KR20200016691A - Composition for treating skin disease and antibiosis of pet animals - Google Patents
Composition for treating skin disease and antibiosis of pet animals Download PDFInfo
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Abstract
Description
본 발명은 애완동물의 피부질환 개선과 항균을 위해 사용되는 천연조성물에 관한 것이다.The present invention relates to a natural composition used for improving skin diseases and antibacterial of pets.
애완동물인 개나 고양이의 피부 및 털에는 비듬 각질, 진드기, 모낭충, 기타 각종 세균 등이 기생하여 모발을 손상시키고 탈모를 유발함은 물론 피부병까지도 자주 발병시키는데, 특히 개나 고양이는 표피가 털에 덮혀 있어 외부 공기와 접촉되지 않아 발진이나 염증이 쉽게 진정되지 않는다.Dandruff keratin, mites, Demodex, and other bacteria are parasitic on the skin and hair of pets such as dogs and cats, which damage hair, cause hair loss, and often cause skin diseases. Especially, dogs and cats have epidermis covered with hair. The rash or sores do not soothe easily due to lack of contact with outside air
이와 같은 애완동물의 피부질환을 완화하고 피부에 기생하는 세균이나 기생충을 제거하기 위하여, 대한민국 공개특허공보 제2011-0011418호에 피톤치드를 함유한 애완동물용 샴푸 조성물이 제안되었다. 하지만, 상기 샴푸 조성물은 피부진정 효과의 지속성이 떨어져 애완동물을 자주 세정하여야만 하는 번거로움이 있다.In order to alleviate such skin diseases of pets and to remove the parasitic bacteria or parasites on the skin, the shampoo composition for pets containing phytoncide in the Republic of Korea Patent Publication No. 2011-0011418 has been proposed. However, the shampoo composition has a hassle of having to wash the pet frequently, the durability of the soothing effect is poor.
애완동물의 피부질환을 개선하는 다른 방법으로 대한민국 공개특허공보 제2006-0058531호와 같은 애완동물 피부치료용 약제가 제안되었다. 상기 약제는 6-펜틸-알파-피론(6-pentyl-alpha-pyrone)을 함유하고 있어 항균 및 살충활성을 가지는데, 하지만 위 6-펜틸-알파-피론을 자주 사용하는 경우 애완동물의 신장, 간, 피부 조직에 면역성을 약화시키는 문제가 있다.As another method of improving skin diseases of pets, a drug for treating pet skin, such as Korean Patent Laid-Open Publication No. 2006-0058531, has been proposed. The medicament contains 6-pentyl-alpha-pyrone, which has antibacterial and insecticidal activity. However, if the 6-pentyl-alpha-pyrone is frequently used, the height of pets, There is a problem of weakening immunity to liver and skin tissue.
따라서, 애완동물의 피부질환을 안전하고 효과적으로 완화 및 진정시킬 수 있는 조성물의 개발이 요구되고 있다. Therefore, there is a need for the development of a composition that can safely and effectively alleviate and soothe pet skin diseases.
본 발명은 이와 같은 문제점을 해결하기 위하여 창안된 것으로서, 본 발명은 애완동물의 피부에 항균, 항염증 효능 및 보습효과가 있어 애완동물의 피부질환을 개선할 수 있고 천연성분으로 이루어져 안전하게 사용할 수 있는 천연조성물을 제공하고자 한다.The present invention has been made to solve the above problems, the present invention has an antibacterial, anti-inflammatory effect and moisturizing effect on the skin of the pet can improve the skin disease of the pet and can be used safely made of natural ingredients To provide a natural composition.
본 발명은 상기 과제를 해결하기 위하여, 본 발명은 애완동물의 피부질환을 개선하기 위한 조성물로 황백, 싸리나무, 작약, 백선피, 황금, 박하, 지모, 자근, 한련초, 용뇌가 배합된 추출물을 유효성분으로 함유하는 천연조성물을 제공한다.The present invention, in order to solve the above problems, the present invention is a composition for improving skin diseases of pets, yellow white, Prunus, peony, ringworm, golden, peppermint, Jimo, Root, nasturtium, blended extract It provides a natural composition containing as an active ingredient.
