JP5164454B2 - Blood circulation promoter, joint pain relieving agent, tendonitis relieving agent, and stiff shoulder relieving agent containing hot water extract of Miso bamboo - Google Patents

Description

  The present invention relates to a blood circulation promoter and an external preparation for skin containing the hot water extract of Miso bamboo as an active ingredient, and more specifically, the blood circulation promoting action and the surface active effect exhibited by the active ingredient of the hot water extract of Miso bamboo are used for blood circulation. The present invention relates to a blood circulation promoter that improves the condition of the skin or skin caused by defects and is excellent in stability over time, and a skin external preparation that can be applied to pharmaceuticals, quasi drugs, cosmetics, and the like.

  Conventionally, various plant components and plant extracts have been proposed as active ingredients for external preparations for skin. For example, capsaicin and mugwort extract are known to have a blood circulation promoting action and have been used to promote skin metabolism and maintain moist and youthful skin.

In addition, it is known that bamboo extract is blended into cosmetics, and it has been reported that moisturizing effect by bamboo extract, improving rough skin, antiseptic sterilization, anti-tyrosinase activity (melanin inhibiting effect), etc. Yes.
Japanese Patent Laid-Open No. 10-194935 Japanese Patent Laid-Open No. 11-1428 Japanese Patent No. 3623930 JP 2000-247864 A

  Japanese Patent Application Laid-Open No. 10-194935 (Patent Document 1) discloses a hair nourishing and hair restorer containing an extract from a plant such as mugwort or dokudami and a synthetic drug component such as a blood circulation promoter. Japanese Patent Application Laid-Open No. 11-1428 (Patent Document 2) discloses a poultice for the purpose of warmth effect (blood circulation promoting effect) using a red pepper extract.

  However, the hair nourishing and hair restorer disclosed in Patent Document 1 may not be effective when blended with the synthetic drug part if the amount is less than a predetermined amount, and may cause dermatitis if more than the predetermined amount, In any case, there is a concern that the effects of the components of the extract of the plant (such as mugwort and wolfberry) are impaired. Moreover, the extraction method of these plant extracts is mainly a method using an organic solvent, and there is a description that water is also used as an extraction solvent, but the extraction solvent is not as useful as an organic solvent, but rather is an extracted plant. Used as a base when using extracts.

  The warming wrap sheet disclosed in Patent Document 2 uses a medicine that provides a warming effect as a poultice on the affected area, so that the range of application (sticking) is limited, and the warming effect is provided only in that range. However, it does not disclose improvement of stiff shoulders and joint pain.

  Japanese Patent No. 3623930 (Patent Document 3) and Japanese Patent Application Laid-Open No. 2000-247864 (Patent Document 4) disclose cosmetics utilizing the moisturizing effect of bamboo extract.

  However, although the cosmetic described in Patent Document 3 describes the effect of improving the surface of the skin (rough skin portion) using the moisturizing effect, the underlying cause of the rough skin (skin disease, poor circulation, etc.) is improved. Is not disclosed. In addition, the cosmetic composition described in Patent Document 4 mentions anti-tyrosinase activity as a causative measure for the antibacterial and antibacterial properties and rough skin of the bamboo extract. No mention is made of supplements such as vitamins for countermeasures).

  The present invention has been made under the circumstances as described above, and the object of the present invention is to exhibit an effect superior to a preparation containing a conventional plant extract as an active ingredient. An object of the present invention is to provide a blood circulation promoter and an external preparation for skin that promote blood circulation by improving blood circulation and surface-active effects, and improve the subcutaneous or skin condition resulting from poor blood circulation.

