KR102602204B1 - 식이 지방산 수요를 공급하기 위한 방법들, 조성물들 및 디바이스들 - Google Patents
식이 지방산 수요를 공급하기 위한 방법들, 조성물들 및 디바이스들 Download PDFInfo
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Priority Applications (1)
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KR1020237038788A KR20230162123A (ko) | 2012-02-17 | 2013-02-14 | 식이 지방산 수요를 공급하기 위한 방법들, 조성물들 및 디바이스들 |
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US201261600207P | 2012-02-17 | 2012-02-17 | |
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PCT/US2013/026063 WO2013123139A1 (en) | 2012-02-17 | 2013-02-14 | Methods, compositions, and devices for supplying dietary fatty acid needs |
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Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL288929B (en) | 2012-02-17 | 2022-09-01 | Alcresta Inc | Methods, preparations and devices for supplying dietary fatty acid needs |
CN105658216A (zh) * | 2013-10-28 | 2016-06-08 | 雀巢产品技术援助有限公司 | 用于治疗消化不良的单酰基甘油和脂溶性营养物质 |
CN106687014A (zh) * | 2014-07-21 | 2017-05-17 | 雅培制药有限公司 | 包含含有磷脂以改善润湿性的营养粉末的营养物递送系统 |
WO2016073335A1 (en) * | 2014-11-05 | 2016-05-12 | Omthera Pharmaceuticals Inc. | Methods of treatment |
NO20150142A1 (en) * | 2015-01-30 | 2016-08-01 | Pronova Biopharma Norge As | Enteral feeding device |
US10258590B2 (en) * | 2015-10-14 | 2019-04-16 | Alcresta Therapeutics, Inc. | Enteral feeding device and related methods of use |
WO2017156379A2 (en) * | 2016-03-10 | 2017-09-14 | Arthrex, Inc. | Systems and methods for preparing protein enhanced serums |
IL261057B (en) | 2016-03-10 | 2022-08-01 | Arthrex Inc | System and methods for preparing thrombin serum |
US20200085774A1 (en) * | 2016-12-23 | 2020-03-19 | Basf As | Omega-3 Fatty Acid Composition for Preventing and/or Treating Cachexia |
US10716761B2 (en) * | 2017-07-24 | 2020-07-21 | Alcresta Therapeutics, Inc. | Ingestible medical delivery devices |
US11045396B2 (en) * | 2017-08-17 | 2021-06-29 | Alcresta Therapeutics, Inc. | Devices and methods for the supplementation of a nutritional formula |
US20190075835A1 (en) * | 2017-09-08 | 2019-03-14 | Alcresta Therapeutics, Inc. | Devices and methods for preparing and administering a nutritional formula |
US11291236B2 (en) | 2017-09-11 | 2022-04-05 | Alcresta Therapeutics, Inc. | Devices and methods for the preparation of a nutritional formula |
TWI729831B (zh) * | 2020-05-29 | 2021-06-01 | 蘇建忠 | 鼻胃管餵食系統 |
US11628124B2 (en) * | 2021-04-28 | 2023-04-18 | Silviya Das | Feeding tube management |
CN113397981B (zh) * | 2021-05-06 | 2022-09-16 | 山西白求恩医院 | 一种使用方便的儿科用药品喂药器及使用方法 |
TWI842214B (zh) * | 2022-11-21 | 2024-05-11 | 慈濟學校財團法人慈濟科技大學 | 用於灌食空針的手動攪拌器 |
CN115590768B (zh) * | 2022-12-15 | 2023-03-10 | 吉林大学第一医院 | 一种基于重症监护用冠心病病人喂药装置 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100239559A1 (en) | 2007-04-13 | 2010-09-23 | Beth Israel Deaconess Medical Center, Inc. | Novel nutritional food products for improved digestion and intestinal absorption |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2807384A (en) | 1956-03-12 | 1957-09-24 | Lipari Michael | Compartmental dispensing receptacle |
US3838784A (en) | 1973-04-12 | 1974-10-01 | Mead Johnson & Co | Diet feeding container |
US4225575A (en) | 1978-05-15 | 1980-09-30 | Ventrex Laboratories, Inc. | Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system |
EP0003479B1 (de) * | 1978-02-11 | 1981-09-16 | Schering Aktiengesellschaft | Härtungsmittel und Verfahren zur Herstellung von Epoxid-Polyaddukten |
JPS54132291A (en) | 1978-04-03 | 1979-10-15 | Kuraray Co Ltd | Novel bioreactor |
DE2935546C2 (de) * | 1979-09-03 | 1983-05-11 | Lepharm- Pharmazeutische Entwicklungs- und Vertriebsgesellschaft mbH, 5000 Köln | Diätetische Lebensmittel mit Monoglyceriden von Fettsäuren |
US5292649A (en) | 1983-03-29 | 1994-03-08 | Agency Of Industrial Science & Technology, Ministy Of International Trade & Industry | Method for reaction of lipase upon fatty acid |
