KR102138336B1 - Skin external composition for treating skin disease and antibiosis of pet animals - Google Patents
Skin external composition for treating skin disease and antibiosis of pet animals Download PDFInfo
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Abstract
본 발명은 애완동물의 피부질환 개선과 항균을 위해 사용되는 피부외용 조성물로 황백, 싸리나무, 작약, 백선피, 황금, 박하, 지모, 자근, 한련초, 용뇌가 배합된 추출물을 유효성분으로 함유한다.
본 발명의 조성물은 애완동물의 피부에 발현되는 염증을 완화시킴과 동시에, 피부표면을 보습할 수 있으며, 애완견의 피부나 몸에 질병을 유발하는 세균에 대하여 항균활성 효능이 있으며, 황백을 포함한 10가지의 천연약재를 증류 추출하여 얻어짐에 따라 안전하게 사용할 수 있다.The present invention is an external composition for skin used for improving and improving the skin disease of pets, and contains extracts containing yellow, white, peony, peony, ringworm, golden, peppermint, zymophilus, root, scented herb, and cerebrum as active ingredients. .
The composition of the present invention can alleviate the inflammation expressed on the skin of a pet, and at the same time, moisturize the skin surface, has antibacterial activity against bacteria that cause disease on the skin or body of a pet dog, and includes 10 It can be safely used as it is obtained by distilling and extracting the natural herbs of eggplant.
Description
본 발명은 애완동물의 피부질환 개선과 항균을 위해 사용되는 피부외용 조성물에 관한 것이다.The present invention relates to a composition for external application of skin used for improving and improving antibacterial skin diseases of pets.
애완동물인 개나 고양이의 피부 및 털에는 비듬 각질, 진드기, 모낭충, 기타 각종 세균 등이 기생하여 모발을 손상시키고 탈모를 유발함은 물론 피부병까지도 자주 발병시키는데, 특히 개나 고양이는 표피가 털에 덮혀 있어 외부 공기와 접촉되지 않아 발진이나 염증이 쉽게 진정되지 않는다.Dandruff keratin, ticks, hair follicles, and other bacteria parasitize on the skin and hair of pet dogs and cats, causing damage to the hair and causing hair loss, as well as often developing skin diseases. Especially, dogs and cats are covered with hair. The rash or inflammation does not calm down easily because it does not come in contact with the outside air.
이와 같은 애완동물의 피부질환을 완화하고 피부에 기생하는 세균이나 기생충을 제거하기 위하여, 대한민국 공개특허공보 제2011-0011418호에 피톤치드를 함유한 애완동물용 샴푸 조성물이 제안되었다. 하지만, 상기 샴푸 조성물은 피부진정 효과의 지속성이 떨어져 애완동물을 자주 세정하여야만 하는 번거로움이 있다.In order to alleviate such skin diseases of pets and remove bacteria or parasites parasitic on the skin, a shampoo composition for pets containing phytoncide has been proposed in Korean Patent Publication No. 2011-0011418. However, the shampoo composition has the hassle of having to clean the pet frequently due to the poor persistence of the skin soothing effect.
애완동물의 피부질환을 개선하는 다른 방법으로 대한민국 공개특허공보 제2006-0058531호와 같은 애완동물 피부치료용 약제가 제안되었다. 상기 약제는 6-펜틸-알파-피론(6-pentyl-alpha-pyrone)을 함유하고 있어 항균 및 살충활성을 가지는데, 하지만 위 6-펜틸-알파-피론을 자주 사용하는 경우 애완동물의 신장, 간, 피부 조직에 면역성을 약화시키는 문제가 있다.As another method of improving the skin disease of pets, a drug for treating pet skin, such as Republic of Korea Patent Publication No. 2006-0058531, has been proposed. The agent contains 6-pentyl-alpha-pyrone, which has antimicrobial and insecticidal activity.However, when the stomach 6-pentyl-alpha-pyrone is frequently used, the kidneys of the pet, There is a problem that weakens immunity to the liver and skin tissues.
따라서, 애완동물의 피부질환을 안전하고 효과적으로 완화 및 진정시킬 수 있는 조성물의 개발이 요구되고 있다. Therefore, there is a need to develop a composition that can safely and effectively alleviate and soothe pet skin diseases.
본 발명은 이와 같은 문제점을 해결하기 위하여 창안된 것으로서, 본 발명은 애완동물의 피부에 항균, 항염증 효능 및 보습효과가 있어 애완동물의 피부질환을 개선할 수 있고 천연성분으로 이루어져 안전하게 사용할 수 있는 피부외용 조성물을 제공하고자 한다.The present invention was devised to solve this problem, and the present invention has antibacterial, anti-inflammatory and moisturizing effects on the skin of pets, which can improve skin diseases of pets and consist of natural ingredients that can be safely used. It is intended to provide an external skin composition.