The above-mentioned object of the present invention is a blood circulation promoter comprising a hot water extract of Miso bamboo as an active ingredient, wherein the hot water extract of Miso bamboo is extracted with hot water at 95 to 100 ° C. The extraction retention time with water is 2 hours 45 minutes to 3 hours 15 minutes, and the hot water extract of Miso bamboo is a hot water extract of adult bamboo taken from October to December, and hot water extract, based on the total weight of the blood circulation promoters, the blood circulation promoter, which is a 0.01 to 50.00 parts by mass, the hot water extract or bamboo as an active ingredient An arthralgia relieving agent, wherein the hot water extract of Miso bamboo is extracted with hot water at 95-100 ° C., and the extraction retention time with the hot water is 2 hours 45 minutes to 3 hours 15 minutes. The hot water extract of Sosetsu bamboo is Narutake collected from October to December It is a hot water extract, and the hot water extract of Miso bamboo is 0.01 to 50.00 parts by mass with respect to the total mass of the joint pain relieving agent. Is a tendonitis inflammation relieving agent, wherein the hot water extract of Munetake bamboo is extracted with hot water at 95-100 ° C., and the extraction retention time with the hot water is 2 hours 45 minutes-3. The hot water extract of Miso bamboo is a hot water extract of adult bamboo collected from October to December, and the hot water extract of Miso bamboo is the total mass of the tendonitis mitigating agent. On the other hand, by being 0.01 to 50.00 parts by mass, it is a stiff shoulder relieving agent comprising a hot water extract of Miso bamboo as an active ingredient, wherein the hot water extract of Miso bamboo is Extracted with hot water of 95-100 ° C., extracted and retained with the hot water Between 2 hours 45 minutes to 3 hours 15 minutes, the hot water extract of Miso bamboo is a hot water extract of adult bamboo taken from October to December, and the hot water extract of Miso bamboo Is achieved by being a shoulder stiffening agent characterized by being 0.01 to 50.00 parts by weight with respect to the total weight of the shoulder stiffening agent.

The above-described object of the present invention, in the blood circulation promoters, by hot water extraction of the bamboo is contained in the excipients, it is accomplished effectively.

  The hot water extract of Somune bamboo is excellent in blood circulation promoting action, and the blood circulation promoter and external preparation for skin of the present invention contain the hot water extract of Shoso bamboo as an active ingredient, so it is useful for improving poor blood circulation. By applying it to the skin, it is possible to reduce stiffness such as stiff shoulders due to poor circulation, joint pain, tendonitis pain and discomfort.

  According to the present invention, a skin external preparation having a blood circulation promoting action can be obtained. The external preparation for skin of the present invention can be applied to various uses such as cosmetics and quasi drugs, and can be formulated into various dosage forms as cosmetics, for example. The external preparation for skin of the present invention, specifically, cosmetics, is useful for improving skin morphology, rough skin, wrinkles, spots and the like caused by poor circulation.

  The above effect is considered to be caused by the action of plant hormones such as auxin, gibberellin, and abscisic acid contained in Miso bamboo.

  The hot water extract of Misotake, which is an active ingredient to be blended with the blood circulation promoter and external preparation for skin of the present invention, also has a surface active effect. Therefore, it is possible to provide stability over time to the formulation containing it, and reduce and eliminate the amount of chemically synthesized products that were conventionally used to impart a surfactant effect to the composition. A preparation with good stability over time can be provided.

  As a result of intensive research to solve the problems of the prior art, the present inventors applied a hot water extract of Somune bamboo to the skin, so that the extracted active ingredient of the bamboo has a remarkable blood circulation promoting action. It was found that Furthermore, it has been found that the effect of improving rough skin, the effect of moisturizing, and the effect of improving stains are excellent by the blood circulation promoting action of the hot water extract of Misotake.

  First, the hot water extract of Miso bamboo used in the present invention will be described. Phyllostachyheterocycla is a plant belonging to the genus Mushroom. Miso bamboo is native to China, distributed in warm and humid regions of Asia, and cultivated in the warm and warm regions of Japan.

  In the present invention, it is preferable to use a bamboo extract component, in particular, an adult bamboo from Munetake bamboo as an extraction raw material, and this adult bamboo means one that has passed 3 to 5 years from the state of the bamboo shoot. In the present invention, it is further preferable to use adult bamboo from Sosou bamboo collected from October to December. An extract effective particularly in the present invention can be obtained by adult bamboo at such a time.

