KR102564771B1 - 약물 전달을 위한 생체내 약물 전달 장치 - Google Patents
약물 전달을 위한 생체내 약물 전달 장치 Download PDFInfo
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- KR102564771B1 KR102564771B1 KR1020197025677A KR20197025677A KR102564771B1 KR 102564771 B1 KR102564771 B1 KR 102564771B1 KR 1020197025677 A KR1020197025677 A KR 1020197025677A KR 20197025677 A KR20197025677 A KR 20197025677A KR 102564771 B1 KR102564771 B1 KR 102564771B1
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- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0216—Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201762453333P | 2017-02-01 | 2017-02-01 | |
| US62/453,333 | 2017-02-01 | ||
| US201762480744P | 2017-04-03 | 2017-04-03 | |
| US62/480,744 | 2017-04-03 | ||
| PCT/US2018/016463 WO2018144738A1 (en) | 2017-02-01 | 2018-02-01 | In vivo drug delivery devices and methods for drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190115035A KR20190115035A (ko) | 2019-10-10 |
| KR102564771B1 true KR102564771B1 (ko) | 2023-08-07 |
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| HR (1) | HRP20210571T1 (enExample) |
| HU (1) | HUE054587T2 (enExample) |
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| MX (2) | MX2019009080A (enExample) |
| PL (1) | PL3432970T3 (enExample) |
| PT (1) | PT3432970T (enExample) |
| RS (1) | RS62459B1 (enExample) |
| RU (1) | RU2759868C2 (enExample) |
| SG (1) | SG11201907033SA (enExample) |
| SI (1) | SI3432970T1 (enExample) |
| SM (1) | SMT202100310T1 (enExample) |
| WO (1) | WO2018144738A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019178134A1 (en) * | 2018-03-13 | 2019-09-19 | Semma Therapeutics, Inc. | Implantation devices, system, and methods |
| MX2021001264A (es) | 2018-08-01 | 2021-07-02 | Taris Biomedical Llc | Métodos para tratar la vejiga hiperactiva con el uso de trospio. |
| CN109765118B (zh) * | 2018-12-22 | 2021-09-17 | 临沂协润工贸有限公司 | 一种纺织品韧性测试仪 |
| KR20220146361A (ko) * | 2021-04-23 | 2022-11-01 | 김승범 | 과민성 방광 치료 장치 |
| CN113274624B (zh) * | 2021-07-06 | 2023-05-12 | 中南大学湘雅医院 | 一种可视化尿道扩张术后治疗仪 |
| WO2023122058A1 (en) | 2021-12-21 | 2023-06-29 | Taris Biomedical Llc | Urinary placement catheter for intravesical devices |
| TW202400174A (zh) | 2022-02-18 | 2024-01-01 | 美商塔里斯生物醫學有限責任公司 | 用於膀胱內施用的Erdafitinib調配物及滲透系統 |
| WO2024092159A1 (en) | 2022-10-28 | 2024-05-02 | Taris Biomedical Llc | Methods of treating bladder cancer with gemcitabine |
| CN120731077A (zh) | 2023-02-17 | 2025-09-30 | 塔里斯生物医药公司 | 膀胱内施用厄达替尼以用于治疗膀胱癌 |
| AU2024249710A1 (en) | 2023-04-10 | 2025-11-20 | Taris Biomedical Llc | Gemcitabine for use in methods of treating high-risk non-muscle invasive bladder cancer unresponsive to bacillus calmette-guerin therapy |
| WO2025076007A1 (en) | 2023-10-02 | 2025-04-10 | Taris Biomedical Llc | Methods of treating high-risk non-muscle invasive bladder cancer unresponsive to bacillus calmette-guérin therapy |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210139A (en) | 1979-01-17 | 1980-07-01 | Alza Corporation | Osmotic device with compartment for governing concentration of agent dispensed from device |
| US4657536A (en) | 1979-04-13 | 1987-04-14 | Regents Of The University Of Minnesota | Check valve catheter |
| US5340590A (en) | 1987-06-25 | 1994-08-23 | Alza Corporation | Delivery system with bilayer osmotic engine |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5221278A (en) | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| DE69425453T2 (de) | 1993-04-23 | 2001-04-12 | Novartis Ag, Basel | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
| ZA981610B (en) * | 1997-03-24 | 1999-08-26 | Alza Corp | Self adjustable exit port. |
