KR102141337B1 - Functional food having composition for prevention and treatment atopic dermatitis comprising extracts of a mulberry tree as active ingredient - Google Patents

Abstract

The present invention relates to health functional food containing a composition for preventing atopic dermatitis which contains a Cudrania tricuspidata extract as an active ingredient. By indirectly heating a heating container in which Cudrania tricuspidata is contained, water vapor that evaporates from the Cudrania tricuspidata is obtained, and the water vapor is liquefied after being cooled and condensed.

Description

Functional food having composition for prevention and treatment atopic dermatitis comprising extracts of a mulberry tree as active ingredient}

The present invention relates to a health functional food comprising a composition for preventing atopic dermatitis containing an extract of Cudrania mulberry obtained by cooling and condensing vaporized water vapor by indirect heating of Cudrania.

Atopic dermatitis is a chronic inflammatory disease that occurs before the development of asthma and allergic diseases. It varies according to the concentration, quantitative change, or activity of chemokine, and Th2 type lymphocytes are lesions (lesionalskin). ) Also refers to the phenomenon of invasion. Atopic dermatitis is a phenomenon in which the proliferation of keratinocytes is abnormal due to immunological factors. When exposing keratinocytes to IFN-γ (interferon-γ) or TNF-α (tumor necrosis factor-α), TARC , It can be confirmed that chemokines such as MDC and CTACK are abnormally expressed. This phenomenon is due to an increase in the phenomenon that the monocytes/T cells penetrate the skin as the inflammatory reaction occurs.

The exact pathophysiology of atopic dermatitis is not yet fully understood, but it is believed that immunological and non-immunological mechanisms are involved along with genetic predisposition. Exogenous atopic dermatitis, which accounts for the majority of atopic dermatitis, is caused by an immune mechanism associated with IgE. There are many reports that a delayed immune response by T cell abnormality is involved rather than an immediate immune response against a specific allergen. In addition, recently, Th2 related cytokines such as IL-4, which induces the production of IgE from B cells, are reported to be the cause of atopy (JS Kang et al, Ihhibition of atopic dermatitis by topical application of silymarin in NC /Nga mice Int Immunopharm (2008) 8: 1475-1480).

Since the treatment of atopic dermatitis is not easy to find and treat its roots, it is common to control the symptoms of atopic dermatitis by avoiding triggers and by appropriate treatment rather than aiming at cure. The prescription for atopic dermatitis mainly consists of drug therapy such as steroids, antihistamines, antibiotics, etc. Steroids (adrenal cortical hormones) have a great anti-inflammatory and immunosuppressive effect and are excellent, but steroids are epidermal. May cause adverse effects such as growth inhibition or side effects, urea peroxide may cause excessive irritation of the skin, and antibiotics such as antihistamines may cause side effects such as bacteria resistance and photosensitivity. There is a high problem. In addition, when applied to the skin for a long period of time, there is a concern that serious side effects such as telangiectasia and/or an increase in the thickness of the stratum corneum or expansion may occur, and gamma-linoleic acid, which is frequently used for alleviating atopy (Korea Patent Publication No. 2000-0046633 Arc) is easily oxidized, so it is inferior in stability and has relatively strong skin irritation, making it difficult to use for sensitive skin.

Therefore, there is a need to develop a new concept of atopic dermatitis prevention composition that is effective in atopic dermatitis and has no side effects.

In addition, it has recently focused on exploring natural substances that have an effect on atopy. Representatively, wormwood extract (Republic of Korea Patent Registration No. 10-0377262), Youngji mushroom, Yugeunpi, Licorice, Baekbongryeong, Baekjima and Baeknyeoncho extract (Republic of Korea Patent Registration No. 10-0517465), evening primrose, aloe, grass, violet Jujube, Matsutake mushroom, Eur, Ginseng, Green tea, Duchung, Bokbunja, Omija, Mugwort, Pogongyeong, Sambaekcho, Hwanggi, Hagocho, Haesong, Golden and hyssul extract (Republic of Korea Patent Registration No. 10-0451444), celadon lobule and deficit Extracts of lobule (Republic of Korea Patent Registration No. 10-0454752), extracts of dry-skinned, Eui-in, Omija, Gilkyung, Nabokja, Macmun-dong and Seokchangpo (Republic of Korea Patent Registration No. 10-0483539), lavender, eucalyptus and tea tree oil (Korean patents) Registration No. 10-0597997), etc., in addition, it is known that the above mentioned students, haphwanpi, changja, malt, etc. are effective.

However, the above natural substances have a disadvantage in that their efficacy is insignificant, or even if they are effective, they show an allergic hypersensitivity reaction on sensitive skin, and their use is limited.

On the other hand, Cudrania tricuspidata (Cudrania tricuspidata) is a small-leaved tree belonging to the genus Mulberry and Cudrania, and grows in the foothills or fields in the south-southeast of south and south of Korea. Unlike regular mulberry trees, the Cudrania mulberry has long thorns, the edges of the leaves are flat, and when the leaves are cut, white liquid like milk appears and the same liquid comes out from the fruits. Cudrania contains bioactive substances such as planoids, gaba, rutin, and aspartic acid, and is known to have anti-cancer, analgesic, antibacterial, blood removal, diabetes, hypertension, brain hemorrhage, dysmenorrhea, cold relief, and anti-inflammatory properties.

Korea has been cultivating Cudrania mulberry for the purpose of providing stable supply of mulberry leaves to silkworms during the sericulture industry. The cultivar cultivated as described above is pruned every year for mass production of mulberry leaves. Although the cultivar cut as described above has excellent medicinal efficacy as described above, the wood is soft, The amount is so great that it is difficult to deal with it.

On the other hand, in general, the method of extracting mulberry oil from a mulberry tree uses two jars, one jar is filled with mulberry, the other is buried in the ground, and the manure function between the muzzle and the muzzle of the jar The muzzles of the two pots are put together through the burlap. The burlap blocks the introduction of carbonized pieces to be burned by the mulberry tree. Located on the ground, and covered with rice husk around the jar full of mulberry trees, the rice husk is lit and carbonized by heating the mulberry in the jar. In this process, when water vapor evaporated from water evaporates into the ground and flows into the inside of a jar that maintains a low temperature, condensation occurs due to the difference in temperature between the two jars to produce mulberry oil. This production method of mulberry oil is very useful for extracting mulberry oil from hardwood mulberry trees.

However, in the case of extracting mulberry oil from a mulberry branch that is not hard-wooded, the water evaporation rate is so fast that the mulberry branch itself burns out, so there is a disadvantage that it cannot be extracted. In addition, the above method takes too long time (7 to 10 days), so there is a limit in improving productivity, and there is a limit in continuously increasing the temperature, so that various components contained in the mulberry oil extracted from the mulberry tree cannot be formed. , The yield is also low. In addition, the tar generated from chaff is mixed into the jar, it smells of tar from mulberry oil, there is a limit to clean use, and the quality of carbide (char) obtained as a by-product is low, so that the odor is severely generated even when recycled as charcoal. There is, there is a risk of damage due to heat or external impact by using the jar.

