KR102532005B1 - A composition for improving and treating alopecia, hair damage, and skin disease of animal - Google Patents

Abstract

The present invention relates to a composition for hair loss, hair damage, skin antioxidant, and skin disease improvement of companion animals containing a natural complex extract, and more particularly, a natural complex composition prepared by mixing extracts extracted from self-pollination, sorghum ginseng, and sancho. It relates to a companion animal skin disease improving composition containing an extract, and it is possible to provide a companion animal skin anti-inflammatory composition comprising at least one of sancho oil, sorghum ginseng extract, and self-injection extract.

Description

Companion animal skin anti-inflammatory composition {A COMPOSITION FOR IMPROVING AND TREATING ALOPECIA, HAIR DAMAGE, AND SKIN DISEASE OF ANIMAL}

The present invention relates to a composition for anti-inflammatory skin of companion animals.

Hair loss or dermatitis in companion animals is an incurable disease that is difficult to cure. Dermatitis occurs in about 10% of the total population, and most of the symptoms appear at the age of 1 to 3 years, and the symptoms become more severe with age. Since it develops at a young age, many people suffer from dermatitis for almost their entire lives, and as the symptoms get worse as they get older, it is a disease that is difficult to manage over time.

In addition, atopic dermatitis occurs mostly in animals living in the house, and since house dust or house dust mites act as an allergen that causes atopy, the incidence rate is increasing in social environments where companion animals are mainly raised in the house as industrialization and urbanization and the number of single-person households increase. this will increase

Until now, companion animals suffering from dermatitis in Korea are only managed with drugs such as steroids because there is no fundamental treatment method. Drugs such as steroids can be expected to improve immediate and rapid clinical symptoms, but long-term administration has very large side effects and is highly likely to cause other secondary diseases, so it is not the best method. Therefore, research on products effective in managing dermatitis while reducing side effects of drugs is continuously required.

The present invention provides a product for improving the skin disease and hair loss of companion animals through the strengthening of the skin barrier through continuous management of skin diseases of companion animals and at the same time anti-inflammatory and antifungal effects.

The present invention describes a composition for improving hair loss, hair damage and skin antioxidant and skin disease of companion animals, containing natural complex extracts.

The present invention describes a companion animal skin disease improvement composition containing a natural complex extract composed by mixing extracts extracted from perilla, ginseng, and sancho.

The present invention may provide a composition for anti-inflammatory companion animal skin containing at least one of sancho oil, sorghum ginseng extract, and self-injection extract.

The present invention can have the ability to improve companion animal skin diseases by mixing sancho oil with excellent anti-inflammatory and antioxidant action, and hot-water extracts of sorghum and perilla.

The composition having an ability to improve companion animal skin diseases according to the present invention has no toxicity to keratinocytes, has strong antioxidant capacity, and does not cause microbial transition even after long-term storage, so it is added to cosmetics that can cause skin irritation when used for a long time. Addition of preservatives is not necessary. Also, as a nature-friendly natural substance, it is very effective in treating pet skin diseases.

1 is data according to a test example of the present invention.
2 to 11 show the progress before treatment of companion animals with skin diseases and after treatment using the present invention.

In general, dandruff, keratin, mites, hair follicles, and other various bacteria are parasitic on the skin and hair of animals, especially companion animals, which damages hair, causes hair loss, and often causes skin diseases. In addition, there are many cases where a companion animal's body smells unique to companion animals. Therefore, in order to prevent the onset of companion animals and to remove the peculiar smell, a detergent or functional shampoo containing a bactericidal component was used.

However, detergents or functional shampoos have insignificant persistence of their sterilization and deodorizing effects and have functional limitations, so companions have the trouble of frequently washing their pets to prevent skin diseases. In general, skin diseases that are prevalent in companion animals include fungal dermatosis, mimic dermatitis, eczema, seborrheic dermatitis, pyoderma, allergic dermatitis, or demodex dermatitis. In general, in order to treat skin diseases of companion animals, treatment using expensive ointments, oral preparations, and injections is usually performed after treatment at a veterinary hospital. Due to the nature of skin diseases that require long-term steady treatment, excessive use of chemical synthetic agents containing bactericidal ingredients not only damages the kidneys, liver, and skin tissues of companion animals, but also weakens the immunity of the individual and causes expensive Even when ointments, oral preparations, and injections are administered, the skin disease recurs, and it is difficult to cure and causes secondary complications.

Therefore, in order to treat skin diseases of companion animals, not only a large economic burden, but also continuous care and attention to companion animals are required in the long term. It's not easy. In some cases, treatment of companion animals exposed to the disease is abandoned or even abandoned.

