KR102506053B1 - Cleanser Composition - Google Patents

Abstract

상기 식에서, m 및 n은 각각 독립적으로 1~10의 정수이다. 본 발명의 클렌저 조성물은 기포 형성능뿐만 아니라 기포 유지력이 우수하며, 피부에 자극이 적다. 본 발명의 클렌저 조성물을 이용함으로써, 적은 자극으로 꼼꼼한 세안이 가능하므로 모공 안의 피지, 노폐물 등을 잘 제거할 수 있고, 우수한 여드름 개선, 예방, 또는 치료 효과를 나타낼 수 있다.The present invention is a surfactant; anti-inflammatory; And a polyol represented by Formula 1 below; provides a cleanser composition comprising:
[Formula 1]

In the above formula, m and n are each independently an integer of 1 to 10. The cleanser composition of the present invention is excellent in bubble-forming ability as well as bubble-holding power, and is less irritating to the skin. By using the cleanser composition of the present invention, since thorough face washing is possible with little irritation, sebum and wastes in pores can be well removed, and excellent acne improvement, prevention, or treatment effects can be exhibited.

Description

Cleanser Composition {Cleanser Composition}

The present invention relates to a cleanser composition.

Acne is an inflammatory disease of the hair follicle or sebaceous gland that presents various skin lesions such as closed or open comedones, papules, cysts, and nodules on the face, chest, back, and arms. presumed to be involved. However, fundamentally, there are two factors caused by the hyperactivity of the gonadal function, which is thought to be caused by hormones and genetic background, and the action of acne bacteria that reproduce in the hair follicle and decompose sebum to produce free fatty acids. In particular, sebum stagnant in the hair follicles blocks the hair follicles and blocks the circulation of air, so the inside of the hair follicles becomes an environment where anaerobic bacteria residing there can grow well. The thus-produced cotton cloth creates a living environment for microorganisms, such as Propionibacterium acnes ( P. Acnes ), Staphylococcus epidermidis ( Staphylococcus epidermidis ), and Pityrosporum ovale ( Pityrosporum ovale ). These are lipophilic microorganisms, Staphylococcus epidermidis is aerobic and grows in the outer follicle or in the middle of the hair follicle, and Propionibacterium acnes is anaerobic and grows in the interior of the hair follicle.

In order to manage inflammatory skin diseases such as acne, it is important to thoroughly wash your face using a cleanser that does not irritate the skin while inhibiting the growth of harmful bacteria such as acne bacillus and removing sebum and wastes in the pores. . Therefore, research on anti-acne cleanser compositions containing raw materials with low skin irritation has been continuously conducted, and a composition for treating acne using natural substances such as dill extract as a hypoallergenic raw material has also been disclosed (Patent Document 1).

When only hypoallergenic raw materials, including natural substances, are mainly used in the cleanser composition, there is a problem in that the foaming ability is not good or the time for which the foam is maintained is short, making it difficult to thoroughly wash the face and lowering the user's preference. Accordingly, while the present inventors continued research on a cleanser composition containing natural substances, when an amino acid-based surfactant and a polyol are used together, the bubble formation ability and bubble holding power are excellent, enabling meticulous cleansing with low irritation, and acne. It was found that the improvement effect was excellent and the present invention was completed.

Korean Registered Patent Publication No. 10-0981038 (2010.09.01.)

An object of the present invention is to provide a cleanser composition that contains a natural substance such as an extract as an anti-inflammatory agent, has good bubble forming ability and bubble holding power, and has an excellent effect on improving acne.

The present invention is a surfactant; anti-inflammatory; And a polyol represented by Formula 1 below; provides a cleanser composition comprising:

[Formula 1]

In the above formula, m is an integer of 1 to 10, n is an integer of 1 to 10.

The cleanser composition of the present invention is excellent in bubble-forming ability as well as bubble-holding power, and is less irritating to the skin as a neutral or slightly alkaline cleanser. By using the cleanser composition of the present invention, since thorough face washing is possible with little irritation, sebum and wastes in pores can be well removed, and excellent acne improvement, prevention, or treatment effects can be exhibited.

1 shows the foam-forming ability of cleanser compositions according to Examples and Comparative Examples.
Figure 2 shows the bubble holding power over time of the cleanser compositions according to Examples and Comparative Examples.
Figure 3 shows the results of confirming the cleaning effect using the cleanser composition of Example.

Hereinafter, the present invention will be described in more detail to aid understanding of the present invention.

Terms or words used in this specification and claims should not be construed as being limited to ordinary or dictionary meanings, and the inventor may appropriately define the concept of terms in order to explain his or her invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention based on the principle that there is.