Republic of Korea Patent Publication No. 2000-0046633 Republic of Korea Patent Registration No. 10-0377262 Republic of Korea Patent Registration No. 10-0517465 Republic of Korea Patent Registration No. 10-0451444 Republic of Korea Patent Registration No. 10-0454752 Republic of Korea Patent Registration No. 10-0483539 Republic of Korea Patent Registration No. 10-0597997

JS Kang et al, Ihhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice Int Immunopharm (2008) 8:1475-1480

The problem to be solved according to one embodiment of the present invention is indirect heating of the Cudrania mulberry tree, comprising a composition for preventing atopic dermatitis containing an extract of the Cudrania mulberry obtained by cooling and condensing evaporating water vapor as an active ingredient The purpose is to provide food.

In addition, the problem to be solved according to another embodiment of the present invention is to use a mulberry tree with soft wood, and a mulberry oil extract obtained using a mulberry oil extractor capable of obtaining clean active ingredients from such a mulberry tree with high yield. It is an object to provide a health functional food comprising a composition for preventing atopic dermatitis containing an extract of a tree as an active ingredient.

An embodiment of the present invention is a composition for preventing atopic dermatitis, by indirectly heating the heating vessel in which the Cudrania is stored at a temperature of 150 to 500° C. to obtain water vapor evaporating out of the Cudrania and evaporating. Cooling and condensing to a temperature of to 15 ℃, to provide a composition for preventing atopic dermatitis containing liquefied mulberry extract as an active ingredient.

Cudrania mulberry accommodated in the heating container may be a tree having a stem having an average diameter of 7 cm or less.

The composition for preventing atopic dermatitis is di-alose, di-mannitol, talos, vanillin, acetobanilone, desspirinol, 1,4:3,6-dianhydro-alpha-di-glucopyranose , 1H-indole-2-carboxylic acid, myo-inositol, levoglucosan, monoterpene, propiobanilone and 4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid It may be to include a mulberry extract containing.

The Cudrania mulberry extract is extracted by a mulberry oil extractor, and the mulberry oil extractor is made of an inner wall 12a and an outer wall 12 by overlapping stainless steel sheets having different thicknesses in the storage section 17 in which the Cudrania mulberry is housed. As a double body (11) structure, a number of far-infrared irradiation holes (14) to allow the far-infrared rays generated from the ocher wall (13) coated and formed with the outer wall (12) to be cleaved in the Cudrania stored in the storage section (17) (12a) and the outer wall (12) is formed through, the bottom of the mulberry oil extracted from Cudrania mulberry oil is passed through the mulberry oil storage container (30) is installed so that the mulberry oil extraction is installed (16) A heating container 10 having a furnace 15 and a fixing pin 19 for fixing the lid 20 on the upper flange 18; A fixing groove 21a into which the fixing pin 19, which is installed on the upper flange 18 of the heating vessel 10 via a hinge shaft, is fitted, is formed on the flange 21, and the interior of the heating vessel 10 is formed. A safety cock (22) that is opened when the temperature is above a certain temperature is installed, and the lid (20) is provided with a temperature sensor (23) for detecting the internal temperature of the heating vessel (10); The body of the heating vessel 10 is screwed into the mulberry oil extraction furnace 15 formed under the body 11, and water vapor in the heating vessel 10 generated by moisture extracted from the mulberry tree is caused by temperature difference. It is a dual structure having a cooling water circulation space 32 through which cooling water pumped by the cooling water pump 31 is circulated so that it can be condensed, and the discharge valve 34 is provided at the outlet 33 to allow the collection of the extracted mulberry oil. ) Is installed mulberry oil storage container 30 and; The refractory insulating bricks 42 are constructed to minimize heat loss on the upper portion of the plate 41, but are constructed to have a space 43 capable of seating the heating vessel 10. , Heat-resistant heater 44 is installed along the inner surface of the refractory insulation brick 42, a high-temperature temperature detection rod 45 is installed to detect the heating temperature of the heat-heating heater 44, the refractory insulation brick ( 42) a gas 40 wrapped in a stainless cover 46; It may be to include a control box 50 for controlling the internal temperature detection rod 23 and the high temperature temperature detection rod 45 and the heating heater 44 of the heating vessel.

The Cudrania mulberry extract is indirectly heated to a temperature of 350 to 500 °C in which the Cudrania is stored, to obtain water vapor evaporating from the Cudrania and condensing it by cooling to a temperature of 3 to 10 °C, Cudrania mulberry extract to extract liquefied Cudrania mulberry extract: and indirectly heating the heating vessel in which the Cudrania mulberry is stored at a temperature of 150 to 250° C. to obtain water vapor evaporating out of the Cudrania mulberry, 3 to 10° C. Cooling to the temperature of the condensation, may be a mixture of kkujimul tree extract to extract the liqueured mulberry extract in a weight ratio of 3: 1.

Another embodiment of the present invention is a health functional food comprising a composition for preventing atopic dermatitis according to an embodiment of the present invention, wherein the health functional food is a powder, granule, tablet, capsule, syrup or beverage Provide health functional food.

Another embodiment of the present invention is a cosmetic composition comprising a composition for preventing atopic dermatitis according to an embodiment of the present invention, wherein the cosmetic composition is a cream, skin, lotion, essence, emulsion, gel, lipstick, cleansing Provides a cosmetic composition that is a foam, cleansing cream, cleansing water, spray, shampoo, conditioner, treatment, body cleanser, soap, pack, massage agent, face powder, compact, foundation, two-way cake or makeup base.

Another embodiment of the present invention is an external preparation for skin comprising the composition for preventing atopic dermatitis according to one embodiment of the present invention, wherein the external preparation for skin is an ointment, cream, lotion, liquid, dressing, patch, Provides an external preparation for skin, which is a blister, tape, mist, external acid or spray.

The composition for preventing atopic dermatitis according to an embodiment of the present invention, a health functional food containing it, a cosmetic composition, and an external preparation for skin are indirect heating of the Cudrania mulberry tree, thereby cooling and condensing the vaporized water vapor to extract the Cudrania mulberry extract as an active ingredient By containing, it has the effect of alleviating the symptoms of atopic dermatitis. More specifically, through in vivo experiments (in vivo), the Cudrania extract of the present invention induced atopic dermatitis with 2,4-dinitrochlorobenzene (DNCB), an immuno-disrupting substance. When administered or applied to animals, it has the activity of alleviating atopic dermatitis symptoms such as erythema, hemorrhage, dryness, scarring, lichenification, and erosin. Therefore, by orally administering such a composition for preventing atopic dermatitis, or by directly applying it to the skin, it can be very useful in pharmacy. In particular, it can be very useful as a health functional food for preventing atopic dermatitis, cosmetic composition, and an external preparation for skin.

