CN102526562A - Lotion for preventing and killing fungi and bacteria on dog/ cat body surface and preparation method thereof - Google Patents
Lotion for preventing and killing fungi and bacteria on dog/ cat body surface and preparation method thereof Download PDFInfo
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Abstract
The invention relates to lotion combining Chinese and Western medicines and used for killing, preventing and controlling fungal and bacterial diseases on dog/ cat body surfaces. The lotion consists of bactericidal and bacteriostatic Chinese medicinal herbs such as pseudolarix, smilax glabra, common cnidium fruit, sophora flavescens, cortex dictamni, phellodendron, Szechuan pepper and dried alum, broad-spectrum efficient miconazole fungicide and efficient chlorhexidine acetate bactericide according to a scientific formula. By combining the Chinese and Western medicines, the bactericidal and bacteriostatic effect is enhanced, the antibacterial spectrum is enlarged, the medicament tolerance produced by long-term use is avoided, and the toxicity of blindly used chemicals is reduced. The lotion for pets has wide spectrum for killing fungi and bacteria, high safety and low toxic or side effects, and can be used for a long term. The formulation can be prepared into spray, lotion, liniment and externally applied ointment by adopting pharmaceutically medicament preparation technologies.
Description
Technical field
The present invention relates to a kind of washing liquid of preventing and killing dog cat body surface fungus and antibacterial and preparation method thereof.Particularly relate to the bonded washing liquid of killing and preventing and treating dog cat body surface fungus and bacillary illness of a kind of Chinese medicine and western medicine, adopt the pharmaceutical preparation technology on the pharmaceutics to process spray, washing liquid, liniment and externally used paste belong to animal health article field.
Background technology
Along with the raising of living standard, people have had higher pursuit to quality of life, and house pet has become an one's share of expenses for a joint undertaking of liking to dote on personage family, or even urbanite's spirit and emotion sustenance.Whether each house pet goes out all adheres to meadow, soil at sole, fur, other body surface positions inevitably, is harmful to parasite egg, Ticks worm etc.; Also there is acarid in dust in the environment such as ground, antibacterial, fungus also can take advantage of the occasion to grow at the pet body epidermal hair.House pet and human health life relation are more and more closer, and house pet health and human health problems also occur thereupon, are common in report when causing " people dotes on ill altogether " such as rabies, toxoplasmosis, mycotic dermatitis etc.Owner generally pays attention to the disease of house pet itself, as canine distemper, and parvovirus, mycosis; Cat distemper heat, cat leukemia etc., and the disease of the cross infection between those animal and humans is often out in the cold.In recent years; The people dotes on tetanus, tuberculosis, brucellosis, parainfluenza, clostridium botulinum toxin poisoning, nocardiasis, cryptococcosis, candidiasis, coccidioidomycosis of common trouble etc. and not only house pet is threatened, and simultaneously owner is also caused certain potential hazard; Toxoplasmosis is mainly encroached on and is breathed and nervous system; Brucellosis then causes orchitis of anemia of pregnant woman's miscarriage, arthritis and male or the like.Therefore how scientific and periodic is carried out the body surface hygiene to house pet has become the key issue for people and house pet harmonious coexistence.But common on the market property of medicine shampoo is low owing to its property of medicine concentration, acts on single or cause easily all getting a desired effect poisoning.More can't effectively reduce the health concerns that the people dotes on common trouble property cross infection of disease according to house pet body condition and living environment, this makes the people of hobby house pet at a loss as to what to do.
Modern medicine shows that multiple herbal medicine has sterilization and bacteriostasis, and the little but effect of safe side effect relaxes.And synthetic chemicals antibacterial is rapid, can take effect, but side effect is bigger, and life-time service also is prone to cause drug resistance." combination of Chinese and Western medicine " treatment and prevent disease also are one of effective important aspect of generally acknowledging at present.The purpose of the combination of Chinese and Western medicine is to lower toxic and side effects, strengthens the interaction of medicine, improves curative effect.