본 발명은 상기 과제를 해결하기 위하여, 본 발명은 애완동물의 피부질환을 개선하기 위한 조성물로 황백, 싸리나무, 작약, 백선피, 황금, 박하, 지모, 자근, 한련초, 용뇌가 배합된 추출물을 유효성분으로 함유하는 피부외용 조성물을 제공한다.The present invention, in order to solve the above problems, the present invention is a composition for improving the skin disease of a pet, an extract containing a mixture of yellow and white, saffron, peony, ringworm, golden, peppermint, jimo, freckle, yeonryongcho, cerebrum Provided is an external composition for skin containing as an active ingredient.
이를 위해 본 발명의 피부외용 조성물은 황백 15~25중량%, 싸리나무 10~25중량%, 작약 4~10중량%, 백선피 4~10중량%, 황금 3~8중량%, 박하 3~8중량%, 지모 3~8중량%, 자근 3~8중량%, 한련초 3~8중량%, 용뇌 3~8중량%으로 배합되어 추출되는 유효성분을 함유한다.To this end, the composition for external application of the present invention is 15 to 25% by weight of yellow white, 10 to 25% by weight of fern tree, 4 to 10% by weight of peony, 4 to 10% by weight of ringworm skin, 3 to 8% by weight of gold, 3 to 8% peppermint Contains the active ingredient extracted by blending with 3% to 8% by weight, 3 to 8% by weight, 3 to 8% by weight of roots, 3 to 8% by weight of Hannyeoncho, and 3 to 8% by weight of cerebral brain.
본 발명의 피부외용 조성물은 애완동물의 피부에 염증완화, 보습 및 항균효능을 가지는데, 상기 천연조성물은 황색포도상구균(Staphylococcus aureus), 페렴간균(Klebsiella pneumoniae), 대장균(Escherichia coli), 및 녹농균(Pseudomonas aeruginosa)에 대하여 항균작용을 나타낸다.The composition for external application of the present invention has an effect of alleviating inflammation, moisturizing and antibacterial effects on the skin of a pet, and the natural composition is Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. (Pseudomonas aeruginosa).
이와 같은 본 발명의 대상물은 애완동물 중 특히 애완용 개를 대상으로 한다.This object of the present invention is particularly targeted for pet dogs.
본 발명의 조성물은 애완동물의 피부에 발현되는 염증을 완화시킴과 동시에, 피부표면을 보습할 수 있으며, 애완견의 피부나 몸에 질병을 유발하는 세균에 대하여 항균활성 효능이 있으며, 황백을 포함한 10가지의 천연약재를 증류 추출하여 얻어짐에 따라 안전하게 사용할 수 있다.The composition of the present invention can alleviate the inflammation expressed on the skin of a pet, and at the same time, moisturize the skin surface, has antibacterial activity against bacteria that cause disease on the skin or body of a pet dog, and includes 10 It can be safely used as it is obtained by distilling and extracting the natural herbs of eggplant.
도 1은 본 발명의 일 실시예에 따른 조성물의 항균실험 시험성적서이다.1 is a test report of the antibacterial experiment of the composition according to an embodiment of the present invention.
이하에서는 실시예를 통하여 본 발명을 보다 상세하게 설명한다. 단, 이들 실시예는 본 발명의 예시적인 기재일 뿐이며 본 발명의 범위가 이들 실시예에 국한되는 것은 아니다.Hereinafter, the present invention will be described in more detail through examples. However, these examples are merely illustrative of the present invention, and the scope of the present invention is not limited to these examples.
실시예 1. 한약재 추출 조성물의 제조Example 1. Preparation of herbal medicine extract composition
황백, 싸리나무, 작약, 백선피, 황금, 박하, 지모, 자근, 한련초, 용뇌의 10가지 한약재를 정제수로 세척한 후, 황백 160g, 싸리나무 120g, 작약 60g, 백선피 60g, 황금 50g, 박하 50g, 지모 50g, 자근 50g, 한련초 50g, 용뇌 50g을 진공 저온추출기에 정제수 20ℓ를 투여하여 80℃에서 70분 동안 증류추출하여 조성물을 수득하였다.After washing 10 herbal medicines of Hwangbaek, Sari tree, Peony, Ringworm, Golden, Peppermint, Jimo, Jageun, Hannyeoncho, and Dragon Brain with purified water, 160g of Hwangbaek, 120g of Saffron, 60g of Peony, 60g, 50g of Golden, Mint The composition was obtained by distilling and extracting 50 l, 50 g, 50 g of root, 50 g of Hannyeoncho, 50 g of cerebrum, and 20 l of purified water in a vacuum low temperature extractor at 80°C for 70 minutes.