In addition, the composition for preventing atopic dermatitis according to an embodiment of the present invention, a health functional food containing it, a cosmetic composition, and an external preparation for skin utilize a Cudrania mulberry with soft wood and clean active ingredients from the Cudrania mulberry tree By using a mulberry oil extractor that can be obtained with high yield, there is an effect that can be provided with very high productivity.

1 is a cross-sectional configuration of the mulberry oil extractor according to the present invention.
Figure 2 is an exemplary view of the initial state of opening the lid to put a mulberry in the heating vessel body of the mulberry oil extractor according to the present invention.
Figure 3 is an exemplary view of the lid open to put a mulberry tree in the heating vessel body of the mulberry oil extractor according to the present invention.
Figure 4 is an exemplary view of a state put a mulberry mulberry in the heating vessel body of the mulberry oil extractor according to the present invention.
Figure 5 is an exemplary view of the initial state of positioning the fixing pin in the fixing groove by positioning the lid on the heating container body of the mulberry oil extractor according to the present invention.
6 is an exemplary view showing a state in which the lid is mounted by tightening the tightening nut of the fixing pin of the heating container body of the mulberry oil extractor according to the present invention.
Figure 7 is an exemplary view of the process of extracting the mulberry oil from the Cudrania mulberry tree by applying heat from the heating heater to the heating vessel of the mulberry oil extractor according to the present invention.
Figure 8 is an exemplary view of a state in which the heat is applied from the heating heater to the heating container of the mulberry oil extractor according to the present invention, the mulberry oil extracted from the mulberry tree is introduced into the mulberry oil storage container.
9 is GC / MS component analysis results according to Test Example 1 of Cudrania mulberry extract.
10 is a pyrolysis GC / MS component analysis results according to Test Example 2 of Cudrania mulberry extract.
11 is a graph showing the degree of skin damage caused by oral administration of the composition for preventing atopic dermatitis according to Test Example 3.
12 is an image showing the effect of oral administration of the composition for preventing atopic dermatitis according to Test Example 3 on skin lesions.
13 is an optical microscope image of the skin epidermis, such as Hematoxylin & eosin (H&E) staining according to Test Example 3.
14 is a graph showing the weight of the spleen according to oral administration of the composition for preventing atopic dermatitis according to Test Example 3.
15 is a graph showing the comparison of serum IgE expression levels according to oral administration of the composition for preventing atopic dermatitis according to Test Example 3.
16 is a graph showing the degree of skin damage according to skin application of the composition for preventing atopic dermatitis according to Test Example 4.
17 is a graph showing the degree of physical symptom relief according to skin application of the composition for preventing atopic dermatitis according to Test Example 4.

Hereinafter, preferred embodiments according to the present invention will be described in detail. However, the following embodiments are provided to those of ordinary skill in the art to fully understand the present invention and may be modified in various other forms, and the scope of the present invention is limited to the embodiments described below. It is not.

The present invention relates to a composition for preventing atopic dermatitis.

The composition for preventing atopic dermatitis according to an embodiment of the present invention is indirectly heated to a temperature of 150 to 500° C. for a heating container in which the Cudrania is stored, to obtain water vapor evaporating out of the Cudrania and evaporating. Cooling and condensing to a temperature of 0 to 15 ℃, characterized in that it contains a liquefied mulberry extract as an active ingredient.

At this time, the indirect heating may be performed for 2 to 5 hours to obtain a Cudrania extract excellent in preventing or treating atopic dermatitis. In addition, it can provide high productivity with a very short time than the conventional mulberry oil extraction method (7 to 10 days).

Cudrania used in the present invention can be extracted from not only leaves, but also outposts and stems. In particular, the Cudrania mulberry housed in the heating container may include a Cudrania mulberry branch having an average diameter of 7 cm or less. Such woody (wooden) branches can include all of the leaves of the Cudrania tree, as well as outposts and stems. As a result, not only can the woody (wooden) softly utilize the soft Cudrania tree, but also has the effect of obtaining a Cudrania tree extract more effective in preventing or treating atopic dermatitis of the present invention.

In addition, the Cudrania extract contained in the composition for preventing atopic dermatitis according to an embodiment of the present invention is the Cudrania extract according to the extraction methods such as conventional cold needle extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, or heating extraction method The method is based on a completely different method, and the components extracted accordingly are also completely different.

More specifically, the composition for preventing atopic dermatitis is di-alose, di-mannitol, talos, vanillin, acetobanilone, desspirinol, 1,4:3,6-dianhydro-alpha-di- Glucopyranose, 1H-indole-2-carb oxylic acid, myo-inositol, levoglucoic acid, monoterpene, propiobanilone and 4H-pyrido[1,2-a]pyrimidine-3-carb oxyl By containing an acid as an active ingredient, it is possible to obtain a better effect of preventing or treating atopic dermatitis.

In particular, the Cudrania mulberry extract indirectly heats the heating vessel in which the Cudrania is stored at a temperature of 350 to 500°C to obtain water vapor that evaporates from the Cudrania and evaporates, and condenses the water by cooling to a temperature of 3 to 10°C Let, kkuji mulberry extract to extract the liquefied mulberry extract: and indirectly heating the heating vessel in which the mulberry extract is stored at a temperature of 150 to 250° C. to obtain water vapor evaporating out of the mulberry and evaporating. Cooling to a temperature of 10 ℃ and condensing, using the can be a mixture of the weight ratio of 3: 1 by extracting the mulberry extract liqueured mulberry extract, can further improve the above effect.

The composition for preventing atopic dermatitis according to an embodiment of the present invention may include the above-mentioned Cudrania extract at a concentration of 0.01 to 50% by weight. If the content of the Cudrania extract is too small, the effect may be negligible, and if the content is too large, a problem that the above-described improvement effect is no longer expressed may occur. More preferably, it is preferably included in an amount of 10 to 50% by weight.

The composition for preventing atopic dermatitis according to an embodiment of the present invention is preferably extracted by a mulberry oil extractor. The mulberry oil extractor may be extracted by a mulberry oil extractor as shown in FIGS. 1 to 8.

