CN107050184A - A kind of peach blossom ma bartender's health-care oral liquid and its preparation method and application - Google Patents

A kind of peach blossom ma bartender's health-care oral liquid and its preparation method and application Download PDF

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Publication number
CN107050184A
CN107050184A CN201710108600.3A CN201710108600A CN107050184A CN 107050184 A CN107050184 A CN 107050184A CN 201710108600 A CN201710108600 A CN 201710108600A CN 107050184 A CN107050184 A CN 107050184A
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parts
chinese medical
medical extract
peach blossom
health
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丘苑新
柳建良
赵丽
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Zhongkai University of Agriculture and Engineering
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Zhongkai University of Agriculture and Engineering
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention provides a kind of peach blossom ma bartender's health-care oral liquid and its preparation method and application.Peach blossom ma bartender's health-care oral liquid provided by the present invention, including yellow rice wine, Chinese medical extract, the volume ratio of the yellow rice wine and Chinese medical extract is 8~12:1, wherein, the raw material of the Chinese medical extract is counted by weight, including:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 15~25 parts of the Radix Astragali, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, 0.5~5 part of plant ash.Not only raw material is natural for the peach blossom ma bartender health-care oral liquid provided by the present invention, preparation method simple, and effect is significantly, with beauty, strengthen immunity, the effect for alleviating physical fatigue, is applicable crowd extensively, the market space is big, has a good application prospect;In summary, peach blossom ma bartender's health-care oral liquid provided by the present invention has high use value and economic value.

Description

A kind of peach blossom ma bartender's health-care oral liquid and its preparation method and application
Technical field
The invention belongs to health products and manufacture field, and in particular to a kind of peach blossom ma bartender's health-care oral liquid and preparation method thereof And application.
Background technology
With the development of society, health care requirement of the people to body is also improved constantly.Due to the increase of life stress, life The speed-raising of rhythm, the factor such as the deterioration of living environment causes modern's fatiguability, easy aging, immunity reduction, endocrine to be lost The problems such as tune, memory and fecundity are reduced.Therefore health products turn into the object that people pursue.Chinese health-care and nutritious wine market It is still within the stage of growth at present.China just has from ancient times to drink medicinal liquor, tonic wine and comes health, salubrity, the tradition for being healthy and strong to get rid of illness, But individual workship and family's brewed stage personal from drink are rested on always.The market of health-care and nutritious wine, which never has, to grow up, Just propose, and distinguished with medicinal liquor until the eighties in last century.In the 1990s, proposition and prevailing, guarantor with " inferior health " Strong health preserving wine is commercially available drastically develops, and some enterprises show one's talent, such as Jin Liquor, YEDAO LUGUI JIU, gold wine.
But, above-mentioned health-care and nutritious wine is all the white wine wine base for having used Alcohol degree to be higher than 30 degree, and medical research shows, Human liver etc. can be hurt by drinking the white wine of this number of degrees for a long time, in addition, in existing health-care and nutritious wine, some use prescriptions Numerous and jumbled, complex process, the rare preciousness of prescription of use, causes cost higher, is difficult to be received by consumers in general;Have and formula Simply, effect is single, therefore, it is necessary to provide, a kind of Alcohol degree is low, effect is obvious, cost is low and preparation method is simply protected Strong wine.
The content of the invention
In view of the shortcomings of the prior art, the invention provides a kind of peach blossom ma bartender's health-care oral liquid and preparation method thereof and should With peach blossom ma bartender's health-care oral liquid has beauty, strengthen immunity, the effect for alleviating physical fatigue, makes with high With value and economic value.
In a first aspect, the invention provides a kind of peach blossom ma bartender's health-care oral liquid, including yellow rice wine, Chinese medical extract, it is described The volume ratio of yellow rice wine and Chinese medical extract is 8~12:1, wherein, the Chinese medical extract is using solvent impregnation, alcohol water lift Any one in heavy method, ultrasonic extraction, continuous ethanol reflux extraction, fermentation extraction method is made;The Chinese medical extract Raw material, count by weight, including:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 15~25 parts of the Radix Astragali, 15~25 parts of maca, Chinese holly 15~25 parts of Qi, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, 0.5~5 part of plant ash.
Preferably, the raw material of the Chinese medical extract, is counted by weight, including:1.5~3 parts of peach blossom, Radix Codonopsis 18~22 Part, 15~20 parts of the Radix Astragali, 15~20 parts of maca, 15~20 parts of matrimony vine, 25~32 parts of jujube, 18~22 parts of Radix Angelicae Sinensis, dalbergia wood leaf 15 ~22 parts, 1~2 part of plant ash.
Preferably, the plant ash is included in rice-straw ash, straw ash, cornstalk ash, sugarcane skin ash, pine and cypress branch ash at least It is a kind of.
It is further preferred that the plant ash is rice-straw ash.
It is understood that the present invention does not have special limitation to the preparation method of the Chinese medical extract, it can use Method well known to those skilled in the art for preparing the Chinese medical extract.
Preferably, the preparation method of the Chinese medical extract, comprises the following steps:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, the Radix Astragali 15~25 Part, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 part, after the raw material of the Chinese medical extract is mixed, according to the material quality and alcohol by volume of the Chinese medical extract Ratio be 1:2~5 ratio, after the raw material of the Chinese medical extract and alcohol are mixed, stir 3 under the conditions of 60~80 DEG C~ 6h, the first filtrate and the first filter residue are obtained through filtering;Ratio according to the first filter residue quality and water volume is 1:2~5 ratio Example, after first filter residue and the water are mixed, stirs 1.5~3h under the conditions of 80~100 DEG C, and obtaining second through filtering filters Liquid and the second filter residue;Ratio according to the second filter residue quality and water volume is 1:2~5 ratio, by second filter residue and After water mixing, 1.5~3h is stirred under the conditions of 80~100 DEG C, the 3rd filtrate and the 3rd filter residue are obtained through filtering;By described first After filtrate, the second filtrate, the 3rd filtrate merge, it is concentrated in vacuo under the conditions of 60~80 DEG C and the Chinese medical extract is made.
Preferably, the preparation method of the Chinese medical extract, comprises the following steps:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, the Radix Astragali 15~25 Part, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 part, after the raw material of the Chinese medical extract is mixed, it is according to the raw material of the Chinese medical extract and the mass ratio of water 1:5~10 ratio, wears into slurries after water is mixed with the raw material of the Chinese medical extract of gained, is heated with stirring to and is not less than 90 DEG C, 30~60min is kept, reduction temperature is not higher than to after 20 DEG C, add the Mixed Microbes of slurry weight 5~15%, stirring fermentation 48~96h, through filtering, sterilizing, obtains Chinese medical extract.
It is further preferred that the Mixed Microbes include but is not limited in mould, head mold, bacillus subtilis, aspergillus niger At least one.
