JP2002020245A - Cleaning agent for pore care - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cleaning agent which has a high sebum-removing action and is useful for the maintenance of the hair and the prevention of hair falling. SOLUTION: This cleaning agent for the hair or scalp, characterized by containing a sebum-dissolving agent comprising a compound represented by the general formula (I) (R1, R2, R3 and R4 are each independently H, OH or a 1 to 4C alkyl; X is oxygen atom or methylene group whose hydrogen atom may be replaced with a hydroxyl group as a substituent; R5 is a 1 to 4C alkyl which may have one to four hydroxyl groups, and the compound has two or more hydroxyl groups in the molecule).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cleaning agent, and more particularly to a cleaning agent suitable for a hair cleaning agent such as a shampoo.

[0002]

2. Description of the Related Art The post-war and post-bubble consumer lifestyles have dramatically changed the dietary habits of modern people. To summarize the change, westernization is remarkable, and the intake of fat or animal protein has been drastically increased. With such a change in diet,
The physiology of modern humans has also changed significantly, resulting in new diseases or non-health conditions that do not lead to diseases. Such adverse events on health include a sudden increase in circulatory diseases, an increase in cerebral dysfunction, and occurrence of various adverse events associated with abnormal lipid metabolism.
Among them, rapid increase of circulatory disease and increase of cerebral dysfunction are issues in the field of medicine, but in the field of cosmetics,
The occurrence of inconvenient events associated with abnormal lipid metabolism has become a major issue. Specifically, such problems include problems such as increased makeup collapse and inhibition of hair growth due to increased lipid metabolism. In particular, the problem of hair loss is a serious problem in men, not to mention the explosive hit of minoxidil formulations. Against this background, there has been a demand for the development of a technique for removing excess or deteriorated metabolic lipids from the hair surrounding tissue. Furthermore, in such a site, blood flow in peripheral blood vessels is inhibited,
It is said that such poor blood circulation is also a factor that promotes hair loss. From the viewpoint of hair care, it is considered preferable to expand peripheral blood vessels and improve peripheral blood flow. However, it has never been known that coexistence of such a substance that increases blood flow helps to remove lipids when removing lipids and dirt from the skin.

On the other hand, means for removing lipid metabolized from the human body include washing with an anionic surfactant such as ordinary soap or alkyl sulfate, removal with an oily cream such as a cleansing cream, and removal by adsorption with an adhesive sheet. Although such a technique is already known, there is no known component capable of specifically dissolving and removing sebum, and a usual detergent contains such a sebum-soluble component to further remove sebum. No cleaning agent with enhanced removal action was known. Therefore, it has not been conceived that such a dissolving / removing action can be improved by combining such a component with a component for improving peripheral blood flow.

Many of the compounds represented by the general formula (I) such as dipropylene glycol and isoprene glycol are widely used in the field of cosmetics, but they are known to have a sebum removing effect. The cleaning agent containing such ingredients is excellent in removing sebum in pores and dirt such as aged stratum corneum, and is useful for maintaining healthy hair and skin and preventing hair loss. Was also not known at all.

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide a cleansing agent which enhances sebum removing action and is useful for maintaining healthy hair and skin and preventing hair loss. As an issue.

[0006]

SUMMARY OF THE INVENTION In view of such circumstances, the present inventors have made intensive research efforts to provide a cleansing agent that enhances sebum removing action and is useful for maintaining hair and preventing hair loss. ,
Such properties were found in a group of compounds represented by the following general formula (I). As a result of further study, they have found that combining this with a component that increases peripheral blood flow can enhance such sebum removing action, and have completed the invention. That is, the present invention relates to the following technology. (1) 1) One or two or more selected from compounds represented by the following general formula (I) and 2) One or two or more selected from substances having a peripheral vasodilatory action A cleaning agent, characterized in that: (2) One or two or more compounds selected from the compounds represented by the general formula (I) are dipropylene glycol and / or
Or isoprene glycol,
The cleaning agent according to (1). (3) the substance having a peripheral vasodilatory action is a terpene, a steroid or a glycoside thereof;
The cleaning agent according to (1) or (2). (4) The detergent according to any one of (1) to (3), wherein the terpene and the steroid are menthol, thymol, ursolic acid, oleanolic acid, ecdysone, polyporsterone, estradiol and estriol. (5) The cleaning agent according to any one of (1) to (4), further comprising a hydroxy acid and / or a salt thereof. (6) The cleaning agent according to (5), wherein the hydroxy acid is an α-hydroxy acid. (7) The cleaning agent according to (6), wherein the α-hydroxy acid is lactic acid. (8) The cleaning agent is for hair.
(1) The cleaning agent according to any one of (7) to (7). (9) The cleaning agent according to any one of (1) to (8), which has an action of removing sebum from pores. (10) being a scalp cleansing agent,
(1) The cleaning agent according to any one of (9) to (9). (11) For hair containing one or more selected from the compounds represented by the above general formula (I) and one or two or more selected from terpenes, steroids and glycosides thereof. Washing soap. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0007]