The mulberry oil extractor has a double body 11 structure in which the stainless steel sheets having different thicknesses of the storage section 17 in which the Cudrania is housed are overlapped to form the inner wall 12a and the outer wall 12, to the outer wall 12 A number of far-infrared irradiation holes 14, which allow the far-infrared rays generated from the coated formed ocher wall 13 to be cleaved in the Cudrania stored in the storage section 17, are formed through the inner wall 12a and the outer wall 12, In the lower part, a mulberry oil extraction furnace 15 is installed in which a filter screen 16 is installed so that only the mulberry oil extracted from the Cudrania mulberry tree passes through and is recovered to the mulberry oil storage container 30, and the upper flange 18 ) A heating container 10 having a fixing pin 19 for fixing the lid 20; A fixing groove 21a into which the fixing pin 19, which is installed on the upper flange 18 of the heating vessel 10 via a hinge shaft, is fitted, is formed on the flange 21, and the interior of the heating vessel 10 is formed. A safety cock (22) that is opened when the temperature is above a certain temperature is installed, and the lid (20) is provided with a temperature sensor (23) for detecting the internal temperature of the heating vessel (10); The body of the heating vessel 10 is screwed into the mulberry oil extraction furnace 15 formed under the body 11, and water vapor in the heating vessel 10 generated by moisture extracted from the mulberry tree is caused by temperature difference. It is a dual structure having a cooling water circulation space 32 through which cooling water pumped by the cooling water pump 31 is circulated so that it can be condensed, and the discharge valve 34 is provided at the outlet 33 to allow the collection of the extracted mulberry oil. ) Is installed mulberry oil storage container 30 and; The refractory insulating bricks 42 are constructed to minimize heat loss on the upper portion of the plate 41, but are constructed to have a space 43 capable of seating the heating vessel 10. , Heat-resistant heater 44 is installed along the inner surface of the refractory insulation brick 42, a high-temperature temperature detection rod 45 is installed to detect the heating temperature of the heat-heating heater 44, the refractory insulation brick ( 42) a gas 40 wrapped in a stainless cover 46; It may be used to include a control box 50 for controlling the internal temperature sensing rod 23 and the high temperature temperature sensing rod 45 and the heating heater 44 of the heating vessel.

Hereinafter, the mulberry oil extractor will be described in more detail.

The mulberry oil extractor is in a heating container 10 in which a Cudrania tree is housed, a lid 20 covered with an upper portion of the heating container 10, and a lower mulberry oil extraction furnace 15 of the heating container 10. It includes a screw-type mulberry oil storage container 30 to be fastened, and a gas 40 surrounding the heating container 10.

The heating container 10 has a double body 11 structure in which two stainless steel sheets having different thicknesses overlap the inner wall 12a and the outer wall 12 in which the storage section 17 in which the Cudrania is stored is stacked.

The outer wall 12 of the body 11 is coated with ocher wall 13, and far-infrared rays generated from the ocher wall 13 formed by coating with the outer wall 12 are squeezed into the mulberry tree stored in the storage unit 17. A number of far-infrared irradiation holes 14 that can be filtered are formed through the inner wall 12a and the outer wall 12.

At the bottom of the body 11, a mulberry oil extraction furnace 15 is formed in which a strainer 16 is installed so that only the mulberry oil extracted from the Cudrania tree passes through and is recovered into the mulberry oil storage container 30.

A fixing pin 19 for fixing the lid 20 is installed on the flange 18 above the body.

The ocher wall 13 may have a thickness of 5 to 20 cm.

The lid 20 installed above the body 11 of the heating vessel 10 has a fixing groove 21a into which a fixing pin 19 installed in a flange 18 formed as an upper portion of the body 11 is fitted (a flange ( 21).

In addition, a safety cock 22 that is opened when the internal temperature of the heating vessel 10 is above a certain temperature is installed, and a temperature sensing rod 23 is installed to sense the internal temperature of the heating vessel 10.

The safety cock 22 is opened when the internal temperature of the heating vessel 10 exceeds 500°C to prevent the pressure inside the heating vessel from becoming too high.

It is preferable that the temperature in the storage portion 17 of the heating container 10 is heated to have a maximum heat of 500°C.

The mulberry oil storage container 30, which is screwed to the mulberry oil extraction furnace 15 formed under the body 11 of the heating container 10, is screwed to the mulberry oil extraction furnace 15.

The mulberry oil storage container 30 is a cooling water circulation in which cooling water pumped by the cooling water pump 31 is circulated so that water vapor in the heating container 10 generated by moisture extracted from the Cudrania mulberry can be condensed due to a temperature difference. It is a double structure with space 32.

At the bottom of the mulberry oil storage container 30, an outlet 33 is formed to enable collection of the extracted mulberry oil, and a discharge valve 34 is installed at the outlet 33.

The gas 40 on which the heating container 10 is seated is a fireproof insulating brick 42 on the upper part of the plate 41, which is constructed, but provides a space 43 where the heating container 10 can be seated. The heating heater 44 is installed along the inner surface of the refractory insulating brick 42, and a high-temperature temperature sensing rod 45 is installed to sense the heating temperature of the heating heater 44. There is, the refractory insulating brick 42 is formed by being wrapped in a stainless cover 46.

The heating heater 44 installed inside the refractory insulating brick 42 of the gas 40 generates a heating temperature of up to 900°C, and the internal temperature of the heating container 10 is desired up to 500°C by the heating temperature. It will be able to maintain at temperature.

The heating heater 44 of the gas 40, the inner temperature sensing rod 23 and the high temperature sensing rod 45 of the lid 20 are controlled by the control means of the control box 50.

A carbon packing 60 may be interposed between the heating container 10 and the lid 20 to maintain airtightness.

When extracting the mulberry oil using the mulberry oil extractor of the present invention made of the above-described configuration, as shown in FIGS. 2 to 3, the lid 20 mounted to the top of the heating container 10 is removed.

When removing the lid 20 from the heating container 10, tightening of the fixing pin 19 installed on the upper flange 18 of the body 11 via a hinge shaft (not indicated by a specific symbol in the drawing) After loosening the nut 18a, the fixing pin 19 is loosened from the fixing groove 21a of the flange 21 of the lid 20, and then, as shown in FIG. 2, the lid 20 is separated. 3)

In the state in which the lid 20 is removed from the heating container 10 as described above, the cut-out mulberry cut short as shown in FIG. 4 is filled in the storage portion 17 of the body 11.

When the lid portion 20 is placed on the body 11 of the heating container 10 in a state in which the mulberry tree is filled in the storage portion 17, the lid 20 is fixed when the lid 20 is mounted. In a state where the groove 21a is positioned on the fixing pin 19, the fixing pin 19 is erected as shown in FIG.

Afterwards, as shown in FIG. 6, the tightening nut 19a is tightened, and the flange 21 of the lid 20 is pressed against the flange 18 on the upper portion of the body 11 of the lid 20 heating container 10.

At this time, the airtightness may be improved by the carbon packing 60.

As described above, the mulberry tree is filled in the body 11 of the heating container 10 and the storage portion 17, and the operation button of the control box 50 (not indicated by a specific code) in the state in which the lid 20 is mounted. Um).

The heat of the heating heater 44 generated by the operation of the operation button of the control box 50 conducts the ocher wall 13 and the outer wall 12 and the inner wall 12a constituting the body 11, and the storage unit 17 ) The stored Cudrania is heated.

The heat generated from the heating heater 44 is conducted through the space 43 to carbonize the Cudrania by indirect heat.

When the heat of the heating heater 44 is applied to the kkuji mulberry stored in the storage section 17 of the body 11, the moisture of the kkuji mulberry comes out and evaporates.