In the present invention, "extract" refers to a material extracted from a raw material by any method, and is used in the sense of including all of the extracted extract, the concentrate obtained therefrom, and the dried product and powder of the concentrate without limitation.

In the present invention, "acne" is typically any one selected from the group consisting of Propionibacterium acnes, Staphylococcus epidermidis, and Pityrosporum ovale; or any skin condition, including pyogenic acne, nodular acne, or cystic acne, caused at least in part by other microorganisms capable of producing acne, and comedones, closed or open.

In the present invention, "acne improvement" is a term that includes treatment or prevention of acne. The "treatment" includes partial cure, improvement and relief of acne symptoms as well as complete cure of acne symptoms as a result of applying the pharmaceutical composition of the present invention to the acne area, and the "prevention" refers to applying the pharmaceutical composition of the present invention to the body. By applying to the site, it means to suppress or block the infection or growth of acne bacteria such as Propionibacterium acnes so that acne symptoms do not occur in advance.

The present invention is a surfactant; anti-inflammatory; And a polyol represented by Formula 1 below; provides a cleanser composition comprising:

[Formula 1]

In the above formula, m is an integer of 1 to 10, n is an integer of 1 to 10.

The surfactant may be an amino acid-based surfactant, an anionic surfactant, or a nonionic surfactant.

Specifically, the amino acid-based surfactant is potassium cocoyl glycinate (Potassium Cocoyl Glycinate), sodium lauroyl aspartate (Sodium Lauroyl Aspartate), cocoyl glutamic acid, potassium cocoyl glutamate (potassium cocoyl glutamate), potassium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, sodium stearoyl glutamate, tea TEA cocoyl glutamate, sodium hydrogenated tallowoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, and sodium palmo One or more selected from the group consisting of glutamate (sodium palmoyl glutamate) may be included.

The anionic surfactant may be alkyl polyglucoside or sodium alkyl sulfate, and specific examples thereof include decyl glucoside, lauryl diglucoside, lauryl glucoside, and coco glucoside. ), sodium cetyl sulfate, and sodium cetearyl sulfate.

The nonionic surfactant may be an alkyl glucamide or an alkyl glucoside, and specific examples thereof include lauryl diglucamide, lauroyl methyl glucamide, and decyl glucoside. ), lauryl glucoside, and coco glucoside.

The surfactant may be an amino acid-based surfactant, preferably an amino acid-based surfactant derived from natural materials. In this case, since it has good bubble-forming ability and less irritation, it may be suitable for washing sensitive skin due to inflammation. Specifically, the surfactant is potassium cocoyl glycinate and sodium lauroyl aspartate, sodium cocoyl glutamate, potassium cocoyl glutamate, TEA-cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, And it may include at least one selected from the group consisting of sodium palmoyl glutamate. The potassium cocoyl glycinate is a vegetable amino acid-based anionic surfactant extracted from coconut fruit. The sodium lauroyl aspartate is an amino acid-based anionic surfactant with high safety made from natural fatty acid and aspartic acid, a kind of amino acid.

In one embodiment, the surfactant may include potassium cocoyl glycinate and sodium lauroyl aspartate.

The cleanser composition contains potassium cocoyl glycinate and sodium lauroyl aspartate in a weight ratio of 3:1 to 1:3, or 2:1 to 1:2, or 5:3 to 3:5. can include When the above numerical range is satisfied, the foam-forming ability of the cleanser composition or the foam-holding ability over time may be excellent.

The cleanser composition contains 5 to 45% by weight, or 8 to 40% by weight, or 10 to 40% by weight, or 8 to 35% by weight, or 13 to 35% by weight, or 8 to 35% by weight, based on the total weight of the cleanser composition. 20% by weight, or 13 to 20% by weight. When the above numerical range is satisfied, not only the bubble forming ability but also the bubble holding power can be maintained at an excellent level.

In Formula 1, m and n may each independently be an integer of 1 to 10, an integer of 1 to 7, an integer of 1 to 5, or an integer of 1 to 3.

Most preferably, the polyol is diglycerin. When diglycerin is included as the polyol, the cleanser composition of the present invention can exhibit excellent bubble retention.

The cleanser composition of the present invention may contain 1 to 35% by weight, or 3 to 25% by weight, or 5 to 20% by weight, or 5 to 17% by weight, or 5 to 12% by weight of the polyol, based on the total weight of the cleanser composition. there is. When the above numerical range is satisfied, not only the bubble forming ability but also the bubble holding power can be maintained at an excellent level.