Cortex Pseudolaricis is bark or the root bark of golden larch.Main component contains Cortex Pseudolaricis acid, phenolic constituent, tannin and pigment.Main effect is an Anti-Puritic and insecticidal, antifungic action.Be used for the animal tinea corporis among the Chinese veterinarian, neurodermatitis, eczema, leprosy dysentery head.
Rhizoma Smilacis Glabrae is climbed the shape shrub for the Liliaceae perennial evergreen, and rhizome contains Saponin, tannin, resin etc.Proved 1 liang of every day clinically in the prevention that prevents and treats the zoonosis leptospirosis, 1 time or 2 decoctions serve on 3 weekly, obey for 5 weeks altogether.The people result that takes medicine shows surplus in the of 2000, and the group of taking medicine is 1:5.58 with the ratio of the group sickness rate of not taking medicine.People's clinical research shows that Rhizoma Smilacis Glabrae has antibacterial and significantly kills or inhibitory action.
Fructus Cnidii is the dry mature fruit of samphire cnidium monnieri.In the last few years, more to the research of Fructus Cnidii, find increasing pharmacological action.Act on mainly at antifungic action about resisting pathogenic microbes: osthole, bergapton and isopimpinellin in vitro tests have strong activity to the Trichophyton mentagrophytes of Trichophyton; Xanthotoxol has significant antifungal effect.
The plant that Radix Sophorae Flavescentis belongs to for the pulse family Radix Sophorae Flavescentis.Acting in vitro tests about resisting pathogenic microbes proves; 1% matrine all has obvious inhibitory action to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus. and in test tube, Radix Sophorae Flavescentis decoct high concentration (1:100) has inhibitory action to tubercule bacillus. and decoct (8%), water logging agent (1:3) have inhibitory action in various degree external to some common skin fungus.
Cortex Dictamni is the root bark of Rutaceae herbaceos perennial shaggy-fruited dittany and narrow leaf shaggy-fruited dittany.Has heat clearing and damp drying, the effect of the detoxifcation of dispeling the wind.Research shows that Cortex Dictamni has good antifungic action.Cortex Dictamni water logging agent (1:4), in vitro to multiple pathomycete such as trichophyton, Trichophyton concentricunm, permitted blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore's tinea bacterium, ulotrichy microspore's tinea bacterium, epidermophyton inguinale, epidermophyton rubrum, star-shaped nocardia etc. inhibitory action in various degree all arranged.
Cortex Phellodendri is the dry bark of rutaceae wampee or Cortex Phellodendri.Modern medicine is following with research proof Cortex Phellodendri antibiotic effect: Cortex Phellodendri water decoction or pure preserved material external to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Diplococcus pneumoniae, anthrax bacillus, vibrio cholera, diphtheria corynebacterium, bacillus subtilis, escherichia coli, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, meningococcus etc.; Inhibitory action is in various degree all arranged. experiment also shows, Cortex Phellodendri has stronger inhibitory action to shigella flexneri, dysentery bacterium. in addition, Cortex Phellodendri decoct, water logging agent all have inhibitory action in various degree in external to multiple pathogenic dermatophytes, trichomonas vaginitis etc.
Fructus Zanthoxyli shows in the pharmacology bacteriostatic test in modern times: Pericarpium Zanthoxyli is to 10 kinds of gram positive bacterias such as anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and Staphylococcus albus, bacillus subtilis, and enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have the obvious suppression effect.The water logging agent of 1:4 also has inhibitory action to star nocardia.
The antibacterial action of dried Alumen: staphylococcus aureus and Bacillus proteus are had inhibitory action (test tube method).To escherichia coli, bacillus pyocyaneus, anthrax bacillus, dysentery bacterium (Fu Shi, will Hayes), Bacillus typhi, paratyphoid fever bacillus, Bacillus proteus, and staphylococcus, Candida albicans etc. also have obvious suppression to render a service (paper dish, flat band method); The strongest to viridans streptococci, Hemolytic streptococcus, streptococcus pneumoniae, diphtheria corynebacterium effect; Cattle type Brucella, bordetella pertussis, meningococcus effect are taken second place, hemophilus influenza is not had effect (paper disk method).High concentration dried Alumen liquid also has inhibitory action to human-like and bacillus tuberculosis bovis.