As described above, water vapor evaporating out of the mulberry tree is screwed to the mulberry oil extraction furnace 15 formed under the body 11 of the heating container 10, and at the same time, the cooling water is pumped into the cooling water circulation space 32. ) Due to the difference in temperature in the mulberry oil storage container circulated by ), the mulberry oil storage container and neighboring water vapor condense to turn into mulberry oil (see FIG. 7 ).

The mulberry oil changed as described above passes through the filter net 16 installed on the mulberry oil extraction furnace 15 so that only pure mulberry oil is introduced into the mulberry oil storage container 30 (see FIG. 8).

As described above, heat is heated by the heat of the heating heater 44, and moisture is evaporated, and carbonized Cudrania is indirectly passed through the space 43 rather than being directly transferred to the heating container 10 by the heat of the heating heater 44. According to this, the Cudrania tree is not carbonized rapidly, but is gradually carbonized to obtain high quality carbide (charcoal).

In addition, the body 11 formed by the outer wall 12 and the inner wall 12a constituting the body 11 of the heating vessel 10 has a number of far-infrared radiation holes 14 formed thereon, and discharged from the ocher wall 13 The far-infrared rays are split on the Cudrania mulberry tree to purify the odor of mulberry oil and carbides (charcoal), and there is no mixing of smoke generated when burning chaff, which is a heat source, as in the past. The smell of tar from oil is significantly reduced.

When the mulberry oil flows into the mulberry oil storage container 30, the discharge valve 34 installed in the outlet 33 is opened to be packed in a container (bottle).

On the other hand, the carbide (charcoal) of the body 11 of the heating container 10 is opened and collected by opening the lid 20 to be sold and sold as charcoal used to grill meat through unit packaging.

After taking out the carbide (charcoal), the Cudrania can be stored again to produce mulberry oil and carbide (charcoal) by the above-described method.

By using the above-described mulberry oil extractor, the composition for preventing atopic dermatitis according to an embodiment of the present invention has improved productivity in a very high yield and can be obtained cleanly.

The composition for preventing atopic dermatitis according to one embodiment of the present invention contains an active ingredient derived from Cudrania, which has an activity of alleviating atopic dermatitis symptoms, and is very useful in pharmaceutical use for preventing or treating atopic dermatitis. Can be. Thus, it can be very usefully included in functional pharmaceutical products, food, cosmetics, external preparations, and feed.

In the specification of the present invention, "pharmaceutical (pharmaceutical)" means that other chemical components such as diluents or carriers can be mixed with the active ingredient derived from the Cudrania. That is, in the present invention, the term "prevention composition" is intended to include the meaning of the "pharmaceutical composition". At this time, the "carrier" is defined as a compound that facilitates the addition of a compound into a cell or tissue. For example, dimethyl sulfoxide (DMSO) is a commonly used carrier that facilitates the introduction of many organic compounds into a cell or tissue of an organism. In addition, "diluent" is defined as a compound that dilutes in water (purified water) that not only stabilizes the biologically active form of the target compound, but also dissolves the compound. Salts dissolved in buffer solutions are used in the art as diluents. A commonly used buffer solution is phosphate buffered saline because it mimics the salt state of human body fluids. Because buffer salts can control the pH of the solution at low concentrations, buffer diluents rarely modify the biological activity of the compound.

Another embodiment of the present invention is a health functional food comprising a composition for preventing atopic dermatitis according to an embodiment of the present invention, wherein the health functional food is a powder, granule, tablet, capsule, syrup or beverage Provide health functional food.

The health functional food according to another embodiment of the present invention may include the composition for preventing atopic dermatitis according to an embodiment of the present invention in an amount of 0.01 to 50% by weight. If the content of the composition for preventing atopic dermatitis is too small, the effect may be insignificant, and if the content is too large, the taste and flavor of the health functional food containing it may be affected, resulting in a problem that customer preference may be reduced. Can. More preferably, it is preferably included in an amount of 10 to 50% by weight.

In addition, the health functional food may further include a known additive. These well-known additives include citric acid, saccharides, white sugar, etc., and various additives added to well-known foods. In addition, the food composition of the present invention does not limit its intake.

There are no particular restrictions on the type of the functional food, and examples include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, various soups, beverages, tea , Drinks, alcoholic beverages and vitamin complexes.

Illustratively, when the health functional food is a beverage, it may contain various flavoring agents or natural carbohydrates, etc., as additional components, like a normal beverage. The above-mentioned natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as textrin and cyclotenstrin, and sugar alcohols such as xylitol, sorbitol and erythritol. As the sweetener, natural sweeteners such as taumatin and stevia extract, synthetic sweeteners such as saccharin and aspartame can be used.

Another embodiment of the present invention is a cosmetic composition comprising a composition for preventing atopic dermatitis according to an embodiment of the present invention, wherein the cosmetic composition is a cream, skin, lotion, essence, emulsion, gel, lipstick, cleansing Provides a cosmetic composition that is a foam, cleansing cream, cleansing water, spray, shampoo, conditioner, treatment, body cleanser, soap, pack, massage agent, face powder, compact, foundation, two-way cake or makeup base.

The cosmetic composition in addition to the extract of the present invention, fatty substances, organic solvents, solubilizers, thickeners and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ions Mold or nonionic emulsifiers, fillers, metal ion blockers and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any commonly used in cosmetics It may contain adjuvants commonly used in the cosmetic field, such as other ingredients.

Another embodiment of the present invention is an external preparation for skin comprising the composition for preventing atopic dermatitis according to one embodiment of the present invention, wherein the external preparation for skin is an ointment, cream, lotion, liquid, dressing, patch, Provides an external preparation for skin, which is a blister, tape, mist, external acid or spray.

The external preparation for skin is a fat substance, an organic solvent, a solubilizer, a thickening agent and a gelling agent, an emollient, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, and ions in addition to the extract of the present invention. Type or nonionic emulsifier, filler, metal ion blocker and chelating agent, preservative, vitamin, blocker, wetting agent, essential oil, dye, eye

It may contain adjuvants commonly used in the field of skin science, such as medical agents, hydrophilic or lipophilic actives, lipid vesicles, or any other ingredient commonly used in external preparations for skin. In addition, the ingredients can be introduced in an amount commonly used in the field of skin science. The dosage of the extract to the external preparation for skin is 0.0001 to 100 mg/kg, preferably 0.001 to 10 mg/kg, but is not limited thereto. The dosage can be changed according to the weight, age, sex, health status, duration of administration, removal rate, and severity of the disease.