Embedded image General formula (I) (wherein, R1, R2, R3, and R4 each independently represent a hydrogen atom, a hydroxyl group or an alkyl group having 1 to 4 carbon atoms, and X represents an oxygen atom or a hydroxyl group as a substituent and a hydrogen atom. It represents a methylene group which may be substituted, R5 represents an alkyl group having 1 to 4 carbon atoms and having 0 to 4 hydroxyl groups, and having 2 or more hydroxyl groups in one molecule. )

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION (1) A compound represented by the general formula (I) which is an essential component of the present invention is characterized by containing a compound represented by the general formula (I). Examples of such compounds include dipropylene glycol, ethylene glycol glyceryl ether, propylene glycol glyceryl ether, sorbit, isoprene glycol, 1,4-butanediol diethylene glycol, and the like. Among these, dipropylene glycol and isoprene Glycols are particularly preferred. All of these compounds are excellent in dissolving sebum, and have an effect of removing sebum which is clogged in pores and the like and is difficult to remove by shampoo or the like. These compounds are the sebum dissolving agents of the present invention. In the detergent of the present invention, these compounds represented by the general formula (I) may contain only one kind, or may contain two or more kinds in combination. The preferred content of these compounds in the detergent of the present invention is 0.1 to 30% by weight, more preferably 1 to 15% by weight, based on the total amount of the detergent. This differs depending on the dosage form, but if it is too small, it may not be able to exhibit sebum removal action, and if it is too large, the feeling of use may be impaired by stickiness etc., or the flexibility of prescription may be impaired. It is.

(2) An essential component of the cleaning agent of the present invention,
Substance having Peripheral Vasodilatory Effect The detergent of the present invention is characterized by containing a substance having peripheral vasodilatory action as an essential component. Here, the substance that dilates peripheral blood vessels according to the present invention is different from a peripheral vasodilator usually defined in the field of medicine, for example,
It may be such that an increase in blood flow of about 5% is observed in screening using microvessels on the oral mucosa of hamsters. Such components include, for example, menthol (11% increase), thymol (8% increase), sodium ursoleate (7%), sodium oleanolate (6%).
%), Steroids such as estradiol (7% increase), polyporsterone (11% increase), ecdysterone (6% increase), capsaicin (12% increase)
Glucosides such as glycerol monomenthyl ether (8% increase), menthol glucoside (6% increase), ursolic acid glucoside (5% increase), and steroids such as ecdysterone glucoside (5% increase). Preferred examples include glycosides. In addition, crude drug extracts containing these components in high concentrations, for example, mint extract,
Juniper berry extract, eucalyptus extract, capsicum extract, rosemary extract and the like also belong to the substance having a peripheral vasodilatory action referred to in the present invention. In the cleaning agent of the present invention, these components may contain only one kind alone, or may contain two or more kinds in combination. The preferable content of such components in the detergent of the present invention is 0.01 to 5% by weight, more preferably 0.05 to 2% by weight, based on the total amount of the cosmetic.

(3) Hydroxy acid and / or salt thereof preferably contained in the detergent of the present invention It is preferable that the detergent of the present invention contains a hydroxy acid and / or a salt thereof. This is because such components have the effect of softening the skin and making sebum stains easily detach from the skin. Examples of such hydroxy acids include α-hydroxy acids such as lactic acid, glycolic acid and malic acid, β
And β-hydroxy acids such as lactic acid, etc., among which α-hydroxy acids are more preferred, and lactic acid and glycolic acid are particularly preferred. The salts of these hydroxy acids can be used without any particular limitation as long as they are usually used in cosmetics, for example, alkali metal salts such as sodium and potassium, and alkaline earth salts such as calcium and magnesium. Metal salts, ammonium salts,
Preferred examples include organic amine salts such as triethanolamine salt, diethanolamine salt and triethylamine salt, and basic amino acid salts such as lysine salt and arginine salt.
In the cleaning agent of the present invention, these hydroxy acids and / or
Alternatively, the salt thereof may contain only one kind or two or more kinds in combination. The preferred content of these hydroxy acids and / or salts thereof in the detergent of the present invention is 0.01 to 0.01 wt.
-10% by weight, more preferably 0.05-2% by weight.