Miconazole is the imidazoles antifungal agent; In clinical verification to deep fungal and some epidermis funguses such as pathomycete such as Candida albicans, aspergillosis, newborn recessive bacterium, blastomyces, coccidioides immitis, Pseudosaccharomyceteses; And yeast etc., good antibacterial action is all arranged.Also gram positive bacterias such as staphylococcus, streptococcus and anthrax bacillus there is bacteriostasis.
Chlorhexidine is a surfactant, has great broad-spectrum antibacterial, bactericidal action, and various bacteria is had effect.Be adsorbed on the permeability barrier of antibacterial endochylema film, cellular content is spilt, be bacteriostasis during low concentration, then be bactericidal action during high concentration.Research has bactericidal action with proof to staphylococcus aureus, streptococcus, escherichia coli, anaerobism propionibacterium and Candida albicans.
The washing liquid product that the dog cat of being sold is in the market killed external fungus and antibacterial seldom; The present invention is theoretical according to Chinese veterinarian; With principle, carry out scientific composition, with Cortex Pseudolaricis, Rhizoma Smilacis Glabrae, Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri, Fructus Zanthoxyli, dried Alumen, miconazole and chlorhexidine according to modern pharmacology and " combination of Chinese and Western medicine "; These 10 kinds of Chinese medicine and western medicine compatibilities together; Be intended to better raising and effectively kill external fungus of dog cat and noxious bacteria, control dog cat skin skin disease reduces the toxic and side effects of using single high dose chemical drugs to cause simultaneously.
Through patent retrieval, the patent of publication number CN101564519 by name " a kind of topical agent of treating house pet parasite, fungus, bacterial infection and preparation method thereof " discloses to cross with the Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, sulfur, BOHE TONG processes pharmaceutical preparation; Publication number be in the CN102100864A patent of by name " a kind of prevention dog is because the pathogenic infection microorganism causes dermopathic Chinese medicine spray and preparation method thereof " wherein with the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae and Cortex Hibisci are the prescription that Chinese medicine is associated with; Publication number is that liniment is made up of Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Herba Potentillae Chinensis, Mentholum, Camphora, nitroimidazoles medicine described in CN102106901A " a kind of dermopathic liniment of treatment dog cat and preparation technology thereof " the present invention by name; Publication number is that lotion is made up of Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Herba Potentillae Chinensis, Mentholum, Alumen etc. described in the present invention of CN102106902A by name " a kind of treatment dermopathic lotion of dog cat and preparation technology thereof ".Publication number CN1876144 " a kind of dermopathic Chinese medicine of treatment fur-bearing animal and preparation technology thereof " patent by name discloses and has contained Radix Sangusorbae, Folium Artemisiae Argyi, the Radix Stemonae, Radix Sophorae Flavescentis, Ailanthus altissima Swingle; Cortex Phellodendri, Fructus Cnidii, Fructus Atriplicis Sibiricae, Herba Schizonepetae; Windproof, Borneolum Syntheticum, the Radix Angelicae Dahuricae, Herba Portulacae; Rhizoma Smilacis Glabrae, bilobate, Radix Polygoni Multiflori, the prescription of Flos Chrysanthemi Indici and Periostracum Cicadae.Patent retrieval does not find to contain Cortex Pseudolaricis, Rhizoma Smilacis Glabrae, Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri, Fructus Zanthoxyli, dried Alumen, miconazole and chlorhexidine acetate, the associate with publication of dosage forms such as being used for dog cat washing liquid, spray, liniment of these 10 kinds of Chinese medicine and western medicine.Also do not see the report of dosage forms such as the washing liquid that is used for the dog cat that these 10 kinds of Chinese medicine and western medicine associate with, spray, liniment through non-patent retrieval.
Summary of the invention
It is a kind of efficient that the present invention will provide, the washing liquid of killing and preventing and treating dog cat body surface fungus and bacteroidal illness that toxic and side effects is little.The invention still further relates to the method for preparing of this washing liquid.
The present invention is to provide the bonded washing liquid of killing and preventing and treating dog cat body surface fungus and bacillary illness of a kind of Chinese medicine and western medicine, the spray that the dosage form of this washing liquid also can adopt the pharmaceutical preparation technology on the pharmaceutics to process, liniment and externally used paste etc.