It is further preferred that the Mixed Microbes include mould and head mold, wherein, the weight ratio of the mould and head mold is 1:1~4.
It is further preferred that the raw material of the Chinese medical extract is the powder of 10~200 mesh sizes.
Preferably, the alcoholic strength of the yellow rice wine is 1~10 degree (more preferably 2 degree).
Preferably, the yellow rice wine is black glutinous rice ma's wine, and the black glutinous rice ma wine is to be made using following methods:By black glutinous rice Be soaked in water 12~16h, and clear water is placed into after draining the water and cooks into ma's meal, and ma's meal is cooled into temperature is not higher than 50 DEG C Afterwards, the mixed fermenting agent that gross mass is ma's meal quality 1~5%, and sealing and fermenting 10~18 days are added, quality is added For the rice wine of 0.5~2 times of ma's meal quality, and continue sealing and fermenting 10~18 days, then seal it is heat-insulated boil 3~5 times, pass through Black glutinous rice ma's wine is made in cooling, evaporation.
It is further preferred that the mixed fermenting agent includes at least one of yeast, red yeast rice.
It is further preferred that the mixed fermenting agent includes yeast and red yeast rice, wherein, the matter of the yeast and red yeast rice Amount is than being 1~3:1.
It is further preferred that the alcoholic strength of the rice wine is 10~20 degree.
It is further preferred that the black glutinous rice ma wine is to be made using following methods:Black glutinous rice is soaked in water 12~ 16h, places into clear water and cooks into ma's meal after draining the water, ma's meal is cooled into temperature is not higher than after 50 DEG C, by ma's meal and always After quality is the mixed fermenting agent mixing of ma's meal quality 1~5%, and sealing and fermenting 10~18 days, adding quality is The rice wine of 0.5~2 times of ma's meal quality, and continue sealing and fermenting 10~18 days, then seal it is heat-insulated boil 3~5 times, through cold But, evaporate and black glutinous rice ma's wine is made.
It is further preferred that the mixed fermenting agent includes yeast, red yeast rice, wherein, the yeast, the quality of red yeast rice Than for 1~3:1~3.
It is understood that the step of rotary evaporation in vacuo may separate out alcohol, it may also be used for prepare traditional Chinese medicine extraction Thing, is conducive to improving the utilization ratio of raw material, reduces the preparation cost of peach blossom ma bartender's health-care oral liquid of the present invention.
Second aspect, the invention provides a kind of preparation method of peach blossom ma bartender's health-care oral liquid, comprises the following steps:
(1) raw material of the Chinese medical extract of following portions by weight is taken:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, plant ash 0.5 ~2 parts, 15~25 parts of the Radix Astragali, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, dalbergia wood leaf 15~25 parts, 0.5~5 part of plant ash, are extracted using solvent impregnation, ethanol extract from water precipitation, ultrasonic extraction, continuous alcohol reflux Chinese medical extract is made in any one raw material for extracting the Chinese medical extract in method, fermentation extraction method;
(2) it is 8~12 according to the volume ratio of yellow rice wine and Chinese medical extract:1 ratio, by the Chinese medical extract and yellow rice wine Sterilized after well mixed and peach blossom ma's bartender's health-care oral liquid is made.
Preferably, in the step (1), the raw material of the Chinese medical extract is counted by weight, including:Peach blossom 1.5~ 3 parts, 18~22 parts of Radix Codonopsis, 15~20 parts of the Radix Astragali, 15~20 parts of maca, 15~20 parts of matrimony vine, 25~32 parts of jujube, Radix Angelicae Sinensis 18~ 22 parts, 15~22 parts of dalbergia wood leaf.
Preferably, in the step (1), the plant ash includes rice-straw ash, straw ash, cornstalk ash, sugarcane skin ash, pine At least one of cypress branch ash.
It is further preferred that in the step (1), the plant ash is rice-straw ash.
It is understood that the present invention does not have special limitation to the preparation method of the Chinese medical extract of the step (1), The method well known to those skilled in the art for preparing the Chinese medical extract can be used.
Preferably, in the step (1), the preparation method of the Chinese medical extract comprises the following steps:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, the Radix Astragali 15~25 Part, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 part, after the raw material of the Chinese medical extract is mixed, according to the material quality and alcohol by volume of the Chinese medical extract Ratio be 1:2~5 ratio, after the raw material of the Chinese medical extract and alcohol are mixed, stir 3 under the conditions of 60~80 DEG C~ 6h, the first filtrate and the first filter residue are obtained through filtering;Ratio according to the first filter residue quality and water volume is 1:2~5 ratio Example, after first filter residue and the water are mixed, stirs 1.5~3h under the conditions of 80~100 DEG C, and obtaining second through filtering filters Liquid and the second filter residue;Ratio according to the second filter residue quality and water volume is 1:2~5 ratio, by second filter residue and After water mixing, 1.5~3h is stirred under the conditions of 80~100 DEG C, the 3rd filtrate and the 3rd filter residue are obtained through filtering;By described first After filtrate, the second filtrate, the 3rd filtrate merge, it is concentrated in vacuo under the conditions of 60~80 DEG C and the Chinese medical extract is made.
Preferably, in the step (1), the preparation method of the Chinese medical extract comprises the following steps:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, the Radix Astragali 15~25 Part, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 part, after the raw material of the Chinese medical extract is mixed, it is according to the raw material of the Chinese medical extract and the mass ratio of water 1:5~10 ratio, wears into slurries after water is mixed with the raw material of the Chinese medical extract of gained, is heated with stirring to and is not less than 90 DEG C, 30~60min is kept, reduction temperature is not higher than to after 20 DEG C, add the Mixed Microbes of slurry weight 5~15%, stirring fermentation 48~96h, through filtering, sterilizing, obtains Chinese medical extract.
It is further preferred that in the step (1), the Mixed Microbes include but is not limited to mould, head mold, bacillus subtilis At least one of bacterium, aspergillus niger.
It is further preferred that in the step (1), the Mixed Microbes include mould and head mold, wherein, the mould and The weight ratio of head mold is 1:1~4.
Preferably, in the step (1), the raw material of the Chinese medical extract is the powder of 10~200 mesh sizes.
Preferably, in the step (2), the alcoholic strength of the yellow rice wine is 1~10 degree (more preferably 2 degree).
Preferably, in the step (2), the yellow rice wine is black glutinous rice ma's wine.
It is further preferred that in the step (2), the black glutinous rice ma wine is to be made using following methods:By black glutinous rice Be soaked in water 12~16h, and clear water is placed into after draining the water and cooks into ma's meal, and ma's meal is cooled into temperature is not higher than 50 DEG C Afterwards, after ma's meal and gross mass being mixed for the mixed fermenting agent of ma's meal quality 1~5%, and sealing and fermenting 10~18 days, Add quality and be the rice wine of 0.5~2 times of ma's meal quality, and continue sealing and fermenting 10~18 days, then seal heat-insulated boil Boiling 3~5 times, black glutinous rice ma's wine is made through cooling, evaporation.