| US6436091B1 (en) * | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US8740973B2 (en) * | 2001-10-26 | 2014-06-03 | Icon Medical Corp. | Polymer biodegradable medical device |
| CA2520610A1 (en) | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic pump with means for dissipating internal pressure |
| CA2538043A1 (en) | 2003-09-30 | 2005-04-14 | Alza Corporation | Osmotically driven active agent delivery device providing an ascending release profile |
| US7455688B2 (en) * | 2004-11-12 | 2008-11-25 | Con Interventional Systems, Inc. | Ostial stent |
| EP1933810B1 (en) | 2005-08-11 | 2012-10-10 | Massachusetts Institute of Technology | Intravesical drug delivery device and method |
| AU2007284759B2 (en) | 2006-08-09 | 2010-10-28 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| ES2481454T3 (es) * | 2007-12-11 | 2014-07-30 | Massachusetts Institute Of Technology | Dispositivo implantable de administración de fármacos |
| CN102176931B (zh) * | 2008-08-09 | 2015-03-04 | 麻省理工学院 | 治疗男性泌尿生殖组织和外周组织的可植入药物递送设备和方法 |
| AU2010265866B2 (en) | 2009-06-26 | 2012-07-12 | Taris Biomedical Llc | Solid drug tablets for implantable drug delivery devices |
| US9017312B2 (en) * | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| US8167836B2 (en) | 2009-12-08 | 2012-05-01 | Taris Biomedical, Inc. | Tissue expander configured for drug delivery |
| AU2010339821B2 (en) | 2009-12-17 | 2015-02-19 | Taris Biomedical Llc | Implantable device with intravesical tolerability and methods of treatment |
| US20110218488A1 (en) | 2010-03-05 | 2011-09-08 | Taris Biomedical, Inc. | Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites |
| PT2600800T (pt) * | 2010-08-05 | 2020-11-05 | Taris Biomedical Llc | Dispositivo de administração de drogas por stent ureteral, kit e método |
| JP5945544B2 (ja) | 2010-10-06 | 2016-07-05 | タリス バイオメディカル エルエルシー | 時間選択的に生体吸収可能または崩壊可能な薬剤送達システムおよび方法 |
| WO2012048104A1 (en) * | 2010-10-06 | 2012-04-12 | Taris Biomedical, Inc. | Implantable drug delivery device with bladden retention feature |
| EP2663300B1 (en) | 2011-01-10 | 2023-03-08 | TARIS Biomedical LLC | Lidocaine regimen for the use of sustained treatment of bladder pain and irritative voiding |
| KR20140048086A (ko) * | 2011-02-04 | 2014-04-23 | 타리스 바이오메디컬 인코포레이티드 | 저 용해성 약물의 제어 방출을 위한 이식가능한 디바이스 |
| EP3492076A1 (en) * | 2012-04-30 | 2019-06-05 | Allergan, Inc. | Methods for treatment of pelvic pain and/or comorbid conditions |
| CN104582782B (zh) * | 2012-08-20 | 2018-11-27 | 奥雷制药有限公司 | 用于制备药物递送制剂的方法 |
| WO2014047221A1 (en) | 2012-09-18 | 2014-03-27 | Taris Biomedical, Inc. | Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium |
| US10137287B2 (en) * | 2013-03-05 | 2018-11-27 | Taris Biomedical Llc | Drug delivery devices and methods for controlled drug release through device orifice |
| US9533101B2 (en) | 2013-03-14 | 2017-01-03 | Leonard Allen Massey, JR. | Multi-cycle and auto-disable syringe and method of use thereof |
| SG10201708522SA (en) * | 2013-03-15 | 2017-12-28 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| MX391755B (es) * | 2013-03-15 | 2025-03-21 | Taris Biomedical Llc | Dispositivos de administración de medicamentos y métodos para administración de medicamentos. |
| CN113413537A (zh) | 2013-08-19 | 2021-09-21 | 塔里斯生物医药公司 | 多单元药物递送装置和方法 |
| WO2015069723A1 (en) * | 2013-11-05 | 2015-05-14 | Taris Biomedical Llc | Osmotic drug delivery devices, kits, and methods |
| WO2016040904A1 (en) * | 2014-09-12 | 2016-03-17 | Taris Biomedical Llc | Ph-modulating drug delivery devices and methods |
| CN104998344A (zh) * | 2015-07-27 | 2015-10-28 | 肖雁冰 | 记忆合金硅胶宫内缓释系统 |
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| BR112019015812B1 (pt) | Dispositivo de distribuição de droga |
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