Accordingly, the present invention is to produce and supply a composition capable of improving skin diseases of companion animals at an economical price, thereby relieving the burden not only of companion animals but also of guardians.

The present invention relates to a herbal composition having an anti-inflammatory antioxidant function having an ability to improve skin diseases of companion animals and a method for preparing the same.

The composition having the ability to improve companion animal skin diseases according to the present invention has no toxicity to keratinocytes, has strong antioxidant activity, and does not cause microbial transition even after long-term storage, adding a preservative for cosmetics that can cause skin irritation when used for a long time. is unnecessary Also, as a nature-friendly natural substance, it is effective in treating pet skin diseases.

The composition having the ability to improve companion animal skin diseases according to the present invention is non-toxic to keratinocytes, has strong antioxidant activity, and does not cause microbial transition even after long-term storage, so it is a preservative for cosmetic additives that can cause skin irritation during long-term use. Addition is not necessary. Also, as a nature-friendly natural substance, it is effective in treating skin diseases of companion animals.

Gosam (scientific name: Sophorae flavescens Ait) is also called a thief's cane. The name Gosam was given because the taste is very bitter. It reaches 1m in height and is green, but turns black when young. The root is used as a medicinal material, and matrine is contained as an active ingredient, and the extract of sorghum ginseng shows strong antibacterial activity against Propionibacterium acnes, the causative agent of acne. In addition, at 8% concentration, it inhibits the growth of various skin fungi. Sophoraflavone G has antibacterial activity against Porphyromanas, Prevotella, Actinobacillus, and Capnocytopaga. (+)-matrine and (+)-oxymatrine have central inhibitory actions such as lowering body temperature and blockade of glutamic acid on neuromuscular specimens. Also, (+)-matrine significantly reduces skin inflammation caused by croton oil. In animal experiments, antipyretic and diuretic effects were recognized. It is also effective for suppuration and eczema of the skin, and even when itching is severe, decoct ginseng and wash the affected area to treat it. It is effective in clearing heat, wind, insecticide, stomach upset, and anti-inflammation, so it is effective in treating hemorrhage, rectal ulcer bleeding, and jaundice. ), red white fever, pediatric pneumonia, acute tonsillitis, perianal fistula, prolapse, and burns.

Lithospermum erythrorhizon (scientific name: Lithospermum erythrorhizon) is a perennial plant belonging to the taxonomyaceae, also called weedy grass. It is 30 to 70 cm high, and the roots extend deep into the ground and are thick and purple. The dried root is called purple root, and in oriental medicine, it is used for detoxification, fever, swelling, burns, frostbite, eczema, and blisters.

Self-inflicted has antibacterial and anti-inflammatory effects, and suppresses virus suppression and Staphylococcus aureus. It is used as an external medicine for children's poisoning, hair loss, acne, itching throughout the body, pus and discharge that cannot be treated for a long time, and burns.

Self-injection contains ingredients such as shikonin and acetyl shikonin, which are polysaccharides, such as lysoseperman, and has blood circulation promoting, detoxifying, antibacterial and anti-inflammatory effects, so it can be used to treat various wounds, boils, burns, and eczema. It is known as a herbal medicine used to treat the back. In addition, it has a very strong collagen synthesis promoting effect, which helps improve skin wrinkles.

Shikonin (chemical formula C16H16O5, molecular weight 288.29524 g/mol) is a reddish-brown needle-shaped crystalline powder with a naphthoquinone skeleton extracted from the roots of the plant Borage. Shikonin has mild anti-inflammatory and bactericidal effects. . Shikonin is an organic solvent such as ethanol and ether, and is soluble in animals and plants and insoluble in water. Shikonin is generally extracted from purple roots with an organic solvent such as ether or benzene, and shikonin is obtained by hydrolyzing the ester of a shikonin derivative in an alkaline aqueous solution.

Shikonin has bactericidal and wound healing properties and is used as medicines and dyes. For the same purpose, it is also used in cosmetics such as lotion, cream, emulsion, lipstick, and soap.

Sancho is a sable tree Zanhosylum piperitum DC. Or, as much as possible, seeds are removed from the pericarp of other plants of the same genus (Corthaceae Rutaceae). Sanshoolfb and sanshoamid, which are contained in sancho, are novel substances with local paralysis, and have insecticidal and detoxifying effects against fish poison. Both α-sanshool and β have almost the same level of insecticidal and antibacterial activity.