It is further preferred that in the step (2), the mixed fermenting agent includes yeast, red yeast rice, wherein, it is described Yeast, the mass ratio of red yeast rice are 1~3:1.
It is further preferred that in the step (2), the alcoholic strength of the rice wine is 10~20 degree.
It is understood that the step of evaporation may separate out alcohol, it may also be used for prepare Chinese medical extract, be conducive to The utilization ratio of raw material is improved, the preparation cost of peach blossom ma bartender's health-care oral liquid of the present invention is reduced.
Preferably, peach blossom ma bartender health-care oral liquid as described in relation to the first aspect is using peach blossom ma's wine described in second aspect The preparation method of health care oral liquid is made.
The third aspect, the invention provides a kind of peach blossom ma bartender health-care oral liquid or such as second party as described in relation to the first aspect Application of the preparation method of peach blossom ma's bartender's health-care oral liquid described in face in terms of medicine or health products is prepared.
Chinese medical extract of the present invention and other components have following effect and feature:
Black glutinous rice ma's wine, ma's wine is that Han nationality Hakka is brewageed with glutinous rice, belongs to yellow rice wine, primary raw material is glutinous rice, with natural The pure red koji fermentation of microorganism is formed, and is not added with alcohol and any additive, is fully natural green drink, can directly be drunk, contain The nutritional ingredients such as more than 40% glucose, abundant vitamin, amino acid, have lively atmosphere blood-nourishing, it is active stimulate the menstrual flow, enrich blood green blood and The effect of moistening lung.
Peach blossom:China ancients recognize its cosmetic values of peach blossom, the pharmacy monograph of earliest extant very early《Legendary god of farming's book on Chinese herbal medicine Through》In speak of, peach blossom have " having made us color " the effect of.The beautification function of peach blossom, stem primarily from spending containing Kaempferol, The nutriments such as fragrant, beans essence, trifolin and vitamin.These materials can expand blood vessel, and promotion of blood circulation, skin of moistening improves Blood circulation, promotes skin-nourishing and oxygen supply, makes the lipofuscin element excretion of promotion human senility, prevents melanin in skin Chronic deposition, so as to effectively prevent in chloasma, freckle, blackspot, flowering peach also rich in vegetable protein and in free state Amino acid, is easily absorbed by the skin, to preventing and treating dry skin, coarse and wrinkle etc. effectively, can also strengthen the resistance against diseases of skin, It is of great advantage to skin so as to prevent and treat skin disease, seborrhea, suppurative dermatitis, scurvy etc..
Radix Codonopsis:Radix Codonopsis contains various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, With effects such as strengthen immunity, expansion blood vessel, decompression, improvement microcirculation, enhancing hematopoiesis functions.In addition chemotherapy radiotherapy is caused Leucocyte decline have castering action.
The Radix Astragali:The Radix Astragali is leguminous herbaceous plant, is a kind of traditional Chinese medicine, with the adjustment effect to blood glucose, tonifying Qi The effects such as table profit water detumescence, pus draining and toxin expelling, myogenic;Modern study shows, the Radix Astragali containing saponin, sucrose, polysaccharide, several amino acids, The Multiple components such as folic acid and selenium, zinc, copper, wherein astragalus polyose are the principle active components of the Radix Astragali.
Maca:Also known as agate card, it is a kind of annual herb plant.Contain the vegetable active composition that two classes are new, agate in agate card Card acid amides and Ma Ka are dilute, and determine that both materials have remarkable effect to balanced human's hormone secretion, so Ma Ka is claimed again For natural hormone engine;Maca has antifatigue, anti-oxidant, strengthen immunity, improves sexual function, regulation endocrine, carries The effects such as high fertility, anti-anemia action, anticancer, anti-leukocythemia, treatment climacteric metancholia;Maca is in nutritional ingredient and increasing simultaneously It can be matched in excellence or beauty in terms of strong energy, effect of endurance with ginseng.
Matrimony vine:Profit and nourish, and can bring down a fever, and it is special in kidney tonifying, moistening lung, promote the production of body fluid, QI invigorating, be liver kidney kidney-KIN being deficient, tired Inside vulcanize the key medicine of benefit.
Jujube:Also known as jujube, containing sugar, vitamin C, also containing abundant protein, fat, phosphorus, calcium, iron, potassium, sodium, magnesium, The multivitamins such as chlorine, iodine, niacin and vitamin;The sweet and refreshing delicate fragrance of taste, and with higher nutritive value;It is considered as good Invigorant, with invigorating heart moistening lung, close spleen stomach invigorating, nourishing generate fluid, the function of blood-enriching face-nourishing.《Compendium of Materia Medica》Carry:" the sweet property of jujube Temperature, sweet energy bowl spares, temperature energy QI invigorating ";《This warp》Claim:" jujube supports spleen in pacifying, and helps 12 warps, and flat stomach gas leads to nine orifices, and the few gas of benefit is few Tianjin, and hundred medicines ";Clinically be applied to treat weakness of the spleen and the stomach, the deficiency of vital energy is not enough, anaemia is sallow, cough due to deficiency of the lung, insomnia, lassitude hypodynamia, The diseases such as hypertension, hepatitis.
Radix Angelicae Sinensis:It is sweet, pungent, warm-natured, enter liver, the heart, the spleen channel, with replenishing and activating blood, menstruction regulating and pain relieving, the effect relaxed bowel, Having a dizzy spell for deficiency of heart-blood is cured mainly, lassitude hypodynamia, palpitation, the sea of blood is hollow, and the menstruation of the cold and deficiency of chong and ren channels or congestion blood block is not Adjust, dysmenorrhoea, production or suffer from abdominal pain, and other blood stasis have a pain and the few intestinal dryness of deficiency of Yin blood the card such as constipation, its blood that can improve uterus follows Ring, mitigation pelvic congestion, alleviate dysmenorrhoea.
Green bamboo snake:It can quench one's thirst and relieve summer heat, diuresis of detoxifying is reduced internal heat, its taste delicate fragrance is tasty, its light yellow complexion pale green, its soup is sparkling and crystal-clear It is bright, include saponin(e, sugar and vitamin, with promoting the production of body fluid to quench thirst, heat reliving and toxin-eliminating, resolving sputum, anti-inflammatory, diuresis defaecation, long-term consumption can Toxin expelling, the effect of making skin smooth, whitening functions of removing chloasma.
Lotus nut:Heart heat can be controlled.There are drop heat, gas of relieving summer heat, the function with the irritated, internal heat of dispelling that clears away heart-fire, pacifies.
Dalbergia wood leaf:The main component of dalbergia wood leaf volatile oil should belong to palm acids and phytic acid class by chemical classification, with removing Free radical ability, can be for preparing natural additive application food industry.