실험예 1: 조성물의 애완견 피부 염증완화 실험Experimental Example 1: Composition of pet dog skin inflammation relief experiment
0.01mg/ml 농도의 히스타민(histamine phosphate) 0.1ml을 실험견 3마리(실험견1,2,3. 2~3년령인 암컷 비글)의 피부에 주사하여 염증을 유발하였다. 그리고, 히스타민의 주사 15분 후 실험견1의 염증발병 부위에 실시예 1에서 제조한 조성물을 하루 8시간 간격으로 3회에 걸쳐 3일 동안 분사하였고, 실험견2의 염증발병 부위에는 정제수를 분사하였으며, 실험견3에는 아무런 조치도 하지 않았다. 히스타민이 주사된 실험견 1,2,3에 대하여 주사일로부터 1, 3, 5일에 피부에 유발된 염증크기를 측정하였다. 측정결과가 아래 표 1,2에 도시되어 있는데, 실험견1은 1일차에 직경 8mm의 염증이 점차 감소되어 5일차에는 직경 2mm로 측정되었고, 정제수로 분사된 실험견2는 직경 9mm의 염증이 10mm로 측정되었으며, 아무런 조치를 하지 않은 실험견3은 직경 9mm의 염증이 11mm로 측정되었다. 따라서, 실험견1은 실험견2,3에 비해 염증의 크기가 1/5이하로 감소하여 본 발명의 조성물이 실험견 피부에 유발된 염증크기를 완화한다는 것을 확인할 수 있었다.Inflammation was induced by injecting 0.1 ml of histamine (histamine phosphate) at a concentration of 0.01 mg/ml into the skin of three experimental dogs (female beagles 1, 2, 3. 2-3 years old). Then, 15 minutes after the injection of histamine, the composition prepared in Example 1 was sprayed on the site of inflammation of experimental dog 1 for 3 days at 8-hour intervals for 3 days, and purified water was sprayed on the site of inflammation of experimental dog 2 No action was taken on Experiment Dog 3. For the experimental dogs 1,2,3 in which histamine was injected, the size of inflammation induced on the skin was measured on the 1st, 3rd and 5th days from the injection day. The measurement results are shown in Tables 1 and 2 below. In experimental dog 1, inflammation of 8 mm in diameter gradually decreased on the first day, and was measured to be 2 mm in diameter on the fifth day. In experimental dog 2 sprayed with purified water, inflammation of 9 mm in diameter was observed. It was measured to be 10mm, and the experimental dog 3 without any action was measured to have an inflammation of 9mm in diameter and 11mm. Therefore, the experimental dog 1 was confirmed that the size of the inflammation is reduced to 1/5 or less compared to the experimental dogs 2 and 3, so that the composition of the present invention relieves the size of the inflammation caused by the skin of the experimental dog.
실험예 2: 조성물의 애완견 피부 보습효능 실험Experimental Example 2: Composition of pet dog skin moisturizing effect experiment
염증이 유발된 실험견1,2,3의 피부 표면의 보습도를 히스타민 주사일로부터 1, 3, 5일에 각각 측정하였다. 측정은 델핀 베이포미터 와이어리스(Delfin vapometer wireless; Technologies ltd. SWL 4001)를 이용하여 염증이 유발된 피부표면으로부터 증발되는 수분의 량(경표피 수분 손실량. Trans-Epidermal Water Loss, TEWL)을 측정한 후, 수치가 안정화되는 구간의 평균값을 측정하였다. 측정결과가 아래 표 2에 도시되어 있다. 표 2를 참조하면, 실험견1의 증발되는 수분의 량은 7.8~9.4g/m2h로 비교적 낮았으나, 실험견2는 12.4~17.3g/m2h 이고 실험견3은 15.3~18.8g/m2h로 실험견1에 비해 2배 이상 높았다. 따라서, 본 발명의 조성물이 실험견 피부로부터 수분의 증발을 막는 보습작용이 있음을 확인할 수 있었다.Moisturization of the skin surface of the experimental dogs 1, 2, and 3 caused by inflammation was measured on days 1, 3, and 5 from the histamine injection day, respectively. The measurement was performed by measuring the amount of moisture evaporated from the skin surface causing inflammation (Trans-Epidermal Water Loss, TEWL) using a delfin vapometer wireless (SWL 4001). Then, the average value of the section where the numerical value is stabilized was measured. The measurement results are shown in Table 2 below. Referring to Table 2, the amount of water evaporated from the experimental dog 1 was relatively low, 7.8 to 9.4 g/m 2 h, but the experimental dog 2 was 12.4 to 17.3 g/m 2 h and the experimental dog 3 was 15.3 to 18.8 g. The /m 2 h was more than twice that of the experimental dog 1. Therefore, it was confirmed that the composition of the present invention has a moisturizing effect to prevent evaporation of moisture from the skin of the experimental dog.