(4) Cleaning agent of the present invention The cleaning agent of the present invention contains one or two or more compounds selected from the compounds represented by the above general formula (I), and as an optional component, hydroxy acid and And / or a salt thereof is preferably contained. Here, the cleaning agent referred to in the present invention removes components and stains, such as excessively secreted sebum, aged stratum corneum and the like, which are not preferably left on the living body, and complexes thereof. Means cosmetics used for the purpose, for example, head washing such as shampoo, rinse,
Examples include body cleansing agents such as soap and body shampoo, and facial cleansing agents such as facial cleanser and facial soap. Among them, the washing agent of the present invention is particularly preferably used as such a washing agent for the head, because it has an excellent action of removing sebum particularly around the scalp or around the pores of the head.
The cleaning agent of the present invention has the effect that the scalp or the scalp is difficult to remove by using only a surfactant such as a conventional anionic surfactant such as shampoo or a nonionic surfactant as an active ingredient of the cleaning agent. It has the effect of removing sebum near pores. When the cleaning agent of the present invention is used as a head cleaning agent, it can be formulated into a shampoo or the like together with the surfactant, or can be formulated together with a nonionic surfactant as a pre-shampoo cleansing. You can also. Particularly preferred among them is cleansing for pre-shampoo. This is because the components of the cleaning agent of the present invention can significantly increase the cleaning ability of the surfactant contained in the shampoo by removing sebum and oily stains in advance. In order to prepare such a cleansing dosage form for pre-shampoo, the general formula (I) which is an essential component of the detergent of the present invention is used.
And a nonionic surfactant which is well compatible with sebum stains. Preferred examples of such nonionic surfactants include, for example, fatty acid esters of polyglycerin. In this case, the preferable average degree of polymerization of polyglycerin is, for example, 4 to 20, and more preferably, 7 to 15. Further, as the fatty acid residue, a lauric acid residue can be particularly preferably exemplified. The preferred content of these nonionic surfactants is from 0.01 to
20% by weight, more preferably 0.05 to 10% by weight. This is because if the amount is too large, the feeling of use such as stickiness may be impaired, and if the amount is too small, the effect of addition may not be obtained.

[0012] In addition to the above-mentioned components, the cleaning composition of the present invention may contain optional components commonly used in cosmetics as long as the effects of the present invention are not impaired.
Such optional components include, for example, hydrocarbons such as squalane, petrolatum, and microcrystalline wax;
Esters such as jojoba oil, carnauba wax, octyldodecyl oleate, triglycerides such as olive oil, tallow, coconut oil, silicones such as dimethicone, femethicone, and amodimethicone; fatty acids such as stearic acid, oleic acid, and ritinoleic acid; Oleyl alcohol,
Higher alcohols such as stearyl alcohol and octyl dodecanol; anionic surfactants such as sulfosuccinates and sodium polyoxyethylene alkyl sulfate; amphoteric surfactants such as alkyl betaine salts; and cationic surfactants such as dialkyl ammonium salts. Nonionic surfactants such as sorbitan fatty acid esters, fatty acid monoglycerides, polyoxyethylene adducts thereof, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, etc., and general compounds such as polyethylene glycol, glycerin, 1,3-butanediol, etc. Thickening / gelling agents such as polyhydric alcohols not included in the formula (I), xanthan gum, guar gum, carboxyvinyl polymer, cationized cellulose ether, cationized guar gum, antioxidants, purple Linear absorption agents, perfumes, coloring materials, preservatives,
Preferred examples include powders, refreshing ingredients such as pepper tincture and menthol. By treating these components according to a conventional method, the detergent of the present invention can be produced. Of course, it can also be formulated into a body wash or face wash together with the above optional components.
Since it can remove excess secretory sebum in the skin, it belongs to the technical scope of the present invention.

[0013]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited only to these Examples.