  In the present invention, the site used as an extraction raw material for Somune bamboo can use each part such as trunk, bamboo skin (skin) part, stem part, branch part, leaf part, etc. Alternatively, two or more types of sites can be mixed and used as an extraction raw material. As for the extraction raw material of Sosou bamboo, it is possible to use what is cut into appropriate lengths, broken pieces, crushed pieces, powdered powders, etc. After being cut into pieces, bamboo pieces divided by an appropriate width in the vertical direction, for example, a width of 3 to 5 cm, can be used as the extraction raw material. Among the bamboo parts, in particular, the trunk part of the scorpion bamboo can be preferably used as the extraction material for the sect bamboo used in the present invention.

  The amount of water used as the extraction solvent is suitably 0.5 to 1.5 times the mass of the extraction raw material, and preferably 0.9 to 1.1 times the amount. Most preferably, the mass ratio is Munetake bamboo: water = 1: 1.

  In an appropriate extraction apparatus such as a pan, the above-mentioned extraction raw material is immersed in an appropriate amount of water, and is usually heated to 95 ° C. or higher and 100 ° C. or lower, and the temperature is about 1 to 10 hours, preferably 2 to 6 hours, more preferably. Hold for about 2 hours 45 minutes to 3 hours 15 minutes. The apparatus used for such extraction operation is not particularly limited, and for example, a device that heats the bottom of a pan (container) having a depth of about 50 cm with a kettle of gas or the like can be used.

  Thereafter, in a state where the hot water maintains the temperature of 95 to 100 ° C., the extraction raw material of Misotake is removed from the container, and the extract remaining in the container is cooled to a temperature of 20 to 50 ° C. and filtered. This filtration can be performed with, for example, a fine cloth or a wire mesh. The filtrate (extract) thus obtained may be concentrated by an appropriate concentration operation, for example, concentration under reduced pressure to obtain a concentrated solution, or a dried product may be obtained. Alternatively, the powder can be obtained by an appropriate drying method such as spray drying or freeze drying.

  As the hot water extract of Miso bamboo used in the present invention, the above-mentioned filtrate (extract) may be used as it is, or a dry powder such as a concentrated solution, a dried product, or freeze-dried may be used. Among these, it is convenient and advantageous to use the above extract. The extract may be filtered again.

  In addition, the manufacturing method of the bamboo extract described in the patent 3554684 gazette which this inventor developed as one of the manufacture examples of the hot water extract of the 孟 宗 bamboo used by this invention is mentioned.

  In the present invention, the extract obtained by filtration as described above can be used as the hot water extract of Misotake, or the extract may be further filtered.

  Alternatively, as another aspect, after holding the extract obtained by filtration as described above for about 1 month, herbs such as rosemary, fennel, marjoram and red shiso are selected for about 3 days to 1 week. You may immerse in an extract. As a specific example, it is preferable to immerse 2 parts by weight of marjoram or 10 parts by weight of red purple soda for 3 days to 1 week with respect to 100 parts by weight of the extract. Thereafter, the herbs may be lifted from the extract and filtered with, for example, a fine cloth. Such a soaking operation of herbs is useful for removing the smell peculiar to bamboo.

  The extract obtained as described above may be sterilized at 95 ° C. or higher for about 10 minutes, and then subjected to a sterilization step of cooling to room temperature.

  The hot water extract of Misotake used in the present invention has extremely low toxicity, specifically, extremely low acute toxicity, and no mutagenicity is observed.

  The blood circulation promoter of the present invention contains the hot water extract of Misotake obtained as described above as an active ingredient and can be easily used if it is contained in an excipient. Such a blood circulation promoter is preferably formulated in a dosage form that is applied to the skin. Therefore, the present invention is directed to a blood circulation promoter and a skin external preparation characterized by containing a hot water extract of Miso bamboo.