The anti-inflammatory agent is Jijil extract, Baekchul extract, Sukjihwang extract, Cnidium extract, Self-injection extract, Golden extract, Cypress extract, Injin extract, Licorice extract, Peony extract, Yugeunpi extract, Woobangja extract, Barberry extract, Hwangbaek extract, Baiseonpi extract, Houttuynia cordata It may include at least one selected from the group consisting of extract, Shiho extract, portulaca extract, motherwort extract, and ginkgo leaf extract.

The cleanser composition of the present invention may include 0.01 to 10% by weight, or 0.1 to 5% by weight, or 0.3 to 3% by weight, or 0.5 to 2% by weight, or 1.0 to 1.5% by weight based on the total weight of the cleanser composition of the anti-inflammatory agent. there is. When included below the numerical range, the anti-inflammatory effect may be insignificant, and when included in excess of the above numerical range, the extent to which the effect increases compared to the increase in cost as the content increases may be insignificant and uneconomical.

The cleanser composition of the present invention may be a cosmetic composition or a pharmaceutical composition.

One aspect of the present invention is a surfactant; anti-inflammatory; And a polyol represented by Formula 1; provides a cleanser cosmetic composition comprising a.

In the present invention, the "cosmetic composition" is a composition used for the human body to clean and beautify the human body to brighten the appearance or to maintain or promote the health of the skin and hair, and includes cleansers and detergents.

The cosmetic composition of the present invention may be prepared in liquid or solid form using bases, adjuvants and additives commonly used in the field of cosmetics. Cosmetics in liquid or solid form may include, but are not limited to, cosmetic products, creams, lotions, and bath products.

Bases, adjuvants and additives commonly used in the field of cosmetics are not particularly limited, and examples thereof include water, alcohol, propylene glycol, stearic acid, glycerol, cetyl alcohol, and liquid paraffin.

When the composition of the present invention is prepared as a cosmetic composition, the composition of the present invention may include ingredients commonly used in cosmetic compositions, as well as the surfactant, polyol and anti-inflammatory agent, such as antioxidants, metal ion sequestering agents, Conventional adjuvants such as preservatives, stabilizers, solubilizers, vitamins or derivatives thereof, pigments and flavors, and carriers may further be included. Specific examples thereof may be obtained by conventional techniques and are not particularly limited.

The cosmetic composition of the present invention can be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, cleansers, oils, and It may be formulated as a spray or the like, but is not limited thereto. More specifically, it may be formulated into a cleansing cream, cleansing foam, cleansing water, cleansing pack, or cleansing spray or cleansing powder.

When the formulation of the present invention is a cleanser, sulfosuccinic acid monoesters, imidazolinium derivatives, methyl taurates, sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid di Ethanolamide, vegetable oil, lanolin derivatives, ethoxylated glycerol fatty acid esters and the like may be used.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylene glycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Star cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

The metal ion sequestering agent is from the group consisting of disodium EDTA, tetrasodium EDTA, sodium polyphosphate, sodium citrate, sodium metaphosphate, anhydrous trisodium phosphate, anhydrous tetrasodium pyrophosphate, and anhydrous citric acid. One or more selected species are included.

The vitamin or derivative thereof includes at least one selected from the group consisting of vitamin A and derivatives thereof, vitamins B1, B2, B6, E and derivatives thereof, vitamins D, H, K, pantothenic acid and derivatives thereof, biotin, and panthenol. can do.

The preservative is 1,2-alkanediol, such as 1 selected from the group consisting of pentylene glycol, 1,2-hexanediol, caprylyl glycol, decylene glycol, glyceryl caprylate, and ethylhexyl glycerin. May include more than one species.

The cosmetic composition of the present invention may be used alone or overlappingly applied, or may be used overlappingly with other cosmetic compositions other than the present invention. In addition, the cosmetic composition according to the present invention can be used according to a conventional method of use, and the number of times of use can be varied according to the user's skin condition or taste.

After applying the cosmetic composition of the present invention to the skin, it can be wiped off, removed, or washed with water. As a specific example, the cleanser composition is from the group consisting of liquid soap, powdered soap, solid soap, oil soap, cleansing foam, cleansing water, cleansing towel, cleansing pack, bubble cleanser, cleansing cream, cleansing lotion, cleansing water and cleansing spray. It may include one or more selected species, but is not limited thereto.

Another aspect of the present invention is a surfactant; anti-inflammatory; And a polyol represented by Formula 1; provides a cleanser pharmaceutical composition comprising a.

In addition to the surfactant, polyol, and anti-inflammatory agent, the pharmaceutical composition of the present invention may contain other components that can give synergistic effects to the improvement, prevention, or treatment of acne, preferably within a range that does not impair the desired effect of the present invention. and the like may be further included. For example, antioxidants, metal ion sequestering agents, preservatives, stabilizers, solubilizers, vitamins or their derivatives, pigments and flavorings, or conventional adjuvants such as, or carriers may be included. Specific examples thereof may be obtained by conventional techniques and are not particularly limited.