Example 1 Cleansing 1 for pre-shampoo, which is a cleaning agent of the present invention, was prepared according to the following formulation. That is, the prescription component was heated and stirred at 70 ° C. to solubilize, and then stirred and cooled to obtain cleansing 1 for pre-shampoo. Separately, Comparative Example 1 in which all of the dipropylene glycol was replaced with 1,3-butanediol,
Comparative Example 2 in which L-menthol and capsicum tincture were replaced by water and Comparative Example 3 in which dipropylene glycol was replaced by 1,3-butanediol and L-menthol and capsicum tincture by water were also prepared. Using these,
A study was conducted to remove lipids from the oily human scalp. That is, half of the head was sprinkled with 5 ml of the cleansing 1 of the present invention, massaged well, and then washed away. Similarly, the other half of the head was processed in Comparative Example 1, and photographs after these processing were taken with a video microscope. FIG. 1 shows a photograph of a part treated by cleansing 1. FIG. 2 shows a photograph of the part treated in Comparative Example 1, FIG. 3 shows a photograph after treatment in Comparative Example 2, and FIG. 4 shows a photograph after treatment in Comparative Example 3. Comparison of these shows that the treatment with the cleansing agent of the present invention, Cleansing 1, significantly removes lipid stains. It can also be seen that this is due to a synergistic effect between the compound represented by the general formula (I), which is an essential component of the present invention, and L-menthol, which is a substance having a peripheral vasodilatory effect. Dipropylene glycol 15 parts by weight Ethanol 15 parts by weight Carboxyvinyl polymer 0.5 parts by weight 10% aqueous solution of potassium hydroxide 2 parts by weight Silicone emulsion 3 parts by weight L-menthol 1 part by weight Xanthan gum 0.1 part by weight Sodium lactate 0.1 part by weight Deca Glycerin laurate 10 parts by weight Pepper tincture 1 part by weight Water 52.3 parts by weight

<Example 2> Remaining sebum soil when shampooed by pretreatment with cleansing 1 of Example 1 using a shampoo having the following formulation, and when shampooed without pretreatment. Was observed. Half of the head of the oily panelist was pre-treated with cleansing 1, and the other half was not pre-treated, but was continuously washed with the following shampoo and observed with a video macroscope. FIG. 5 shows a photograph of a shampoo after the pretreatment, and FIG. 6 shows a photograph of the hair washed without the pretreatment. From this, the cleansing lipid removing effect for the pre-shampoo of the present invention is understood. (Shampoo formulation) Polyoxyethylene sodium lauryl sulfate 10 parts by weight Polyoxyethylene coconut oil fatty acid monoethanolamide 5 parts by weight Sodium lauryl sulfate 2 parts by weight 1,3-butanediol 10 parts by weight Water 73 parts by weight

Example 3 Cleansing 2 for pre-shampoo, which is a cleaning agent of the present invention, was prepared according to the following formulation. That is, the ingredients were heated and stirred at 70 ° C. to solubilize them, and then stirred and cooled to obtain cleansing 2 for pre-shampoo. The processed photograph was taken with a video microscope in the same manner as in Example 1. This had the same lipid removing effect as in Example 1. Isoprene glycol 15 parts by weight Ethanol 15 parts by weight Carboxyvinyl polymer 0.5 parts by weight 10% aqueous solution of potassium hydroxide 2 parts by weight Silicone emulsion 3 parts by weight L-menthol 1 part by weight Xanthan gum 0.1 part by weight Sodium lactate 0.1 part by weight Decaglycerin Lauric ester 10 parts by weight Pepper tincture 1 part by weight Water 52.3 parts by weight

Example 3 Cleansing 3 for pre-shampoo, which is a cleaning agent of the present invention, was prepared according to the following formulation. That is, the prescription component was heated and stirred at 70 ° C. to solubilize, and then stirred and cooled to obtain cleansing 3 for pre-shampoo. The processed photograph was taken with a video microscope in the same manner as in Example 1. This had the same lipid removing effect as in Example 1. Sorbit 15 parts by weight Ethanol 15 parts by weight Carboxyvinyl polymer 0.5 part by weight 10% aqueous solution of potassium hydroxide 2 parts by weight Silicone emulsion 3 parts by weight L-menthol 1 part by weight Xanthan gum 0.1 part by weight Potassium glycolate 0.1 part by weight Decaglycerin Lauric ester 10 parts by weight Pepper tincture 1 part by weight Water 52.3 parts by weight