Sancho tree belongs to Rutaceae, and the essential oil extracted from the fruit is mainly used for food and medicine. Acid fruit contains limonene (58%), citronellal (22%), beta-perandrene (β6.4%), cineol (2.2%), and dipentene (1.2%). ) and other essential oils. Most Sancho oil is divided into saturated fatty acids and unsaturated fatty acids with about 30 kinds of fatty acids, among which unsaturated fatty acids are composed of monounsaturated fatty acids and polyunsaturated fatty acids. Among the components of Japanese pepper oil (moisture 10.5%, crude protein 9%, crude fat 37.8%, crude fiber 14.5%, crude ash 8%, other 20.3%), the fat content is about 38%, of which linoleic acid (26%) and linolenic acid ( Most of them are composed of unsaturated fatty acids such as linolenic (29.2%) and oleic acid (35%).

In particular, Sancho oil is known to play an essential fatty acid role as it contains more than 45% of linoleic acid and linolenic acid, which are polyunsaturated fatty acids that act as carriers of fat-soluble vitamins such as A, D, E, and K.

Limonene has stress, inflammation suppression and skin cell regeneration. As a result, it can be used as a product to improve skin diseases because it is effective in suppressing skin inflammation and acne and atopy in companion animals.

Table 1 summarizes the main components and pharmacological actions of the extracts of gosam, sancho, and perilla ginseng used in the present invention.

main ingredient pharmacological action gosam Matrine antibacterial Sancho Limonene, Citronellal Skin cell regeneration, anti-inflammatory self-inflicted Shikonin antibacterial, anti-inflammatory

[First liquid phase (mist) manufacturing method]

Sancho is extracted in the form of oil by pressing the fruit containing a portion of the fruit skin. Hansancho, Jacho, and Gosam were immersed at room temperature for 3 days by adding three times the 70% alcohol solution per gram weight, and then extracted three times using an ethanol extraction method.

The extract of each medicinal material was filtered under reduced pressure using a paper filter paper (Advantec, No.5) with a pore size of 5 μm.

Mist can be prepared by mixing distilled water, Napri, ethanol, glycerin, and extract.

The extract may be prepared by including at least one of Sancho, Jacho or Kosam, and when two or more extracts are mixed, the same ratio or different ratios may be set, but the total mixture ratio may be adjusted not to exceed 100%. An anti-inflammatory composition for companion animal skin can be prepared in a first liquid form by adding ingredients as shown in Table 2 below.

1st liquid (mist) ratio(%) Content (ml) distilled water (water) 75 7.5 Nafri One 0.1 Ethanol 17 1.7 Glycerine 2 0.2 Extract (an extract that is a mixture of at least one or more of Sancho, Jacho, or Gosam) 5 0.5 total 100 10

In Table 2, the extract may be prepared by including 1-15 parts by weight of Sancho oil, 1-10 parts by weight of Kosam extract, and 1-5 parts by weight of self-injection extract, based on the total 100 parts by weight.

[Second Liquid Production Method]

raw material information division material name Amount added paid floor
olive oil 5g donji 7g beeswax 2 extract At least one of Sancho, Jacho, or Gosam 2g Sum 16g

As shown in Table 3, after measuring the oil layer, heat it at 65 to 70 degrees, and when more than 2/3 of the wax is melted, get off the hot plate and melt the remaining wax with residual heat. After that, when the temperature drops below 50 to 55 degrees, at least one of Japanese pepper, Chinese pepper, or Japanese ginseng is added, thoroughly mixed, and cooled in a container to prepare a composition for companion animal skin anti-inflammatory in a second liquid form.

In Table 3, the extract is formulated with 1-15 parts by weight of Sancho oil, 1-10 parts by weight of Kosam extract, and 1-5 parts by weight of self-injection extract, the solids are filtered and separated from the mixture, the solids are removed from the mixture, and the remaining liquid It may be prepared by cooling to room temperature.

<Test Example>

In order to test the alleviating or inhibiting effect on companion animal skin diseases, the ointment-like skin external preparation for companion animal skin disease relief prepared in Example was divided into a control group and a test group, and 3 animals in each group were applied to the affected area. It was applied every 4 hours, 3 times a day.

The condition of scratching the affected area within one hour after application was evaluated, and the average value was calculated, and the results are shown in FIG. 1 . In addition, after receiving the external skin preparation for relieving companion animal skin diseases of the present invention for 4 days, the improvement situation is attached to FIG. 3.

control group Sancho self-inflicted gosam Sanchojacho sanchogosam Jachogosam Sanchojachogosam 1 day 8 5.3 5.5 6.5 4.3 4.3 5.1 2.1 2 days 7.7 3.4 6.5 5.4 3.9 4.2 3.2 2.8 3 days 7.9 3.3 4.3 5.3 3.8 3.2 4.1 2.4 4 days 7.8 4.2 5.4 5.2 4.2 3.1 4.1 1.8

As shown in Table 4 and FIG. 1, no outliers were found in the control group over time.