  The skin external preparation of the present invention is not particularly limited, and specifically includes a wide range of general cosmetics such as pharmaceutical external preparations, pharmaceutical cosmetics (quasi-drugs), cosmetics, and toiletry products. Further, the external preparation for skin of the present invention can be in various forms, for example, lotion, cream, milky lotion, pack, foundation, cosmetic liquid, cosmetic oil, ointment, gel, deodorant deodorant, hair nourishing tonic, hair mist. , Hair gel, hair shampoo, hair rinse, face wash, body soap, cleansing and the like. Of these, gel and cleansing forms are preferred.

  The amount of hot water extract of Miso bamboo in the external preparation for skin of the present invention is based on the total mass (100 parts by mass) of the external skin preparation when using the extract obtained by hot water extraction from Miso bamboo as described above. 0.01 to 50.00 parts by mass is suitable, preferably 0.1 to 40.0 parts by mass, and more preferably 3 to 35 parts by mass.

  In formulating the external preparation for skin of the present invention, bases and additives can be appropriately used depending on the dosage form and form.

  Examples of the base and additive used in the external preparation for skin of the present invention include mineral oil, animal and vegetable oil, wax, fatty acid, fatty alcohol, ester oil, surfactant, moisturizer, polymer compound, animal and plant extract, and amino acid. , Vitamins, solvents, preservatives, ultraviolet absorbers, sequestering agents (builders), antioxidants, etc., and the effects of the present invention, that is, as long as the active ingredients of the hot water extract of Somune bamboo are not impaired. Can be blended.

  In the formulation, active ingredients are immediately infiltrated by the effect of surfactant hormones such as lecithin and saponin contained in the Sosou bamboo extract, so oil-based components such as mineral oil and animal and vegetable oils, especially animal and vegetable oils such as horse It is desirable to mix oil and formulate the active ingredient so that it stays in the skin. Specific examples of bases and additives are given below.

  Mineral oil includes liquid paraffin and liquid isoparaffin. Animal and vegetable oils include squalane, squalene, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea oil, palm oil, hardened oil, horse oil, lanolins, egg yolk oil, clove oil, rosehip oil , Lavender oil, mint oil, spearmint oil, rosemary oil and the like. Examples of the wax include microcrystalline wax, solid paraffin, and beeswax.

  Examples of fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, and isostearic acid. Examples of fatty alcohols include lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyl decanol, behenyl alcohol, octyldodecanol, and lanolin alcohol. As ester oil (fatty acid ester), glyceryl tri (capryl / caprate), cetyl 2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, isocetyl octanoate, isononyl isononanoate, ethylene glycol dioctanoate, isopropyl myristate Isopropyl palmitate, isocetyl myristate, cetyl palmitate and the like.

  Surfactants include lauryl sulfate, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, lauroyl sarcosine salt, alkylmethyl-β-alanine salt, polyoxyethylene Alkyl ether phosphate, fatty acid soap, N-acyl glutamate, lauric acid diethanolamide, coconut oil fatty acid diethanolamide, alkyl dimethylamine oxide, alkyl methyl taurate, alkyl amino propionate, polyoxyethylene alkyl ether carboxylic acid Salt, alkyl phosphate, alkyl glucoside, polyether-modified silicon, halogenated (chloride or bromide) alkyltrimethylammonium, amidoamine, dialkyldimethylammonium chloride Alkyl dimethyl betaines, alkyl amidopropyl betaines, lecithin (soy or egg yolk) derivative, propylene glycol fatty acid esters, glycerin fatty acid esters, polyoxyethylene glycerin fatty acid ester, and the like polyglycerol fatty acid ester. Regarding these surfactants, whether to use an ionic (cationic, anionic) or nonionic system can be freely selected depending on the relationship with other bases and additives.

  Examples of humectants include propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-hexanediol, glycerin, diglycerin, isoprene glycol, polyethylene glycol, sorbit, xylit, maltitol, trehalose, and seawater dried products. is there. Skin conditioning agents include whey and lactoferrin.

