KR102520978B1 - 성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도 - Google Patents

성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도 Download PDF

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KR102520978B1
KR102520978B1 KR1020167029710A KR20167029710A KR102520978B1 KR 102520978 B1 KR102520978 B1 KR 102520978B1 KR 1020167029710 A KR1020167029710 A KR 1020167029710A KR 20167029710 A KR20167029710 A KR 20167029710A KR 102520978 B1 KR102520978 B1 KR 102520978B1
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antibody
amino acid
ser
acid sequence
seq
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외르크 비쉬후젠
마르쿠스 윤커
티나 섀퍼
디르크 퓌링거
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율리우스-막시밀리안스 우니버지태트 뷔르츠부르크
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
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KR1020167029710A 2014-03-26 2015-03-26 성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도 Active KR102520978B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1405475.3 2014-03-26
GB1405475.3A GB2524552B (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
GB1405477.9 2014-03-26
GB1405477.9A GB2524553C (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
PCT/EP2015/056654 WO2015144855A1 (en) 2014-03-26 2015-03-26 Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

Publications (2)

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KR20160139005A KR20160139005A (ko) 2016-12-06
KR102520978B1 true KR102520978B1 (ko) 2023-04-11

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KR1020167029710A Active KR102520978B1 (ko) 2014-03-26 2015-03-26 성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도

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US (6) US20170204174A1 (https=)
EP (3) EP3122775B1 (https=)
JP (3) JP6865585B2 (https=)
KR (1) KR102520978B1 (https=)
CN (1) CN106536553B (https=)
AU (2) AU2015238264B2 (https=)
BR (1) BR122023027559A2 (https=)
CY (1) CY1122456T1 (https=)
DK (2) DK3653644T5 (https=)
ES (2) ES2763859T3 (https=)
FI (1) FI3653644T3 (https=)
HR (2) HRP20200034T1 (https=)
HU (2) HUE064573T2 (https=)
IL (2) IL248038B (https=)
LT (2) LT3122775T (https=)
NZ (1) NZ724649A (https=)
PL (2) PL3653644T3 (https=)
PT (2) PT3653644T (https=)
RS (1) RS59700B1 (https=)
SI (1) SI3122775T1 (https=)
SM (1) SMT202000064T1 (https=)
WO (1) WO2015144855A1 (https=)

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CN118878677A (zh) * 2024-09-29 2024-11-01 江苏凯基生物技术股份有限公司 一种IgM亚型单克隆抗体及其制备方法和应用

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PT3122775T (pt) 2019-12-26
CN106536553B (zh) 2021-03-12
DK3122775T3 (da) 2020-02-03
JP2017508475A (ja) 2017-03-30
JP7607498B2 (ja) 2024-12-27
SI3122775T1 (sl) 2020-02-28
US20230382987A1 (en) 2023-11-30
IL276405B (en) 2021-07-29
EP3653644B1 (en) 2023-11-15
EP4316596A3 (en) 2024-04-17
EP3122775A1 (en) 2017-02-01
US20200308265A1 (en) 2020-10-01
US20200308264A1 (en) 2020-10-01
WO2015144855A1 (en) 2015-10-01
LT3122775T (lt) 2020-02-10
JP6865585B2 (ja) 2021-04-28
DK3653644T5 (da) 2024-08-26
KR20160139005A (ko) 2016-12-06
RS59700B1 (sr) 2020-01-31
SMT202000064T1 (it) 2020-03-13
PL3653644T3 (pl) 2024-03-04
IL248038A0 (en) 2016-11-30
FI3653644T3 (fi) 2023-12-12
US11760795B2 (en) 2023-09-19
ES2965626T3 (es) 2024-04-16
IL276405A (en) 2020-09-30
JP2023098966A (ja) 2023-07-11
IL248038B (en) 2020-08-31
NZ724649A (en) 2022-07-01
BR112016022013A2 (pt) 2017-10-31
HUE047398T2 (hu) 2020-04-28
AU2020260440B2 (en) 2024-03-21
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US20170204174A1 (en) 2017-07-20
EP3653644A1 (en) 2020-05-20
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ES2763859T3 (es) 2020-06-01
CY1122456T1 (el) 2021-01-27
PL3122775T3 (pl) 2020-05-18
AU2015238264B2 (en) 2020-09-03
CN106536553A (zh) 2017-03-22
AU2015238264A1 (en) 2016-10-20
US11634482B2 (en) 2023-04-25
BR122023027559A2 (pt) 2024-01-30
LT3653644T (lt) 2024-01-25
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HRP20200034T1 (hr) 2020-03-20
CA2943694A1 (en) 2015-10-01
US10604565B2 (en) 2020-03-31
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PT3653644T (pt) 2023-12-19
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