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In Table 4, the prescriptions of Japanese pepper, self-pollination, and gosam were prescribed for the first liquid phase and the second liquid phase of the same concentration, and looking at the case where each extract was prescribed alone, rather than a mixed composition, the efficacy of Japanese pepper and Gosam in scratch frequency was was found to be superior to that of In the case of high ginseng, it shows progressively better results, but in the case of self-injury, it shows lower result values on the second day than other test days, but it shows significant results as an overall average.

Looking at the case of prescribing a composition in which the two extracts were mixed, the difference in daily intervals was small in the case of the mixed prescription of Sancho and Japonica extract, and the symptom improved over time in the case of the mixture of Sancho and Gosam extract. show what

In the case of prescription with a mixture of extracts of self-injection and ginseng, temporary improvement was observed.

In the case of Sancho and Gosam, skin diseases of companion animals are improved both when the two extracts are prescribed alone and when they are mixed. However, looking at the test examples in the case of prescribing a single extract of self-injection and the case of prescribing a mixture of extracts of self-inflicted and sorghum ginseng extract, it can be confirmed that it shows an unstable appearance on the second day. It was confirmed that it showed improvement compared to the control group in terms of itching relief and skin regeneration effects.

As a result of testing the mixed extracts of Sancho, Jacho and Gosam by equating parts by weight and concentration, it was confirmed that the improvement of symptoms was distinguishable with the naked eye compared to a single extract or two mixed extracts.

While there was no significant change in the control companion animals after 4 days of using the external preparation for companion animal skin diseases according to the present invention, the scratching frequency was significantly reduced in the test group using each extract alone and in the test group animals prescribed by mixing the extracts The symptoms were improved, such as the stoppage of the discharge and the formation of scabs, and there were no specific abnormal symptoms. In particular, judging from the fact that the scratch frequency was the lowest in the test group in which all of the extracts of Sancho, Jacho and Gosam, which are the compositions of the present invention, were mixed, the anti-inflammatory composition for companion animal skin according to the present invention has a calming effect on companion animal skin diseases. It can be seen that it works.

2 to 5 are photographs showing the course of treatment with the composition of the present invention for a week or more at regular intervals, showing the course before treatment of a companion animal with a skin disease and after treatment using the present invention.

Figure 2 is a photograph of a companion animal having a skin disease before treatment, and shows the progress after treatment over time from periodic application of the composition of the present invention to Figs. 3 to 5. It shows that the skin is regenerated by soothing and antibacterial action on companion animal skin diseases.

In particular, it has the effect of hair growth of the original color without bleaching the hair after skin treatment, and has an excellent improvement effect of hair growth without discoloration.

From FIG. 2 to FIG. 5, it can be seen that the dermatitis wound is healed and the white hair grows as it is.

6 to 8 are photographs of a Maltese 6-year-old female suffering from bacterial skin disease on the left and right hips for 2 and a half years. 9 is a photograph showing the results of treatment with the composition of the present invention. Referring to Figure 9, it can be seen that the skin disease is improved and the wool effect without bleaching is confirmed.

10 is a photograph of a 3-month-old Yorkshire Terrier suffering from a skin disease caused by a fungus, and FIG. 11 shows a state treated with the treatment agent of the present invention.

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Claims (5)

Contains sancho oil, sorghum extract and self-injection extract,
It is manufactured in the form of an ointment applied to the skin of a companion animal,
15 to 20 parts by weight of beeswax and 1.5 to 2 parts by weight of pork are mixed with 100 parts by weight of olive oil and heated to become liquid,
1-15 parts by weight of the Japanese pepper oil, 1-10 parts by weight of the Kosam extract, and 1-5 parts by weight of the self-injection extract are mixed with the liquid to make a formulation,
Anti-inflammatory composition for companion animal skin, wherein the solids are filtered and separated from the formulation, the solids are removed from the formulation, and the remaining liquid is cooled to room temperature.
delete delete delete Contains sancho oil, sorghum extract and self-injection extract,
It is prepared in a first liquid phase to spray on the skin of a companion animal in the form of a mist, or in a second liquid phase to apply to the skin of a companion animal in the form of an ointment,
The first liquid phase has a lower viscosity than the second liquid phase,
The first liquid phase is a companion animal skin anti-inflammatory composition having a higher concentration of the sancho oil, the ginseng extract, and the self-inflicted extract compared to the second liquid phase.

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