이를 위해 본 발명의 천연조성물은 황백 15~25중량%, 싸리나무 10~25중량%, 작약 4~10중량%, 백선피 4~10중량%, 황금 3~8중량%, 박하 3~8중량%, 지모 3~8중량%, 자근 3~8중량%, 한련초 3~8중량%, 용뇌 3~8중량%으로 배합되어 추출되는 유효성분을 함유한다.To this end, the natural composition of the present invention is 15 to 25% by weight of yellowish white, 10 to 25% by weight of pear tree, 4 to 10% by weight of peony, 4 to 10% by weight of white pine, 3 to 8% by weight of gold, 3 to 8% of mint %, 3-8% by weight, 3-8% by weight of root root, 3-8% by weight of nasturtium, 3-8% by weight of brain contains the active ingredient extracted.
본 발명의 천연조성물은 애완동물의 피부에 염증완화, 보습 및 항균효능을 가지는데, 상기 천연조성물은 황색포도상구균(Staphylococcus aureus), 페렴간균(Klebsiella pneumoniae), 대장균(Escherichia coli), 및 녹농균(Pseudomonas aeruginosa)에 대하여 항균작용을 나타낸다.The natural composition of the present invention has an anti-inflammatory, moisturizing and antibacterial effect on the skin of pets. The natural composition is Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. Pseudomonas aeruginosa) antimicrobial activity.
이와 같은 본 발명의 천연대상물은 애완동물 중 특히 애완용 개를 대상으로 한다.Such natural objects of the present invention are intended for pets, especially pet dogs.
본 발명의 조성물은 애완동물의 피부에 발현되는 염증을 완화시킴과 동시에, 피부표면을 보습할 수 있으며, 애완견의 피부나 몸에 질병을 유발하는 세균에 대하여 항균활성 효능이 있으며, 황백을 포함한 10가지의 천연약재를 증류 추출하여 얻어짐에 따라 안전하게 사용할 수 있다.The composition of the present invention can alleviate the inflammation expressed on the skin of pets and at the same time moisturize the skin surface, have antimicrobial activity against bacteria causing diseases on the skin and body of pet dogs, As it is obtained by distillation and extraction of natural herbs of eggplant, it can be used safely.
도 1은 본 발명의 일 실시예에 따른 조성물의 항균실험 시험성적서이다.1 is an antimicrobial test report of the composition according to an embodiment of the present invention.
이하에서는 실시예를 통하여 본 발명을 보다 상세하게 설명한다. 단, 이들 실시예는 본 발명의 예시적인 기재일 뿐이며 본 발명의 범위가 이들 실시예에 국한되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples. However, these Examples are only illustrative description of the present invention and the scope of the present invention is not limited to these Examples.
실시예 1. 한약재 추출 조성물의 제조Example 1 Preparation of Herbal Medicine Extract Composition
황백, 싸리나무, 작약, 백선피, 황금, 박하, 지모, 자근, 한련초, 용뇌의 10가지 한약재를 정제수로 세척한 후, 황백 160g, 싸리나무 120g, 작약 60g, 백선피 60g, 황금 50g, 박하 50g, 지모 50g, 자근 50g, 한련초 50g, 용뇌 50g을 진공 저온추출기에 정제수 20ℓ를 투여하여 80℃에서 70분 동안 증류추출하여 조성물을 수득하였다.After washing 10 kinds of medicinal herbs of baekbaek, pear tree, peony, ringworm, golden, peppermint, jimo, root, nasturtium, and green onion with purified water, baekbaek 160g, pear tree 120g, peony 60g, ringworm 60g, golden 50g, mint 50 g, 50 g hair, 50 g root, 50 g of nasturtium, 50 g of green onion were administered to a vacuum cold extractor with 20 L of purified water and distilled at 80 ° C. for 70 minutes to obtain a composition.