The administration route of the pharmaceutical composition may be applied in a topical application method by application.

The pharmaceutical composition of the present invention can be administered in a pharmaceutically effective amount.

In the present invention, "pharmaceutically effective amount" means an amount sufficient to treat a disease with a reasonable benefit / risk ratio applicable to medical treatment, and the effective dose level is the type and severity of the subject, age, sex, type of disease, It may be determined according to the activity of the drug, the sensitivity to the drug, the time of administration, the route of administration and the rate of excretion, the duration of treatment, factors including drugs used concurrently, and other factors well known in the medical field. The composition of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents. And it can be single or multiple administrations. It is important to administer the amount that can obtain the maximum effect with the minimum amount without side effects in consideration of all of the above factors, and can be easily determined by a person skilled in the art.

The pharmaceutical composition of the present invention is not particularly limited as long as it is a subject for the purpose of improving, preventing or treating acne, and any one can be applied. For example, the pharmaceutical composition of the present invention can be used not only for humans but also for non-human animals such as monkeys, dogs, cats, rabbits, guinea pigs, rats, mice, cows, sheep, pigs, goats, birds and fish. do.

The pharmaceutical composition may contain one or more active ingredients exhibiting the same or similar functions in addition to the surfactant, polyol and anti-inflammatory agent. The composition may be formulated and used in the form of oral formulations such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, external preparations, suppositories and sterile injection solutions according to conventional methods, respectively.

Solid preparations for oral administration include powders, granules, tablets, capsules, soft capsules, pills and the like. Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, aromatics, and preservatives may be included. there is.

Formulations for parenteral administration include powders, granules, tablets, capsules, sterilized aqueous solutions, solutions, non-aqueous solutions, suspensions, emulsions, syrups, suppositories, aerosols, etc., and sterile injection preparations according to conventional methods, respectively. It can be formulated and used in the form of a cream, gel, patch, spray, ointment, warning, lotion, liniment, pasta, or cataplasma. , but is not limited thereto. Propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate may be used as non-aqueous solvents and suspending agents. As a base for the suppository, witepsol, macrogol, tween 61, cacao butter, laurin paper, glycerogeratin and the like may be used.

The composition may further contain adjuvants such as preservatives, stabilizers, hydration agents or emulsification accelerators, salts and/or buffers for osmotic pressure control, and other therapeutically useful substances, which are conventional methods such as mixing, granulation or It can be formulated according to the coating method.

The dose of the pharmaceutical composition may vary depending on various factors including age, body weight, general health, sex, administration time, route of administration, excretion rate, drug combination, and severity of a specific disease.

In addition, the pharmaceutical composition of the present invention can be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers. In addition, the pharmaceutical composition may be administered in a dosage within the range of 0.001 to 200 mg / kg on an adult basis, and when the pharmaceutical composition is an external agent, it is administered in an amount of 1.0 to 3.0 ml on an adult basis once a day to 5 It is recommended to apply once and continue for 1 month or longer, but the dosage is not intended to limit the scope of the present invention.

The pharmaceutical composition may be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers.

Hereinafter, the present invention will be described in detail with Examples and Comparative Examples.

However, the following Preparation Examples and Experimental Examples are only for exemplifying the present invention, and the contents of the present invention are not limited by the following Preparation Examples and Experimental Examples.

Example 1 - Preparation of Cleanser Composition

A cleanser composition was prepared according to the composition shown in Table 1 below. First, raw materials 1 to 5 of Table 1 were mixed and stirred while loosening well. Here, amino acid-based surfactants of raw materials 6 to 7 mixed in advance were added and stirred to dissolve well to prepare a mixture.

Raw materials 8 to 10 were put in a separate container and heated to 45°C. The warmed raw materials 8 to 10 are added to the mixture to solubilize. The solution was cooled to 30° C. to prepare a transparent liquid cleanser composition.

division Raw material name (manufacturer, product name) Content (% by weight) One Purified water balance 2 Disodium EDT
(MITWSUBISHI, EDTA-2Na) 0.20 3 panthenol
(BASF, D-PANTHENOL) 1.00 4 diglycerin
(SAKAMOTO, Diglycerin 801) 5.00 5 eggplant extract
(Bioland, eggplant extract) 1.00 6 Potassium Cocoyl Glycinate (30%)
(AJINOMOTO, AMILITE GCK-12H) 5.00 7 Sodium lauroyl aspartate (30%)
(ASAHI KASEI, Aminoformer FLDS-L) 3.00 8 antiseptic Appropriate amount 9 incense Appropriate amount 10 solubilizing agent Appropriate amount Sum 100.00

