KR102504316B1 - 폭스바이러스 벡터를 이용하여 증강된 면역 반응을 유도하기 위한 조성물 및 방법 - Google Patents

폭스바이러스 벡터를 이용하여 증강된 면역 반응을 유도하기 위한 조성물 및 방법 Download PDF

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KR102504316B1
KR102504316B1 KR1020167013453A KR20167013453A KR102504316B1 KR 102504316 B1 KR102504316 B1 KR 102504316B1 KR 1020167013453 A KR1020167013453 A KR 1020167013453A KR 20167013453 A KR20167013453 A KR 20167013453A KR 102504316 B1 KR102504316 B1 KR 102504316B1
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위르겐 하우즈만
미하엘 볼퍼슈테터
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버베리안 노딕 에이/에스
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KR1020167013453A 2013-11-28 2014-11-25 폭스바이러스 벡터를 이용하여 증강된 면역 반응을 유도하기 위한 조성물 및 방법 Active KR102504316B1 (ko)

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Application Number Priority Date Filing Date Title
EP13005541.1 2013-11-28
EP13005541 2013-11-28
PCT/EP2014/075522 WO2015078856A1 (en) 2013-11-28 2014-11-25 Compositions and methods vectors for inducing an enhanced immune response using poxvirus vectors

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KR20160087814A KR20160087814A (ko) 2016-07-22
KR102504316B1 true KR102504316B1 (ko) 2023-02-24

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US (2) US20160376596A1 (https=)
EP (2) EP3971298A3 (https=)
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CN111050790B (zh) * 2017-08-24 2024-07-12 巴法里安诺迪克有限公司 通过静脉内施用重组mva和抗体治疗癌症的组合疗法
KR20210031485A (ko) 2018-07-13 2021-03-19 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 Tnf를 발현하는 점액종 바이러스로 암을 치료하는 방법
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
TW202122411A (zh) 2019-09-02 2021-06-16 美國亞利桑那州立大學亞利桑那州評議委員會 以黏液瘤(myxoma)病毒治療癌症之新穎溶瘤病毒平臺
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
EP3957322A1 (en) * 2020-08-19 2022-02-23 Eberhard Karls Universität Tübingen Medizinische Fakultät Recombinant poxviridae vector expressing co-stimulatory molecules
CN117999090A (zh) * 2021-05-13 2024-05-07 托马斯杰弗逊大学 鼠痘病毒用于癌症免疫治疗和疫苗的用途
CN115043948B (zh) * 2022-06-24 2024-05-28 青岛硕景生物科技有限公司 一种猴痘病毒特异性融合蛋白抗原及其制备方法和应用
GB202407035D0 (en) * 2024-05-17 2024-07-03 Uncommon Bio Ltd RNA constructs with immune blocking agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050281782A1 (en) * 2004-06-21 2005-12-22 Howard Kaufman Novel recombinant poxvirus composition and uses thereof
US20060073594A1 (en) * 2004-10-05 2006-04-06 Jiansheng Yao Chimeric vectors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5519239A (en) * 1978-07-28 1980-02-09 Green Cross Corp:The Interferon-producing attractant
CA1341245C (en) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
EP1167379A3 (en) 1994-07-15 2004-09-08 University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6969609B1 (en) 1998-12-09 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Serivces Recombinant vector expressing multiple costimulatory molecules and uses thereof
DK1137792T3 (da) * 1998-12-09 2007-09-10 Us Gov Health & Human Serv En rekombinant vektor, der udtrykker adskillige costimulatoriske molekyler, og anvendelser deraf
DE60038011T2 (de) * 1999-04-08 2009-02-12 Novartis Vaccines and Diagnostics, Inc., Emeryville Verbesserung der immunantwort als anwendung in impfstoff und gentherapie
KR20070118315A (ko) * 1999-04-21 2007-12-14 와이어쓰 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물
UA76731C2 (uk) 2000-11-23 2006-09-15 Баваріан Нордік А/С Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації
EP2345665A3 (en) 2001-12-04 2012-02-15 Bavarian Nordic A/S Flavivirus NS1 subunit vaccine
AU2003249059A1 (en) * 2002-07-24 2004-02-09 Arizona Board Of Regents Use of vaccinia virus deleted for the e3l gene as a vaccine vector
EP2316942B1 (en) * 2004-12-22 2021-04-21 Alnylam Pharmaceuticals, Inc. Conserved hbv and hcv sequences useful for gene silencing
EP2042604A1 (en) * 2007-09-26 2009-04-01 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) VV promoter driven overexpression of recombinant antigens
CA2786333C (en) 2010-01-28 2018-03-20 Bavarian Nordic A/S Vaccinia virus mutants containing the major genomic deletions of mva

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050281782A1 (en) * 2004-06-21 2005-12-22 Howard Kaufman Novel recombinant poxvirus composition and uses thereof
US20060073594A1 (en) * 2004-10-05 2006-04-06 Jiansheng Yao Chimeric vectors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF BIOTECHNOLOGY. 1996, vol. 44, no. 1, pages 97-103.*
TRICOM Vector Based Cancer Vaccines, CURRENT PHARMACEUTICAL DESIGN. 2006, vol. 12, no. 3, pages 351-361.*

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EA201691120A1 (ru) 2016-09-30
JP6641276B2 (ja) 2020-02-05
IL245509A0 (en) 2016-06-30
CA2929600A1 (en) 2015-06-04
US20200325477A1 (en) 2020-10-15
CY1124707T1 (el) 2022-07-22
JP2020072693A (ja) 2020-05-14
DK3074517T3 (da) 2021-11-08
BR112016011866A2 (pt) 2017-09-26
JP7050044B2 (ja) 2022-04-07
IL245509B (en) 2020-09-30
AU2024202790A1 (en) 2024-07-04
CN105829537A (zh) 2016-08-03
AU2021200985A1 (en) 2021-03-11
ES2895977T3 (es) 2022-02-23
SI3074517T1 (sl) 2021-12-31
JP2017503479A (ja) 2017-02-02
EP3074517B1 (en) 2021-08-11
UA127337C2 (uk) 2023-07-26
WO2015078856A1 (en) 2015-06-04
KR20160087814A (ko) 2016-07-22
ZA201603187B (en) 2023-12-20
PT3074517T (pt) 2021-11-03
AU2021200985B2 (en) 2024-02-01
MY188100A (en) 2021-11-18
EA039037B1 (ru) 2021-11-24
EP3074517A1 (en) 2016-10-05
HUE056105T2 (hu) 2022-01-28
NZ759538A (en) 2022-10-28
EP3971298A2 (en) 2022-03-23
NZ719934A (en) 2022-10-28
EP3971298A3 (en) 2022-04-27
MX2016006758A (es) 2016-09-06
MX377258B (es) 2025-03-07
US20160376596A1 (en) 2016-12-29
AU2014356546A1 (en) 2016-06-02
CN105829537B (zh) 2020-09-22
LT3074517T (lt) 2021-11-25

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