실험예 3: 조성물의 항균효능 실험Experimental Example 3: Antibacterial efficacy test of the composition
애완견의 피부나 몸에 질병을 유발할 수 있는 병원균에 대한 항균실험을 2018.05.24.에 한국표준시험연구원에 의뢰하여 실시하였다. 항균실험은 애완견의 피부나 털에 기생하는 황색포도상구균(Staphylococcus aureus), 페렴간균(Klebsiella pneumoniae), 대장균(Escherichia coli), 및 녹농균(Pseudomonas aeruginosa)의 4개 균을 배양한 후, 실시예1의 조성물을 투여하여 항균활성 효능을 측정하였다. 이의 결과가 도 1의 시험성적서에 도시되어 있는데, 이를 참조하면 본 조성물이 위 4가지 균주에서 99.9%의 세균감소율을 보이는 바, 본 발명의 조성물은 위 4가지 균에 대하여 강력한 항균 효과가 있음을 알 수 있다.An antibacterial experiment against pathogens that can cause disease on the skin or body of a pet dog was commissioned by the Korea Research Institute of Standards and Testing on May 24, 2018. The antibacterial experiment was performed after culturing four bacteria of Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa, which are parasitic on the skin or hair of a pet dog. By administering the composition of the antibacterial activity was measured. The results are shown in the test report of FIG. 1, referring to this, the present composition shows a bacterial reduction rate of 99.9% in the above 4 strains, indicating that the composition of the present invention has a strong antibacterial effect against the above 4 bacteria. Able to know.
이와 같은 실험을 통해 본 발명의 조성물은 애완견의 피부에 발현되는 염증을 완화시킴과 동시에, 피부표면을 보습하여 보호할 수 있어 애완동물의 피부질환에 효과적으로 사용될 수 있다. 또한, 본 발명의 조성물은 황색포도상구균, 페렴간균, 대장균, 및 녹농균에 대한 강력한 항균효능이 있어, 이와 같은 균들에 의해 애완견의 피부나 몸에 질병을 유발되는 것을 막을 수 있으며, 천연약재를 증류 추출하여 얻어짐에 따라 안전하게 사용될 수 있다.Through such experiments, the composition of the present invention can relieve inflammation expressed on the skin of a pet dog and, at the same time, moisturize and protect the skin surface, so that it can be effectively used for skin diseases of pets. In addition, the composition of the present invention has a strong antibacterial effect against Staphylococcus aureus, pneumoniae, E. coli, and Pseudomonas aeruginosa, and can prevent the skin or body of pet dogs from being caused by these bacteria, distilling natural medicines It can be safely used as it is obtained by extraction.
Claims (6)
황백 15~25중량%, 싸리나무 10~25중량%, 작약 4~10중량%, 백선피 4~10중량%, 황금 3~8중량%, 박하 3~8중량%, 지모 3~8중량%, 자근 3~8중량%, 한련초 3~8중량%, 용뇌 3~8중량%으로 배합되어 추출된 유효성분을 함유하여, 히스타민에 의해 유발된 애완동물의 피부에 염증완화와 보습효능을 가지는 것을 특징으로 하는 피부외용 조성물.A composition for external application of skin to improve skin diseases of pets,
15~25% by weight of yellow white, 10~25% by weight of saree tree, 4~10% by weight of peony, 4~10% by weight of ringworm, 3-8% by weight of gold, 3-8% by weight of mint, 3-8% by weight , 3-8% by weight, 3-8% by weight of Hannyeoncho, 3-8% by weight of cerebrum contains the active ingredient extracted, it has the effect of alleviating inflammation and moisturizing effect on the skin of pets caused by histamine A composition for external application to the skin.
상기 천연조성물은 황색포도상구균(Staphylococcus aureus), 페렴간균(Klebsiella pneumoniae), 대장균(Escherichia coli), 및 녹농균(Pseudomonas aeruginosa)에 대하여 항균작용을 나타내는 것을 특징으로 하는 피부외용 조성물.According to claim 1,
The natural composition is a composition for external application to the skin, characterized in that it exhibits antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
상기 애완동물은 애완용 개인 것을 특징으로 하는 피부외용 조성물.According to claim 1,
The pet is a composition for external use of the skin, characterized in that the pet personal.
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