<Example 4> Shampoo 1, a cleaning agent of the present invention, was prepared according to the following formulation. That is,
The prescription component was heated and stirred at 70 ° C. to solubilize, and then stirred and cooled to obtain shampoo 1. The photograph was taken with a video microscope after washing the hair. This product was superior to the conventional shampoo in removing lipids, but was inferior to that of shampooed after pre-shampooing. Further, Comparative Example 4 in which sodium lactate was replaced with water was further inferior in lipid-removing action to this, and the effect of adding hydroxy acid was confirmed. Isoprene glycol 5 parts by weight Sodium lactate 0.5 parts by weight Polyoxyethylene sodium lauryl sulfate 10 parts by weight Polyoxyethylene coconut oil fatty acid monoethanolamide 5 parts by weight Sodium lauryl sulfate 2 parts by weight 1,3-butanediol 5 parts by weight Eucalyptus extract 0.1 parts by weight Water 72.4 parts by weight

[0019]

According to the present invention, the sebum removing action is enhanced,
It is possible to provide a cleaning agent that is useful for maintaining hair and preventing hair loss.

[Brief description of the drawings]

FIG. 1 is a diagram showing a result of processing by cleansing 1 of Example 1. (Drawing substitute photo)

FIG. 2 is a diagram showing a result of processing in Comparative Example 1 of Example 1. (Drawing substitute photo)

FIG. 3 is a diagram showing a result of processing in Comparative Example 2 of Example 1. (Drawing substitute photo)

FIG. 4 is a diagram showing a result of processing in Comparative Example 3 of Example 1. (Drawing substitute photo)

FIG. 5 shows the results of shampooing after pretreatment in Example 2. (Drawing substitute photo)

FIG. 6 shows the results of shampooing without pretreatment in Example 2. (Drawing substitute photo)

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) C11D 3/37 C11D 3/37 7/26 7/26 F term (Reference) 4C083 AA112 AB032 AC102 AC111 AC112 AC122 AC132 AC301 AC302 AC402 AC422 AC542 AC782 AD092 AD111 AD112 AD152 AD352 AD391 AD491 AD531 AD532 BB60 CC23 CC38 CC39 4H003 AC03 DA02 DB01 EA21 EB04 EB06 EB07 EB08 EB30 EB37 EB41 EB43 EB46 ED02 FA21 FA33

Claims (11)

[Claims] 1) One or two or more compounds selected from the compounds represented by the following general formula (I) and 2) one or two or more compounds selected from substances having a peripheral vasodilatory action. A cleaning agent characterized by containing. Embedded image General formula (I) (wherein, R1, R2, R3, and R4 each independently represent a hydrogen atom, a hydroxyl group or an alkyl group having 1 to 4 carbon atoms, and X represents an oxygen atom or a hydroxyl group as a substituent and a hydrogen atom. It represents a methylene group which may be substituted, R5 represents an alkyl group having 1 to 4 carbon atoms and having 0 to 4 hydroxyl groups, and having 2 or more hydroxyl groups in one molecule. ) 2. The method according to claim 1, wherein one or more kinds selected from the compounds represented by the general formula (I) are dipropylene glycol and / or isoprene glycol. Washing soap. 3. The detergent according to claim 1, wherein the substance having a peripheral vasodilatory action is a terpene, a steroid, or a glycoside thereof. 4. The method of claim 1, wherein the terpene and the steroid are menthol,
The cleaning agent according to any one of claims 1 to 3, which is thymol, ursolic acid, oleanolic acid, ecdysone, polycarbonate, estradiol, and estriol. 5. The cleaning agent according to claim 1, further comprising a hydroxy acid and / or a salt thereof. 6. The cleaning agent according to claim 5, wherein the hydroxy acid is an α-hydroxy acid. 7. The cleaning agent according to claim 6, wherein the α-hydroxy acid is lactic acid. 8. The cleaning agent according to claim 1, wherein the cleaning agent is for hair. 9. The cleaning agent according to claim 1, which has an action of removing sebum from pores. 10. The cleaning agent according to claim 1, which is a scalp cleansing agent. 11. A hair containing one or more selected from the compounds represented by the above general formula (I) and one or two or more selected from terpenes, steroids and glycosides thereof. Cleaning agent.