Technical scheme of the present invention.
A kind of dog cat provided by the present invention is killed the washing liquid compositions of body surface fungus and antibacterial, it be Chinese medicinal herbs raw material etc. with following raw materials in weight portion, the washing liquid that is prepared into by the pharmaceutical dosage form preparation process: Cortex Pseudolaricis 5-80 weight portion; Rhizoma Smilacis Glabrae 5-80 weight portion, Fructus Cnidii 5-80 weight portion, Radix Sophorae Flavescentis 5-80 weight portion; Cortex Dictamni 5-80 weight portion; Cortex Phellodendri 5-80 weight portion, Fructus Zanthoxyli 5-80 weight portion, dried Alumen 5-50 weight portion; Miconazole is the 0.1-20% of total weight parts, and chlorhexidine acetate is the 0.1-20% of total weight parts.[0021] technical scheme of the present invention can be the Cortex Pseudolaricis 10-30 weight portion that comprises following weight parts, Rhizoma Smilacis Glabrae 10-30 weight portion, Fructus Cnidii 10-30 weight portion; Radix Sophorae Flavescentis 10-30 weight portion, Cortex Dictamni 10-30 weight portion, Cortex Phellodendri 10-40 weight portion; Fructus Zanthoxyli 10-30 weight portion; Dried Alumen 5-25 weight portion, miconazole are the 2-5% of total weight parts, and chlorhexidine acetate is the 2-5% of total weight parts.
The preferred technology of the present invention can be to be: Cortex Pseudolaricis 15 weight portions, Rhizoma Smilacis Glabrae 10 weight portions, Fructus Cnidii 10 weight portions; Radix Sophorae Flavescentis 15 weight portions, Cortex Dictamni 15 weight portions, Cortex Phellodendri 15 weight portions; Fructus Zanthoxyli 12 weight portions; Dried Alumen 8 weight portions, miconazole are 3% of total weight parts, and chlorhexidine is 3% of a total weight parts.
The method for preparing of can prevention and killing the washing liquid of dog cat body surface fungus and antibacterial provided by the invention is: Fructus Zanthoxyli and Fructus Cnidii are mixed, add water logging bubble 0.5-1 hour that 5-10 doubly measures, distilled 3-5 hour collection volatile oil saturated aqueous solution with steam distillation.Get Cortex Pseudolaricis by weight, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri adds 5-10 75-95% ethanol doubly, extracts 2-3 time with ethanol reflux extraction, reclaims ethanol and gets extracting solution.Fructus Zanthoxyli and Fructus Cnidii volatilization saturated aqueous solution and alcohol reflux liquid close the extraction mixed liquor.Both medicinal residues merge, and add dried Alumen, add water 5-10 water gaging and decoct 2 times, each 1-2 hour, filter and collect decoction liquor, and with extract mixed liquor and merge.Be concentrated into relative density 1.02-1.08 after the filtration, obtain the concentrated solution of full dose Chinese medicinal herbs.Mix by measuring miconazole and Polyethylene Glycol in addition, let it be dissolved in the ethanol, obtain miconazole ethanol liquid.With miconazole ethanol liquid, chlorhexidine adds in the concentrated solution of Chinese medicinal herbs successively again, leaves standstill, and filters, and gets the finished product medicinal liquid.
The present invention provides the washing liquid method for preparing that can prevent and kill dog cat body surface fungus and antibacterial, can also be prepared into external spraying agent and liniment.Its preparation method is: with the concentrated solution of the full dose Chinese medicinal herbs that obtains; Adopt the conventional preparation technology of Chinese medicine that it is concentrated into every milliliter of medicinal liquid that contains crude drug in whole 1g; Mix by measuring miconazole and Polyethylene Glycol in addition, let it be dissolved in the ethanol, obtain miconazole ethanol liquid.Miconazole ethanol liquid, chlorhexidine acetate add in the concentrated solution successively, by conventional pharmaceutical technology, add appropriate amount of auxiliary materials (such as tween 80, dimethyl sulfoxide, propylene glycol etc.) and make spray and liniment.