  Examples of the polymer compound include cellulose derivatives such as methyl cellulose, ethyl cellulose, and cationized cellulose, carboxyvinyl polymer, polyvinyl alcohol, polyvinyl pyrrolidone, cationized guagam, sodium hyaluronate, sodium polyacrylate, xanthan gum, and carrageenan. These are used for shaping agents, thickeners and the like.

Animal and plant extracts include placenta extract, hydrolyzed collagen, hydrolyzed keratin, hydrolyzed silk, hydrolyzed elastin, yeast extract, aloe extract, comfrey extract, glaze extract, shiso extract, assembly extract, hamamelis water, hyacinth extract, Hop extract, sage extract, marronnier extract, peach leaf extract, yukinoshita extract, melissa extract, mugwort extract, rosemary extract, rice bran extract, pine extract, prune extract,
There are Yokuinin extract, grapefruit extract, fermented soybean extract, cucumber extract, chlorella extract, arge extract, gardenia extract, cuckoo extract, kiwi extract, grape seed extract, grape leaf extract, wine extract, fennel extract, aloe vera extract and so on. In addition, some of these animal and plant extracts are used as the moisturizer and bamboo extract auxiliary component described above.

  Amino acids include L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-cysteine, L-serine, L-tyrosine, L-proline, pyrrolidone carboxylate, glycine and the like.

  Examples of vitamins include vitamin A, retinol acetate, pyridoxine hydrochloride, pyridoxine dicaprylate, biotin, nicotinic acid, nicotinic acid amide, benzyl nicotinate, riboflavin, calcium pantothenate, D-pantothenyl alcohol, ascorbic acid, ascorbyl palmitate, Examples include L-ascorbyl magnesium phosphate, ergocalciferol, vitamin E, tocopherol acetate and the like.

  Purified water or water is used as a solvent for dissolving or dispersing the base and additives. If necessary, alcohols such as ethanol and isopropanol, or purified water or a mixed solvent obtained by adding these alcohols to water may be used.

  Examples of preservatives include methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isobutyl paraben, phenoxyethanol, bisabolol, hinokitiol, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate, undecylenic acid, pionine, l -Menthol, d-camphor, etc.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, sodium dihydroxydimethoxybenzophenonesulfonate, sodium hydroxymethoxybenzophenonesulfonate, octyl salicylate. and so on.

  The sequestering agent (builder) includes edetic acid, edetate, trisodium ethylenediaminehydroxyethyl triacetate, diethylenetriaminepentaacetic acid, pentasodium diethylenetriaminepentaacetate, ethylenediaminetetrakis (2-hydroxyisopropyl) diolate, hydroxyethanedisulfone Acids, tetrasodium hydroxyethanedisulfonate, phytic acid, and the like.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, octyl gallate, d-δ-tocopherol and the like.

  As mentioned above, although the specific example, such as a compound used as a base and an additive, was given, the combination of these compounds can be freely selected by the relationship with another base and an additive. Moreover, although specific examples, such as a compound, are not enumerated, a pH adjuster, a pigment | dye (pigment), a fragrance | flavor, etc. can be added as an additive in the range which does not impair the active ingredient and effect of a hot water extract of Miso bamboo.

  Although the hot water extract of Soso bamboo contains abundant calcium and magnesium, the iron content is relatively low, so please add a plant extract containing a lot of iron such as pine extract and prune extract when formulating. Can do.

  The external preparation for skin of the present invention can be produced according to a conventional method according to its form, and a hot water extract of Miso bamboo is blended at an appropriate stage of the production process.

  Hereinafter, although the adjustment method and effect of the blood circulation promoter and skin external preparation of this invention are demonstrated as an Example, this invention is not limited to these.

  The hot water extract of Sosetsu bamboo was adjusted. Details will be described below.

  As an apparatus for hot water extraction of Miso bamboo, an iron pan with a depth of 50 cm and a diameter of 1 m was used, and the bottom was heated with a kettle.