Plant ash:Plant ash is a kind of trona, containing the various nutrient elements extracted in plant, calcium, magnesium, silicon, The micronutrient element such as sulphur and iron, manganese, copper, zinc, boron, molybdenum.
Beneficial effects of the present invention are as follows:
(1) peach blossom ma bartender's health-care oral liquid action temperature provided by the present invention and, do not stimulate body, safety non-toxic, no pair Effect;
(2) peach blossom ma bartender's health-care oral liquid raw material provided by the present invention is natural, edible safety, and effect is notable, through function Experiment proves to have effects that beauty, strengthen immunity, alleviates physical fatigue;
(3) preparation method of peach blossom ma bartender's health-care oral liquid provided by the present invention is simple, curative effect and definite ingredients, is applicable Crowd is wide, and the market space is big, has a good application prospect.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in the embodiment of the present invention Technical scheme is clearly and completely described, it is clear that described embodiment is this part of embodiment, rather than whole Embodiment.Based on the embodiment in the present invention, those of ordinary skill in the art institute on the premise of creative work is not made The every other embodiment obtained, belongs to the scope of protection of the invention.
Embodiment 1
The embodiments of the invention provide a kind of preparation method of peach blossom ma bartender's health-care oral liquid, comprise the following steps:
(1) preparation of ma's wine:Black glutinous rice is soaked in water 16h, black glutinous rice is put into cauldron after draining the water, is placed into clear Water cooks into ma's meal, is put into after steamed ma's meal is naturally cooled into not higher than 50 DEG C in wine vat, then by the hair of ma's meal quality 3% Ferment yeast and the red yeast rice of ma's meal quality 2% are added in wine vat, are closed the lid, and put the insulation materials such as a little straw or cotton-wadded quilt covering Sealing and fermenting 15 days;Add that quality is 1 times of ma's meal quality and Alcohol degree is that 12 degree of rice wine continues sealing and fermenting 15 days;With Wine sieve is put into the wine in wine vat in wine jar, and wine jar is sealed with turf, then coats sposh on the wine jar whole body, and heating is boiled 5 times, After wine jar is cooled down, then black glutinous rice ma's wine that rotary evaporation in vacuo collects alcohol and Alcohol degree is 2 degree;
(2) preparation of Chinese medical extract:Take 2 parts of peach blossom, it is 20 parts of Radix Codonopsis, 20 parts of the Radix Astragali, 20 parts of maca, 20 parts of matrimony vine, red 30 parts of jujube, 20 parts of Radix Angelicae Sinensis, 20 parts of dalbergia wood leaf, 2 parts of rice-straw ash, co-grinding to size are not more than 100 mesh, obtain Chinese medical extract Raw material;It is 1 according to the material quality of the Chinese medical extract and the ratio of alcohol by volume:3 ratio, by the Chinese medical extract Raw material and alcohol mixing after, stir 4h under the conditions of 80 DEG C, the first filtrate and the first filter residue obtained through filtering;According to described The ratio of one filter residue quality and water volume is 1:4 ratio, after first filter residue and the water are mixed, under the conditions of 100 DEG C 2h is stirred, the second filtrate and the second filter residue are obtained through filtering;Ratio according to the second filter residue quality and water volume is 1:4 ratio Example, after second filter residue and water are mixed, 2h is stirred under the conditions of 100 DEG C, the 3rd filtrate and the 3rd filter residue are obtained through filtering; After first filtrate, the second filtrate, the 3rd filtrate are merged, it is concentrated in vacuo under the conditions of 70 DEG C and the traditional Chinese medicine extraction is made Thing;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 2 degree With the Chinese medical extract obtained by step (2) according to volume ratio be 10:After 1 ratio merging shakes up, peach blossom ma's wine health care mouth is made Liquid one is taken, then peach blossom ma bartender's health-care oral liquid is fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be filled The vial for having peach blossom ma bartender's health-care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 2
The embodiments of the invention provide a kind of preparation method of peach blossom ma bartender's health-care oral liquid, comprise the following steps:
(1) preparation of ma's wine:Black glutinous rice is soaked in water 12h, black glutinous rice is put into cauldron after draining the water, is placed into clear Water cooks into ma's meal, is put into after steamed ma's meal is naturally cooled into 50 DEG C in wine vat, then by the fermented yeast of ma's meal quality 3% Add in wine vat, close the lid, and the insulation material sealing and fermenting such as a little straw or cotton-wadded quilt is put covering with the red yeast rice of ma's meal quality 1% 15 days;Add that quality is 2 times of ma's meal quality and Alcohol degree is that 20 degree of rice wine continues sealing and fermenting 18 days;Handle is sieved with wine Wine in wine vat is put into wine jar, and wine jar is sealed with turf, then coats sposh on the wine jar whole body, and heating is boiled 4 times, treats wine jar After cooling, black glutinous rice ma's wine that rotary evaporation in vacuo collects alcohol and Alcohol degree is 1 degree;
(2) preparation of Chinese medical extract:Take 4 parts of peach blossom, it is 22 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of maca, 18 parts of matrimony vine, red 32 parts of jujube, 18 parts of Radix Angelicae Sinensis, 18 parts of dalbergia wood leaf, 1.5 parts of rice-straw ash, are crushed to 200 mesh after combination drying, obtain Chinese medical extract Raw material;It is 1 according to the material quality of the Chinese medical extract and the ratio of alcohol by volume:2 ratio, by the Chinese medical extract After raw material and alcohol mixing, 3h is stirred under the conditions of 80 DEG C, the first filtrate and the first filter residue are obtained through filtering;According to described first The ratio of filter residue quality and water volume is 1:2 ratio, after first filter residue and the water are mixed, is stirred under the conditions of 80 DEG C 1.5h, the second filtrate and the second filter residue are obtained through filtering;Ratio according to the second filter residue quality and water volume is 1:2 ratio Example, after second filter residue and water are mixed, 1.5h is stirred under the conditions of 80 DEG C, and the 3rd filtrate and the 3rd filter are obtained through filtering Slag;After first filtrate, the second filtrate, the 3rd filtrate are merged, the obtained Chinese medicine is concentrated in vacuo under the conditions of 60 DEG C and is carried Take thing;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 1 degree 1200ml merges with the Chinese medical extract 100ml obtained by step (2) shake up after, peach blossom ma bartender health-care oral liquid two is made, then will Peach blossom ma bartender's health-care oral liquid is fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be equipped with the peach blossom ma The vial of bartender's health-care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 3
The embodiments of the invention provide a kind of preparation method of peach blossom ma bartender's health-care oral liquid, comprise the following steps:
(1) preparation of ma's wine:Black glutinous rice is soaked in water 14h, black glutinous rice is put into cauldron after draining the water, is placed into clear Water cooks into ma's meal, is put into after steamed ma's meal is naturally cooled into not higher than 50 DEG C in wine vat, then by quality be ma's meal quality 1% fermented yeast and quality is added in wine vat for the red yeast rice of ma's meal quality 1%, is closed the lid, and cover put a little straw or The insulation material such as cotton-wadded quilt sealing and fermenting 12 days;Add quality be 0.5 times of ma's meal quality and Alcohol degree be 15 degree rice wine after Continuous sealing and fermenting 10 days;The wine in wine vat is put into wine jar with wine sieve, wine jar is sealed with turf, then is coated on the wine jar whole body Sposh, heating is boiled 3 times, after wine jar is cooled down, then the black glutinous rice ma that rotary evaporation in vacuo collects alcohol and Alcohol degree is 5 degree Wine;
(2) preparation of Chinese medical extract:Take 3 parts of peach blossom, it is 18 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 18 parts of maca, 15 parts of matrimony vine, red 25 parts of jujube, 22 parts of Radix Angelicae Sinensis, 22 parts of dalbergia wood leaf, 1.2 parts of rice-straw ash, are crushed to 100 mesh after combination drying, obtain Chinese medical extract Raw material;It is 1 according to the material quality of the Chinese medical extract and the ratio of alcohol by volume:5 ratio, by the Chinese medical extract After raw material and alcohol mixing, 6h is stirred under the conditions of 60 DEG C, the first filtrate and the first filter residue are obtained through filtering;According to described first The ratio of filter residue quality and water volume is 1:2 ratio, after first filter residue and the water are mixed, is stirred under the conditions of 100 DEG C 3h is mixed, the second filtrate and the second filter residue are obtained through filtering;Ratio according to the second filter residue quality and water volume is 1:2 ratio Example, after second filter residue and water are mixed, 1.5h is stirred under the conditions of 100 DEG C, and the 3rd filtrate and the 3rd filter are obtained through filtering Slag;After first filtrate, the second filtrate, the 3rd filtrate are merged, the obtained Chinese medicine is concentrated in vacuo under the conditions of 80 DEG C and is carried Take thing;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 5 degree 800ml merges with the Chinese medical extract 100ml obtained by step (2) shake up after, be made peach blossom ma bartender health-care oral liquid three, then by institute State peach blossom ma's bartender's health-care oral liquid to be fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be equipped with the peach blossom ma wine The vial of health care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 4
The embodiments of the invention provide a kind of preparation method of peach blossom ma bartender's health-care oral liquid, comprise the following steps:
(1) preparation of ma's wine:Black glutinous rice is soaked in water 14h, black glutinous rice is put into cauldron after draining the water, is placed into clear Water cooks into ma's meal, is put into after steamed ma's meal is naturally cooled into not higher than 50 DEG C in wine vat, then by quality be ma's meal quality 2% fermented yeast and quality is added in wine vat for the red yeast rice of ma's meal quality 1%, is closed the lid, and cover put a little straw or The insulation material such as cotton-wadded quilt sealing and fermenting 12 days;Add quality be 1.5 times of ma's meal quality and Alcohol degree be 15 degree rice wine after Continuous sealing and fermenting 10 days;The wine in wine vat is put into wine jar with wine sieve, wine jar is sealed with turf, then is coated on the wine jar whole body Sposh, heating is boiled 3 times, and alcohol and Alcohol degree are collected after obtained black glutinous rice ma's wine after wine jar cooling, then rotary evaporation in vacuo For 10 degree of black glutinous rice ma's wine;
(2) preparation of Chinese medical extract:Take 5 parts of peach blossom, it is 15 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of maca, 15 parts of matrimony vine, red 30 parts of jujube, 22 parts of Radix Angelicae Sinensis, 15 parts of dalbergia wood leaf, 1 part of rice-straw ash, are crushed to 100 mesh after combination drying, obtain the original of Chinese medical extract Material;It is 1 according to the material quality of the Chinese medical extract and the ratio of alcohol by volume:2 ratio, by the original of the Chinese medical extract After material and alcohol mixing, 6h is stirred under the conditions of 80 DEG C, the first filtrate and the first filter residue are obtained through filtering;According to the described first filter The ratio of slag amount and water volume is 1:3 ratio, after first filter residue and the water are mixed, is stirred under the conditions of 100 DEG C 3h, the second filtrate and the second filter residue are obtained through filtering;Ratio according to the second filter residue quality and water volume is 1:3 ratio, After second filter residue and water are mixed, 1.5h is stirred under the conditions of 100 DEG C, the 3rd filtrate and the 3rd filter residue are obtained through filtering; After first filtrate, the second filtrate, the 3rd filtrate are merged, it is concentrated in vacuo under the conditions of 70 DEG C and the traditional Chinese medicine extraction is made Thing;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 10 degree 800ml merges with the Chinese medical extract 100ml obtained by step (2) shake up after, be made peach blossom ma bartender health-care oral liquid four, then by institute State peach blossom ma's bartender's health-care oral liquid to be fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be equipped with the peach blossom ma wine The vial of health care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 5
(1) black glutinous rice ma's wine is made according to (1) the step of the embodiment of the present invention 1;
(2) preparation of Chinese medical extract:Take 2 parts of peach blossom, it is 20 parts of Radix Codonopsis, 20 parts of the Radix Astragali, 20 parts of maca, 20 parts of matrimony vine, red 30 parts of jujube, 20 parts of Radix Angelicae Sinensis, 20 parts of dalbergia wood leaf, 2 parts of rice-straw ash, are crushed to 100 mesh after combination drying, obtain the original of Chinese medical extract Material;It is 1 according to the raw material of the Chinese medical extract and the mass ratio of water:10 ratio, by the Chinese medical extract of water and gained (pH value is 7.0~7.5) is worn into slurries and is transferred in fermentation tank after raw material mixing, is heated to more than 90 DEG C, keeps 45min, Reducing temperature, (Mixed Microbes are 1 to the Mixed Microbes for after 20 DEG C, adding slurry weight 10%:1 mould and head mold), stirring fermentation 96h, rotating speed is 10r/min, after terminating, with 100 mesh sieve net filtrations, through high-temperature sterilization, obtains Chinese medical extract;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 2 degree With the Chinese medical extract obtained by step (2) according to volume ratio be 10:After 1 ratio merging shakes up, peach blossom ma's wine health care mouth is made Liquid five is taken, then peach blossom ma bartender's health-care oral liquid is fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be filled The vial for having peach blossom ma bartender's health-care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 6