The composition for preventing atopic dermatitis according to an embodiment of the present invention, a health functional food containing it, a cosmetic composition, and an external preparation for skin are effective in cooling the condensed mulberry extract obtained by indirectly heating and condensing the vaporized water vapor. Contains as an ingredient, it has the effect of alleviating the symptoms of atopic dermatitis. More specifically, through in vivo experiments (in vivo), the Cudrania extract of the present invention induced atopic dermatitis with 2,4-dinitrochlorobenzene (DNCB), an immuno-disrupting substance. When administered or applied to animals, it has the activity of alleviating atopic dermatitis symptoms such as erythema, hemorrhage, dryness, scarring, lichenification, and erosin. Therefore, by orally administering such a composition for preventing atopic dermatitis, or by directly applying it to the skin, it can be very useful in pharmacy. In particular, it can be very useful as a health functional food for preventing atopic dermatitis, cosmetic composition, and an external preparation for skin.

In addition, the composition for preventing atopic dermatitis according to an embodiment of the present invention, a health functional food containing it, a cosmetic composition, and an external preparation for skin utilize a Cudrania mulberry with soft wood and clean active ingredients from the Cudrania mulberry tree By using a mulberry oil extractor that can be obtained with high yield, there is an effect that can be provided with very high productivity.

As described above, the preferred embodiments of the present invention have been described in detail, but the present invention is not limited to the above embodiments, and various modifications by those skilled in the relevant art within the scope of the technical spirit of the present invention This is possible.

<Production Example: Extract of Cudrania mulberry extract>

Cudrania mulberry branches having a tree diameter of 7 cm or less with an average diameter including all of the leaves, as well as the outposts and stems, were prepared.

Using the mulberry oil extractor shown in Figure 1, the extract Cudrania mulberry tree. More specifically, the prepared Cudrania is washed and placed in the storage portion 17 of the mulberry oil extractor, and the internal temperature of the storage portion 17 is maintained at about 420°C, heated for 2 hours, and then cooled to 5°C. By cooling with furnace, Cudrania extract (420°C) was obtained.

On the other hand, separately from the above, using the mulberry oil extractor shown in Figure 1, extract the Cudrania mulberry extract. More specifically, the prepared Cudrania is washed, placed in the storage unit 17 of the mulberry oil extractor, and the internal temperature of the storage unit 17 is maintained at about 180° C., heated for 3 hours, and then cooled to 0° C. By cooling with, a Cudrania extract (180°C) was obtained.

The prepared mulberry extract (420 °C: 180 °C) was mixed at a weight ratio of 3:1, respectively.

<Test Example 1: Component analysis of Cudrania mulberry extract>

The components of the Cudrania extract obtained in the above Preparation Example were performed by GC/MS (Agilent 6890GC/5973MS, Palo Alto, USA) analysis. Prior to the analysis, N,O-bis(trimethylsilyl)trifluoroacetamide(BSTFA) + trimethylchlorosilane(TMCS) was used for the polar part of the substituent such as amine group, -OH, -COOH, etc., which can indicate the polarity of each component,- It was easily volatilized by OSi(CH3)3 and derivatized according to the following procedure to facilitate GC/MS analysis.

a) After lyophilization of the Cudrania extract extracted in the preparation example, 1.5 ml was taken and transferred to a 1.5 ml conical tube.

b) 300 μl of 1N NaOH was added to the conical tube and titrated to pH=12.

c) 3 ml of Hexane was added to the conical tube, stirred for 2 minutes, and centrifuged at 16000 rpm for 5 minutes.

d) The aqueous solution layer centrifuged was taken out and transferred to a new conical tube so that the hexane layer was not attached.

e) The new conical tube was titrated again to pH=1 using 2N HCl.

f) 1 g of NaCl was added to the new conical tube.

g) 3 ml of ethyl acetate was added to the new conical tube and stirred for 2 minutes, followed by centrifugation at 16000 rpm for 5 minutes.

h) Centrifuged ethyl acetate layer was extracted and transferred to a new conical tube.

i) The above steps g) and h) were repeated twice more, and then nitrogen was blown at 30°C to evaporate all ethyl acetate.

k) 100 μl of BSTFA with 1% TMCS solution was added to dissolve the sample, and reacted at 80° C. for 30 min to derivatize.

l) After allowing to stand at room temperature and sufficiently cooled, 1 μl of the derivatized extract was injected into GC/MS to perform component analysis of the Cudrania extract. At this time, peaks separated by GC-MS were identified based on the NIST chemical library (Wiley 275 L). The operating conditions of the GC/MS were as follows. As a GC, an Agilent 6890N (USA) equipped with a DB-5 (0.25 mm×60 m, film thickness 0.25 μm) column was used, and the temperature of the injector was 280°C. The temperature of the oven was maintained at 70°C for 3 minutes, and then heated at a rate of 10°C/min and maintained at 300°C for 5 minutes. Helium (He) was used as a carrier gas at a flow rate of 1 ml/min, and 1 μl of the sample was injected to analyze at a split ratio of 30:1. GC/MS had an interface temperature of 250°C and an EI ionization voltage of 70eV. In the analysis range of the molecular weight, 50 to 550 m/z region was analyzed in SCAN mode, and all substances were qualitative through the fragmentation of each substance.

The results of GC/MS component analysis of the Cudrania extract according to Test Example 1 are shown in FIG. 9.

As shown in FIG. 9, the kkujimul tree extract includes 1H-Indole-2-carb oxylic acid and 4H-pyrido[1,2-a]pyrimidine-3 -It was confirmed that carb oxyacid (4H-Pyrido[1,2-a]pyrimidine-3-carb oxylic acid) was contained.

<Test Example 2: Component analysis of Cudrania mulberry extract>

The components of the Cudrania extract obtained in the above preparation example were performed by pyrolysis GC/MS (Agilent 6890GC/5973MS, Palo Alto, USA) analysis. More specifically, 5 μl of the extract derivatized in l) of Test Example 1 was wrapped in pyrofoil ^TM (jaie, JAPAN) at 590° C. and injected into GC/MS under the same conditions as in Experimental Example 1 (direct injection) system).

The results of GC/MS component analysis of the Cudrania extract according to Test Example 2 are shown in FIG. 10.

As shown in FIG. 10, the Cudrania extract contains acetovanillone, D-Allose, desaspidinol, 1,4:3,6-dianhydro-alpha -Di-glucopyranose (1,4:3,6-Dianhydro-alpha-d-glucopyranose), Myo-Inositol, Levoglucosan, Di-mannitol , It was confirmed that the monoterpene (Monoterpene), propiovanilone (Propiovanillone), talos (Talose) and vanillin (Vanillin) is contained.

This can continuously increase the temperature and pressure before the mulberry tree is completely carbonized in the mulberry oil extractor, so that more various components can be contained than the components contained in the extract extracted from the conventional mulberry oil extractor.

Meanwhile, the Cudrania extract, which was confirmed in FIGS. 9 and 10, was identified by cross-searching with data of the National Institute of Standards and Technology (NIST), and the results are shown in Table 1 below.

<Test Example 3: Effect of the composition for preventing atopic dermatitis on systemic atopic dermatitis induced by DNCB (oral administration)>

Preparation of experimental animals

4 week old male Balb/c mice (Daehan biolink, Korea) were purchased and used for experiment after adaptation and purification for 1 week. The temperature of the breeding room was maintained at 22±2℃, and the humidity was 50±5%, and the photoperiod and dark cycle were set to 12 hours.