Comparative Examples 1 to 5. Preparation of cleanser compositions according to different polyols

In Example 1, instead of diglycerin, glycerin (Emery, glycerin 99.5% USP), butylene glycol (OXEA, 1.3.B.G), dipropylene glycol (SKC, DPG), glycereth-26 (LIPO, GELANT G10 ) and propanediol (DUPON, ZEAMEA SELECT PROPANDIOL) were prepared in the same manner as in Example 1, except that the cleanser compositions of Comparative Examples 1 to 5 were prepared.

Experimental Example 1. Comparative evaluation of bubble forming ability

In order to check the bubble-forming ability of the cleanser compositions of Examples and Comparative Examples, each composition was pumped 3 times, then wetted with water and rubbed 5 times, and then the degree of bubble formation was compared with the naked eye. As a result, as shown in FIG. 1, the cleanser compositions of Comparative Examples 1 to 5 did not foam well, and in particular, in the case of Comparative Examples 1 to 3, little foam was formed. this was absolutely necessary. On the other hand, since the cleanser composition of Example 1 produces very rich and dense foam, it was confirmed that sufficient face washing is possible using this.

Experimental Example 2. Comparative evaluation of bubble holding power

In order to compare the bubble holding power of the cleanser compositions of Examples and Comparative Examples, they were put in a foam dispenser and pumped three times each, and then applied with a foil on a flat floor. After initial, 10 minutes, 30 minutes, and 60 minutes, bubbles were maintained. The degree was visually compared. As a result, as shown in FIG. 2, it was confirmed that the cleanser compositions of Comparative Examples 1 to 5 were free of bubbles over time. In particular, in the case of Comparative Example 4, bubbles had already almost disappeared after 10 minutes had elapsed.

On the other hand, it was confirmed that the cleanser composition of Example 1 not only had abundant and dense initial foaming power, but also maintained the foaming ability even after 60 minutes without extinguishing the foam well over time.

Experimental Example 3. Cleaning effect

In order to check the cleansing power of Example 1, 5 minutes after applying the foundation and lipstick to the back of the hand, respectively, the cleanser composition of Example 1 was applied, and the foam was rubbed well 5 to 10 times, and then washed off with lukewarm water. As a result, it was confirmed that the makeup products of the foundation and lipstick were cleaned cleanly, and this process was photographed and shown in FIG. 3.

Claims (12)

As surfactants, potassium cocoyl glycinate and sodium lauroyl aspartate;
anti-inflammatory; and
A cleanser composition comprising a polyol represented by Formula 1 below,
The surfactant is included in 8 to 20% by weight based on the total weight of the cleanser composition, and the polyol is included in 5 to 12% by weight based on the total weight of the cleanser composition Cleanser composition:
[Formula 1]

In the above formula, m and n are each independently an integer of 1 to 10. The method of claim 1,
In Formula 1, m and n are each independently an integer of 1 to 3 composition. The method of claim 1,
The composition of claim 1, wherein the polyol is diglycerin. The method of claim 1,
Wherein the potassium cocoyl glycinate and sodium lauroyl aspartate are included in a weight ratio of 3:1 to 1:3. The method of claim 1,
Wherein the potassium cocoyl glycinate and sodium lauroyl aspartate are included in a weight ratio of 2:1 to 1:2. The method of claim 1,
Wherein the potassium cocoyl glycinate and sodium lauroyl aspartate are included in a weight ratio of 5:3 to 3:5. delete delete The method of claim 1,
The anti-inflammatory agent is Jijil extract, Baekchul extract, Sukjihwang extract, Cnidium extract, Self-injection extract, Golden extract, Cypress extract, Injin extract, Licorice extract, Peony extract, Yugeunpi extract, Woobangja extract, Barberry extract, Hwangbaek extract, Baiseonpi extract, Houttuynia cordata A composition comprising at least one selected from the group consisting of extract, Shiho extract, portulaca extract, motherwort extract, and ginkgo leaf extract. The method of claim 1,
The cleanser composition is a composition for improving, preventing or treating acne. The method of claim 1,
The cleanser composition is a cosmetic composition composition. The method of claim 1,
The cleanser composition is one selected from the group consisting of liquid soap, powdered soap, solid soap, oil soap, cleansing foam, cleansing water, cleansing towel, cleansing pack, bubble cleanser, cleansing cream, cleansing lotion, cleansing water, and cleansing spray. A composition comprising the above.

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