KR102504849B1 - 치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법 - Google Patents

치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법 Download PDF

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KR102504849B1
KR102504849B1 KR1020177010551A KR20177010551A KR102504849B1 KR 102504849 B1 KR102504849 B1 KR 102504849B1 KR 1020177010551 A KR1020177010551 A KR 1020177010551A KR 20177010551 A KR20177010551 A KR 20177010551A KR 102504849 B1 KR102504849 B1 KR 102504849B1
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amino
substituted
compound
pyran
unsubstituted
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KR20170063740A (ko
Inventor
매튜 알렉산더
소고르 바만야
존 프레드레릭 보이랜
조슈아 한센
더화 황
로버트 허바드
브랜돈 제피
짐 레이스텐
메흐란 모가담
라즈 케이. 라헤자
헤더 레이몬
킴버리 슈바르츠
마리안느 슬로스
에두아르도 토레스
탐 민 트란
슈이찬 슈
징징 자오
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시그날 파마소티칼 엘엘씨
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Priority to KR1020237006598A priority Critical patent/KR20230035424A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177010551A 2014-10-06 2015-10-05 치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법 Active KR102504849B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237006598A KR20230035424A (ko) 2014-10-06 2015-10-05 치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060339P 2014-10-06 2014-10-06
US62/060,339 2014-10-06
PCT/US2015/053941 WO2016057370A1 (en) 2014-10-06 2015-10-05 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

Related Child Applications (1)

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KR1020237006598A Division KR20230035424A (ko) 2014-10-06 2015-10-05 치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법

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KR20170063740A KR20170063740A (ko) 2017-06-08
KR102504849B1 true KR102504849B1 (ko) 2023-03-02

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KR1020237006598A Withdrawn KR20230035424A (ko) 2014-10-06 2015-10-05 치환된 아미노퓨린 화합물, 그의 조성물 및 그를 사용한 치료 방법

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CN (2) CN113248506A (enExample)
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PT (1) PT3204386T (enExample)
RS (1) RS61884B1 (enExample)
SG (2) SG10202009598VA (enExample)
SI (1) SI3204386T1 (enExample)
SM (1) SMT202100302T1 (enExample)
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EA032315B1 (ru) 2015-03-18 2019-05-31 Бристол-Маерс Сквибб Компани Замещенные трициклические гетероциклические соединения
ES2797685T3 (es) 2015-03-18 2020-12-03 Bristol Myers Squibb Co Compuestos heterocíclicos tricíclicos útiles como inhibidores de TNF
KR102696304B1 (ko) 2015-03-18 2024-08-16 브리스톨-마이어스 스큅 컴퍼니 Tnf의 억제제로서 유용한 헤테로시클릭 화합물
CN107922287B (zh) 2015-07-24 2021-04-09 细胞基因公司 合成(1r,2r,5r)-5-氨基-2-甲基环己醇盐酸盐的方法和其中可用的中间体
CN108137609B (zh) 2015-08-03 2021-07-16 百时美施贵宝公司 用作TNFα的调节剂的环状化合物
CN109069512B (zh) * 2016-04-01 2022-06-14 西格诺药品有限公司 取代的氨基嘌呤化合物、其组合物以及相关治疗方法
PT3436019T (pt) * 2016-04-01 2021-11-04 Signal Pharm Llc (1s,4s)-4-(2-(((3s,4r)-3-fluorotetra-hidro-2h-piran-4- il)amino)-8-((2,4,6-triclorofenil)amino)-9h-purin-9-il)-1- metilciclo-hexano-1-carboxamida e métodos de utilização dos mesmos
WO2017210399A1 (en) * 2016-06-02 2017-12-07 Celgene Corporation Animal and human anti-malarial agents
CN109476696B (zh) * 2016-06-02 2022-06-10 细胞基因公司 动物及人抗锥虫和抗利什曼原虫剂
CN111432841A (zh) 2017-10-04 2020-07-17 细胞基因公司 顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的组合物和使用方法
US10590136B2 (en) 2017-10-04 2020-03-17 Celgene Corporation Processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide
TW202202498A (zh) * 2020-07-01 2022-01-16 大陸商四川海思科製藥有限公司 一種並環雜環衍生物及其在醫藥上的應用
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
CN114478326B (zh) * 2022-01-21 2023-10-03 安徽宁亿泰科技有限公司 一种苯嘧磺草胺关键中间体的合成方法

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CY1124173T1 (el) 2022-05-27
US20170296546A1 (en) 2017-10-19
ES2871142T3 (es) 2021-10-28
CA2963639C (en) 2023-07-04
AR102171A1 (es) 2017-02-08
CN107001372A (zh) 2017-08-01
US20160096841A1 (en) 2016-04-07
MX388321B (es) 2025-03-19
JP2020033352A (ja) 2020-03-05
IL251566A0 (en) 2017-05-29
SG10202009598VA (en) 2020-10-29
US10646493B2 (en) 2020-05-12
EP3204386A4 (en) 2018-04-18
EA201790779A1 (ru) 2017-09-29
SMT202100302T1 (it) 2021-07-12
JP2023027269A (ja) 2023-03-01
US20170042902A1 (en) 2017-02-16
RS61884B1 (sr) 2021-06-30
AU2020201486A1 (en) 2020-03-19
IL277069B (en) 2022-05-01
DK3204386T3 (da) 2021-05-25
US20190336507A1 (en) 2019-11-07
EP3822274B1 (en) 2024-03-06
PT3204386T (pt) 2021-05-31
CO2017003838A2 (es) 2017-07-11
JP6987823B2 (ja) 2022-01-05
LT3204386T (lt) 2021-07-12
NZ730753A (en) 2024-02-23
CA2963639A1 (en) 2016-04-14
ES2980464T3 (es) 2024-10-01
US11590139B2 (en) 2023-02-28
JP7196270B2 (ja) 2022-12-26
ECSP17026210A (es) 2017-05-31
US10398700B2 (en) 2019-09-03
WO2016057370A1 (en) 2016-04-14
US20190091230A1 (en) 2019-03-28
EP3204386B1 (en) 2021-03-03
PL3204386T3 (pl) 2021-09-20
US20230158035A1 (en) 2023-05-25
EP3204386A1 (en) 2017-08-16
US9737541B2 (en) 2017-08-22
NZ767954A (en) 2024-02-23
MX2017004600A (es) 2017-06-30
SG11201702759XA (en) 2017-05-30
AU2015328414A1 (en) 2017-04-27
AR128748A2 (es) 2024-06-12
TW201629063A (zh) 2016-08-16
US20210128565A1 (en) 2021-05-06
HUE054694T2 (hu) 2021-09-28
US10940152B2 (en) 2021-03-09
JP2017530199A (ja) 2017-10-12
KR20230035424A (ko) 2023-03-13
CN113248506A (zh) 2021-08-13
IL251566B (en) 2020-09-30
CN107001372B (zh) 2021-04-27
CL2017000820A1 (es) 2017-12-15
BR112017006998A2 (pt) 2018-01-16
IL277069A (en) 2020-10-29
JP6884701B2 (ja) 2021-06-09
US20200237768A1 (en) 2020-07-30
AU2015328414B2 (en) 2020-03-19
AU2020201486B2 (en) 2021-07-08
HRP20210656T1 (hr) 2021-07-23
JP2022033858A (ja) 2022-03-02
SI3204386T1 (sl) 2021-08-31
US9512124B2 (en) 2016-12-06
MX2021014531A (es) 2022-01-06
EP3822274A1 (en) 2021-05-19
US10149849B2 (en) 2018-12-11
KR20170063740A (ko) 2017-06-08

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