JPS6027380A (ja) * | 1983-07-25 | 1985-02-12 | Nitto Electric Ind Co Ltd | 酵素反応装置 |
US4637934A (en) | 1984-04-12 | 1987-01-20 | Baxter Travenol Laboratories, Inc. | Liquid container with integral opening apparatus |
US4629742A (en) * | 1986-01-27 | 1986-12-16 | Akzo America Inc. | Hydrolysis of fats |
JPH0787793B2 (ja) * | 1986-10-22 | 1995-09-27 | 日本油脂株式会社 | 高度不飽和脂肪酸の分離方法 |
WO1989002916A1 (en) | 1987-09-28 | 1989-04-06 | Novo-Nordisk A/S | Method for immobilizing lipase |
JPH0198494A (ja) * | 1987-10-09 | 1989-04-17 | Agency Of Ind Science & Technol | バイオリアクター |
US4944944A (en) | 1987-11-19 | 1990-07-31 | Oklahoma Medical Research Foundation | Dietary compositions and methods using bile salt-activated lipase |
JP2581749B2 (ja) * | 1988-04-27 | 1997-02-12 | 株式会社資生堂 | 固定化酵素を用いた油脂の分解槽およびこの分解槽を用いた油脂の分解装置並びに油脂の分解方法 |
US5922345A (en) | 1990-12-07 | 1999-07-13 | Scotia Holdings Plc | Nutrition |
US5902617A (en) | 1992-05-19 | 1999-05-11 | Pabst; Patrea L. | Enzyme supplemented baby formula |
US5259587A (en) | 1992-06-08 | 1993-11-09 | Whitman Medical Corporation | Roller clamp |
US5342790A (en) | 1992-10-30 | 1994-08-30 | Becton Dickinson And Company | Apparatus for indirect fluorescent assay of blood samples |
FI930440A0 (fi) | 1993-02-01 | 1993-02-01 | Labsystems Oy | Bestaemningsfoerfarande |
US5362442A (en) | 1993-07-22 | 1994-11-08 | 2920913 Canada Inc. | Method for sterilizing products with gamma radiation |
JPH08178926A (ja) | 1994-10-25 | 1996-07-12 | Sumitomo Pharmaceut Co Ltd | イムノアッセイプレートおよびその用途 |
US5531681A (en) * | 1995-01-13 | 1996-07-02 | Abbott Laboratories | Apparatus for altering composition of nutritional product during enteral tube feeding |
US5531734A (en) | 1995-01-13 | 1996-07-02 | Abbott Laboratories | Method of altering composition of nutritional product during enteral tube feeding |
FR2731015B1 (fr) | 1995-02-24 | 1997-05-30 | Sci Sartone | Procede d'enrichissement enzymatique d'huiles d'origine marine et les triglycerides d'acides gras polyinsatures ainsi obtenus |
US5707353A (en) | 1995-12-21 | 1998-01-13 | Abbott Laboratories | Oral administration of beneficial agents |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
WO2000030753A1 (en) | 1998-11-23 | 2000-06-02 | Usamriid | Purification method and apparatus |
ES2249868T3 (es) | 1999-02-12 | 2006-04-01 | Societe Des Produits Nestle S.A. | Composicion liquida estabilizada, procedimento de preparacion y producto nutritivo que la contiene. |
JP2001231848A (ja) * | 2000-02-21 | 2001-08-28 | Nippon Electric Glass Co Ltd | 生体活性セメント組成物 |
US6749851B2 (en) | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
IL147942A0 (en) | 2002-01-31 | 2002-08-14 | Enzymotec Ltd | Method of fractionation of phytosterol esters in oil and products obtained thereby |
JP4268473B2 (ja) * | 2002-08-07 | 2009-05-27 | 花王株式会社 | 油脂組成物 |
US7410663B2 (en) * | 2002-08-07 | 2008-08-12 | Kao Corporation | Oil or fat composition |
KR100951758B1 (ko) | 2002-08-07 | 2010-04-08 | 가오 가부시키가이샤 | 유지 조성물 |
US20040209953A1 (en) * | 2002-12-06 | 2004-10-21 | Wai Lee Theresa Siu-Ling | Glyceride compositions and methods of making and using same |
JP2004248671A (ja) * | 2003-01-31 | 2004-09-09 | Rinoru Oil Mills Co Ltd | 共役リノール酸異性体の精製方法およびその用途 |
US20060233863A1 (en) | 2003-02-10 | 2006-10-19 | Enzymotec Ltd. | Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy |
US8052992B2 (en) | 2003-10-22 | 2011-11-08 | Enzymotec Ltd. | Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions |
WO2005072306A2 (en) * | 2004-01-19 | 2005-08-11 | Martek Biosciences Corporation | Reelin deficiency or dysfunction and methods related thereto |
CA2557927A1 (en) * | 2004-03-04 | 2005-09-15 | Htl High-Tech Lipids Ltd. | Structured triglycerides and emulsions comprising same |
JP2005272307A (ja) | 2004-03-23 | 2005-10-06 | Dd Planning Kk | 抗菌・防カビ・消臭剤の噴霧方法及びその噴霧装置 |
SE0401145D0 (sv) | 2004-04-30 | 2004-04-30 | Mats Malmqvist | Continuous flow reaction vessel system |