(1) black glutinous rice ma's wine is made according to (1) the step of the embodiment of the present invention 2;
(2) preparation of Chinese medical extract:Take 4 parts of peach blossom, it is 22 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of maca, 18 parts of matrimony vine, red 32 parts of jujube, 18 parts of Radix Angelicae Sinensis, 18 parts of dalbergia wood leaf, 1.5 parts of rice-straw ash, are crushed to 200 mesh after combination drying, obtain Chinese medical extract Raw material;It is 1 according to the raw material of the Chinese medical extract and the mass ratio of water:5 ratio, by the Chinese medical extract of water and gained (pH value is 7.0~7.5) is worn into slurries and is transferred in fermentation tank after raw material mixing, is heated to more than 90 DEG C, keeps 45min, Reducing temperature, (Mixed Microbes are that weight ratio is 1 to the Mixed Microbes for after 20 DEG C, adding slurry weight 5%:2 mould and head mold), stir Fermentation 72h is mixed, rotating speed is 10r/min, after terminating, with 100 mesh sieve net filtrations, through high-temperature sterilization, obtain Chinese medical extract;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 1 degree 1200ml merges with the Chinese medical extract 100ml obtained by step (2) shake up after, peach blossom ma bartender health-care oral liquid six is made, then will Peach blossom ma bartender's health-care oral liquid is fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be equipped with the peach blossom ma The vial of bartender's health-care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 7
(1) black glutinous rice ma's wine is made according to (1) the step of the embodiment of the present invention 3;
(2) preparation of Chinese medical extract:Take 5 parts of peach blossom, it is 15 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of maca, 15 parts of matrimony vine, red 30 parts of jujube, 22 parts of Radix Angelicae Sinensis, 22 parts of dalbergia wood leaf, 1.2 parts of rice-straw ash, are crushed to 100 mesh after combination drying, obtain Chinese medical extract Raw material;It is 1 according to the raw material of the Chinese medical extract and the mass ratio of water:10 ratio, by water and the Chinese medical extract of gained Raw material mixing after (pH value be 7.0~7.5) wear into slurries and be transferred in fermentation tank, be heated to more than 90 DEG C, holding 30min, (Mixed Microbes are that weight ratio is 1 to reduction temperature to the Mixed Microbes for after 20 DEG C, adding slurry weight 10%:4 mould and root It is mould), stirring fermentation 96h, rotating speed is 20r/min, after terminating, with 100 mesh sieve net filtrations, through high-temperature sterilization, obtains traditional Chinese medicine extraction Thing;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 5 degree 800ml merges with the Chinese medical extract 100ml obtained by step (2) shake up after, be made peach blossom ma bartender health-care oral liquid seven, then by institute State peach blossom ma's bartender's health-care oral liquid to be fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be equipped with the peach blossom ma wine The vial of health care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Embodiment 8
(1) black glutinous rice ma's wine is made according to (1) the step of the embodiment of the present invention 2;
(2) preparation of Chinese medical extract:Take 5 parts of peach blossom, it is 15 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of maca, 15 parts of matrimony vine, red 30 parts of jujube, 22 parts of Radix Angelicae Sinensis, 15 parts of dalbergia wood leaf, 1 part of rice-straw ash, are crushed to 100 mesh after combination drying, obtain the original of Chinese medical extract Material;It is 1 according to the raw material of the Chinese medical extract and the mass ratio of water:10 ratio, by the Chinese medical extract of water and gained (pH value is 7.0~7.5) is worn into slurries and is transferred in fermentation tank after raw material mixing, is heated to more than 90 DEG C, keeps 60min, Reducing temperature, (Mixed Microbes are that weight ratio is 1 to the Mixed Microbes for after 20 DEG C, adding slurry weight 15%:2 mould and head mold), stir Fermentation 48h is mixed, rotating speed is 30r/min, after terminating, with 100 mesh sieve net filtrations, through high-temperature sterilization, obtain Chinese medical extract;
(3) preparation of peach blossom ma bartender health-care oral liquid:By black glutinous rice ma's wine that the Alcohol degree obtained by step (1) is 10 degree 800ml merges with the Chinese medical extract 100ml obtained by step (2) shake up after, be made peach blossom ma bartender health-care oral liquid eight, then by institute State peach blossom ma's bartender's health-care oral liquid to be fitted into the vial through 100 DEG C of hot water high-temperature sterilization 10min, will be equipped with the peach blossom ma wine The vial of health care oral liquid is placed in pasteurize 30min in 80 DEG C of water, seals while hot.
Comparative example 1
In order to further illustrate beneficial effects of the present invention, the step of repeating the embodiment of the present invention 5, by the embodiment of the present invention " mixed bacteria is 1 in 5 the step of (2):1 mould and head mold " is substituted for that " mixed bacteria is 1:1 aspergillus niger and withered grass gemma Bacillus ", is made peach blossom ma bartender health-care oral liquid nine.
Comparative example 2
In order to further illustrate beneficial effects of the present invention, the step of repeating the embodiment of the present invention 5, by the embodiment of the present invention " mixed bacteria is 1 in 5 the step of (2):1 mould and head mold " is substituted for that " mixed bacteria is 1:1 mould and bacillus subtilis Bacterium ", is made peach blossom ma bartender health-care oral liquid ten.
Comparative example 3
In order to further illustrate beneficial effects of the present invention, the step of repeating the embodiment of the present invention 5 (2) and (3) sends out this " mixed bacteria is 1 in the step of bright embodiment 5 (2):1 mould and head mold " is substituted for that " mixed bacteria is 1:1 head mold and black Aspergillus ", is made peach blossom ma bartender health-care oral liquid 11.
Peach blossom ma each 100g of bartender's health-care oral liquid is taken, the detection that following method carries out active ingredient is respectively adopted:
Using Water distillation extractor, the interior standard specimen ethyl caprate 0.1ml that extractant adds 200mg/L, continuous steaming are of ether Extraction 45min is evaporated, the VFA in peach blossom ma's bartender's health-care oral liquid is fully extracted concentration by ether, extraction is collected Liquid, plus 5g anhydrous sodium sulfates are statically placed at 4 DEG C and dehydrate 12h in refrigerator, then filter, Rotary Evaporators are at 45 DEG C in filtrate Vacuumize after evaporation ether solvent, be concentrated into 0.1~0.2ml, obtain pale yellow oily liquid, sealing refrigeration treats that GC-MS is analyzed With.
GC conditions:Japanese Shimadzu gas chromatography-mass spectrograph band digital display processor, DB-5MS quartz capillary columns (29m × 0.25mm, 0.25 μm).Temperature programming:50 DEG C of column temperature, 8 DEG C/min of heating rate, to 150 DEG C of holding 2.00min;Rise Warm 5 DEG C/min of speed, to 180 DEG C of holding 2.00min;To 230 DEG C of holding 7.50min;3 DEG C/min of heating rate, to 280 DEG C of guarantors Hold 5.00min;220 DEG C of injector temperature, 280 DEG C of interface temperature does not shunt (pulse) sample introduction, pulse 50kPa, carrier gas N2, flow velocity 0.8ml/min, detector FID.
