchial inflammation inhibition rate of the beverage composition for improving respiratory disease of Examples 1 to 3 according to an embodiment of the present invention was significantly improved compared to the composition of Comparative Examples 1 to 3.

<Experimental Example 3> Sensory experiment for each item through survey

Regarding Examples 1 to 3 and Comparative Examples 1 to 3, a total of 150 people (50 each for allergic rhinitis patients, smokers, asthma and bronchial diseases) were tested, and each person was asked to drink 1 sachet 2 to 3 times a day for 3 months. Depending on the perceived degree, the effect of improving rhinitis, phlegm, asthma, and bronchial function (coughing frequency) was evaluated using the 9-point scoring method below, and the results are shown in Table 4 below.

[Evaluation method: 9-point scoring method]

9: It has an effect close to a complete cure.

7: Significant improvement is good

5: There is some improvement

3: Little improvement effect

1: No improvement effect

division Rhinitis sputum asthma bronchial function
(coughing frequency) Example 1 7.1 7.3 7.2 7.4 Example 2 7.3 7.5 7.4 7.5 Example 3 7.5 7.6 7.5 7.8 Comparative Example 1 5.8 5.9 5.8 6.0 Comparative Example 2 6.0 6.5 6.3 6.3 Comparative Example 3 6.0 6.2 6.3 6.5

As shown in Table 4, the beverage compositions for improving respiratory diseases of Examples 1 to 3 had superior satisfaction compared to Comparative Examples 1 to 3 in terms of improvement effects on rhinitis, phlegm, asthma, and bronchial function (coughing frequency). I was able to confirm.

As described above, a person skilled in the art to which the present invention pertains will understand that the present invention can be implemented in other specific forms without changing its technical idea or essential features. Therefore, all embodiments described above should be understood as illustrative and not restrictive. The scope of the present invention should be construed as including all changes or modified forms derived from the meaning and scope of the claims described below and their equivalent concepts rather than the detailed description above.

10: heating container 11: body
12: outer wall 12a: inner wall
13: Red clay wall 14: Far infrared irradiation hole
15: mulberry oil extractor 16: strainer
17: storage part 18, 21: flange
19: fixing pin 19a: tightening nut
20: Lid 21a: Fixing groove
22: fundus cock 23: internal temperature sensing rod
30: mulberry oil storage container 31: coolant pump
32: Cooling water circulation space 33: Outlet
34: discharge valve 40: gas
41: Plate 42: Fireproof insulation brick
43: Space 44: Heater
45: High heat temperature sensing rod 46: Stainless steel cover
50: Control box 60: Carbon packing

Claims (5)

A beverage composition for improving respiratory diseases containing a complex distilled extract of Cujippong,
The Cudrania complex distilled extract contains 1 part by weight of the hot water extract of Cudrania leaves and stems, 2.5 to 5.5 parts by weight of distilled Cudrania tree extract, and 0.1 to 0.5 parts by weight of distilled-electrolyzed extract of Cudrania chinensis,
The distilled extract of the Cudrania tree is
A heating container containing the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less is stored at a temperature of 420 to 500 ° C. for 1 to 2 hours. A first step of preparing an extract by heating and indirectly heating at a temperature of 60 to 80° C. for 3 to 4 hours to obtain water vapor evaporating from the Cudrania tree and cooling and condensing the water vapor to a temperature of 3 to 10° C.;
Step 2 of producing a redistilled extract by concentrating the extract at 0.7 to 0.9 atm and 65 to 75°C for 1 to 2 hours to obtain evaporated water vapor and cooling and condensing the extract to a temperature of 3 to 10°C; and
It is prepared by a method comprising the step 3 of producing a distilled extract of Cudrania tree by repeating step 2 of the redistilled extract 2 to 5 times,
The distilled-electrolyzed extract of Cudrania mulberry tree is
A heating container containing the leaves, outposts, and soft woody branches of the Cudrania tree with stems with an average diameter of 7 cm or less is stored at a temperature of 420 to 500 ° C. for 1 to 2 hours. A first step of preparing an extract by heating and indirectly heating at a temperature of 60 to 80° C. for 3 to 4 hours to obtain water vapor evaporating from the Cudrania tree and cooling and condensing the water vapor to a temperature of 3 to 10° C.;
Step 2 of preparing an electrolyzed extract by adding the cooled and condensed extract to an electrolyte solution with a concentration of 0.25 to 0.5 M and electrolyzing it at a glow discharge voltage of 10 to 280 V for 10 to 90 minutes; and
Step 3 of producing a distillation-electrolyzed extract by indirectly heating the electrolyzed extract at a temperature of 90 to 100 ° C. for 30 minutes to 1 hour to obtain evaporating water vapor and cooling and condensing it to a temperature of 3 to 10 ° C. A beverage composition for improving respiratory diseases, characterized in that it is manufactured by a method.
According to paragraph 1,
The hot water extract of the Cudrania leaves and stems is
Hot air drying the washed kkujippong leaves and stems at a temperature of 55 to 65°C;
Add 10 to 25 times the weight of water and 0.1 to 0.5 times the weight of neem fermented extract compared to the weight of the dried Cudrania leaves and stems, heat at a temperature of 100 to 120 ° C. for 0.5 to 1 hour, and then heat to 65 to 75 ° C. Preparing an aqueous extract by extracting at a temperature of ℃ for 3 to 5 hours; and
A beverage composition for improving respiratory diseases, characterized in that it is prepared by a method comprising the step of heating the extract to 75 to 90 ° C and keeping it warm for 15 to 30 minutes to deactivate the enzyme.
According to paragraph 2,
The neem tree fermentation extract is
Preparing a neem tree water extract by adding 8 to 18 times the weight of water compared to the weight of neem tree fruit and extracting it for 1.5 to 3 hours at a pressure of 0.7 to 0.8 atmosphere and a temperature of 85 to 105 ° C.
A beverage composition for improving respiratory diseases, characterized in that it is manufactured by a method comprising the step of producing a fermented neem extract by inoculating the prepared neem water extract with Lactobacillus delbrueckii.
According to paragraph 1,
The electrolyte solution of the distilled-electrolyzed extract of the Cudrania tree is
An aqueous solution of at least one organic acid selected from the group consisting of citric acid (C ₆ H ₈ O ₇ ), formic acid (HCOOH), acetic acid (CH ₃ COOH), and mixtures thereof with the fermented neem extract at a weight ratio of 1: 0.05 to 0.3. It is mixed with;
The neem tree fermentation extract is
Preparing a neem tree water extract by adding 8 to 18 times the weight of water compared to the weight of neem tree fruit and extracting it for 1.5 to 3 hours at a pressure of 0.7 to 0.8 atmosphere and a temperature of 85 to 105 ° C.
A beverage composition for improving respiratory diseases, characterized in that it is manufactured by a method comprising the step of preparing a neem fermented extract by inoculating the prepared neem water extract with Bifidobacterium longum.
A beverage for improving respiratory diseases, comprising the beverage composition for improving respiratory diseases according to any one of claims 1 and 4.