The washing liquid that the present invention could prevent and kill dog cat body surface fungus and antibacterial is Chinese medicinal herbs Cortex Pseudolaricis, Rhizoma Smilacis Glabrae, Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri, Fructus Zanthoxyli and dried Alumen by bactericidal; Fungicide miconazole in conjunction with broad-spectrum high efficacy; Antibacterial chlorhexidine acetate scientific composition forms efficiently; Both combine Chinese medicine and western medicine, have not only strengthened the effect of bactericidal, and have enlarged antimicrobial spectrum; The drug resistance that should not cause life-time service to produce has reduced the toxicity of use chemistry medicine simply simultaneously.
So washing liquid of the present invention is that a kind of anti-spectrum of killing fungus and antibacterial is wide, safe, toxic and side effects is little, and house pet that can life-time service is used washing liquid.
The preparation technology that the present invention adopts, equipment is prone to purchase, and raw material is easy to get, and produce easily, and the extract drugs rate is high, does not cause the wasting of resources, makes product quality more stable, is fit to modern industrialization production.
The specific embodiment:
Embodiment 1: filling a prescription is native rose of Sharon 15kg weight portion, Rhizoma Smilacis Glabrae 10kg weight portion, Fructus Cnidii 10kg weight portion; Radix Sophorae Flavescentis 15kg weight portion, Cortex Dictamni 15kg weight portion, Cortex Phellodendri 15kg weight portion; Fructus Zanthoxyli 12kg weight portion, dried Alumen 8kg weight portion amounts to Chinese medicinal herbs 100kg weight portion.Miconazole is 3% of a total weight parts, chlorhexidine acetate be total weight parts 3% as raw material.Get Fructus Zanthoxyli and Fructus Cnidii and mix, add 8 times and soaked 1 hour,, collect volatile oil saturated aqueous solution 80kg as " No. 1 " liquid with steam distillation distillation 3 hours; Get Cortex Pseudolaricis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri is extracted 2-3 time with ethanol reflux extraction, removes ethanol and gets extracting solution 200kg " No. 2 " liquid the most.Fructus Zanthoxyli and Fructus Cnidii volatilization saturated aqueous solution " No. 1 " liquid and alcohol reflux liquid " No. 2 " liquid close extraction mixed liquor (A liquid).Both medicinal residues merge, and add dried Alumen, add water 5-10 water gaging and decoct 2 times, each 1-2 hour; Filter to collect decoction liquor " 3 " number liquid, and with extract mixed liquor (A liquid) and merge, be concentrated into relative density 1.02-1.08 after the filtration, obtain the concentrated solution (B liquid) of full dose Chinese medicinal herbs; Miconazole 15kg (dissolve with ethanol), chlorhexidine acetate 15kg joins concentrated solution (B liquid) successively, and adding distil water transfers to 500L; Leave standstill, filter, get the finished product medicinal liquid.Usage and dosage: dilute with 1:10, elder generation carries out bathing to the dog body surface, lets the back carry out whole body immersion bath to the washing liquid of dilution and washes, and 1-2 week once.
Effect is tested as follows: only 30 of dog fields, Beijing, experimental dog, and be divided into two groups of a groups at random and be matched group, the b group is an experimental group.
Matched group is daily only uses common body lotion in having a bath, and b organizes with the same frequency, in body lotion, adds 1 (body lotion): 2 (medicinal liquid) aforementioned proportion medicinal liquid is had a bath.Observed the ill total quantity of dermatosis in 180 days:
Remarks: every group of 15 dogs.
A organizes matched group: 9/15 * 100%=60%; B organizes experimental group: 2/15 * 100%=13%.
Experiment effect shows, and is apparent in view from sickness rate in-vitro antibacterial fungistatic effect.