Mass Spectrometry Conditions:Bombard electronic capability:70eV, electron source ionization mode:EI, 200 DEG C of ion source temperature, level Four bar temperature 50 DEG C of degree, electron multiplier voltage:Low 50V, sample size under automatic tuning:2 μ l, scanning range:20~500amu, solvent retardation Time:3.00min, scan mode:Full scan (scan).
Analyzed by GC-MS and calculate relative amount of the n- palmitic acid compositions for obtaining each sample in volatile oil (such as Shown in table 1).
As shown in Table 1, the n- palmitic acid contents with the sample of the gained of embodiment 1~4 are contrasted, the gained sample of embodiment 5~8 In n- palmitic acids have on percentage contents and increase by a relatively large margin, the volatile oil compositions of Chinese herbal medicine are complicated, mostly volatile, It is unstable, the complicated chemistry such as oxidation, polymerization, condensation, group transfer, photochemical reaction easily occurs in extraction process anti- Should, and the extraction efficiency that the extracting process that embodiment 1~4 is used easily causes volatile organic matter is low, and embodiment 5~8 is adopted Microbe fermentation method, and Institute of Micro-biology secretion ectoenzyme chemical catalysis effect, the secondary metabolism of microorganism in itself with And the hyther in fermentation process, also Chinese herbal medicine can be made to produce more active ingredients during the fermentation.
Compared with the content of the n- palmitic acid compositions in the feed addictive obtained by embodiment 5~8, the institute of comparative example 1~3 The n- palmitic acid comparison of ingredients of obtained feed addictive is low, and this is mainly due to dalbergia wood leaf essential oil to bacillus subtilis and black Aspergillus has preferable inhibitory activity so that the n- palmitic acid compositions of peach blossom ma's bartender's health-care oral liquid obtained by comparative example 1~3 Than relatively low.
Relative amount of the n- palmitic acid compositions of table 1 in volatile oil
Effect example 1
In order to further illustrate beneficial effects of the present invention, the method system for taking the embodiment of the present invention 1~8 and comparative example 1~3 The oral liquid and commercially available millet man peach blossom wine obtained carries out beautifying face and moistering lotion effect experiment.
Female volunteers of the age of the partially black property skin of every group of collection 100 at 28~45 years old, try out the present invention by totally 7 groups The oral liquid of embodiment 1~8 and the oral liquid of comparative example 1~3 and commercially available millet man peach blossom wine observe result after 120 days. Experimental result is referring to table 2.
Experimental result:From table 2 it can be seen that the oral liquid of the gained of the embodiment of the present invention 1~8, the gained of comparative example 1~3 Oral liquid and commercially available millet man peach blossom wine are black to skin quality, skin is dark yellow, spot has different degrees of improvement, the institute of embodiment 5~8 Oral liquid it is black to skin quality, skin is dark yellow, spot improvements degree is apparently higher than the oral liquid obtained by embodiment 1~4 and right The oral liquid of the gained of ratio 1~3 and commercially available millet man peach blossom wine.
The beauty functions evaluation result of table 2
Influence of the effect example 2 to caused by cyclophosphamide immunologic hypofunction immune function of mice
The preparation of medicine:Take respectively according to oral liquid made from the method for the embodiment of the present invention 1~8 and according to comparative example 1 Oral liquid made from~3 method, after volatilizing, adds water and is settled to containing 1 part/ml of crude drug.
Using healthy Kun Ming mice as experimental subjects, 18~20 parts of body weight, male and female half and half are randomly divided into 13 groups, i.e., empty White control group, model group, numbering are respectively 1,2,3,4,5,6,7,8,9,10,11 experimental group, and every group 10, every group is pressed daily 10ml/k parts are administered once, blank control group, model group gavage physiological saline, 1~8 mouthful of the difference gavage of experimental group 1~8 embodiment Take liquid preparation medicine, continuous 7 days, in the 2nd day be administered after, in addition to control group, remaining each group ip in mice endoxan 100mg/ kg.In 1h after last dose, weigh in, de- cervical vertebra is put to death into mouse, spleen and thymic factor D injection are weighed respectively, chest is calculated respectively Gland coefficient and Spleen coefficient.Experimental result is shown in Table 4.
Experimental result:As known from Table 3, compared with blank control group, model group thymus gland coefficient and Spleen coefficient are substantially reduced, Show that immunodeficiency models are formed, compared with model group, experimental group 1~8 is (using prepared by the oral liquid of the embodiment of the present invention 1~8 Medicine) and experimental group 9~11 (using the medicine prepared by the oral liquid of comparative example 1~3 of the present invention) thymus gland of mouse can be improved Coefficient and Spleen coefficient, i.e. using the medicine and 1~3 mouthful of comparative example of the present invention prepared by the oral liquid of the embodiment of the present invention 1~8 The immunologic function of hypoimmunity mouse can be improved by taking the medicine prepared by liquid, wherein, the immunologic function of hypoimmunity mouse It is followed successively by from big to small:Experimental group 5~8 (using the medicine prepared by the oral liquid of the embodiment of the present invention 5~8), experimental group 1~4 (using the medicine prepared by the oral liquid of the embodiment of the present invention 1~4), experimental group 9~10 are (oral using comparative example 1~3 of the present invention Medicine prepared by liquid), this explanation n- palmitic acid content is higher, is more favorably improved the immunologic function of hypoimmunity mouse.
The influence of the normal mouse immune organ of 3 pairs of table
Note:*The P < 0.05 compared with model group;**The P < 0.01 compared with model group.
Finally it should be noted that:Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations;To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that:Its according to The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered Row equivalent substitution;And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology The scope of scheme.

Claims (10)

1. a kind of peach blossom ma bartender's health-care oral liquid, it is characterised in that including yellow rice wine, Chinese medical extract, the yellow rice wine is carried with Chinese medicine The volume ratio for taking thing is 8~12:1, wherein, the Chinese medical extract is using solvent impregnation, ethanol extract from water precipitation, ultrasonic extraction Any one in method, continuous ethanol reflux extraction, fermentation extraction method is made;The raw material of the Chinese medical extract, by weight Number meter, including:It is 1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 15~25 parts of the Radix Astragali, 15~25 parts of maca, 15~25 parts of matrimony vine, red 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, 0.5~5 part of plant ash.