SI2198880T1 (sl) * | 2004-10-14 | 2017-02-28 | Eli Lilly And Co. | Sestavki, ki vsebujejo lipazo, proteazo in amilazo, za zdravljenje pankreasne insuficience |
GB0504333D0 (en) * | 2005-03-02 | 2005-04-06 | Btg Int Ltd | Treatment of cytokine dysregulation |
JP5013679B2 (ja) | 2005-04-28 | 2012-08-29 | 天野エンザイム株式会社 | 含油脂廃水処理装置及び含油脂廃水処理方法 |
CA2624616A1 (en) | 2005-05-12 | 2006-11-23 | Martek Biosciences Corporation | Biomass hydrolysate and uses and production thereof |
US7582474B2 (en) | 2005-07-11 | 2009-09-01 | Honeywell International Inc. | Process reactor with layered packed bed |
WO2008054192A1 (en) | 2006-11-02 | 2008-05-08 | N.V. Nutricia | Use of nutritional compositions for preventing disorders |
BRPI0620451A2 (pt) * | 2005-12-23 | 2011-04-12 | Nutricia Nv | uso de uma composição compreendendo um lipìdeo, proteìna e componente de carboidrato digerìvel |
ATE458789T1 (de) | 2006-07-26 | 2010-03-15 | Basf Se | Thermoplastische formmassen mit hoher steifigkeit |
UA97127C2 (uk) * | 2006-12-06 | 2012-01-10 | Бандж Ойлз, Инк. | Спосіб безперервної ферментативної обробки композиції, що містить ліпід, та система для його здійснення |
DE102007031689A1 (de) | 2007-07-06 | 2009-01-08 | Evonik Goldschmidt Gmbh | Enzympräparate |
CN103168860A (zh) | 2007-08-31 | 2013-06-26 | 马太克生物科学公司 | 含多不饱和脂肪酸的固体脂肪组合物及其制备与应用 |
WO2009033135A1 (en) * | 2007-09-06 | 2009-03-12 | Suremilk, Llc. | Universal drinking adapter for beverage bottles to allow for liquid consumption and devices and kits for determining small molecules, metal ions, endotoxins, and bacteria found in milk, and methods of use thereof |
JP5356399B2 (ja) * | 2007-10-31 | 2013-12-04 | ティ エイチ エックス リミテッド | イヤホン装置 |
RU2488283C2 (ru) | 2007-11-01 | 2013-07-27 | Энзимотек Лтд. | Липидная смесь для детского питания |
US8206772B2 (en) * | 2007-11-08 | 2012-06-26 | Kraft Foods Global Brands Llc | Structured lipid compositions and methods of formulation thereof |
CA2712207A1 (en) | 2008-01-24 | 2009-07-30 | Nestec S.A. | Capsule containing nutritional ingredients and method of delivery of a nutritional liquid from the capsule |
EP2110027A1 (en) | 2008-04-01 | 2009-10-21 | Nestec S.A. | Long-chain polyunsaturated fatty acids (LC-PUFA) in maternal nutrition during pregnancy and lactation |
US20120279939A1 (en) * | 2008-10-27 | 2012-11-08 | Lee Jeong-Min | Bottle cap |
JP5481903B2 (ja) | 2009-03-30 | 2014-04-23 | ダイソー株式会社 | 高純度長鎖不飽和脂肪酸メントールエステルの製造方法 |
DK2443248T3 (en) | 2009-06-16 | 2018-03-12 | Du Pont | IMPROVEMENT OF LONG-CHAIN POLYUM Saturated OMEGA-3 AND OMEGA-6 FATTY ACID BIOS SYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYL TRANSFERASES |
FR2955459B1 (fr) * | 2010-01-28 | 2013-11-22 | Polaris | Composition huileuse riche en monoglycerides de dha |
UY33548A (es) * | 2010-08-06 | 2012-02-29 | Eurand Pharmaceuticals Inc | Formula nutricional predigerida |
US9078847B2 (en) | 2010-12-29 | 2015-07-14 | Abbott Laboratories | Nutritional products including a novel fat system including monoglycerides |
IL288929B (en) * | 2012-02-17 | 2022-09-01 | Alcresta Inc | Methods, preparations and devices for supplying dietary fatty acid needs |
US20140378419A1 (en) | 2013-06-21 | 2014-12-25 | Mead Johnson Nutrition Company | Compositions and Methods for Nutrient Delivery |
EP3329899B1 (en) | 2014-09-04 | 2019-11-06 | Corpak Medsystems, Inc. | Gastric systems, apparatus, and methods for use with enteral feeding |
NO20150142A1 (en) | 2015-01-30 | 2016-08-01 | Pronova Biopharma Norge As | Enteral feeding device |
US11045396B2 (en) | 2017-08-17 | 2021-06-29 | Alcresta Therapeutics, Inc. | Devices and methods for the supplementation of a nutritional formula |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100239559A1 (en) | 2007-04-13 | 2010-09-23 | Beth Israel Deaconess Medical Center, Inc. | Novel nutritional food products for improved digestion and intestinal absorption |
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