Embodiment 2: filling a prescription is Cortex Pseudolaricis 20kg weight portion, Rhizoma Smilacis Glabrae 8kg weight portion, Fructus Cnidii 8kg weight portion; Radix Sophorae Flavescentis 20kg weight portion, Cortex Dictamni 20kg weight portion, Cortex Phellodendri 10kg weight portion; Fructus Zanthoxyli 14kg weight portion, dried Alumen 5kg weight portion amounts to Chinese medicinal herbs 100kg weight portion.Miconazole is 2% of a total weight parts, chlorhexidine acetate be total weight parts 4% as raw material.Method for making is concentrated into 100L by the Chinese medicine common process with concentrated solution more again with embodiment 1., promptly gets every milliliter and contains the medicinal liquid of giving birth to former medicine 1g. miconazole 2% and chlorhexidine acetate 4% content, leaves standstill, and filters, and gets the finished product medicinal liquid.Usage and dosage: directly medicinal liquid is smeared or is sprayed at house pet body surface site of disease, every day 2-3 time, 3-5 days courses of treatment.Prevention can dilute with water 5-10 doubly, carry out bathing or body surface spray disinfection.The effect experiment as follows.
The ancient shepherd dog of 1: one Britain of case, 1.5 years old, general was suffered from fungus and acarid mixed infection, obstinate.Symptom is before the experiment: become thin, whole skin is coarse, the chaeta rareness, and scurf is more, incrustation, rounded shape, Pyoderma appears in the part, and the back uses this washing liquid to carry out outer 1:10 bathing every day, presses body weight again at a distance from week injection ivermectin injection, logotype 3 times.Effect observation was following in 7 days: skin Pyoderma sx incrustation, and scurf reduces, progressively reduction of circular incrustation, chaeta is obviously long and increase.Change into after 7 days at a distance from dipping in 3 days once, effect observation was following in 30 days: chaeta grows virgin wool basically, and body constitution is clearly better, and scurf disappears basically, and circular incrustation disappears, and site of disease grows virgin wool, the prognosis bona.
Case 2: loose lion dog, 2 years old, the buttocks part suffered from the erythra dermatitis, and hair is gnawed by dog, and site of disease is rubescent and transudate arranged, and the back is carried out the part with the 1:5 medicinal liquid and is embrocated, and symptom and transudate reduce after 2 days, incrustation in 3 days, fully recovering basically in 7 days begins to grow virgin wool.
Also have many instances, can not state to the greatest extent.Comprehensive Experiment explains that washing liquid of the present invention is a kind of has a broad antifungal spectrum, and safe, toxic and side effects is little, and house pet that can life-time service is used washing liquid.
Claims (9)
1. washing liquid of preventing and killing dog cat body surface fungus and antibacterial, it is characterized in that: it is mainly by Chinese medicinal herbs raw material Cortex Pseudolaricis 5-80 weight portion, Rhizoma Smilacis Glabrae 5-80 weight portion; Fructus Cnidii 5-80 weight portion, Radix Sophorae Flavescentis 5-80 weight portion, Cortex Dictamni 5-80 weight portion; Cortex Phellodendri 5-80 weight portion, Fructus Zanthoxyli 5-80 weight portion, dried Alumen 5-50 weight portion; With miconazole be the 0.1-20% total weight parts, chlorhexidine is processed for the 0.1-20% total weight parts.
2. prevention according to claim 1 and kill the washing liquid of dog cat body surface fungus and antibacterial is characterized in that the incremental raio of raw material is: Cortex Pseudolaricis 10-30 weight portion, Rhizoma Smilacis Glabrae 10-30 weight portion; Fructus Cnidii 10-30 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Cortex Dictamni 10-30 weight portion; Cortex Phellodendri 10-40 weight portion, Fructus Zanthoxyli 10-30 weight portion, dried Alumen 5-25 weight portion; Miconazole is the 2-5% total weight parts, and chlorhexidine is the 2-5% total weight parts.
3. prevention according to claim 2 and kill the washing liquid of dog cat body surface fungus and antibacterial is characterized in that the weight ratio of raw material is: Cortex Pseudolaricis 15 weight portions, Rhizoma Smilacis Glabrae 10 weight portions; Fructus Cnidii 10 weight portions, Radix Sophorae Flavescentis 15 weight portions, Cortex Dictamni 15 weight portions; Cortex Phellodendri 15 weight portions, Fructus Zanthoxyli 12 weight portions, dried Alumen 8 weight portions; Miconazole is 3% of a total weight parts, and chlorhexidine is 3% of a total weight parts.