Induction of atopic dermatitis and sample treatment

After epilation of the experimental animal's back, 2,4-dinitrochlorobenzene (DNCB, Sigma, USA) was diluted with 10% acetone and olive oil (3:1 volume ratio) from the next day, and 200 uL was applied to the back area for 3 days. Two days after inducing the primary immune response, 100 μl of a DNCB solution diluted to 0.5% was applied every other day to induce atopic dermatitis.

Thereafter, after 4 days, the Cudrania extract was diluted in distilled water to a concentration of 4% (low concentration group), 8% (medium concentration group), and 12% (high concentration group) to prepare a composition for preventing atopic dermatitis, 100 μl of the composition for preventing atopic dermatitis was orally administered once a day for 11 days. In addition, natural healing was suppressed by continuously applying DNCB every other day during the sample administration period.

On the other hand, as a control, instead of the composition for preventing atopic dermatitis, 100 μl of purified water was administered orally once a day for 11 days, and as a positive control, Dexamethasone was diluted in distilled water to a concentration of 1 mg/kg to 100. μl was administered orally once a day for 11 days.

Test result

end. Measurement of skin damage

The clinical skin evaluation method was used to measure the clinical skin severity score. When the DNCB solution is applied, the experimental animal has erythema/pigmentation, edema, bleeding, exudation/wound, scratches, lichenification, keratin/skin dryness, and none of these items (0), mild (1), and severe (2) , High score (3) was divided and scored. The results were as shown in FIG. 11. In addition, images of the skin before treatment, on the 5th day of treatment, and on the 11th day of treatment are shown in FIG. 12.

As a result of measuring the degree of skin damage of the experimental animals, as shown in FIGS. 11 and 12, the control group coated with DNCB was able to confirm that the skin was significantly damaged compared to the normal group applied only with purified water as a solvent. . In addition, it was confirmed that the symptoms of atopic dermatitis were improved by significantly reducing the clinical score at a level similar to that of the positive control group DNCB+Dexa group in the high concentration administration group (DNCB+CT-H) of the sample.

I. Hematoxylin & eosin (H&E) staining

For the experiment, the back skin of the sacrificed experimental animal was collected and fixed in a 4% formaldehyde solution, and then sliced to a thickness of 4 μm through paraffin embedding. In addition, Hematoxylin & Eosin staining was performed to identify epidermis and dermis causing inflammation, and this was photographed using an optical microscope (×100, Leica, Germany). And the results are shown in FIG. 13.

As shown in Figure 13, the epidermis thickness of the normal group, the normal group, is atopy-like with DNCB.

It was confirmed that it was thicker than the epidermis thickness of the control group. This means that the skin is hyperplastic and expanded due to skin wounds and irritations. In addition, it was confirmed that the control group (DNCB+CT-H) of the sample was thinner than the epidermis thickness of the control group, and the positive control group DNCB+Dexa group was also thinner than the epidermis thickness of the control group. Through this, it was confirmed that the damage due to skin damage caused by DNCB was reduced by the treated sample.

All. Measurement of spleen weight

The spleen is characterized by both primary and secondary lymphoid organs, consists of red pulp filtering red blood cells and with pulp showing humoral and cellular immune activity, and is another important organ in the immune response (Mebius, RE and Kraal, G 2005 Structure and function of the spleen Nat Rev Immunol 5, 606-616). In addition, the spleen is where the final stage of B cell development proceeds, and at the same time has a function as a specialized organ that responds to antigens derived from blood (Boehem, T and Bleul, CC 2007 The evolutionary history of lymphoid organs NatImmunol 8, 131 -135). Atopic dermatitis reactions induce various responses within the immune system, and these reactions may primarily affect the spleen weight of the immune system.

Therefore, the weight of the spleen was measured to observe the effect of the composition for preventing atopic dermatitis on the immune organ of Balb/c mice in which atopic dermatitis induced by DNCB occurred. More specifically, after the experiment was completed, the test animal was anesthetized with diethyl ether, and then sacrificed and opened by cervical dislocation to collect spleen tissue. After washing the collected spleen tissue with physiological saline, the water was removed and the weight was measured using a fine scale. And the results are shown in Fig. 14.

As shown in FIG. 14, it was confirmed that the weight of the spleen was significantly increased in the atopy-induced control group of DNCB compared to the normal group. In addition, it was confirmed that the weight increase of the spleen was significantly decreased in the positive control group DNCB+Dexa. In addition, in the sample administration group, it was confirmed that the weight increase of the spleen was reduced, although not as much as the positive control group DNCB+Dexa.

la. Measurement of serum IgE expression

After the experiment was over, blood was collected from the abdominal vena cava of the experimental animal and left at room temperature for 30 minutes so that the serum was well separated. Thereafter, the amount of expression of total IgE in the serum was measured using a Mouse IgE ELISA kit (BD Biosciences, San Jose, CA, USA) with serum obtained by centrifugation at 3,000 rpm for 10 minutes. The results were as shown in FIG. 15.

As shown in FIG. 15, it was confirmed that the serum IgE concentration in the atopy-induced control group with DNCB was 998.92 ng/ml compared to the normal group 459.47 ng/ml. This is an immunoglobulin associated with an allergic reaction, and is believed to have increased levels due to an increased immune response due to atopic induction. In addition, it was confirmed that the total concentration of IgE in the serum was significantly decreased in the medium concentration group (DNCB+CT-M) and the high concentration group (DNCB+CT-H) of the sample.(*p<0.05, ** p<0.01) Thus, it is expected that the concentration value of total IgE in the serum may be reduced to suppress atopy.

<Test Example 4: Effect of the composition for preventing atopic dermatitis on systemic atopic dermatitis induced by DNCB (skin application)>

Preparation of experimental animals

4 week old male Balb/c mice (Daehan biolink, Korea) were purchased and used for experiment after adaptation and purification for 1 week. The temperature of the breeding room was maintained at 22±2℃, and the humidity was 50±5%, and the photoperiod and dark cycle were set to 12 hours.

Induction of atopic dermatitis and sample treatment

After epilation of the experimental animal's back, 2,4-dinitrochlorobenzene (DNCB, Sigma, USA) was diluted with 10% acetone and olive oil (3:1 volume ratio) from the next day, and 200 uL was applied to the back area for 3 days. Two days after inducing the primary immune response, 100 μl of a DNCB solution diluted to 0.5% was applied every other day to induce atopic dermatitis.

Subsequently, after 4 days, the Cudrania extract was diluted in distilled water to a concentration of 2.5% to prepare a composition for preventing atopic dermatitis, and 100 μl of the composition for preventing atopic dermatitis was applied once a day for 4 weeks. It was applied to. In addition, natural healing was suppressed by continuously applying DNCB every other day during the sample administration period.