  Four years have passed since the bamboo shoots, and the trunk of the Sosetsu bamboo collected from October to December was cut to a length of 50 cm, and it was further vertically divided into a width of 3 to 5 cm. The bamboo pieces vertically split in this way are bundled 20 to 30 pieces, 150 kg of these bamboo pieces are immersed in the above-mentioned pan in 150 kg of water, heated to 95 to 100 ° C., and 3 hours at that temperature. Held for a while. After holding in this way, with the temperature maintained, the bunch of bamboo pieces is pulled up from the pan, the extract left in the pan is naturally cooled to 25 ° C, and then filtered with a finely-exposed cloth. An extract was obtained.

  Using the hot water extract of Miso bamboo obtained in Example 1, the composition (unit: part by mass) shown in Table 1 below was adjusted to produce a skin external preparation gel. The total amount was adjusted to 100 with purified water (component number 9). The preparation procedure was performed by uniformly mixing the components No. 1 to No. 7 and the No. 9 component, adding the No. 8 component thereto, and stirring.

  Next, using the hot water extract of Miso bamboo obtained in Example 1, the composition (unit: part by mass) shown in Table 2 below was adjusted to produce cleansing. The total amount was adjusted to 100 with purified water (component No. 7). The procedure is to add the ingredients of ingredient No. 5 and a part of ingredients of ingredient No. 7 to the mixture of ingredients No. 1-3, 6 and 7 gradually and stir evenly. After that, the component No. 4 was added and stirred.

  Table 3 below summarizes the effects (blood circulation promoting effects, etc.) tested by nine subjects using the skin external preparation gel obtained in Example 2 as a sample. Effects such as stiff shoulders, joint pain, and tendonitis were effective within a few minutes immediately after application, and skin diseases such as spots were effective in making the affected area less noticeable within a few months.

Claims (5)

A blood circulation promoter comprising a hot water extract of Somune bamboo as an active ingredient, wherein the hot water extract of Shoso bamboo is extracted with hot water at 95 to 100 ° C., and the extraction retention time by the hot water is: It is 2 hours 45 minutes to 3 hours 15 minutes, and the hot water extract of Miso bamboo is a hot water extract of adult bamboo taken from October to December, and the hot water extract of Miso bamboo is The blood circulation promoter characterized by being 0.01-50.00 mass parts with respect to the total mass of a blood circulation promoter. The blood circulation promoter according to claim 1, wherein the hot water extract of Miso bamboo is contained in a shaping agent. An arthralgia relieving agent comprising a hot water extract of Miso bamboo as an active ingredient, wherein the hot water extract of Miso bamboo is extracted with hot water at 95 to 100 ° C., and the extraction retention time by the hot water is 2 hours and 45 minutes to 3 hours and 15 minutes, the hot water extract of Miso bamboo is a hot water extract of adult bamboo taken from October to December, and the hot water extract of Miso bamboo is The joint pain relieving agent is 0.01 to 50.00 parts by mass with respect to the total mass of the joint pain alleviating agent. A tendonitis inflammation relieving agent containing a hot water extract of Miso bamboo as an active ingredient, wherein the hot water extract of Miso bamboo is extracted with hot water at 95 to 100 ° C., and the extraction retention time by the hot water is: It is 2 hours 45 minutes to 3 hours 15 minutes, and the hot water extract of Miso bamboo is a hot water extract of adult bamboo taken from October to December, and the hot water extract of Miso bamboo is A tendonitis relieving agent characterized by being 0.01 to 50.00 parts by mass with respect to the total mass of the tendonitis relieving agent. A shoulder stiffening agent comprising a hot water extract of Miso bamboo as an active ingredient, wherein the hot water extract of Miso bamboo is extracted with hot water at 95 to 100 ° C., and the extraction retention time by the hot water is 2 hours and 45 minutes to 3 hours and 15 minutes, the hot water extract of Miso bamboo is a hot water extract of adult bamboo taken from October to December, and the hot water extract of Miso bamboo is The shoulder stiffness reducing agent is 0.01 to 50.00 parts by mass relative to the total mass of the shoulder stiffness reducing agent.