4. according to any described prevention of claim 1-3 with kill the washing liquid of dog cat body surface fungus and antibacterial; Its characteristic is that also the dosage form of washing liquid also can adopt spray, liniment, gel and the externally used paste etc. that preparation process is processed on the pharmaceutics; By conventional pharmaceutical technology; Add appropriate amount of auxiliary materials (such as tween 80, dimethyl sulfoxide, propylene glycol etc.) and make spray and liniment.
5. according to the arbitrary described prevention of claim 1-4 with kill the method for preparing of the washing liquid of dog cat body surface fungus and antibacterial, it is characterized in that Fructus Zanthoxyli and Fructus Cnidii mix,, collect the volatile oil saturated aqueous solution with the steam distillation distillation.
6. according to the arbitrary described prevention of claim 1-4 with kill the method for preparing of the washing liquid of dog cat body surface fungus and antibacterial, it is characterized in that Cortex Pseudolaricis, Rhizoma Smilacis Glabrae; Radix Sophorae Flavescentis; Cortex Dictamni, Cortex Phellodendri is extracted with ethanol reflux extraction; Reclaim ethanol and get extracting solution, again Fructus Zanthoxyli and Fructus Cnidii volatilization saturated aqueous solution and alcohol reflux liquid close the extraction mixed liquor.
7. be (2 according to the described miconazole of claim 1-3; The 4-Dichlorobenzene base)-2-[(2; The 4-Dichlorobenzene base) methoxyl group] ethyl]-the 1H-imidazole nitrate, but be not limited only to (2, the 4-Dichlorobenzene base)-2-[(2; The 4-Dichlorobenzene base) methoxyl group] ethyl]-the 1H-imidazole nitrate, can also be the miconazole chemical compound of other hydrochlorates; Chlorhexidine is 1, two (N1-rubigan-N5-biguanide base) the hexane digluconates of 6-, but be not limited only to 1, two (N1-rubigan-N5-biguanide base) the hexane digluconates of 6-can also be acetate, the chlorhexidine compound of forms such as hydrochlorate.
8. according to the described prevention of claim 5-6 with kill the method for preparing of the washing liquid of dog cat body surface fungus and antibacterial, its characteristic is that also both medicinal residues merge, and add dried Alumen; Adding water 5-10 water gaging decocts 2 times; Each 1-2 hour, filter and collect decoction liquor, merge with the extraction mixed liquor.
9. according to the described prevention of claim 7 claim with kill the method for preparing of the washing liquid of dog cat body surface fungus and antibacterial, after its characteristic also was decoction liquor and extracts mixed liquor and merge, filtering and concentrating was to relative density 1.02-1.08; Obtain the concentrated solution of full dose Chinese medicinal herbs, mix by measuring miconazole and cosolvent Polyethylene Glycol in addition, let it be dissolved in the ethanol; Obtain miconazole ethanol liquid; With miconazole ethanol liquid, chlorhexidine acetate adds in the concentrated solution of Chinese medicinal herbs successively, leaves standstill again; Filter, get the finished product medicinal liquid.
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- 2012-01-15 CN CN2012100106524A patent/CN102526562A/en active Pending
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| CN104352390A (en) * | 2014-10-29 | 2015-02-18 | 苗娥 | Traditional Chinese medicine bath liquid for pets and preparation method thereof |
| CN106538848A (en) * | 2016-11-01 | 2017-03-29 | 韦忠 | A kind of black goat culturing feed and preparation method thereof |
| CN107375791A (en) * | 2017-08-29 | 2017-11-24 | 深圳市红瑞生物科技有限公司 | Pet skin cream and preparation method thereof |
| CN113876851A (en) * | 2021-09-27 | 2022-01-04 | 广州中医药大学(广州中医药研究院) | Cedar lotion, preparation method thereof and application thereof in animal fungal dermatopathy |
| CN114010695A (en) * | 2021-11-17 | 2022-02-08 | 四川农业大学 | Traditional Chinese medicine formula for resisting animal dermatomycosis and preparation method |
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