실험예 1: 조성물의 애완견 피부 염증완화 실험Experimental Example 1: Inflammation test of pet dog skin of composition
0.01mg/ml 농도의 히스타민(histamine phosphate) 0.1ml을 실험견 3마리(실험견1,2,3. 2~3년령인 암컷 비글)의 피부에 주사하여 염증을 유발하였다. 그리고, 히스타민의 주사 15분 후 실험견1의 염증발병 부위에 실시예 1에서 제조한 조성물을 하루 8시간 간격으로 3회에 걸쳐 3일 동안 분사하였고, 실험견2의 염증발병 부위에는 정제수를 분사하였으며, 실험견3에는 아무런 조치도 하지 않았다. 히스타민이 주사된 실험견 1,2,3에 대하여 주사일로부터 1, 3, 5일에 피부에 유발된 염증크기를 측정하였다. 측정결과가 아래 표 1,2에 도시되어 있는데, 실험견1은 1일차에 직경 8mm의 염증이 점차 감소되어 5일차에는 직경 2mm로 측정되었고, 정제수로 분사된 실험견2는 직경 9mm의 염증이 10mm로 측정되었으며, 아무런 조치를 하지 않은 실험견3은 직경 9mm의 염증이 11mm로 측정되었다. 따라서, 실험견1은 실험견2,3에 비해 염증의 크기가 1/5이하로 감소하여 본 발명의 조성물이 실험견 피부에 유발된 염증크기를 완화한다는 것을 확인할 수 있었다.Inflammation was induced by injecting 0.1 ml of histamine (histamine phosphate) at a concentration of 0.01 mg / ml into the skin of three test dogs (female beagles 1, 2, 3.2, 3 years old). Then, 15 minutes after the injection of histamine, the composition prepared in Example 1 was sprayed three times at intervals of 8 hours per day for 3 days, and purified water was sprayed at the site of inflammation of test dog 2 for 3 days. No action was taken on test dog 3. Histamine-injected test dogs 1, 2 and 3 were measured for the size of skin-induced inflammation at 1, 3 and 5 days from the injection date. The measurement results are shown in Tables 1 and 2 below. The test dog 1 was gradually reduced in diameter by 8 mm on the first day and measured by 2 mm in diameter on the 5th day, and the test dog 2 sprayed with purified water was 9 mm in diameter. It was measured as 10mm, and the experimental dog 3 without any measures measured 9mm of inflammation with a diameter of 11mm. Therefore, the test dog 1 was confirmed that the size of the inflammation is reduced to less than 1/5 compared to the test dogs 2, 3, it was confirmed that the composition of the present invention to reduce the inflammation size induced on the skin of the test dog.
실험예 2: 조성물의 애완견 피부 보습효능 실험Experimental Example 2: Experiment for Moisturizing Effect of Pet Dog Skin
염증이 유발된 실험견1,2,3의 피부 표면의 보습도를 히스타민 주사일로부터 1, 3, 5일에 각각 측정하였다. 측정은 델핀 베이포미터 와이어리스(Delfin vapometer wireless; Technologies ltd. SWL 4001)를 이용하여 염증이 유발된 피부표면으로부터 증발되는 수분의 량(경표피 수분 손실량. Trans-Epidermal Water Loss, TEWL)을 측정한 후, 수치가 안정화되는 구간의 평균값을 측정하였다. 측정결과가 아래 표 2에 도시되어 있다. 표 2를 참조하면, 실험견1의 증발되는 수분의 량은 7.8~9.4g/m2h로 비교적 낮았으나, 실험견2는 12.4~17.3g/m2h 이고 실험견3은 15.3~18.8g/m2h로 실험견1에 비해 2배 이상 높았다. 따라서, 본 발명의 조성물이 실험견 피부로부터 수분의 증발을 막는 보습작용이 있음을 확인할 수 있었다.Inflammation-induced moisturization of the skin surface of test dogs 1, 2 and 3 was measured on the 1, 3 and 5 days from the histamine injection day, respectively. The measurement was performed using a Delfin vapometer wireless (Technology ltd. SWL 4001) to measure the amount of water evaporated from the irritated skin surface (transepidermal water loss, Trans-Epidermal Water Loss, TEWL). Then, the average value of the section where the numerical value is stabilized was measured. The measurement results are shown in Table 2 below. Referring to Table 2, the amount of evaporated water of test dog 1 was relatively low, 7.8 ~ 9.4 g / m 2 h, while test dog 2 is 12.4 ~ 17.3 g / m 2 h and test dog 3 15.3 ~ 18.8 g / m 2 h was more than twice as high as the test dog 1. Therefore, it was confirmed that the composition of the present invention has a moisturizing effect to prevent evaporation of water from the test dog skin.
