KR102568464B1 - 피롤로[2,3-d]피리미딘 화합물의 제조 방법, 이의 중간체, 및 이의 용도 - Google Patents

피롤로[2,3-d]피리미딘 화합물의 제조 방법, 이의 중간체, 및 이의 용도 Download PDF

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KR102568464B1
KR102568464B1 KR1020217003518A KR20217003518A KR102568464B1 KR 102568464 B1 KR102568464 B1 KR 102568464B1 KR 1020217003518 A KR1020217003518 A KR 1020217003518A KR 20217003518 A KR20217003518 A KR 20217003518A KR 102568464 B1 KR102568464 B1 KR 102568464B1
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acid
pyrrolo
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카필데브 카쉬미리랄 아로라
제이콥 콜 드포레스트
앤드류 케번 힐스
브라이언 패트릭 존스
크리스 니콜 존스
채드 아더 루이스
애닐 마하데오 레인
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화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
KR1020217003518A 2018-07-06 2019-07-03 피롤로[2,3-d]피리미딘 화합물의 제조 방법, 이의 중간체, 및 이의 용도 Active KR102568464B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862694698P 2018-07-06 2018-07-06
US62/694,698 2018-07-06
US201862776642P 2018-12-07 2018-12-07
US62/776,642 2018-12-07
US201962855071P 2019-05-31 2019-05-31
US62/855,071 2019-05-31
PCT/IB2019/055683 WO2020008391A1 (en) 2018-07-06 2019-07-03 Manufacturing process and intermediates for a pyrrolo[2,3- d]pyrimidine compound and use thereof

Publications (2)

Publication Number Publication Date
KR20210029234A KR20210029234A (ko) 2021-03-15
KR102568464B1 true KR102568464B1 (ko) 2023-08-21

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KR1020217003518A Active KR102568464B1 (ko) 2018-07-06 2019-07-03 피롤로[2,3-d]피리미딘 화합물의 제조 방법, 이의 중간체, 및 이의 용도

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US (3) US10815240B2 (enExample)
EP (1) EP3817810B1 (enExample)
JP (1) JP7437646B2 (enExample)
KR (1) KR102568464B1 (enExample)
CN (1) CN112384282B (enExample)
AU (1) AU2019299666B2 (enExample)
BR (1) BR112020025701A2 (enExample)
CA (1) CA3105161C (enExample)
ES (1) ES3045115T3 (enExample)
IL (1) IL279926B2 (enExample)
MX (2) MX2020013896A (enExample)
TW (1) TWI709562B (enExample)
WO (1) WO2020008391A1 (enExample)
ZA (1) ZA202100196B (enExample)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
WO2020232470A1 (en) 2019-05-13 2020-11-19 Boragen, Inc. Chemical compounds
CN113637018A (zh) 2020-04-27 2021-11-12 苏州晶云药物科技股份有限公司 磺酰胺类化合物的晶型及其制备方法
CN112279785B (zh) * 2020-10-29 2022-08-16 苏利制药科技江阴有限公司 3,3-二氟环丁胺盐酸盐中间体及其合成方法和3,3-二氟环丁胺盐酸盐合成方法
CN113583992B (zh) * 2021-07-15 2023-06-27 华东理工大学 一种还原胺化酶及其在仲胺合成中的应用
US20240383893A1 (en) * 2021-09-10 2024-11-21 Haihe Biopharma Co., Ltd. Hydroxamic Acid Compound Having ENPP1 Inhibitory Activity and Use Thereof
ES2993658B2 (es) 2023-06-27 2025-07-02 Moehs Iberica Sl (3-(metil(7h-pirrolo[2,3-d]pirimidin-4-il)amino)ciclobutilo)carbamato de bencilo o una sal del mismo, procedimiento para su preparacion y su uso en la sintesis de abrocitinib
ES3040374A1 (es) 2024-04-30 2025-10-30 Moehs Iberica Sl Cocristales de N-{cis-3-[metil(7H-pirrolo[2,3-d]pirimidin-4-il)amino]ciclobutil}propano-1-sulfonamida

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016024185A1 (en) 2014-08-12 2016-02-18 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JP4126781B2 (ja) 1998-10-26 2008-07-30 宇部興産株式会社 １−スルホニルピラゾール誘導体及びその製造方法
JP2003005323A (ja) 2001-06-20 2003-01-08 Konica Corp 熱現像写真感光材料及び画像形成方法
GB0710528D0 (en) 2007-06-01 2007-07-11 Glaxo Group Ltd Novel compounds
CN102471248B (zh) * 2009-08-10 2015-01-07 Bhi有限合伙公司 用于递送1,3-丙二磺酸的方法、化合物和组合物
BR112014000315A2 (pt) 2011-07-08 2016-08-23 Syngenta Participations Ag processos para a preparação de tietanamina
EP3290421B1 (en) * 2013-02-22 2019-01-02 Pfizer Inc Combination of pyrrolo [2, 3 -d]pyrimidine derivatives with one or more additional agents as inhibitors of janus- related kinases (jak)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016024185A1 (en) 2014-08-12 2016-02-18 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry. Vol. 61, (2018.01.03.), pp. 1130-1152.*

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MX2023006842A (es) 2023-06-22
US20220127274A1 (en) 2022-04-28
IL279926A (en) 2021-03-01
TW202017929A (zh) 2020-05-16
TWI709562B (zh) 2020-11-11
CN112384282A (zh) 2021-02-19
EP3817810A1 (en) 2021-05-12
JP7437646B2 (ja) 2024-02-26
WO2020008391A1 (en) 2020-01-09
CN112384282B (zh) 2024-07-02
US10815240B2 (en) 2020-10-27
CA3105161A1 (en) 2020-01-09
US20210009601A1 (en) 2021-01-14
JP2020007308A (ja) 2020-01-16
IL279926B1 (en) 2023-08-01
AU2019299666A1 (en) 2021-01-07
US11254684B2 (en) 2022-02-22
MX2020013896A (es) 2021-03-09
US20200123159A1 (en) 2020-04-23
ES3045115T3 (en) 2025-11-27
EP3817810B1 (en) 2025-09-17
AU2019299666B2 (en) 2024-07-11
US12018031B2 (en) 2024-06-25
ZA202100196B (en) 2022-09-28
CA3105161C (en) 2022-11-15
IL279926B2 (en) 2023-12-01
BR112020025701A2 (pt) 2021-03-16
EP3817810C0 (en) 2025-09-17
KR20210029234A (ko) 2021-03-15

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