2. the preparation method of peach blossom ma bartender's health-care oral liquid as claimed in claim 1, it is characterised in that the Chinese medical extract Preparation method, comprise the following steps:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 15~25 parts of the Radix Astragali, agate 15~25 parts of coffee, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 Part, after the raw material of the Chinese medical extract is mixed, it is according to the material quality of the Chinese medical extract and the ratio of alcohol by volume 1:2~5 ratio, after the raw material of the Chinese medical extract and alcohol are mixed, stirs 3~6h, warp under the conditions of 60~80 DEG C Filtering obtains the first filtrate and the first filter residue;Ratio according to the first filter residue quality and water volume is 1:2~5 ratio, will After first filter residue and the water mixing, 1.5~3h is stirred under the conditions of 80~100 DEG C, through filtering obtain the second filtrate and Second filter residue;Ratio according to the second filter residue quality and water volume is 1:2~5 ratio, second filter residue and water are mixed After conjunction, 1.5~3h is stirred under the conditions of 80~100 DEG C, the 3rd filtrate and the 3rd filter residue are obtained through filtering;Described first is filtered After liquid, the second filtrate, the 3rd filtrate merge, it is concentrated in vacuo under the conditions of 60~80 DEG C and the Chinese medical extract is made.
3. the preparation method of peach blossom ma bartender's health-care oral liquid as claimed in claim 1, it is characterised in that the Chinese medical extract Preparation method, comprise the following steps:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 15~25 parts of the Radix Astragali, agate 15~25 parts of coffee, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 Part, it is 1 according to the raw material of the Chinese medical extract and the mass ratio of water after the raw material of the Chinese medical extract is mixed:5~10 Ratio, wear into slurries after water is mixed with the raw material of the Chinese medical extract of gained, be heated with stirring to and be not less than 90 DEG C, keep 30 ~60min, reduction temperature is not higher than to after 20 DEG C, adds the Mixed Microbes of slurry weight 5~15%, stirring 48~96h of fermentation, warp Filtering, sterilizing, obtain Chinese medical extract.
4. the preparation method of peach blossom ma's bartender's health-care oral liquid as claimed in claim 1, it is characterised in that the yellow rice wine is black glutinous Rice ma's wine, the black glutinous rice ma wine is to be made using following methods:Black glutinous rice is soaked in water 12~16h, put again after draining the water Enter clear water and cook into ma's meal, ma's meal is cooled into temperature is not higher than after 50 DEG C, addition gross mass be ma's meal quality 1~ 5% yeast and red yeast rice, and sealing and fermenting 10~18 days, add the rice wine that quality is 0.5~2 times of ma's meal quality, and Continue sealing and fermenting 10~18 days, then seal it is heat-insulated boil 3~5 times, black glutinous rice ma's wine is made through cooling, evaporation.
5. a kind of preparation method of peach blossom ma bartender's health-care oral liquid, it is characterised in that comprise the following steps:
(1) raw material of the Chinese medical extract of following portions by weight is taken:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, plant ash 0.5~2 Part, 15~25 parts of the Radix Astragali, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, dalbergia wood leaf 15 ~25 parts, 0.5~5 part of plant ash, are extracted using solvent impregnation, ethanol extract from water precipitation, ultrasonic extraction, continuous alcohol reflux Chinese medical extract is made in any one raw material for extracting the Chinese medical extract in method, fermentation extraction method;
(2) it is 8~12 according to the volume ratio of yellow rice wine and Chinese medical extract:1 ratio, the Chinese medical extract and yellow rice wine are mixed Peach blossom ma's bartender's health-care oral liquid is made in sterilizing after uniform.
6. the preparation method of peach blossom ma bartender's health-care oral liquid as claimed in claim 5, it is characterised in that step (1) tool Body includes:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 0.5~2 part of plant ash, 15~25 parts of the Radix Astragali, 15~25 parts of maca, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, dalbergia wood leaf 15~25 Part, 0.5~5 part of plant ash, after the raw material of the Chinese medical extract is mixed, according to the Chinese medical extract material quality with The ratio of alcohol by volume is 1:2~5 ratio, after the raw material of the Chinese medical extract and alcohol are mixed, in 60~80 DEG C of conditions 3~6h of lower stirring, the first filtrate and the first filter residue are obtained through filtering;Ratio according to the first filter residue quality and water volume is 1: 2~5 ratio, after first filter residue and the water are mixed, stirs 1.5~3h under the conditions of 80~100 DEG C, is obtained through filtering Obtain the second filtrate and the second filter residue;Ratio according to the second filter residue quality and water volume is 1:2~5 ratio, by described After two filter residues and water mixing, 1.5~3h is stirred under the conditions of 80~100 DEG C, the 3rd filtrate and the 3rd filter residue are obtained through filtering;Will After first filtrate, the second filtrate, the 3rd filtrate merge, it is concentrated in vacuo under the conditions of 60~80 DEG C and the traditional Chinese medicine extraction is made Thing.
7. the preparation method of peach blossom ma bartender's health-care oral liquid as claimed in claim 5, it is characterised in that step (1) tool Body includes:
Take the raw material of the Chinese medical extract of following portions by weight:1~5 part of peach blossom, 15~25 parts of Radix Codonopsis, 15~25 parts of the Radix Astragali, agate 15~25 parts of coffee, 15~25 parts of matrimony vine, 20~40 parts of jujube, 15~25 parts of Radix Angelicae Sinensis, 15~25 parts of dalbergia wood leaf, plant ash 0.5~5 Part, it is 1 according to the raw material of the Chinese medical extract and the mass ratio of water after the raw material of the Chinese medical extract is mixed:5~10 Ratio, wear into slurries after water is mixed with the raw material of the Chinese medical extract of gained, be heated with stirring to and be not less than 90 DEG C, keep 30 ~60min, reduction temperature is not higher than to after 20 DEG C, adds the Mixed Microbes of slurry weight 5~15%, stirring 48~96h of fermentation, warp Filtering, sterilizing, obtain Chinese medical extract.
8. the preparation method of peach blossom ma bartender's health-care oral liquid as claimed in claim 6, it is characterised in that:The yellow rice wine is black glutinous Rice ma's wine, the black glutinous rice ma wine is to be made using following methods:
Black glutinous rice is soaked in water 12~16h, clear water is placed into after draining the water and cooks into ma's meal, ma's meal is cooled to temperature After not higher than 50 DEG C, yeast and red yeast rice that gross mass is ma's meal quality 1~5%, and sealing and fermenting 10~18 days are added, then The rice wine that quality is 0.5~2 times of ma's meal quality is added, and continues sealing and fermenting 10~18 days, then seals and heat-insulated boils 3 ~5 times, black glutinous rice ma's wine is made through cooling, evaporation.
9. a kind of peach blossom ma bartender's health-care oral liquid, it is characterised in that the peach blossom ma bartender health-care oral liquid is will using such as right The preparation method of peach blossom ma's bartender's health-care oral liquid described in 5 is asked to be made.
10. peach blossom ma bartender health-care oral liquid as claimed in claim 1 or peach blossom ma wine health oral as claimed in claim 5 Application of the preparation method of liquid in terms of medicine or health products is prepared.
CN201710108600.3A 2017-02-27 2017-02-27 A kind of peach blossom ma bartender's health-care oral liquid and its preparation method and application Pending CN107050184A (en)

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Application publication date: 20170818