실험예 3: 조성물의 항균효능 실험Experimental Example 3: Antimicrobial efficacy test of the composition
애완견의 피부나 몸에 질병을 유발할 수 있는 병원균에 대한 항균실험을 2018.05.24.에 한국표준시험연구원에 의뢰하여 실시하였다. 항균실험은 애완견의 피부나 털에 기생하는 황색포도상구균(Staphylococcus aureus), 페렴간균(Klebsiella pneumoniae), 대장균(Escherichia coli), 및 녹농균(Pseudomonas aeruginosa)의 4개 균을 배양한 후, 실시예1의 조성물을 투여하여 항균활성 효능을 측정하였다. 이의 결과가 도 1의 시험성적서에 도시되어 있는데, 이를 참조하면 본 조성물이 위 4가지 균주에서 99.9%의 세균감소율을 보이는 바, 본 발명의 조성물은 위 4가지 균에 대하여 강력한 항균 효과가 있음을 알 수 있다.Antimicrobial tests on pathogens that can cause diseases on the skin and body of dogs were conducted by the Korea Institute of Standards and Testing on May 24, 2018. The antibacterial test was carried out by culturing four bacteria, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa, which are parasitic on the skin or hair of a dog. The composition of was administered to determine the antimicrobial efficacy. The results are shown in the test report of FIG. 1. Referring to this, the composition shows a 99.9% bacterial reduction rate in the above four strains. The composition of the present invention has a strong antibacterial effect against the above four bacteria. Able to know.
이와 같은 실험을 통해 본 발명의 조성물은 애완견의 피부에 발현되는 염증을 완화시킴과 동시에, 피부표면을 보습하여 보호할 수 있어 애완동물의 피부질환에 효과적으로 사용될 수 있다. 또한, 본 발명의 조성물은 황색포도상구균, 페렴간균, 대장균, 및 녹농균에 대한 강력한 항균효능이 있어, 이와 같은 균들에 의해 애완견의 피부나 몸에 질병을 유발되는 것을 막을 수 있으며, 천연약재를 증류 추출하여 얻어짐에 따라 안전하게 사용될 수 있다.Through such experiments, the composition of the present invention can alleviate inflammation expressed on the skin of a dog and at the same time can moisturize and protect the skin surface, so that it can be effectively used for skin diseases of pets. In addition, the composition of the present invention has a strong antibacterial effect against Staphylococcus aureus, pneumococcal bacillus, E. coli, and Pseudomonas aeruginosa, can prevent the disease caused to the dog's skin or body by these bacteria, distilled natural medicine It can be used safely as it is obtained by extraction.
Claims (6)
황백, 싸리나무, 작약, 백선피, 황금, 박하, 지모, 자근, 한련초, 용뇌가 배합된 추출물을 유효성분으로 함유하는 천연조성물.As a composition for improving skin diseases of pets,
Natural composition containing extract of Hwangbaek, Prunus chinensis, Peony, White Pine, Golden, Peppermint, Jimo, Root, Nasturtium, and erectrum as active ingredients.
상기 황백 15~25중량%, 싸리나무 10~25중량%, 작약 4~10중량%, 백선피 4~10중량%, 황금 3~8중량%, 박하 3~8중량%, 지모 3~8중량%, 자근 3~8중량%, 한련초 3~8중량%, 용뇌 3~8중량%으로 배합되어 추출된 유효성분을 함유하는 천연조성물.The method of claim 1,
15 to 25% by weight of yellowish white, 10 to 25% by weight of birch, 4 to 10% by weight of peony, 4 to 10% by weight of white pine, 3 to 8% by weight of gold, 3 to 8% by weight of mint, 3 to 8% of weight Natural composition containing the active ingredient extracted by blending in 3% to 8% by weight, 3-8% by weight of root root, 3-8% by weight of Nasturtium, and 3-8% by weight of green onion.
상기 천연조성물은 애완동물의 피부에 염증완화 효능을 가지는 것을 특징으로 하는 천연조성물.The method of claim 1,
The natural composition is a natural composition, characterized in that it has an anti-inflammatory effect on the skin of the pet.
상기 천연조성물은 애완동물의 피부에 보습효능을 가지는 것을 특징으로 하는 천연조성물.The method of claim 1,
The natural composition is a natural composition, characterized in that it has a moisturizing effect on the skin of pets.
상기 천연조성물은 황색포도상구균(Staphylococcus aureus), 페렴간균(Klebsiella pneumoniae), 대장균(Escherichia coli), 및 녹농균(Pseudomonas aeruginosa)에 대하여 항균작용을 나타내는 것을 특징으로 하는 천연조성물.The method of claim 1,
The natural composition is Staphylococcus aureus, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli (Escherichia coli), and Pseudomonas aeruginosa is a natural composition characterized in that it exhibits antibacterial action.
상기 애완동물은 애완용 개인 것을 특징으로 하는 천연조성물.The method of claim 1,
The pet is a natural composition, characterized in that the pet individual.
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