On the other hand, as a control, instead of the composition for preventing atopic dermatitis, 100 μl of purified water was applied to the skin once a day for 11 days. As a positive control, Dexamethasone was diluted in distilled water at a concentration of 0.1% to 100 μl. Once a day, it was applied to the skin for 4 weeks.

Test result

end. Measurement of skin damage

The clinical skin evaluation method was used to measure the clinical skin severity score. When the DNCB solution is applied, the experimental animal has erythema/pigmentation, edema, bleeding, exudation/wound, scratches, lichenification, keratin/skin dryness, and none of these items (0), mild (1), and severe (2) , High score (3) was divided and scored. The results were as shown in FIG. 16.

As a result of measuring the degree of skin damage of the experimental animal, as shown in FIG. 16, the control group coated with DNCB was able to confirm that the skin was significantly damaged compared to the normal group applied only with purified water as a solvent. In addition, in the sample administration group (DNCB+CT), the clinical score was significantly decreased to a level similar to that of the positive control group DNCB+Dexa, indicating that symptoms of atopic dermatitis were improved.

I. Confirm physical symptom relief effect

Transepidermal water loss (TEWL), epidermal hydration and epidermal erythema were measured using a Dermalab®Combosystem (CortecTechnologyAps, Hudsund, Denmark) instrument. The measurement was performed for 4 weeks on a weekly basis, and the results were as shown in FIG. 17.

As a result of measuring the degree of physical symptom relief of the experimental animals, as shown in FIG. 17, it was confirmed that the amount of epidermal moisture loss decreased and the amount of epidermal moisture increased. In addition, it was confirmed that the degree of epidermal erythema decreased.

As described above, those skilled in the art to which the present invention pertains will understand that the present invention may be implemented in other specific forms without changing its technical spirit or essential features. Therefore, the embodiments described above are all illustrative and should be understood as not limiting. The scope of the present invention should be construed to include all modified or modified forms derived from the equivalent concept and meaning and scope of the claims, which will be described later, rather than the detailed description.

10: heating container 11: body
12: outer wall 12a: inner wall
13: ocher wall 14: far infrared irradiation hole
15: mulberry oil extraction outlet 16: manure net
17: storage unit 18,21: flange
19: fixing pin 19a: tightening nut
20: lid 21a: fixing groove
22: bottom cock 23: internal temperature sensing rod
30: mulberry oil storage container 31: cooling water pump
32: cooling water circulation space 33: outlet
34: discharge valve 40: gas
41: plate 42: fireproof insulating brick
43: space 44: heating heater
45: high temperature temperature sensing rod 46: stainless cover
50: Control box 60: Carbon packing

Claims (4)

As a composition for improvement according to oral administration of atopic dermatitis induced by DNCB,
The heating vessel in which the Cudrania tree containing the Cudrania tree including the Cudrania tree branch, which has the leaves, outposts and stems having an average diameter of 7 cm or less, is stored indirectly at a temperature of 420 to 500° C. Cudrania mulberry extract extracts liquefied mulberry extract by condensing it by cooling to a temperature of 3 to 10° C.
The heating vessel in which the Cudrania tree containing the Cudrania tree including the Cudrania tree branch, which has the leaves, outposts and stems having an average diameter of 7 cm or less, is stored indirectly at a temperature of 150 to 180° C. To obtain water vapor evaporating from the tree, the water vapor is cooled to a temperature of 3 to 10°C and condensed to mix the mulberry extract extracting liquefied mulberry extract in a weight ratio of 3: 1 as an active ingredient, 8 to 50% by weight;
A health food containing a composition for improving atopic dermatitis, which contains an extract of Cudrania that can improve skin damage and reduce the weight gain of the spleen, an immune organ.
According to claim 1,
The health food is a powder, granules, tablets, capsules, syrup or health food comprising a composition for improving atopic dermatitis, containing the extract of Cudrania mulberry as an active ingredient.
According to claim 1,
The composition for improving atopic dermatitis is
Di-allose, di-mannitol, talos, vanillin, acetobanilone, desspirinol, 1,4:3,6-dianhydro-alpha-di-glucopyranose, 1H-indole-2-car Effective for Cudrania extract containing broxyl acid, myo-inositol, levoglucosan, monoterpene, propiobanilone and 4H-pyrido[1,2-a]pyrimidine-3-carb oxylic acid as active ingredients A health food containing a composition for improving atopic dermatitis containing as an ingredient.
According to claim 1,
The Cudrania mulberry extract is extracted by a mulberry oil extractor,
The mulberry oil extractor has a double body 11 structure in which the stainless steel sheets having different thicknesses of the storage section 17 in which the Cudrania is housed are overlapped to form the inner wall 12a and the outer wall 12, to the outer wall 12 A number of far-infrared irradiation holes 14, which allow the far-infrared rays generated from the coated formed ocher wall 13 to be cleaved in the Cudrania stored in the storage section 17, are formed through the inner wall 12a and the outer wall 12, In the lower part, a mulberry oil extraction furnace 15 is installed in which a filter screen 16 is installed so that only the mulberry oil extracted from the Cudrania mulberry tree passes through and is recovered to the mulberry oil storage container 30, and the upper flange 18 ) A heating container 10 in which a fixing pin 19 for fixing the lid 20 is installed;
A fixing groove 21a into which the fixing pin 19, which is installed on the upper flange 18 of the heating vessel 10 via a hinge shaft, is fitted, is formed on the flange 21, and the interior of the heating vessel 10 is formed. A lid 20 having a safety cock 22 that is opened when the temperature is higher than a certain temperature, and is provided with a temperature sensing rod 23 for sensing the internal temperature of the heating vessel 10;
The body of the heating vessel 10 is screwed into the mulberry oil extraction furnace 15 formed under the body 11, and water vapor in the heating vessel 10 generated by moisture extracted from the mulberry tree is caused by temperature difference. It is a dual structure having a cooling water circulation space 32 through which cooling water pumped by the cooling water pump 31 is circulated so that it can be condensed, and the discharge valve 34 is provided at the outlet 33 to allow the collection of the extracted mulberry oil. ) Is installed mulberry oil storage container 30 and;
The refractory insulating bricks 42 are constructed to minimize heat loss on the upper portion of the plate 41, but are constructed so as to have a space 43 where the heating vessel 10 can be seated. , Heat-resistant heater 44 is installed along the inner surface of the fire-resistant insulating brick 42, a high-temperature temperature sensing rod 45 for detecting the heat-heating temperature of the heat-resistant heater 44 is installed, and the fire-resistant insulating brick ( 42) a gas 40 wrapped in a stainless cover 46;
Atopy containing Cudrania mulberry extract as an active ingredient, comprising a control box (50) for controlling the internal temperature sensing rod (23) and the high temperature sensing rod (45) and the heating heater (44) of the heating container. Health food containing a composition for improving sexual dermatitis.

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